LOCUS       X01394                  1643 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for tumor necrosis factor.
ACCESSION   X01394
VERSION     X01394.1
KEYWORDS    tumor necrosis factor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R.,
            Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V.
  TITLE     Human tumour necrosis factor: precursor structure, expression and
            homology to lymphotoxin
  JOURNAL   Nature 312(5996), 724-729(1984).
   PUBMED   6392892
REFERENCE   2
  AUTHORS   Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B.
  TITLE     Cloning and expression in Escherichia coli of the gene for human
            tumour necrosis factor
  JOURNAL   Nature 313(6005), 803-806(1985).
   PUBMED   3883195
COMMENT     In the genomic sequence from ref [2] the mature protein starts
            with Ser (position 387 in this cDNA sequence).
FEATURES             Location/Qualifiers
     source          1..1643
                     /db_xref="H-InvDB:HIT000320894_10"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             153..854
                     /note="TNF precursor"
                     /db_xref="GOA:P01375"
                     /db_xref="H-InvDB:HIT000320894_04.4"
                     /db_xref="HGNC:HGNC:11892"
                     /db_xref="InterPro:IPR002959"
                     /db_xref="InterPro:IPR006052"
                     /db_xref="InterPro:IPR006053"
                     /db_xref="InterPro:IPR008983"
                     /db_xref="InterPro:IPR021184"
                     /db_xref="PDB:1A8M"
                     /db_xref="PDB:1TNF"
                     /db_xref="PDB:2AZ5"
                     /db_xref="PDB:2E7A"
                     /db_xref="PDB:2TUN"
                     /db_xref="PDB:2ZJC"
                     /db_xref="PDB:2ZPX"
                     /db_xref="PDB:3ALQ"
                     /db_xref="PDB:3IT8"
                     /db_xref="PDB:3L9J"
                     /db_xref="PDB:3WD5"
                     /db_xref="PDB:4G3Y"
                     /db_xref="PDB:4TSV"
                     /db_xref="PDB:4TWT"
                     /db_xref="PDB:4Y6O"
                     /db_xref="PDB:5M2I"
                     /db_xref="PDB:5M2J"
                     /db_xref="PDB:5M2M"
                     /db_xref="PDB:5MU8"
                     /db_xref="PDB:5TSW"
                     /db_xref="PDB:5UUI"
                     /db_xref="PDB:5WUX"
                     /db_xref="PDB:5YOY"
                     /db_xref="UniProtKB/Swiss-Prot:P01375"
                     /protein_id="CAA25650.1"
                     /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA
                     TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL
                     QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA
                     VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL
                     DFAESGQVYFGIIAL"
     sig_peptide     153..380
                     /note="put. signal peptide (aa -76 to -1)"
     mat_peptide     381..851
                     /note="mature TNF (aa 1-157)"
     misc_feature    1630..1635
                     /note="put. polyadenylation signal"
BASE COUNT          370 a          495 c          398 g          380 t
ORIGIN      
        1 gcagaggacc agctaagagg gagagaagca actacagacc ccccctgaaa acaaccctca
       61 gacgccacat cccctgacaa gctgccaggc aggttctctt cctctcacat actgacccac
      121 ggctccaccc tctctcccct ggaaaggaca ccatgagcac tgaaagcatg atccgggacg
      181 tggagctggc cgaggaggcg ctccccaaga agacaggggg gccccagggc tccaggcggt
      241 gcttgttcct cagcctcttc tccttcctga tcgtggcagg cgccaccacg ctcttctgcc
      301 tgctgcactt tggagtgatc ggcccccaga gggaagagtt ccccagggac ctctctctaa
      361 tcagccctct ggcccaggca gtcagatcat cttctcgaac cccgagtgac aagcctgtag
      421 cccatgttgt agcaaaccct caagctgagg ggcagctcca gtggctgaac cgccgggcca
      481 atgccctcct ggccaatggc gtggagctga gagataacca gctggtggtg ccatcagagg
      541 gcctgtacct catctactcc caggtcctct tcaagggcca aggctgcccc tccacccatg
      601 tgctcctcac ccacaccatc agccgcatcg ccgtctccta ccagaccaag gtcaacctcc
      661 tctctgccat caagagcccc tgccagaggg agaccccaga gggggctgag gccaagccct
      721 ggtatgagcc catctatctg ggaggggtct tccagctgga gaagggtgac cgactcagcg
      781 ctgagatcaa tcggcccgac tatctcgact ttgccgagtc tgggcaggtc tactttggga
      841 tcattgccct gtgaggagga cgaacatcca accttcccaa acgcctcccc tgccccaatc
      901 cctttattac cccctccttc agacaccctc aacctcttct ggctcaaaaa gagaattggg
      961 ggcttagggt cggaacccaa gcttagaact ttaagcaaca agaccaccac ttcgaaacct
     1021 gggattcagg aatgtgtggc ctgcacagtg aattgctggc aaccactaag aattcaaact
     1081 ggggcctcca gaactcactg gggcctacag ctttgatccc tgacatctgg aatctggaga
     1141 ccagggagcc tttggttctg gccagaatgc tgcaggactt gagaagacct cacctagaaa
     1201 ttgacacaag tggaccttag gccttcctct ctccagatgt ttccagactt ccttgagaca
     1261 cggagcccag ccctccccat ggagccagct ccctctattt atgtttgcac ttgtgattat
     1321 ttattattta tttattattt atttatttac agatgaatgt atttatttgg gagaccgggg
     1381 tatcctgggg gacccaatgt aggagctgcc ttggctcaga catgttttcc gtgaaaacgg
     1441 agctgaacaa taggctgttc ccatgtagcc ccctggcctc tgtgccttct tttgattatg
     1501 ttttttaaaa tatttatctg attaagttgt ctaaacaatg ctgatttggt gaccaactgt
     1561 cactcattgc tgagcctctg ctccccaggg gagttgtgtc tgtaatcgcc ctactattca
     1621 gtggcgagaa ataaagtttg ctt
//