LOCUS       CAA25650.1               233 aa    PRT              HUM 07-OCT-2008
DEFINITION  Homo sapiens protein ( Human mRNA for tumor necrosis factor. ).
ACCESSION   X01394-1
PROTEIN_ID  CAA25650.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R.,
            Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V.
  TITLE     Human tumour necrosis factor: precursor structure, expression and
            homology to lymphotoxin
  JOURNAL   Nature 312(5996), 724-729(1984).
   PUBMED   6392892
REFERENCE   2
  AUTHORS   Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B.
  TITLE     Cloning and expression in Escherichia coli of the gene for human
            tumour necrosis factor
  JOURNAL   Nature 313(6005), 803-806(1985).
   PUBMED   3883195
COMMENT     In the genomic sequence from ref [2] the mature protein starts
            with Ser (position 387 in this cDNA sequence).
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000320894_10"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     protein         /note="TNF precursor"
                     /db_xref="GOA:P01375"
                     /db_xref="H-InvDB:HIT000320894_04.4"
                     /db_xref="HGNC:HGNC:11892"
                     /db_xref="InterPro:IPR002959"
                     /db_xref="InterPro:IPR006052"
                     /db_xref="InterPro:IPR006053"
                     /db_xref="InterPro:IPR008983"
                     /db_xref="InterPro:IPR021184"
                     /db_xref="PDB:1A8M"
                     /db_xref="PDB:1TNF"
                     /db_xref="PDB:2AZ5"
                     /db_xref="PDB:2E7A"
                     /db_xref="PDB:2TUN"
                     /db_xref="PDB:2ZJC"
                     /db_xref="PDB:2ZPX"
                     /db_xref="PDB:3ALQ"
                     /db_xref="PDB:3IT8"
                     /db_xref="PDB:3L9J"
                     /db_xref="PDB:3WD5"
                     /db_xref="PDB:4G3Y"
                     /db_xref="PDB:4TSV"
                     /db_xref="PDB:4TWT"
                     /db_xref="PDB:4Y6O"
                     /db_xref="PDB:5M2I"
                     /db_xref="PDB:5M2J"
                     /db_xref="PDB:5M2M"
                     /db_xref="PDB:5MU8"
                     /db_xref="PDB:5TSW"
                     /db_xref="PDB:5UUI"
                     /db_xref="PDB:5WUX"
                     /db_xref="PDB:5YOY"
                     /db_xref="UniProtKB/Swiss-Prot:P01375"
BEGIN
        1 MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR
       61 EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR
      121 DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE
      181 TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
//