LOCUS X01394 1643 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for tumor necrosis factor. ACCESSION X01394 VERSION X01394.1 KEYWORDS tumor necrosis factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1643) AUTHORS Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R., Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V. TITLE Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin JOURNAL Nature 312(5996), 724-729(1984). PUBMED 6392892 REFERENCE 2 AUTHORS Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B. TITLE Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor JOURNAL Nature 313(6005), 803-806(1985). PUBMED 3883195 COMMENT In the genomic sequence from ref [2] the mature protein starts with Ser (position 387 in this cDNA sequence). FEATURES Location/Qualifiers source 1..1643 /db_xref="H-InvDB:HIT000320894_10" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 153..854 /note="TNF precursor" /db_xref="GOA:P01375" /db_xref="H-InvDB:HIT000320894_04.4" /db_xref="HGNC:HGNC:11892" /db_xref="InterPro:IPR002959" /db_xref="InterPro:IPR006052" /db_xref="InterPro:IPR006053" /db_xref="InterPro:IPR008983" /db_xref="InterPro:IPR021184" /db_xref="PDB:1A8M" /db_xref="PDB:1TNF" /db_xref="PDB:2AZ5" /db_xref="PDB:2E7A" /db_xref="PDB:2TUN" /db_xref="PDB:2ZJC" /db_xref="PDB:2ZPX" /db_xref="PDB:3ALQ" /db_xref="PDB:3IT8" /db_xref="PDB:3L9J" /db_xref="PDB:3WD5" /db_xref="PDB:4G3Y" /db_xref="PDB:4TSV" /db_xref="PDB:4TWT" /db_xref="PDB:4Y6O" /db_xref="PDB:5M2I" /db_xref="PDB:5M2J" /db_xref="PDB:5M2M" /db_xref="PDB:5MU8" /db_xref="PDB:5TSW" /db_xref="PDB:5UUI" /db_xref="PDB:5WUX" /db_xref="PDB:5YOY" /db_xref="UniProtKB/Swiss-Prot:P01375" /protein_id="CAA25650.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" sig_peptide 153..380 /note="put. signal peptide (aa -76 to -1)" mat_peptide 381..851 /note="mature TNF (aa 1-157)" misc_feature 1630..1635 /note="put. polyadenylation signal" BASE COUNT 370 a 495 c 398 g 380 t ORIGIN 1 gcagaggacc agctaagagg gagagaagca actacagacc ccccctgaaa acaaccctca 61 gacgccacat cccctgacaa gctgccaggc aggttctctt cctctcacat actgacccac 121 ggctccaccc tctctcccct ggaaaggaca ccatgagcac tgaaagcatg atccgggacg 181 tggagctggc cgaggaggcg ctccccaaga agacaggggg gccccagggc tccaggcggt 241 gcttgttcct cagcctcttc tccttcctga tcgtggcagg cgccaccacg ctcttctgcc 301 tgctgcactt tggagtgatc ggcccccaga gggaagagtt ccccagggac ctctctctaa 361 tcagccctct ggcccaggca gtcagatcat cttctcgaac cccgagtgac aagcctgtag 421 cccatgttgt agcaaaccct caagctgagg ggcagctcca gtggctgaac cgccgggcca 481 atgccctcct ggccaatggc gtggagctga gagataacca gctggtggtg ccatcagagg 541 gcctgtacct catctactcc caggtcctct tcaagggcca aggctgcccc tccacccatg 601 tgctcctcac ccacaccatc agccgcatcg ccgtctccta ccagaccaag gtcaacctcc 661 tctctgccat caagagcccc tgccagaggg agaccccaga gggggctgag gccaagccct 721 ggtatgagcc catctatctg ggaggggtct tccagctgga gaagggtgac cgactcagcg 781 ctgagatcaa tcggcccgac tatctcgact ttgccgagtc tgggcaggtc tactttggga 841 tcattgccct gtgaggagga cgaacatcca accttcccaa acgcctcccc tgccccaatc 901 cctttattac cccctccttc agacaccctc aacctcttct ggctcaaaaa gagaattggg 961 ggcttagggt cggaacccaa gcttagaact ttaagcaaca agaccaccac ttcgaaacct 1021 gggattcagg aatgtgtggc ctgcacagtg aattgctggc aaccactaag aattcaaact 1081 ggggcctcca gaactcactg gggcctacag ctttgatccc tgacatctgg aatctggaga 1141 ccagggagcc tttggttctg gccagaatgc tgcaggactt gagaagacct cacctagaaa 1201 ttgacacaag tggaccttag gccttcctct ctccagatgt ttccagactt ccttgagaca 1261 cggagcccag ccctccccat ggagccagct ccctctattt atgtttgcac ttgtgattat 1321 ttattattta tttattattt atttatttac agatgaatgt atttatttgg gagaccgggg 1381 tatcctgggg gacccaatgt aggagctgcc ttggctcaga catgttttcc gtgaaaacgg 1441 agctgaacaa taggctgttc ccatgtagcc ccctggcctc tgtgccttct tttgattatg 1501 ttttttaaaa tatttatctg attaagttgt ctaaacaatg ctgatttggt gaccaactgt 1561 cactcattgc tgagcctctg ctccccaggg gagttgtgtc tgtaatcgcc ctactattca 1621 gtggcgagaa ataaagtttg ctt //