LOCUS BC067262 2907 bp mRNA linear HUM 30-MAR-2004
DEFINITION Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA
(cDNA clone MGC:74807 IMAGE:6502165), complete cds.
ACCESSION BC067262
VERSION BC067262.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2907)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2907)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (12-MAR-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 141 Row: i Column: 17
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 15011971.
FEATURES Location/Qualifiers
source 1..2907
/db_xref="H-InvDB:HIT000262507"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:74807 IMAGE:6502165"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_71"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2907
/gene="ARHGEF1"
/gene_synonym="GEF1"
/gene_synonym="LBCL2"
/gene_synonym="P115-RHOGEF"
/gene_synonym="SUB1.5"
/db_xref="GeneID:9138"
/db_xref="MIM:601855"
CDS 8..2854
/gene="ARHGEF1"
/gene_synonym="GEF1"
/gene_synonym="LBCL2"
/gene_synonym="P115-RHOGEF"
/gene_synonym="SUB1.5"
/codon_start=1
/product="ARHGEF1 protein"
/protein_id="AAH67262.1"
/db_xref="GeneID:9138"
/db_xref="MIM:601855"
/translation="MASLSTWSSPAEPREMEDFARGAASPGPSRPGLVPVSIIGAEDE
DFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLVLRVPVPPNVAF
ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAW
VGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG
DKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAE
KPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQ
GPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSL
PKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELI
EVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL
KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE
REKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLD
ITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDG
KTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITET
AGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCR
PGPEGQLAATALRKGVGGGILPPETPPVSAWGELCPPAWLHLRFPPRKAFCKKERNGG
EDVRDHPHPHSCRSISHPEGLRRGSCGPRLGGAQLGLLAPHEPRPSLPPALCLGDSGL
HSGGHHGDPGHLSIACGGHPSTPTPKCLRSVFIP"
misc_feature 1211..1765
/gene="ARHGEF1"
/gene_synonym="GEF1"
/gene_synonym="LBCL2"
/gene_synonym="P115-RHOGEF"
/gene_synonym="SUB1.5"
/note="RhoGEF; Region: Guanine nucleotide exchange factor
for Rho/Rac/Cdc42-like GTPases"
/db_xref="CDD:smart00325"
BASE COUNT 596 a 910 c 919 g 482 t
ORIGIN
1 ggcggcgatg gcttctcttt ccacctggag cagccctgca gagcccaggg agatggaaga
61 cttcgcccga ggggcggcct ccccaggccc ctcccggcct ggcctggttc ccgtcagcat
121 catcggggct gaggatgagg attttgagaa cgagctggag acaaactcag aagagcaaaa
181 cagccagttc cagagcctgg agcaggtgaa gcggcgccca gcccacctca tggccctcct
241 gcagcacgtg gccctgcagt ttgagccagg acccctggtt ctccgggtgc cggtccctcc
301 caacgtcgcc tttgaacttg accgcactag ggctgacctc atctccgagg atgtccagcg
361 gcggttcgtg caggaggtgg tgcaaagcca gcaggtagcc gtgggccggc agctggagga
421 cttccgttcc aagcggctca tgggcatgac gccctgggag caggagctgg cccagctgga
481 ggcttgggtt gggcgggacc gagccagcta cgaggcccgg gagcggcacg tggcggagcg
541 gctgctcatg cacctggagg agatgcaaca taccatctct accgacgaag aaaagagtgc
601 tgccgtggtc aacgccattg gcctgtacat gcgccacctt ggggtgcgga ccaagagtgg
661 agacaagaag tcggggagga acttcttccg gaaaaaggtg atggggaacc ggcggtcgga
721 cgagcctgcc aagaccaaga aggggctgag cagcatcctg gatgccgccc gctggaaccg
781 gggagagccc caggttccag attttcgaca cctcaaagca gaggttgatg ccgagaagcc
841 aggtgctaca gaccggaagg gaggcgtggg gatgccctct cgggaccgga atatcggggc
901 tcctgggcag gacacccctg gagtctctct gcaccctctg tccctggaca gcccagaccg
961 ggaaccaggt gctgacgccc ccctggagct gggggactca tccccgcagg gcccaatgag
1021 cctggagtcc ttggcgcccc cagagagtac cgacgagggg gccgaaaccg agagccccga
1081 gcctggagat gagggggagc cggggcggtc gggactggag cttgaaccag aagagcctcc
1141 cggctggcgg gaactcgtcc ccccagacac cctgcacagc ctgcccaaga gccaggtgaa
1201 gcggcaggag gtcatcagcg agctgctggt gacagaggcg gcccacgtgc gcatgctgcg
1261 ggtgctgcac gacctcttct tccagcccat ggcagaatgc ctgttcttcc ccttggagga
1321 gctgcagaac atcttcccca gcctggacga gctcatcgag gtgcattccc tgttcctcga
1381 tcgcctgatg aagcggaggc aggagagtgg ctacctcatc gaggagatcg gagacgtgct
1441 gctggcccgg tttgatggtg ctgagggctc ctggttccag aaaatctcct cccgcttctg
1501 cagccgccag tcatttgcct tagagcagct caaagccaag caacgcaagg accctcggtt
1561 ctgtgccttc gtgcaggaag ctgagagccg cccgcggtgc cgccgcctgc agctgaagga
1621 catgatcccc acggagatgc agcggctgac caagtacccc ctgctcctgc agagcatcgg
1681 gcagaacaca gaagagccca cagaacggga gaaagtggag ctggcagccg agtgctgccg
1741 ggaaattcta caccacgtca accaagccgt gcgtgacatg gaggacctgc tgaggctcaa
1801 ggactatcag cggcgcctgg acttgtccca ccttcggcag agcagcgacc ctatgctgag
1861 cgagttcaag aacctggaca tcaccaagaa gaaattggtc cacgagggcc cactgacgtg
1921 gcgggtgact aaggacaagg cagtggaggt gcatgtgctg ctgctggacg acctgctgct
1981 gctgctccag cgccaggacg agcggctgct gctcaagtcc catagccgga cactgacgcc
2041 cacgcccgat ggcaagacca tgctgcggcc cgtgctgcgg ctcacctccg ccatgacccg
2101 cgaggtggcc accgatcaca aagccttcta cgtccttttt acctgggacc aggaggccca
2161 gatatacgag ctggtggcac agactgtgtc ggagcggaaa aactggtgtg ctctcatcac
2221 tgagactgcc ggatccctga aagtccctgc ccctgcctct cgccctaagc cccggcccag
2281 cccgagcagc acccgagaac ccctcctcag cagctctgag aacggcaatg gtggccgaga
2341 gacgtctcca gctgatgccc ggaccgagag aatcctcagt gacctcctgc ccttctgcag
2401 accaggcccc gagggccagc tcgctgccac ggcccttcgg aaaggagttg gaggaggaat
2461 tttgccgcct gagacccctc ctgtctcagc ttggggggaa ctctgtcccc cagcctggct
2521 gcacttgagg ttcccgccca ggaaggcctt ttgcaagaag gagaggaatg ggggagagga
2581 cgtgagggac cacccccacc cacacagctg ccgcagcatc tcacaccccg agggcctgag
2641 gagagggagc tgtgggccac gcctgggagg ggcccagctg gggttactgg ccccgcatga
2701 gcctcggcca tctctccctc ctgccctctg cttgggggac tcagggctcc attctggagg
2761 gcaccacggt gacccgggcc atctcagtat tgcctgtggg ggccacccct ccacccccac
2821 ccccaagtgc cttcgctctg tttttatacc ctgaattgga ggtttatttt ttaatatata
2881 ttatctaaga agaaaaaaaa aaaaaaa
//