LOCUS AL035480 34316 bp DNA linear BCT 23-OCT-2008
DEFINITION Mycobacterium leprae cosmid B12.
ACCESSION AL035480
VERSION AL035480.1
KEYWORDS 19 kD antigen; 19 kD lipoprotein; acyl-CoA dehydrogenase; acyl-CoA
synthase; pksB; polyketide synthase; pseudogene; RLEP;
thioesterase.
SOURCE Mycobacterium leprae
ORGANISM Mycobacterium leprae
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium.
REFERENCE 1 (bases 1 to 34316)
AUTHORS Murphy L., Harris D.
JOURNAL Unpublished.
REFERENCE 2 (bases 1 to 34316)
AUTHORS James K.D., Parkhill J., Barrell B.G., Rajandream M.A.
JOURNAL Submitted (15-FEB-1999) to the INSDC. Mycobacterium leprae
sequencing project, Sanger Centre, Wellcome Trust Genome Campus,
Hinxton, Cambridge CB10 1SA E-mail: barrell@sanger.ac.uk Cosmids
supplied by Dr. Stewart T. Cole, [3] Unite de Genetique Moleculaire
Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris
Cedex 15, France Requests for cosmids should be sent to Karin
Eiglmeier (kei@pasteur.fr).
REFERENCE 3 (bases 1 to 34316)
AUTHORS Eiglmeier K., Honore N., Woods S.A., Caudron B., Cole S.T.
TITLE Use of an ordered cosmid library to deduce the genomic organization
of Mycobacterium leprae
JOURNAL Mol. Microbiol. 7(2), 197-206(1993).
PUBMED 8446027
COMMENT Notes:
The Sanger Centre is funded to complete the sequence of M. leprae
by the Heiser Program for Research in Leprosy and Tuberculosis of
The New York Community Trust.
Work in Paris is supported by the Heiser Trust, the Association
Francaise Raoul Follereau and the Groupement de Recherches et des
Etudes des Genomes (GIP-GREG).
Details of M. leprae sequencing at the Sanger Centre
are available on the World Wide Web.
(URL, http://www.sanger.ac.uk/Projects/)
CDS are numbered using the following system eg MLCB33.01c.
ML (M. leprae), cB33 (cosmid name), .01 (first CDS),
c (complementary strand).
The more significant matches with motifs in the PROSITE
database are also included but some of these may be fortuitous.
The length in codons is given for each CDS.
Usually the highest scoring match found by fasta -o is given for
CDS which show significant similarity to other CDS in the database.
The position of possible ribosome binding site sequences are
given where these have been used to deduce the initiation codon.
All CDS over 100 codons have been analysed. Gene prediction
is based on positional base preference in codons especially
where there is an increase in the observed/expected third
position G + C. CAUTION: We may not have predicted the
correct initiation codon. Where possible we choose an
initiation codon (atg, gtg, or ttg) which is preceded by an
upstream ribosome binding site sequence (optimally 5-13bp
before the initiation codon). If this cannot be identified
we choose the most upstream initiation codon.
IMPORTANT: This sequence MAY NOT be the entire insert of
the sequenced clone. It may be shorter because we only
sequence overlapping sections once, or longer, because we
arrange for a small overlap between neighbouring submissions.
FEATURES Location/Qualifiers
source 1..34316
/organism="Mycobacterium leprae"
/mol_type="genomic DNA"
/clone="cosmid B12"
/db_xref="taxon:1769"
misc_feature complement(1..9070)
/note="overlap with EMBL:U00023 cosmid L518 from 9070 to
1. There are 3 conflicts between this sequence and ours.
In each case our sequence has been checked and is thought
to be correct"
CDS complement(52..4674)
/transl_table=11
/gene="MLCB12.01c"
/product="putative polyketide synthase"
/note="MLCB12.01c, probable polyketide synthase, len: 1540
aa; similar to ERY1_SACER (EMBL:M63676) Saccharopolyspora
erythraea erythronolide synthase (3491 aa), fasta scores;
opt: 2230 z-score: 2283.7 E(): 0, 36.6% identity in 1550
aa overlap. N-terminus similar to the N-terminus of
MCAS_MYCBO (EMBL:M95808) Mycobacterium bovis mycocerosic
acid synthase (2110 aa) (42.2% identity in 879 aa
overlap). Also similar to many mycobacterial putative
polyketide synthases e.g. ppsB, Rv2932,
(MTV011.01-MTCY338.21) M.tuberculosis putative polyketide
synthase involved in phenolpthiocerol synthesis (1538 aa)
(76.3% identity in 1561 aa overlap). Annotated as ORF
TR:Q49932, designated pksC in M.leprae cosmid EMBL:U00023.
Contains Pfam match to entry PF00550 pp-binding,
Phosphopantetheine attachment site, score 42.90, E-value
3e-10, Pfam match to entry PF00698 Acyl_transf,
Acyltransferase domain, score 467.00, E-value 1.6e-136,
Pfam match to entry PF001 09 ketoacyl-synt, Beta-ketoacyl
synthase, score 694.00, E-value 7.4e-205, Pfam match to
entry PF00501 AMP-binding, AMP-binding enzyme, score
-162.30, E-value 4.9e-06. Contains PS00606 Beta-ketoacyl
synthases active site"
/db_xref="GOA:Q9S384"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:Q9S384"
/protein_id="CAB36627.1"
/translation="MRTAFSRISGMTTQQRAALIEEFTKLSRIAVAEPIAVVGIGCRF
PGDVTGPDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGGFVSDIAG
FDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGNSRTGVMIGVYFNEYQ
SMLASSLENVDAYSGTGNAHSITVGRISYLLGLRGPSVAVDTACSSSLVAVHLACQSL
RLRETDLVLAGGVSITLRPETQIAISAWGLLSPHGRCAAFDAAADGFVRGEGAGVVVL
KRLTDAVRDGDLVLAVVRGSAVNQDGRSNGVTAPNTAAQCDVITDALRSSDVAPESVN
YVESHGTGTVLGDPIEFEALAATYGRGESACALGAVKTNLGHLEAAAGIAGFIKTVLA
VQRGQIPPNLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRAAVSSFGLGGTN
AHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGPGAEVALAD
VAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGTVFVY
SGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANGKELVGIEQIQL
GLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAP
LSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQN
RFASRVNIEVAPHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSCPVFDAQH
WATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHGTRCISIGTLQRDAD
DTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWITTPLASTTALQHLDRN
RVTTHATGIGNTELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAGLSDELARLV
VLADPASRVEYLAPSALDHDVSTLHDLHNALRGVDNVLYAPSVSTESVDPVDPESGYR
LFHAVRRLAAAMVAGTSKPKLVVVTRNAQPVAVGERANPAHAVLWGFGRTLALEHPEI
WGSVIDLDASMPPELAARCILDEVASQDEKDREDQVVYRACLRRAPRLQRRTASAVSS
VKLSSGQDTTQLVIGATGNIGPHLIRQLAAMGATTIVAVSRNPSTRLLELDKNLAATG
TNLISVAADATDPTAMTALFDRFGVDLPPLEGIYLAAFAGRPVLLSDMTDNDVVAMFR
PKLDVASLLHRLSLKQPVKYFLLFSSISGLIGSRWLAHYTATSAFLDILGYARRLVGL
PATVVAWGLWKSLADAQQDATQVSAESGLQPMTDDVAIGALPLVMSPDAPVHSVVAAA
DWPLLAAAYQTRGVLRMVDDLLPAPGEVLMQESEFRKALRTCQAERRHNMLFDHVSAL
VAKAMGLLPAETLDPSAGFFQLGMDSLMSVTLQRALSDSLGEFLPASVVFDYPTVYSL
TDYLATILPEFLEPEAPSGRTTADAYDEFTESELLDQLSERLRGTQ"
misc_feature complement(181..384)
/note="Pfam match to entry PF00550 pp-binding,
Phosphopantetheine attachment site, score 42.90, E-value
3e-10"
misc_feature 347^348
/note="conflict: A is present in EMBL:U00023"
repeat_region 1981..3367
/note="1387 bp direct repeat"
misc_feature complement(2050..2991)
/note="Pfam match to entry PF00698 Acyl_transf,
Acyltransferase domain, score 467.00, E-value 1.6e-136"
misc_feature complement(3298..4572)
/note="Pfam match to entry PF00109 ketoacyl-synt,
Beta-keto acyl synthase, score 694.00, E-value 7.4e-205"
misc_feature complement(3886..4965)
/note="Pfam match to entry PF00501 AMP-binding,
AMP-binding enzyme, score -162.30, E-value 4.9e-06"
misc_feature complement(4042..4092)
/note="PS00606 Beta-ketoacyl synthases active site"
CDS complement(4675..10290)
/transl_table=11
/gene="MLCB12.02c"
/product="putative polyketide synthase"
/note="MLCB12.02c, probable polyketide synthase, len:
1871aa; similar to MSAS_PENPA (EMBL:P22367) Penicillium
patulum 6-methylsalicylic acid synthase (1774 aa), fasta
scores; opt : 2727 z-score: 2873.8 E(): 0, 33.8% identity
in 1823 aa overlap. Also highly similar to many
mycobacterial putative polyketide synthases and equivalent
to TR:E1299930 (EMBL:Z7469 7) M.tuberculosis ppsA, Rv2931
(MTCY338.20) (1876 aa) (76.1% identity in 1888 aa
overlap). C-terminus annotated as ORF TR:Q49931,
designated pksB in M.leprae cosmid EMBL:U00023. Contains
two Pfam matches to entry PF00550 pp-binding,
Phosphopantetheine attachment site, score 77.40, E-value
8.8e-20 and score 61.30, E-value 2.5e-15, Pfam match to
entry PF00698 Acyl_transf, Acyltransferase domain, score
467.00, E-value 1.6e-136, Pfam match to entry PF00109
ketoacyl-synt, Beta-keto acyl synthase, score 626.50,
E-value 1.5e-184. Contains PS00012 Phosphopantetheine
attachment site, PS00606 Beta-ketoacyl synthases active
site and probable coiled-coil from 1748 to 1781 (34
residues)"
/db_xref="GOA:Q9Z5K6"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:Q9Z5K6"
/protein_id="CAB36628.1"
/translation="MTASIGSEADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSR
DAVVLSGELTDLLGKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQGALEE
PIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNERWELFDDGSPEVKALLARTT
RWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLLLEVAWEALEHAGISSNSLRRSQTG
VFAGSCLSEYGAIASTDLSQVDGWSNTGGAMSIIANRLSYFLDLRGPSVAVDTACSSS
LVAIHLACQSLRTADANLAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGF
VRGEGAGVVVLKRLTDAQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAY
ANAAMPPTAIDYVETHGTGTLLGDPIEARALGAVLGRGRAEDSPLLIGAVKTNLGHLE
AAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMKVVDKHMEWPDTGHLRRA
AVSSFGFGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWV
EGPGAEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPGVVGQQD
GTPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHAGFSLHDVLANG
KELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEGLR
VTATRSRLMAPLSGQGGMALLELDAVETEALIVDYSQVTLAIYNSPRQTVIAGPTEQI
DELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSELADVAPRTPTIPILSTTYAD
LGSCPVFDAQHWATNMRNPVHFQQAIMTAGTDHRTFIEISAHPLLTQAITDTLHGTRC
ISIGTLQRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWIPRKRS
VNSIGLAPQVGTLLGQHTAVSGILPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVL
RTILCAAAELGYSTLFEIRFEQPIFANLPRLIQVVVDNQLISLASSPATETPQHRWTR
HVTAQLSSASARSAVPSDHPDQINGHLEVISDPIPDVASLLALCGVDGLPFEWSVKSW
AKKTQQSTSRTVEIEFPDTLPDGAIAPLLDAAILIPALADVTETQFYVPASIKQVWLG
DTATGPCGAVTLNRTACDDDGITVDVTVADGSGVPLALMRSLRYRALDLDNAQQDYST
VFVESHVDALTDARNFVHAIDWQPRTDLDCSNTPVASSGSVAVIGDARAGFGLLLKEA
GYTLAAPADGVSEVRYVVYVADPHPATTAETDVDFAVRITAEISDLVRALAKREPGKP
VALWIVTRGVYESVASSALRQSFLWGFGGVIAAEHPEMWGGLVDLAASALGADRDDIL
DQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIRSEPVRKSLQCKSDGAYLITGGMG
ALGLLMADWLADRGARRLVLMGRTPLPPRRDWELDTLDAGLRQKIDAICALEMRGVTV
EAVAVDVGHHDDVQALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQVMWPK
IAGCQVLHEAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGCHT
MSIDWVAWRGLGFAANAQIVSDELQRMGSRDITPSEAFTAWEYVDAYDVAQAVVLPVP
RSYGSAGSTAGDSYLVPARNWSQMEAAEVRKELESGLRTIIAAELRVAEAELDTDRPF
AELGLNSLMAMAIRREAEQFIGIELSAIMLFNHPTVALLAAYLTKVVAPQHDSQGDEM
AALSASAGGVLDSLFDRIESTSTEAEGLV"
misc_feature complement(4810..5010)
/note="Pfam match to entry PF00550 pp-binding,
Phosphopantetheine attachment site, score 77.40, E-value
8.8e-20"
misc_feature complement(4888..4935)
/note="PS00012 Phosphopantetheine attachment site"
misc_feature 7274
/note="conflict: G is absent from EMBL:U00023"
repeat_region 7390..8776
/note="1387 bp direct repeat"
misc_feature complement(7459..8400)
/note="Pfam match to entry PF00698 Acyl_transf,
Acyltransferase domain, score 467.00, E-value 1.6e-136"
misc_feature complement(8707..9981)
/note="Pfam match to entry PF00109 ketoacyl-synt,
Beta-keto acyl synthase, score 626.50, E-value 1.5e-184"
misc_feature 9021
/note="conflict: C is A in EMBL:U00023"
misc_feature complement(9451..9501)
/note="PS00606 Beta-ketoacyl synthases active site"
misc_feature complement(10054..10254)
/note="Pfam match to entry PF00550 pp-binding,
Phosphopantetheine attachment site, score 61.30, E-value
2.5e-15"
CDS complement(10287..12038)
/transl_table=11
/gene="MLCB12.03c"
/product="putative acyl-CoA synthase"
/note="MLCB12.03c, probable acyl-CoA synthase, len: 583
aa; highly similar to a family of acyl-CoA synthases
associated with fatty acid or polyketide biosynthesis e.g.
TR:P71495( EMBL:U75685) Mycobacterium bovis acyl-CoA
synthase adjacent to mycocerosic acid synthase gene (582
aa), fasta scores; opt: 2258 z-score: 2574.6 E(): 0, 60.0%
identity in 583 aa overlap. Equivalent to M.tuberculosis
fadD26, Rv2930 (MTCY3 38.19, 73.4% identity in 623 aa
overlap). Contains Pfam match to entry PF00501
AMP-binding, AMP-binding enzyme, score 48.20, E-value
2.4e-17"
/db_xref="GOA:Q9Z5K5"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:Q9Z5K5"
/protein_id="CAB36629.1"
/translation="MVVTNFSVPALLKERADQQADTTAYTYIDYGSDPKGFVESLTWS
QVYMRSCVLADELKLCGVPGDRVAILAPQGLEYIIAFLGALQAGFIAVPLSPPQYAIH
DERVSAVLRDSQPIAILTTSFVVSDVAKYACEQDGWNAPSVIEIDLLDLNASLPLPKV
PQPFTSPAYLQYTSGSTRTPAGVMVSHKNVIANVQQSMNGYFGDAAKTLNTTVVSWLP
LFHDMGLILGVCAPMVAGRSSVLLSPMSFLRRPACWMQLLATTQACFSAAPNFAFELA
VRRTSDDDMNGLDLGDVAGIISGSERVHIATVKRFTERFARFNLSPSVVRPSYGLAEA
TVYVAAPEPGTAPKAVRFDYEYLTASKAKARRAEGSVATELISYGSPDASAVRIVDPE
SMIENPAGMVGEIWVQGDHVAMGYWRKPEQTARTFNAKIVNPAPGTSEGPWLRTGDLG
VMSDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRVAAITVPDDLTEQLVAII
EYKEHGASAEDHMHKVHSVKREVTSAISKLHSLHVADLVLVSPGSIPITTSGKVRRSA
CVERYRSDGFKRLDVTV"
misc_feature complement(10557..11915)
/note="Pfam match to entry PF00501 AMP-binding,
AMP-binding enzyme, score 48.20, E-value 2.4e-17"
CDS complement(12684..13469)
/transl_table=11
/gene="MLCB12.04c"
/product="putative thioesterase"
/note="MLCB12.04c, probable thioesterase, len: 261 aa;
similar to bacterial thioesterases e.g. TR:G3800838
(EMBL:AF079 138) Streptomyces violaceus pikAV thioesterase
II (281 aa), fasta scores; opt: 500 z-score: 600.7 E():
3.8e-26, 36.1%id entity in 227 aa overlap. Equivalent to
M.tuberculosis tesA, Rv2928 (MTCY338.17, 73.2% identity in
261 aa overlap). Contains Pfam match to entry PF00975
Thioesterase, Thioesterase domain, score 195.30, E-value
9.5e-55"
/db_xref="GOA:Q9Z5K4"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR012223"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:Q9Z5K4"
/protein_id="CAB36630.1"
/translation="MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYY
VPFSREFSADIKRIAVHYPGQRDGYGLPALTSIPALADEIFAIMKPSAPPEGAVAFFG
HSMGGMLAFEVALRFQSAGYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTG
MNPDFFEDEEFRVGVLPTLRAARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKP
WRERTTGAFAIRVFPGDHFYLNGNLSELVCDIEDKTLEWCDRA"
misc_feature complement(12708..13385)
/note="Pfam match to entry PF00975 Thioesterase,
Thioesterase domain, score 195.30, E-value 9.5e-55"
CDS complement(13959..14531)
/pseudo
/transl_table=11
/gene="MLCB12.05c"
/product="putative pseudogene"
/note="MLCB12.05c, possible pseudogene, len: 573 bp;
similar to M.tuberculosis hypothetical protein Rv3766
(MTV025.114 )"
CDS 15012..15610
/pseudo
/transl_table=11
/gene="MLCB12.06"
/product="putative pseudogene"
/note="MLCB12.06, possible pseudogene, len: 599 bp;
similar to M.tuberculosis probable two-component system
response regulator Rv3765c (MTV025.113c)"
CDS 15824..17019
/pseudo
/transl_table=11
/gene="MLCB12.07"
/product="putative pseudogene"
/note="MLCB12.07, possible pseudogene, len: 1196 bp;
similar to M.tuberculosis probable two-component system
protein kinase Rv3764c (MTV025.112c)"
CDS complement(17523..17779)
/pseudo
/transl_table=11
/gene="MLCB12.08c"
/product="putative pseudogene"
/note="MLCB12.08c, possible pseudogene, len: 257 bp;
similar to 19KD_MYCTU (EMBL:X07945) Rv3763 (MTV025.111),
lpqH, M.tuberculosis 19 kD lipoprotein antigen precursor
(159 aa)"
CDS 17996..19362
/pseudo
/transl_table=11
/gene="MLCB12.09"
/product="putative pseudogene"
/note="MLCB12.09, possible pseudogene, len: 1367 bp;
similar to M.tuberculosis hypothetical protein Rv3762c
(MTV025.11 0c)"
CDS 22128..23133
/pseudo
/transl_table=11
/gene="MLCB12.10"
/product="putative pseudogene"
/note="MLCB12.10, possible acyl-CoA dehydrogenase
pseudogene, len: 1006 bp; similar to M.tuberculosis
possible acyl-CoA dehydrogenase fadE36, Rv3761c
(MTV025.109c). ORF partially within this region annotated
as TR:Q50095 in M.leprae cosmid EMBL:U15183"
misc_feature complement(22751..34316)
/note="overlap with EMBL:U15183 cosmid B1740 from 25743 to
36800. There are 3 conflicts between this sequence and
ours. In each case our sequence has been checked and is
thought to be correct"
CDS complement(23198..23539)
/transl_table=11
/gene="MLCB12.11c"
/product="hypothetical protein"
/note="MLCB12.11c, possible CDS with RBS, len: 113 aa;
similar to M.tuberculosis hypothetical protein Rv3760
(MTV025.108, 67.7% identity in 99 aa overlap). Annotated
as ORF TR:Q50094 in M.leprae cosmid EMBL:U15183"
/db_xref="GOA:Q50094"
/db_xref="InterPro:IPR010445"
/db_xref="UniProtKB/TrEMBL:Q50094"
/protein_id="CAB36637.1"
/translation="MAFMTSNPSGPPSQPAPAVGLTPGERAVPVTRAGALWSALFAGF
LILILLLIFIAQNTTSTPFTFFGWHWSLPLGVAIMLSAVGGGLLAVAVGTARILQLRR
TVKKRYVAAHR"
CDS 23710..24494
/pseudo
/transl_table=11
/gene="MLCB12.12"
/product="putative pseudogene"
/note="MLCB12.12, possible pseudogene, len: 785 bp;
similar to M.tuberculosis possible secreted protein
Rv3759c (MTV025.107c)"
misc_feature 24429..24430
/note="conflict: GA is AG in EMBL:U15183"
misc_feature 24430^24431
/note="conflict: AT is present in EMBL:U15183"
repeat_region 24499..25167
/note="RLEP repeat with 5' extension, but no 3' extension"
CDS complement(24567..24905)
/transl_table=11
/gene="MLCB12.13c"
/product="hypothetical protein"
/note="MLCB12.13c, hypothetical protein, len: 112 aa; CDS
within RLEP element, highly similar other CDS in RLEP
elements e.g. TR:O07704 (MLCL383.30C), fasta scores;
opt:786 z-score: 926.0 E(): 0, 99.1% identity in 112 aa
overlap"
/db_xref="InterPro:IPR009418"
/db_xref="UniProtKB/TrEMBL:Q9R448"
/protein_id="CAB36639.1"
/translation="MTTPTPQGHDMHTKTPLPRGANNYPHTHACIDIAFSTAQVPSPW
HHQHVDQAAPTTDMLTCAALIVSTAAKHTKPHRKQAVSHPPTKTPQHSKTRQQDSGLP
PTTTEHIGQS"
CDS complement(25391..26234)
/pseudo
/transl_table=11
/gene="MLCB12.14c"
/product="putative pseudogene"
/note="MLCB12.14c, possible PPE pseudogene, len: 844 bp;
similar to M.tuberculosis PPE family protein Rv0442c
(MTV037.06c)"
CDS complement(27079..27405)
/transl_table=11
/gene="MLCB12.15c"
/product="hypothetical protein"
/note="MLCB12.15c, hypothetical protein, len: 108 aa;
improbable CDS based on ORF alone"
/db_xref="UniProtKB/TrEMBL:Q9Z5K3"
/protein_id="CAB36641.1"
/translation="MRTLAEASYGDWSVGLRVAAADHTPDRERINRSRATTPPARRFK
GITKGVVDGGGGRLQCVTDIPAAPAISRCCRRFSMSSRRSGLSVTFTMVFAYAGDPTR
PDKEGQ"
CDS 27903..28211
/transl_table=11
/gene="MLCB12.16"
/product="hypothetical protein"
/note="MLCB12.16, hypothetical protein, len: 102 aa;
improbable CDS based on ORF alone"
/db_xref="UniProtKB/TrEMBL:Q9Z5K2"
/protein_id="CAB36642.1"
/translation="MAVPVAYETKTVRTSGAAKVILEVEIGAASSEEGRGATSTPRRQ
TCPGSLRSLPRPPILLDAYVTGPTPYRVSPRRVWPHEAVPAVQPVIAAQHYRHGLADG
"
CDS complement(28859..29209)
/pseudo
/transl_table=11
/gene="MLCB12.17c"
/product="possible pseudogene"
/note="MLCB12.17c, possible pseudogene, len: 351 bp;
similar to TR:O5373 (EMBL:AL021932) Rv0446c (MTV037.10c)
M.tuberculosis hypothetical protein (256 aa)"
CDS complement(29415..29474)
/pseudo
/transl_table=11
/gene="MLCB12.18c"
/product="putative pseudogene"
/note="MLCB12.18c, possible pseudogene, len: 60 bp;
similar to TR:O53733 (EMBL:AL021932) Rv0448c (MTV037.12c)
M.tuberculosis hypothetical protein (221 aa)"
CDS complement(30142..30624)
/pseudo
/transl_table=11
/gene="MLCB12.19c"
/product="putative pseudogene"
/note="MLCB12.19c, possible pseudogene, len: 483 bp;
similar to TR:O53733 (EMBL:AL021932) Rv0448c (MTV037.12c)
M.tuberculosis hypothetical protein (221 aa)"
CDS complement(31138..33787)
/pseudo
/transl_table=11
/gene="MLCB12.20c"
/product="putative pseudogene"
/note="MLCB12.20c, possible membrane protein pseudogene,
len: 2650 bp; similar to M.tuberculosis putative
transmembrane proteins e.g. Rv0450c (MTV037.14c)"
misc_feature 33808
/note="conflict: T is absent from EMBL:U15183"
CDS complement(34064..34204)
/pseudo
/transl_table=11
/gene="MLCB12.21c"
/product="putative pseudogene"
/note="MLCB12.21c, possible pseudogene, len: 141 bp;
similar to TR:O53737 (EMBL:AL021932) Rv0452 (MTV037.16)
M.tuberculosis possible transcriptional regulator (236
aa)"
BASE COUNT 7854 a 10136 c 9298 g 7028 t
ORIGIN
1 tcttgtgcaa cgcctcggtg atgatcgccc ggcgatcagg tgtcgaggcg gtcattgcgt
61 tcctcttagt ctttccgaaa gttgatccaa caactcggat tcagtgaatt cgtcatatgc
121 gtcggccgtt gtccgcccag atggtgcttc tggttccaga aattcaggca gtatagtggc
181 cagataatcg gtaagactgt acacggtcgg gtagtcaaaa acgacagacg ccggcagaaa
241 ctcgccaagg ctgtccgaca aggctctctg caacgtcacg ctcatcagcg agtccatgcc
301 tagttggaag aagccagccg acgggtcgag tgtttcagcg ggaagcagtc ccatcgcctt
361 ggcgaccaga gcactaacgt ggtcgaacaa catgttatgt cggcgttctg cctggcaagt
421 ccgtagggct ttgcggaatt cactttcctg catcagtacc tcgcccggtg cgggcagcag
481 gtcatcgacc atgcgcagca ccccgcgggt ctggtatgca gcggccagta gcggccaatc
541 cgctgccgcc acaaccgaat gcactggcgc gtccgggctc atcaccaacg gcaatgcccc
601 gatcgctacg tcgtcagtca tgggttgcag gccggattca gcgcttacct gggtcgcgtc
661 ttgctgcgcg tcggccagcg atttccacaa gccccaggcc acgacagtgg caggcaatcc
721 taccagccgc cgggcgtagc ccagaatgtc caggaaagca ctggtcgcgg tgtaatgcgc
781 cagccatcgt gaaccgataa gacctgagat cgaggagaac aaaagaaagt attttacagg
841 ctgtttcagc gacaaacggt gcaacagcga tgcgacgtcc agtttgggtc ggaacatcgc
901 gaccacgtcg ttatcagtca tgtcgctcag caagaccgga cggccagcaa aagccgctaa
961 gtagattccc tctagcggag gcagatccac tccaaaacga tcgaacaacg cagtcatcgc
1021 ggtagggtcg gtcgcatccg ccgcaaccga gatgaggttc gtcccggttg cggcgaggtt
1081 cttatccagc tctaacagcc gggtgctggg attgcgagac acggcgacga tcgtcgtggc
1141 ccccatcgcg gcgagctgac ggatcagatg cggtccgata tttccggtgg ccccgatgac
1201 gagctgagtg gtatcttgcc ccgaactcaa cttcaccgac gacaccgcgg atgcagttcg
1261 cctttgcagc cgtggtgcgc gacgtagaca cgctcggtag acgacctggt cctctcggtc
1321 tttttcgtcc tggctagcga cttcgtccaa tatgcaccgg gcagccaact cgggaggcat
1381 cgacgcatcg agatcgatga cactacccca aatttcggga tgttccagcg ccaatgttcg
1441 gccaaagccc cacaacaccg cgtgggcggg gttggcgcgc tcacccactg caacgggttg
1501 agcattgcga gtcacgacga cgagtttcgg tttcgaagta cccgcaacca tcgcggccgc
1561 caaccgtcgc accgcatgga acagccggta cccggactcc ggatcgacag ggtcgacaga
1621 ttcggtcgag accgatggtg catagagtac gttatcgaca ccccgtaaag cgttatgcag
1681 gtcatgcagc gtgctcacat catgatcaag cgccgaaggt gcgaggtact caacccggga
1741 tgcaggatcg gccaatacca ccaaccgagc cagttcatcc gacagtccgg catcggacac
1801 caccagccac gagccgctgc tggcccacgt cgcaccaggc tcacttgtca ggggccgagt
1861 cggccagtca agctggtaga tccagtcatc gagttccgtg tttccaattc cggtagcgtg
1921 cgtcgtaacc ctgttgcggt cgagatgttg cagcgcggtc gtgcttgcca gcggtgtggt
1981 gatccagtgg cgggtgtgct gccagggagt gctggggata gttacgtgtg gttccgcagg
2041 atgaggggtg tgtggtgggt ggacggtgtg gacgttgttg aggttggtgt gaaaggtgac
2101 ggtgtcgtcg gcatcgcgtt gcagggtccc aatgctgatg caccgggtac cgtgcagggt
2161 gtcagtaatg gcttgggtca gcagcgggtg tgcactgatt tcgatgaaag tgcggtggtc
2221 agttccagcg gtcatgatgg cctgctggaa atgcactggg ttgcgcatgt tggtggccca
2281 gtgctgggca tcgaacaccg ggcacgagcc aaggtcagca taggtggtgg aaaggatcgg
2341 aatcgtcgga gtccgtgggg ccacatcggc gagctcggaa cgcatctgcg gctgcagcgc
2401 atccatcgcc ggattgtggg gggccacttc aatattgacc cgactggcaa accgattctg
2461 cgcgcgcacc cggtcaatca actcatcgat ctgttcagtg ggcccggcaa tcaccgtttg
2521 gcgcggcgaa ttgtaaatcg ccaatgtcac ctgcgagtag tcgacaatca acgcctccgt
2581 ctcgaccgcg tcgagttcga gcagtgccat accgccctgc ccagacagcg gggccatcag
2641 ccgcgaccga gtggctgtca cccgcagccc ctcagcggcg gtaagcgccc cagccaccac
2701 ggcggcggcc acctcaccca gcgaatgccc gatcaccaaa tcaggttgca ccccatagga
2761 acgccacaac tcagtcagcg tcagttgcat gccgattaac cccagctgga tctgctcgat
2821 accaaccagt tctttgccat tagcgagcac atcgtgcaac gagaaaccgg cgtggacaac
2881 aaacaccggt tccaactcgg caaccgcggc cgtgaaagcc ggttcatcgg ccagcaattg
2941 acgccccatc cccgcccact gcgaaccacg tcccgagtac acaaacaccg ttcctgaccc
3001 aggtgtgcca tcctgctgcc cgaccacacc gggcgcctgt ttgccggcgg ccaacgcccg
3061 caatccagcc actgcctgga tccgatcacg ggcaaccacg gtgccgaact tggcgtgccg
3121 cgaccggtga tgattcaatg tatgggccac atcagccaac gccacttcag caccgggccc
3181 ctcaacccaa tcggccagca tccccgccat cgctgccacc cgcgacgccg tcttacccgt
3241 caccaccaac gtcgacaccg cagtgttgga actgcattct gtgaccggtg tcagctcagg
3301 accctgctca atgacaacat gcgcgttcgt cccaccgagg ccaaacgatg acaccgccgc
3361 gcgccgcggc cctgcttgac cgtccgagat cggccacgag gagttctcag tggggacgaa
3421 gaatctagtc gatgcagcgt cgatagccgg attccattgc gaaaaatgca gattcggtgg
3481 aatctggcca cgctgcaccg ccaacactgt cttgatgaag ccggcgatgc ccgcagcagc
3541 ctccaagtga cccaggttag tcttaacagc ccccagcgca catgcgctct caccgcggcc
3601 atacgtggcc gccagcgcct cgaattcgat tgggtcaccc aggacggtac cggtgccatg
3661 ggattcgacg tagttcacgc tttcgggcgc aacgtcacta gagcgcaagg catcggtgat
3721 cacatcacac tgcgccgccg tattcggagc ggtaacgccg ttggagcggc catcctgatt
3781 gacagcagaa ccgcgcacca ccgccaacac cagatctccg tcacgaaccg catcggtcaa
3841 ccgtttaagc accactacgc cagcaccttc accgcgcaca aacccgtccg ccgcagcatc
3901 gaacgccgca cacctgccgt gcggagacaa caatccccat gcagaaattg cgatttgcgt
3961 ctccgggcgc agcgtgatgc tcactccgcc ggcgaggacc aggtcagttt cgcgtagccg
4021 caaactttgg caagctaggt gcaccgccac cagcgacgac gagcacgctg tatcaaccgc
4081 caccgatgga ccacgcagcc ccaacaggta ggagattcgg cctacagtga tgctgtgagc
4141 gtttccggtt ccgctgtagg cgtctacatt ctccagactg gaggccaaca tggattggta
4201 ttcgttgaag tagacgccaa tcatcacgcc ggttcggcta ttacccaggg aatccggtgg
4261 aattccagca ttttcgagag cttcccaggc aacctcgagt agtatccgct gctgcgggtc
4321 catcgctgca gcttcgcgtg gcgtgatacc gaagaatgcc gcgtcgaaac ccgcgatatc
4381 ggagacgaaa ccgccccatt tcgtggtcat ccgacccggc gtcaacgggt cggggtcata
4441 aaacgcatcc gcgtcccaac gatcagccgg cactctcgag atcgcgttgc ggccgtcgat
4501 cagcagatcc cagaagctat ccggcccggt cacgtcccca ggaaaccggc aaccgatccc
4561 cactaccgcg atgggctctg ccacagcaat ccgagagagc ttggtgaatt cttcgataag
4621 agccgcgcgc tgctgcgtgg tcatgccgga aatccggctg aaagcggtcc gcatttacac
4681 caacccttcg gcctcagtcg atgtcgattc gatgcggtcg aagagactat ctaatacgcc
4741 tcctgccgag gcggataagg cggccatctc gtctccttgc gaatcgtgct gcggtgcgac
4801 aacttttgtc agatacgcgg ctagtaacgc aacggttgga tggttgaaca gcatgattgc
4861 cgacagctct ataccaatga attgctcggc ttcacgccga atcgccattg ccataaggga
4921 gttgagtcca agttcggcga atggtcgatc tgtatccagc tccgcctcgg ccacccggag
4981 ctctgcggcg atgatggtcc gtaagccact ttcaagctcc ttccgtacct cggcggcctc
5041 catctgcgac caatttcgtg ccgggactag atagctatcc ccggcagtcg atccggcgga
5101 cccgtaggac ctagggaccg gcaatacaac cgcctgtgca acgtcgtagg catcgacgta
5161 ctcccacgcg gtgaacgctt ccgaaggcgt gatatcacgc gaccccattc gctgcaactc
5221 atcactgaca atctgcgcgt tagcggcgaa tccgagcccg cgccaggcta cccagtcgat
5281 gctcatagtg tggcagccct gctggcgacg cgtacgcgcc aacgcgtcca ggtaggaatt
5341 ggcggcagcg taagagccct gacccgggat gccgaatatt cctgcggccg aggaggtcaa
5401 gtagaaaaag tccacactgc caggtggaaa ggcctcgtgc agcacctggc agccggcgat
5461 cttaggccac ataacttgac gaaccggatc gtcggtcatg ttcgtcacta gttggtcatt
5521 cgtaacgcct gccgcatgaa tgatcccccg gatcggcgcg gcgccgtcac ggtcacgctt
5581 ggccaacaag gcctgcacat cgtcgtggtg tccgacgtca accgcgacgg cttcgactgt
5641 cactccccgc atctcaaggg cgcaaatagc atcgatcttc tgacgcagtc cggcatcgag
5701 agtgtcgagt tcccagtccc gccttggcgg taacggtgta cggcccatca acaccagtcg
5761 acgagcgccg cggtcagcga gccaatcagc catcagcaga ccaagtgcac ccattccgcc
5821 ggtgatgagg taggccccat cggacttgca ttgcaaagat ttgcgcaccg gctcacttcg
5881 gatcggcacc aatgtcgggg caagcacgac gccgtcacgt aataccacga tcgacctggt
5941 cggtgtttga agcagactgg caagcgtcgg cccaaattgg tcgagaatgt cgtcgcgatc
6001 ggctccaaga gcactagccg caagatcgac gagtccaccc cacatctcag gatgctccgc
6061 ggcgatgacg cccccaaaac cccacaggaa gctctggcgt aacgcggacg aggccaccga
6121 ttcgtaaact ccgcgtgtga cgatccacag tgctacaggc ttgcccggct cccgcttcgc
6181 caaagccctc accaaatcgc tgatctcagc agtgattcgc acggcaaagt cgacgtcggt
6241 ctcggcagtg gttgccgggt ggggatccgc gacataaaca acgtaacgta cctcagacac
6301 cccatcagca ggcgcagcca acgtatagcc cgcctccttg agcagcaagc caaacccagc
6361 gcgagcatca ccgattaccg cgacagaccc cgaactggct accggggtgt tggagcaatc
6421 caggtcggtc cgcggttgcc aatcgatcgc atgcacgaaa ttcctggcat ctgtaagggc
6481 atccacatgg gattcaacga aaacagtcga atagtcctgt tgcgcgttgt caaggtctaa
6541 cgctcgatac cgaagtgacc gcatcaacgc caacggcaca ccgctgccgt cggcgacggt
6601 gacatcgacg gtaatcccgt cgtcgtcgca agcagtgcga tttagcgtca ccgcaccaca
6661 tggtcctgta gcggtgtcgc ctaaccacac ctgcttaatg cttgccggca cgtaaaattg
6721 cgtttcggta acgtccgcca gcgctgggat aagaattgcg gcgtcgagta gcggcgcgat
6781 cgccccgtcg ggcagggtat cgggaaattc gatctcaacc gtgcggctgg ttgactgctg
6841 cgtctttttc gcccatgact tgacggacca ctcgaaaggc aggccgtcaa ccccacacag
6901 cgcgagcagc gaagctacgt cgggaatcgg gtccgaaatc acctcaagat gaccattaat
6961 ctgatccggg tggtccgatg gaaccgcgga acgcgccgat gctgaggaaa gctgcgcggt
7021 cacatgccgc gtccaccggt gctgaggagt ttcggtggcc ggacttgagg ccaggctgat
7081 caattggtta tcgacgacga cttggatcaa acgggggaga ttagcgaaaa tgggttgctc
7141 gaatcggatc tcgaatagcg tagaataacc caattctgct gcagcacaaa ggattgtgcg
7201 cagcacaata gaagcaggga ccacctcgac accgtggact cgatgccaac ccctgtacgg
7261 cttggcctgc ggcgctagcc gcgcctgcca caagtggata ggaagaatcc ctgagaccgc
7321 ggtgtgttgg ccaagtagcg tgcccacctg gggtgccaat ccaatagagt tgaccgaacg
7381 tttccgaggg atccagtggc gggtgtgctg ccagggagtg ctggggatag ttacgtgtgg
7441 ttccgcagga tgaggggtgt gtggtgggtg gacggtgtgg acgttgttga ggttggtgtg
7501 aaaggtgacg gtgtcgtcgg catcgcgttg cagggtccca atgctgatgc accgggtacc
7561 gtgcagggtg tcagtaatgg cttgggtcag cagcgggtgt gcactgattt cgatgaaagt
7621 gcggtggtca gttccagcgg tcatgatggc ctgctggaaa tgcactgggt tgcgcatgtt
7681 ggtggcccag tgctgggcat cgaacaccgg gcacgagcca aggtcagcat aggtggtgga
7741 aaggatcgga atcgtcggag tccgtggggc cacatcggcg agctcggaac gcatctgcgg
7801 ctgcagcgca tccatcgccg gattgtgggg ggccacttca atattgaccc gactggcaaa
7861 ccgattctgc gcgcgcaccc ggtcaatcaa ctcatcgatc tgttcagtgg gcccggcaat
7921 caccgtttgg cgcggcgaat tgtaaatcgc caatgtcacc tgcgagtagt cgacaatcaa
7981 cgcctccgtc tcgaccgcgt cgagttcgag cagtgccata ccgccctgcc cagacagcgg
8041 ggccatcagc cgcgaccgag tggctgtcac ccgcagcccc tcagcggcgg taagcgcccc
8101 agccaccacg gcggcggcca cctcacccag cgaatgcccg atcaccaaat caggttgcac
8161 cccataggaa cgccacaact cagtcagcgt cagttgcatg ccgattaacc ccagctggat
8221 ctgctcgata ccaaccagtt ctttgccatt agcgagcaca tcgtgcaacg agaaaccggc
8281 gtggacaaca aacaccggtt ccaactcggc aaccgcggcc gtgaaagccg gttcatcggc
8341 cagcaattga cgccccatcc ccgcccactg cgaaccacgt cccgagtaca caaacaccgt
8401 tcctgaccca ggtgtgccat cctgctgccc gaccacaccg ggcgcctgtt tgccggcggc
8461 caacgcccgc aatccagcca ctgcctggat ccgatcacgg gcaaccacgg tgccgaactt
8521 ggcgtgccgc gaccggtgat gattcaatgt atgggccaca tcagccaacg ccacttcagc
8581 accgggcccc tcaacccaat cggccagcat ccccgccatc gctgccaccc gcgacgccgt
8641 cttacccgtc accaccaacg tcgacaccgc agtgttggaa ctgcattctg tgaccggtgt
8701 cagctcagga ccctgctcaa tgacaacatg cgcgttcgtc ccaccgaagc caaacgatga
8761 caccgccgcg cgccgcagat gccctgtatc cggccattcc atatgcttat caacaacttt
8821 catacgcaac tcagcaaaag gaatatgcag gttcgggctt tcaaaacgct gattcggtgg
8881 aatctggcca cgctgcaccg ccaacactgt cttgatgaag ccggcgatgc ccgcagcagc
8941 ctccaagtga cccaggttag tcttaacagc cccgatcagt agcggagaat cctcggcacg
9001 tccccgaccc agcaccgcac ccaaagcgcg cgcttctatc ggatctccca acagagtccc
9061 ggtcccatga gtttcgacgt agtcaatggc agtcggtggc attgctgcgt tggcatacgc
9121 ggtgcgcaga accgctactt gggccgccgg gttaggagcc atcagcccgt tggagcggcc
9181 atcctgattg acagcagaac cgcggataat ggcaagcacc cgatcaccgt cgcgctgcgc
9241 atcggtcaac cgtttaagca ccactacgcc agcaccttca ccgcgcacaa acccgtccgc
9301 cgcagcatcg aacgcgcggc aacaaccggt aggcgacaac gccccgacct ggtcgaagcc
9361 acgaaatacg gccggagaca atagcaaatt cacgcccgcc gcaatagcca ggttggcatc
9421 cgcggtccgc aggctttggc aggctaagtg gatcgctacc aacgacgacg agcacgccgt
9481 atcaaccgcc accgatggac cacgtaagtc gaggaaatac gaaaggcggt tcgctatgat
9541 gctcatcgcg ccacccgtgt tgctccagcc atccacttgg gagagatcgg tggaagcgat
9601 agcaccatat tcgctcaggc acgatccggc gaatactcct gtttgcgaac gacgcagcga
9661 gttggacgaa attcccgcgt gctccaacgc ctcccaagcc acttccagca gaaggcgctg
9721 ctgcggatcc atcttgtcag cctcgctggg tgagatctcg aaaaattccg agtcaaaggc
9781 gtcaatatcc tccaagaatg acccccaccg cgtagtacgg gcgagcagtg cttttacttc
9841 cggcgagccg tcgtcgaaga gctcccaccg ttcattggga acctgtccga tggaggaacg
9901 acggtcacac agaaactgcc acaacgcttc tggaccagat atcccccctg ggaaacgaca
9961 ccccatcccg atgacagcga tcggctcctc gagtgcaccc tggaccgagc gccgtggcgc
10021 cgattctgat tcggggtcag gtgcgggagc aatgagatag gcggccagcg cgttgatcgt
10081 cggatgctcc cagaagtcaa tcggggatac ggtcttaccc aacaaatcgg tcaattcccc
10141 ggagagcaca actgcatcac gggagctcat acccaagtcg gtcaacgata gattaagatc
10201 gacttcatcc ggtgtgcagc cgatattagt caccaagtag ttgactagcc agtggcaaag
10261 gtcagcttcg ctaccaatgc tcgccgtcat accgtcacgt ccagtcgttt gaatccgtca
10321 ctgcgataac gttcgacaca ggccgaacgt cggaccttgc cgcttgtggt gatcgggatt
10381 gagcccggtg acaccagaac gaggtcggcc acatgcaaac tatgtaactt cgatatagcg
10441 gatgtgactt cacgcttcac cgaatggact ttgtgcatgt ggtcttccgc ggacgctcca
10501 tgttccttgt attcaatgat cgccaccaac tgctcggtga ggtcgtccgg cacagtgatc
10561 gccgcgaccc gaccgccggt gatctcctgg attgtcgctt cgatgtcgtc cgggtagtgg
10621 ttgcgaccat cgacaatgag caagtctttg atgcggccca tgatgaacag ttcgccgtct
10681 gacataacac ccagatctcc ggtccgcagc cacggacctt ccgaagtgcc aggcgcgggg
10741 ttgacaatct ttgcattgaa cgtacgtgca gtctgctcgg gcttccgcca ataccccatg
10801 gcaacgtggt cgccctgtac ccagatctcc ccaaccattc cagcagggtt ctcgatcatg
10861 gactccggat cgacgattcg cacagccgat gcatcagggg agccataact aattagttcg
10921 gtcgcgacac tcccttcggc tcggcgggcc ttagccttac tggccgtcag gtattcgtag
10981 tcaaaacgaa ccgccttagg tgcggtgcca ggttccggag ccgccacgta cacggtcgct
11041 tccgcaagcc cgtacgaggg tcgtaccacc gaggggctga gattgaaccg agcgaagcgc
11101 tcggtgaaac gtttcaccgt tgcgatatgg actcgttcgc tgccgctgat gattccggcc
11161 acatccccga ggtcgagtcc gttcatgtcg tcgtcggacg ttctgcgtac ggccagctca
11221 aaggcaaaat tcggtgccgc agaaaaacac gcctgggtag tggcaagaag ttgcatccaa
11281 caggcggggc gccgcaaaaa tgacataggg ctcaacaaca ccgagcttcg ccccgcgacc
11341 attggagcac agaccccaag aatcaagccc atgtcgtgaa acaagggaag ccatgacacc
11401 acggtcgtgt tcagagtttt tgcggcatcg ccgaaatagc cgttcatgct ttgctgcacg
11461 ttagcgataa cgttcttatg cgacaccata acaccggctg gcgtacgtgt cgacccggat
11521 gtgtattgga ggtaagccgg gctagtaaaa ggctggggga cttttggaag cgggagtgac
11581 gcgttcaagt caagcagatc gatctcaatg acagacggag cgttccaccc atcttgttca
11641 catgcgtatt tcgccacgtc actaaccaca aatgaagttg taagaatagc gatcggttga
11701 gaatcccgta acaccgccga aacgcgttcg tcgtgaatcg catactgcgg tggcgaaaga
11761 ggtaccgcga taaatccggc ctgaagagcc cctaagaacg cgataatata ttccagtccc
11821 tgtggcgcca aaattgcaac tcgatcaccg ggcacaccac acaatttgag ttcgtcagca
11881 aggacgcatg aacgcatata aacttgcgac cacgtcaagc tctcaacaaa acccttcggg
11941 tccgacccgt agtcgatgta tgtgtaggcg gtagtgtcag cctgctgatc cgcccgttct
12001 ttcagcaaag cggggacgga aaagttggtt acgaccatac cacaccttcc accttccgtt
12061 cggtttgaca gctcattggc ctgaccgcgt tcatgatgta cccgaactgt gctacccccc
12121 cgatggatcg cacagctcga cttcccgacg ctgggaaacc tcagcaagct gagctgacca
12181 ggctgctgtg acgattacgc agctctagct atcgaggcac gtctgcgtgc ctaccgaagc
12241 ccatctgcat ggtgtcaaac ctactgtccc ttgactaaac ctgctcccca tacaattccc
12301 cccatacaat cttcctgaca tgttagggta atctcttcca gagacagctg ggtgcattgg
12361 ttgaaaaatc catatgcttc ccagcgatcg tccacatcat cgacaggtgc ttctactcta
12421 ttactctatc agctagacct tgactggtcc ctacccgcga tttctacggc cgttggtatg
12481 acctgtggta aatcggcgga cgatggtcgg ccaagtgcga ttcgtgttac acagggagcc
12541 tgcggccaac tttgggactg atgtcccaat ttgtaacgag attcacacct aactccaact
12601 gcaccggtca tgggtcatgg tgcgtgacag ggtggacaac agttagcgtc gaacgccgac
12661 cgatccgcga ccgatagacc cagctaagct cgatcacacc attcgagggt tttatcttct
12721 atatcgcata ctagctctga caaatttccg ttaaggtaga aatggtcccc aggaaacacg
12781 cgaatcgcga acgctcccgt agttcgctca cgccatggct tcatgtcttc ttgggtagca
12841 atccaatcct tatcgccaat gtaagtataa attgggcatg aaaccgtcgt ctctggcgga
12901 caattataac ctgcaatgat gcgggccgca cgcaatgtag gaagcactcc aacacggaat
12961 tcttcgtcct caaaaaaatc cggattcatg ccggtcatgc ggacgactaa gtccagcata
13021 tcgttatcgg aaaaatcttt gatctgcttg tacctaatat accccggagc cgagcaggcc
13081 gagacgaaaa gggcgataag acgatacccc gccgattgga atctcaacgc aacttcgaaa
13141 gccagcatgc cgcccatgct gtgaccaaaa aaagcgactg ccccctccgg cggcgccgac
13201 ggcttcatga tcgcaaagat ttcgtcagcg agagcgggaa tactagtaag cgccggcaag
13261 ccatacccat cgcgctgccc tgggtagtga acagcgatcc gctttatgtc cgctgaaaac
13321 tcccgggaaa atgggacata gtatgtcgca tctccacctg catgcgggaa aatatatagc
13381 gtaggggtgg tagatgtttc atcatcgttg ccgttgttcg agtgcccgtt caccgcgcca
13441 gcataccctg gtctaagaac gtgcagcatc acttcgagca tcaaacagag acgacgaagt
13501 cttatctgac ggcgttactg aatactttgc cttcgacagc aaccgatttg ggcgacatca
13561 gcacggcact cagcgcagcg acggtctgca cccggtagac atgcggagaa cgctggagcg
13621 cacgagcaca ctggccgcac cggtaccgtc ggacgactat ccggcgagca gagcatgctg
13681 ggatggctaa cctgctcgag gtccgacgca ctctcgtcaa ggaagcaccc gcgatggcaa
13741 cgaagagatg gccgacaaac ggtttggttt gtggccaagc taccttggtg gtgtccactc
13801 agtgttgggc attgatcccg gcggcagcac cacaaaatcg agaacccaat cccacgaaca
13861 attttaatct cggtgcagca tgatagattg acgccaacaa cgagagcaac aagttttcca
13921 catcttgatt gatcgctgct actgcttcaa ccggcgtgga gatccttgcc ttggctgttc
13981 tggcaaagtt gcggtcagcc ggcgccactg ggtccgcata atctagtccc atatacagcg
14041 gacttagcta gcagttcgac ttgttcgtcg tcagtgagcg ccatttgcct atcgttgtta
14101 tacctaaaaa ctatggctaa ccacgctgtc agcccagcgg cagagtagga ttacaatctg
14161 tatcttcagt gtactgatgc gccacttgtc caggcaagtt cagattgaac ctgtacccca
14221 ctactatgac acgcgggcta gatagacgca tctgccaaca tgttggcaga tgcgtaagtg
14281 ttggcataac caatgatcgc atggcattga ccgcgtactc gacaagattc cagtataatt
14341 tggttgatct agcgcgacgc atcgccgggt tgagttttcg ctcgattcga catcgagcat
14401 tagtacagcc tggggtacaa ttcacctcta gcactgagca tagaacgcac cgtaccggcg
14461 ttggccgacc aattcgggcg tacgtgagtg taaacgatcc caaagatcat tcacccactg
14521 tccagtgcgg caaacaccca accataatct ggtagcaaag ttatgattat gagattatga
14581 taggtgccgt cgcaaactcg actcgaaaga acctgatact gatatgggcc attccacggg
14641 tacttgatat tcggctatgt caacgaacaa ggtgtcggtc aagttagctc tttctcggcg
14701 aacatttatc tgcctattat cgacaatggc tatcgactta cgactgaaca gcaggatttt
14761 cctcaaggtc gaagcgggaa accctttacg gcgggactcg ctagcatcat tgctaggcta
14821 gcgccggcgc tccgccaggc aacgtgctct ttgggacgtc ccgtcacgag caagagctac
14881 cgatattgag cccccatcgg gcggcgacga ttccatcgtg cacatcaagg aacgccatag
14941 cgtcgactcg gtcgcacgca gagaccggag cctgtgcgcg ccattccaga accggggctg
15001 atcgtgttgt catgtgccgt actcatggca acccaatcac cgtgctggtt attaacgatg
15061 cagctgtcct cgccgagtta atgtcgatga cgttacgcta cgagaactgg aacatagtcg
15121 ccgcccgata gatcacgggc ggtcgtggca gctccgcacg cagcgaccag atgtggctgt
15181 tctagaggtg atgatacccg acatgagcca gctcgacgtg ctgcacaagt tacacgaaga
15241 ccacccccac tatcgcacgc ggttaaagac cgcatcgctg ggctaactgc aggcggcgat
15301 gatgtcacta aacgttcagc atcgaggagg ttaatgttgc ggttacgcgc ggtgctgcgg
15361 tgcatcgggg ttaagacggt aaacagcgat ggcgaggttg gtggccgaca acttagtgtt
15421 gaacgcggac agtcacgcag taatgcacgc tggtcacaaa tctcgttgac ctccaccgag
15481 ttcgagctgc tacgatttac gatgcacacc gctgagcgaa tatttgagca aggctcagat
15541 cctggaccgg gtgcggagct acgatttcgg cggccactcc aacatcgtct agctgtacat
15601 ctcctaccta tggcaagaag atagacagca gtcttaagcc gatgatccgc acgctacgcg
15661 ggttatccag cccgctagcg tttgccgagc ttggttgctt cggctgggcg gatactagtc
15721 gggcaagtcg tggtgctcac tctggtgtgc gtgggaatta tcgccaccac cgaattagcc
15781 ttgaaccacc atctgatggc gtagctcggc gaaacctctt atttatcgct ccgcgtttac
15841 gtaccttgaa ccccagcatc gggggtgaag acgcgaggaa tccatactag ctatccgagg
15901 ccgggaaggt ccgaggttcc ttaatgcccc ggtccagccg gccgacatgg tggccgcagt
15961 agtcaacaac ggcaaggcag tcgatgacgg ccatctgacc aacagcgatt tccatgccgc
16021 attgaccccc agccgcccag gcccagctga aactaaccgc cggcaggcgt tgactccgcc
16081 atgctccgga tgtggatcgt ctttgcaata gtcaccgtga tcgcgctgaa cgcctagata
16141 accgccggca tgctcataat caaacgggcg ctggcgccgc tgagacgcgt cgtccaaacc
16201 gcgagccatg tggctgttct gccgctggac cgcggtgatg ttgtattgcc ggtgggcagg
16261 ttcccgaacc cgatgcaaac ccgccataaa gaggtgggtc gactcggatc gaccctcaac
16321 cagatgctcg atcacatcac ggccgcaccg gggcacggca agcgaacaaa accagttgca
16381 ccagttcgtc gccaacgcca gtcacgaatt ggacacaccg ctgagcgcca ctataacctg
16441 attagcacaa cggatgggcc ggatggtcga ggccaggagg gggtgcacac acgatgagct
16501 gggtgttacc cgagaccaag cagacaacgc acctcgtcga ggacctactg ctcctggccc
16561 ggctggactc cggtcacccg ttagagcgcg aacaggtgga cccctgtctc gactggccgt
16621 tgacgcagtc agcgaagcac acgtaacaag gaccgggcca ccagtgggag ctttacccac
16681 ctgaagagcc agtgattgtt cccggtgatg aggcgcggtt tcaccaagtg atgactgacc
16741 tgcttgccaa cgtccgcatc catcccggcg ccagcaccgt cgcggttgac caccgacccc
16801 agccatagca tgctgcaggt gatagccaac ggccctggca ttcctttatc acctaagtcg
16861 gaggtgttcg agcggttcgc ccgcggggga accgctcgaa cacaaacggg cagtatcaag
16921 ctgggttagg ctaccgtatt ctcggtagtt aaggcacaca acggaaagat cacggtgaac
16981 aattcacccg gtcacaccga gttcacggtg cggttgccac tcaacgggtg gcaaccgcac
17041 cgtgagctag ttccagatca ccacatagct agtagcagat cacgtcgatt tccaatggcc
17101 tgctcaacgg ccacagggtt gaccagaggc actggcaact gtcattctag atagagattg
17161 acgcgatttc ggttcaacag gcggccgtgc aggttgccgt acttgtccga gtggtcgcat
17221 ttttaggccc gctgctgatg ctggccaaac tgtgcgacga cgaaggctcg tgcgagaccg
17281 caggcacggt aatggcaccc gttcgcatcg ggtcacacgg gccctgcagc acgtgttcgt
17341 catcaccgcc accgacccta ctgccgcgcc cagcctggac accacggtaa tcttgcagct
17401 attgccattc ttgctggcct ctgccgcatc gatcatttta accgcgatcc gacttgtatc
17461 ccagcgtcac accgttaacc ttgccaagca caacggactt cacctcggta ggattacaat
17521 ttggtgagca cggcggcgat gcctgtcgcg gccccaccga tcgtgatgtt gacggtgcca
17581 cccgcagtta tgcatacgac cgcgccagtg atgtcttggt tcttcccgtc ttatgatgcg
17641 tcgacccgtc ggtaacagcc gatgtagcgc ctacactcga ggtcccgctg ctgttagttg
17701 acttgttgct cgaaaagcca aaaacaccag caaccaaaat tgccgccccg gctatcgcga
17761 ctgtcaggcc acgctccacc tgttctcctt tgctcgatct ttgcggttca tcgacgttga
17821 gtaccgtctc agcaatatgc tgagttaaca cgactgaaca aaaaattcgg cgaaaaattc
17881 ttctgatagc cctcagtcct tcgcatggtt attacacgga taggaagtgt atacataact
17941 tttctttctc cggaaaccgg atcgatagcg aggtattgcc tgtggaccac aaacccctac
18001 cgcagtcatc gaatcgtccc acagctaaca cactttgccg ttccacgaca ccacggattt
18061 agacaacgct gatcatggat tcattgttgc cctataccca tgcgcgatca aaaggaccga
18121 caacagcatg ggtggaacaa cgacgtgtac tcgttcctcg gcgccttcgc accgacttcg
18181 gtgcatccca acctctggcg gcaatagacc ctaaccacca aacaagaaat gttcgaagta
18241 gttcgcggta tctatatcta tccgatccgc agcttcgata tatcgaatat caccttcgtt
18301 gaaggcgaca cggggattat cgtaatatat tcgtaattga tcctctggta tccaccgaaa
18361 tgaccgctgc ggcactggac tggtacggca agccatcagg atggtgaccg tcccgtcgtc
18421 gcggttgtct atacctataa ccacgtctag cttcgtcgat catttcaaca gcgttctggg
18481 cctgggcatc accacacaaa cggacgcgta tccggcgatg gcacggcctg caaaactgcc
18541 aggtgggctg caggctcgac caggcctcgt ccaccagcta gatcaccgtc atcgtctcgg
18601 ccaatcgaca tctggacgac cgatgaggca acaccatcga cagtgtggcg gtccatcagc
18661 aggacgtgtc ggacaccgag gtccccaccg agatgcattt tctattcccc acgatttcgc
18721 accctgttca tgaccaggaa tgacacccac aaccacagcc tgctggctct gcggggcaca
18781 ttggtgcgag atccgcacac ctgggcgtgc tatccctaac cgaagcgatt gacaccttcg
18841 ccgatcgaac cgatgcagtg ttctcctcgc accattgacc aacctgggga cgaaagaaca
18901 tcgtcaaatt catgtcactg caacgcgaca tgtatgcata tctgcacaac cagacactgc
18961 aactacttaa ccagaggtgc acaggcgtta acatcgcgaa attgttccaa atgccactcg
19021 tactagaaca gtaccgggta accccagcta ctacgggtta atcagccaca acatgaaggc
19081 ggcctacgag tgctgcatgg gttggttcga tggcaattca gcacggctat agccgcaccc
19141 ccataagcaa tcgggccccg ttacgtcgac gcgatggtcg gaatcgaccg gatagtcgaa
19201 cttgcccaaa cagcattgca atccagcaac ttcctttggg cagcaaagcc actcgattat
19261 gcaatgttca ccgacagcta gtatgccaca ccctgggcag tgcgctccga cacgttggag
19321 aagttggcct acggttaagg aaatactaca tggagcaact gttgaataag ggggtaaaag
19381 aattaagcta cagcaatttc gacaccgcta gcacaatcag ctccgtatca atgcttaatc
19441 agccaactcc tgagcaaatc ttcgaccgga tcgccatccg tgtcaactga ccgtattagc
19501 atctcgatat cgtcattgac atcactttcg caaaccttcg cacaaactac caacttcctt
19561 acgtaacggg gtcataattt accgtcatct cgcagttgta tacgcaacag caaaagttat
19621 aatgaaattg tacaataagt ttcgactact tgagtgtggc gatgaacgat ttcagttcac
19681 ctgaactgga agtttccagc gaccgggccg gactgcaggc attactaaat gtgcttgacg
19741 agccagaccc aacttcaaca tcgtcacgct gtagcactcc ggctgagaac ctcaagtgac
19801 gtggatagcc accttgcact cggcaacaaa tcggaatacc gacggtcgat gaccactcaa
19861 gcggcatagt cagttaattc caggattcga gccttcaggg ccatccagat cgtagtcgac
19921 ggtagccgcc gcgctaccgg tatagctcaa acttctctga cctagacact gccgcacaaa
19981 cccccacctt catggccaca gtcagatcga cagaagctaa ttgtagccca ccgacagcac
20041 ccaaaacaac aaccgattct ccttgcacga catggataat agtctaaagg ggacctcgaa
20101 gttgagagcg accaccgcgg cgaacaaatc cttggtgaag tcgatcagat tgtcgtaaag
20161 cggcgacata tccacgttgt aatcaaggta tccaccctgc cgaagcactc gcaagctatt
20221 tcaaccaaaa tccgtcgatc tggtcccagt gtcctacttg cactttataa gccgcagcag
20281 cgctaccgat ttcggcccca atctcctcgg cggtggcaat gcatttatcc atcttgcggc
20341 tagcgataac cccgccagct ccgcaacgtg cagcgacaaa accgatttcg cgtccccgtc
20401 cgcagctgcc accagtgatc aatactaccc ggtagatggt accgaaagct gacataaata
20461 accttattcg gtgcatcttg gtcggtcgtg accagacgag ctcagctgag gtggggatga
20521 gttgcggaat catcgactcg aaagttacgg tgatcttgac gtcaactttg ccggttctta
20581 cggctccgcg gcgtaggtct tctccagata caatatcaac cttccagttg tccaacgcca
20641 gatagtagtc tattttctcg acggaaaacc acctgaccgt ttcggagcgt tacagcaact
20701 cgctgcgagt tagcatgcca cgcatgttca gatagacgcc atcggcgcag gggtattagc
20761 cgtaataacc cagcagatac cagaagaaat ctaacagcaa gtcaccgatc ttcgtcatct
20821 cccagtccac aatcactgcc agtaaagccg gaatcccgta cgcaaacatc acgttggcga
20881 ctagcggtca acttaacgtt tcatggaatc catcgatatg gcgaaagccg tcgagtcctt
20941 aagcgcgcca atccactctt cctagcttag ctgagccata gacaagctcg aacaccagcc
21001 cgcgacgggc cctgcagagg tagatatcaa acggcgtttg ctatccgcag tccatcgggc
21061 tccacccgtc tactgcttgc atcacataga acggcatacc gagcaccgtg tccgtctcat
21121 cggcgcgaaa cgtcactgcg cgccagagaa cgcctgtatc agcctgatct ttcgcaacaa
21181 gccgtcgata cagcttgcag cggcggtgtg taccggccat ctagagcacc atgcgcgcca
21241 ctgctggttt aggacctcac tcaatcaaac acaatgtgtt ctgcgaacaa ccctttagtt
21301 gtgccagcaa tagctcttag ccgccgcccg gagcgccgtt ttcgtccaac caccgaccac
21361 acatccagct agggcccgga tacttgttga ccattgtcta cacaacactc tcccgataca
21421 gagacagagc attcttacta acgaacttag cagcgccgac aaccactatg ggaagaaaca
21481 tggaggtact cccgacccgg catacgttac cactgcgcaa caatacggtg agagctccga
21541 ccccgacctg tcgaataaag gctggcgtag gtcgcggtct gcccgctgtg gttgcttagt
21601 ttaccataac ccgggtagtg atcagcccgc agcgccgtgc cgaccaaacc gacacactag
21661 tcgcggcggc gtgtaaccca cctgtcgaca tagacgaccg attcgcggaa tacgaccgta
21721 gcggaccact gtatatcccc atcaagcagg tctgtgcgga aaatcccgcg gaatgggtgc
21781 ggatgactca aggccatctg cccggtgtgg tcgcgaggat gtttttcttg catgcggccg
21841 cacagcggtc aataacctgg ttgtcgccgc cgatcccgaa gacactgttg cgatgttcag
21901 ccatgacgag gtaatcaacg tgcttctgca cgatagtctg aggacggccc cacttttatc
21961 acttcccccc tcaactaaca cgtcgctgac acggcggttg tactaacggt ctgatcaggc
22021 aacggtagcg acggtgaatg cagccgaaca tgtgtggatc tgttaccccg aaatcagcgg
22081 tggtgaatcc ggccgcgaca ccagcggtgg tagacaagtt cgagtcgaca acagctgacc
22141 aactcaaggg gctcgacctg tctgcattgg acgggtatct gcgttcattc ggcatcgagc
22201 gctaaagcaa attgcgggca gactttattt tcggtggcca ctccaatccg actgtccgaa
22261 tttacgacga caaaacgaac tggctggttc ggcatccacc gctgcatcgg ctaacgctgt
22321 ccacgcacga tatggcacga gagtcgtcgc gctgcaggac atggccagtt ccggtggcgc
22381 gcaccaccgc cctgtgtcag gacaacgcgg tgctgggtgc accgtttcag gtctcaaatt
22441 cgttgccggg caagtagtgc agcggtgtgt ccagctcgaa gcgttagacg gccgttacgt
22501 aatcgacagc tgcgtcaacg gattgatccg agtactcgtc aacttgcaca gaattaactc
22561 aaacgcggta ggactgagta atttcggcaa attcagcgaa tatctggaac accaggggcg
22621 ccgatgaggt tcgcaatggg acctggtacg actacccggc aaccacccct acgccgacgt
22681 cgatcgacta cattccattc tgcgccaaac tattccacaa cggggccgca cctcgatcgt
22741 gcacagttac tactggatcg accacaccat tctggacgac gacaacccaa cacaagttcg
22801 agttgttgtg gactgggagc tctcgactct aggaggaccc gctcaaacta tacggcgtcg
22861 atgtgcgtgt accactaccc cgagcttgac ttgatcgtca acgcgccaac cgtctggaca
22921 tcgccgctgc taccaacatc cgacaaactt gcagatcggt acttgctggt taccggcttg
22981 cctctagcgc attggaaatg ctacatggcg ctgggctatt tcaagctagc catcatggcc
23041 gcgggcatcg atttgcaaac gtatgtcaga acaggaacag ggaaagacga aacgtttaac
23101 gacaggaagc ttgaagtcgt agcaacgttg atttccctag aactggcgac gcttcatcac
23161 gctgagcatg tagtcaacgg ttttagcact catctcatca ccgatgagcc gccacgtagc
23221 gctttttgac cgtgcggcgc agctgaagga tccgcgcggt gccgactgcc actgctagca
23281 gtccaccacc cacggccgac aacattatgg ctacccccag aggcaagctc caatgccagc
23341 cgaagaaggt gaaaggtgta gacgtagtgt tttgtgcgat gaaaatcagc aacaggatca
23401 agatcaagaa gccggcaaac aatgccgacc acaaagcgcc cgcgcgggta accgggacag
23461 cccgttcccc aggtgtcagt ccgacggcgg gcgctggctg actaggcggg ccagaaggat
23521 tgctggtcat aaatgccatc ttggtcctat ctcaggcaaa atggaaccaa aacgcacgaa
23581 aaatctgcca gtccgcacgc agatgcagca acgcctcatc gtttctgacg ttagagtcgg
23641 cggtatagag attccgcaac gcgtgcgttt gcaatactgc ccgtagaagc atagcgcgtc
23701 accaggttcc tggttgcctc ctgcagcaat tccgatccgt tcggggcaca gactcgcagc
23761 gtgaaattca ccgtgatcaa ttccggtgct tttcggaatc tgcgatcacc gccgaaatct
23821 atgcgcacaa gcgtcgcagg tcatggtttc gacatcgggt ggcggatggg aatgagcaac
23881 tacgaaacgt ataccccgat actcactcaa agaccattcc attgacctag tacagagtac
23941 atcagcaacc tgttgttggt attttcaact tgactccaca acaaccgtgt tcgacgcagt
24001 cgacttggag ctctataagc tccggcccgg agacccatcg attctaacgc catcaccggc
24061 ttctgacacc gacacggtaa ctgtcaccaa tcagacctcc accgcgtggc cactcgaaaa
24121 caatcactaa cttggcgaac acattcgctg gatgtgaagt ttgccgctcc gccagccgta
24181 caaaggattg cgacagaagt tactcactcg atatcagccc gagcaaccta gtggtgccca
24241 acgactacgg cggtgcggta accgtgcaca cccccgggga agggagggtg accgccgcca
24301 acatccttcg gtacatcgca ggccatccca caaaatcacc tggtggcact cgaggatcca
24361 aagcaccact tcctagccag caacatgttc cgctggtcaa ttcgcagcag aaatcggacc
24421 gtctcaaaga tgtgctggac acggtttcag ctggtttggc caccgctgct tcccttgaac
24481 tgcaggttgc tgtcgtgttt gtgtctgtgg cggtgagttg ttcggttggt ttcataggtg
24541 gtgggtgaaa tggctgtttt tgcgttttat gactggccga tatgttcggt agtcgtgggg
24601 ggcagcccgg aatcctgttg acgtgttttg ctgtgttgcg gggtttttgt tggtgggtgg
24661 ctgactgcct gctttcgatg aggcttcgtg tgctttgccg cagtggacac gattagcgcg
24721 gcgcacgtaa gcatgtcggt ggtgggtgct gcttggtcta catgttgatg atgccagggg
24781 ctgggcacct gggctgtgct gaaggcgata tcgatgcagg cgtgagtgtg aggatagttg
24841 ttagcgccgc ggggtagggg cgttttagtg tgcatgtcat ggccttgagg tgtcggcgtg
24901 gtcaatgtgg ccgcacctga acaggcacgt ccccgtgcac ggtataacta ttcgcacctg
24961 atgttatccc ttgcaccatt tctgccgctg gtatcggtgt cggcggcttg ttgaccggcc
25021 ctcagccagc aagcaggcat gccgccgggt gcagcagtat cgtgttagtg aacagtgcat
25081 cgatgatccg gccgtcggcg gcacatacgg caaccttcta gcgcagatca accacccaca
25141 ccccaccagc ccaccacaac accaccctta ggcctcaatc accccaacaa tgccccgtcc
25201 gatgctgact cgcacaaaga ccgacagcga cgatgatcag attaggtgaa caggtagtcg
25261 gtgagagctg ctggctagcc gcttgaggtc caccttcctc gcgcccacgg cttcgaggac
25321 aggcgccaaa ggatgcgatg cagtgagctt actccggatg gaaccggcgc ctggtgtctg
25381 agctcatgat gccggtggcg ctggttgcct tgttgaaaaa gcctgagacc aggatatccg
25441 ctgttaaagg cattcgtacg gagtttctga gggccgagct aggaccagtt gcgcttccga
25501 cgccggccga ggttcgggtt acccgactcg aatccgatga taagatgata acggctatag
25561 cctggtttgg cgcggctgcg ttgagcaaga tcgagtttag atttgccccg ttgagaccac
25621 ccgttacgta gcagcggccg gagtggaaga agctgacgtt gcccgggccg cccagtccgg
25681 gcgtctacca gccgagggtt tcctagtacc ggggtcacgc cggtgacttg ggtgatgccc
25741 gcggttccgc tgcggacgtt accactcgcg aagcttgcgc tattcgtgcc gatgctgata
25801 ccaaggtagc gcaacgttcg ctgccccgaa gccaattgct cagccgctgt agacacgcag
25861 gcgtggtacc ccgaacatcg catctacttc ccacgcccac attattcttg tacgcggctt
25921 agatgtcgac gatcacggga gcctgttttg caccaaccag cttgtggccg ctaacacttg
25981 cactaggacc cgattgaccg ccaccaccgc aagctagact gtggtcgcta ctgtcgcctc
26041 gaacacggct gtagtggcct gagtgctgca ctaaatcatc cacgttggcg tcgccgcagc
26101 cagcatcgct gccgacgaca gaaggtcctc ggacaactgg tttttgctgc agcaagcagt
26161 ggccccgatc cgggaccaac gaacatgagt accgaattga tttcagtcgg caaccaaacg
26221 tgatgccgat gtgtcacaac tcaaacttaa tggtaaagac cactaccgta accgtatcat
26281 ccgcactggg gcgtggattg caggacatgt accagattgc cgggacgggc atcggtcggc
26341 aacctgttgt cgactacata cttggccgac aaccacggtc gcgacgtagc tctcggcgat
26401 ctggtcgtag ttgatcaccg gcttatacac ccgaagggtg atgtggtcga tgacgttcag
26461 gtcggggcct tgtagccgac tgcgatccgg ccgcggtcgg ccgtgccggc gacgcaggcc
26521 ggcaaggagg tgatttcaca ggcaacgaga accgtccacg cgcccagtca catgcccaat
26581 cacgccagga agagcagtcg ggtagctagt gtcgcagatc atgccgtagc atgtgccgcc
26641 gtcgcggtgc agtagctttc cgacgatgtc tcgtgagttg tcttctaggt tgctggtcgc
26701 ggcaagcagc atgacattac cgtcgtcgag aacccgatgt aggagactta catcgggttt
26761 tcgacgacag ccgcgggtac gagtggctat gtagtaatcg ccggtcgagt tcgttattgg
26821 ggttggtccc ctagtgggaa atccagtact gtgcctgcgc cacgtacagg atcggatgat
26881 catgcccagg cttgtcggcc aggatgcggg cgctaacctc gggccagcgt atctgcacga
26941 cgtgctcggc caacgctagc tgggcgattc cgcggtagct ggggtataac acgaacgggt
27001 tgacgaagag ctgcaatccg atcgtacgcg gcaataactg cgcgggtgaa ttgcaaaacc
27061 gccagctcca accctaattt actggccttc tttatccggt cgcgttgggt cacccgcgta
27121 ggcgaaaacc atcgtgaaag tgaccgacaa gccggatctc ctcgacgaca tcgaaaacct
27181 cctgcagcac cggctgatag ccggtgctgc aggaatgtca gtcacgcatt ggagccggcc
27241 accgccgcca tcgaccaccc ccttggtgat ccctttaaat ctcctcgcgg gtggtgtcgt
27301 agctcgggat cggttgatcc gctctcggtc tggtgtatgg tcagcagctg ctacgcgaag
27361 cccaacgctc caatctccat agcttgcttc ggccaacgtg cgcatttacg cgaaatttcc
27421 agtagtggct ggttcgcagt cggctccgcg ctaactcata acgtagaccc gcagcggaga
27481 aggcggcaaa gtaagtagcg acatcaatat cacgtttgtc ggcttccagg gcataacaaa
27541 tactcaaaga aaagtttacc ggtccacggc aggccgtcag tcaccacaac actctagaga
27601 atgtccacga caccccagcc atcacgtcga cgagtacgtc gtggtcttct tggctgcaca
27661 gcgcgaagtc aactccgcag tttcccatcc gttaccccgt gcgcggacga cgggggtcag
27721 ggcgctgcct acctagatgg tctaaccgct gacgagggcg ccacggctcg gtgcccattg
27781 ttcctgcgga tgttcgacct tgaggccgat cgccacaaat agtaaacggt agtccggcaa
27841 cggcgacggc atgttgttaa tcaccagcgc gcccgtgttt cgatcgcaac gagcacatca
27901 tcgtggccgt cccggtagcc tacgaaacaa agacggtccg cacatccggg gccgccaagg
27961 tcattctcga ggtcgagatc ggtgcggcca gcagcgagga aggacgcggg gcgacatcaa
28021 caccccggcg gcaaacgtgt ccggggtcac tacgatcgtt gccgcggccg ccaatactgt
28081 tggacgccta cgtaaccggc ccgaccccgt atcgggtttc accgcggcga gtttggccgc
28141 acgaagctgt tcctgcggta cagccggtga tcgccgccca acattaccgc catggtctcg
28201 cggacggcta gaacttagtt ggtaaaagcg gctgcgtccc accgacaacg cctccaggta
28261 gacgagttac ccgacaacgc tcgtcattgg tcatcgccga ctaagggacc aggtcgtgct
28321 ccgcggcgct ggccgggtct acactggcca cagcgtaata cgattccggc ggctgccggc
28381 ttcttcgctg cgcaccctgt ccgggaaaca cgaccaccgt cttacccacc gacactgctt
28441 gacccatcac cacgccagcg ccccactgcc cgctcttgtc agagtactat tctcacgcca
28501 ctcacgacac cttgtaagta gacatcctga gtggtttctt cgctgtagcc cgaaccacgc
28561 agcgaccgta tcacgggtct gtagacccgc gtcttaatga caagatagcg cgcgacgagc
28621 acgcgcggtt gtcggtgcat gaaatatgcc gttagctttt gatatttagg cgcaaccgag
28681 acggtctttc atgtacttat cggtgagttg gtccccgctc aagtacatca ggaaatgggc
28741 tatcaccaac gatgaaacca tcctggccaa cgatacccag ccgttgatcg tgctcgagtc
28801 acaaaaccca ccacacgcag acgtcaccaa agtagttggg gtggagcgtc caggctcaca
28861 ggtcgcggtc cataatgaac ccggcaattg gccgagtcgg attaaatatc cgcagctgag
28921 aattcccgat aactgtagca gtaatgaaac aaatagcatc aagaagccat gtaagagaaa
28981 gattctttat accacgtgac ccgccgcggc gtcgtgcaac aggttggcgt agcgtgtccc
29041 cgcgctcttg ccagccttct tgcggtaaat gaactagctc agccgcagag cccaggtcgg
29101 cgacagcact agcagcagcc acggcgacaa agcccaggtt ccatgccaca tcaatgatgt
29161 tgtagtgccc cgacctccta ccgatggcaa acgtgatcga atgcaccacc gccagccgct
29221 aacaccgaaa cgtttgcaat cacccgaatg ccgtcatcgt tcacaactcc cgccgcgcgc
29281 gaacgttcac tggtagacac ctagataacc gacccagaag cccaacttcg catataccgc
29341 ggtacagatc gtacatctgc atcttctcga caacctcgtc gaaaaaccaa gtgctccaat
29401 gtatatagcg gctacatgaa cctaccctgc cagagtcgca gaatttcggc atgatgcgta
29461 cgcaataggg tcatatcgac agcacgtacc cagttgtgtc gctcggtgat accgacgatg
29521 gcctccgtga agggtggaag gacgtcagag aagaagatgt acttcgtgaa tccaaagtgt
29581 gttgcaaacg gccaacatca gtgcgttcgg catggttatc gccttgatca cgaggtgcgc
29641 ctaccagcct ttccaaggcg taacaaaata ccgagcccat acaatggtat ccacaccggc
29701 gaaaccatct actcttaccg aacgcagtct aacaccccca acacaattct caacgttcta
29761 acaaccaagg accactagaa agtcatagct tctatcgacg tcgcggtaca tagcgtaggt
29821 caatctcgac ttgatacgac aacccgacta tgacggcacg ttgtcacgtc aggacactgc
29881 tgcttgatga gtaagataac tgagcgggcg taggctccac aagtggccgc gtgtatgccc
29941 agccgaccca cccaattcct atttcgagca cctgtctggt cgcttttaga ctccggccat
30001 attgagcaga cggttgatct tgcgtcgttg agtcgcagcc aaatcgcgcc accgggatgt
30061 tcgagttggc agttgggtta ataacgcgca tgagtacgtc atggcctggt agagaaactc
30121 cacgaacaga tggtgacagg ccaccaccag aaatcggctt aaccacaatg tgattccctg
30181 tattcggcta tgcgtcgcca ccgacaacgg tgccagcggt gaaattattt gcatgatagc
30241 tacttgccgg gttgttgtcg gtcgacgcgc aggctggcta tagctatagg agtcgaccgg
30301 tgattatggt gcaaggtaac ggtgatgtgg accttgctgt cgggttgtgg tgcgtgcacc
30361 gaataagacc atccacctga ttgaacgggg aaacgtagca ggcttttgcc gtcgccacag
30421 gctggtcggc tgatggtaat caagtagtaa taaattttaa aatatagcgt tcaccgtagg
30481 tatcgtgcac ttcgccgacc gaatggcaca taagcccgtc gcgggcgcgg tatcaaaaga
30541 tacgctcaac ggggtaaaga catgcccgag tacacgcgct tgtcgcagtg cggtgatgcg
30601 gccctcaggg aacagcaacc cagcggtcgg tgaagacgac tttaagcaat atagttcagc
30661 cgaatggcgt catcgtcgtt gtcggcgatg gcgtcctggt cctctaaatt ccaggtgctg
30721 cgcagagcga atgcatagta ggtcaactcg tccaagtatc cgaacgttgc gctgcccacc
30781 tgatatttgc cgtagccggg gtagtctccg cttttaccca acacccaggt aggtttaggg
30841 cgtgagcctg gtgtgcgggg tggtgttgac cgactgtgtt gggtctggca atgaaatatc
30901 cggattagca gcaacaagca gttagtagat cagttcttcg gtggcgttta agctgaacaa
30961 gaacatcacc gaaagcaccg gcaagatgca cggcgacatt ccggtaatca ggccactcaa
31021 aatccgatct agcgcgatcg tgtgtatagc ttgctatgcg gatagggtga gattacgggt
31081 gggccgcagc aaccgcgatg gacaccgagc ccgcgtggtc acaccagcta acagttagtc
31141 gctgtacacc agggaccggt ctggaggtaa tccaaccgga gcagccacgg tcaacaacgg
31201 tcgagtgcgg ccctgttgcg gccaccagaa ccagcgtccc agcagggcag cgatcgaggg
31261 catcatgaac gagcgcacga tcaacgtgtc gaacaataga cccagaccga tggtggtacc
31321 cacctgcccg atcacccgca ggtcgctgac gaccatggat gccatcgtga acgcgaacac
31381 cagcccagcg ttcgtcacga ctttgccggt gccgcccatc gaacggatga tgccggtctt
31441 caatccggcc tggatttcct gtttgaaccg cgacaccagc agcaggttgt agtcagatcc
31501 taccgccaac agcacgataa ccgacatcgc aagcaccaga tagtgcaatt cgataccgag
31561 aatatgctgc cagagcaata cggacagtcc aaaggaggcg cctagtgaaa gcgcgaccgt
31621 acccacgata acagcggcgg ctacaaaggc tcgagtaatg atcagcatga tgatgaaaat
31681 caggcaaagc gatgaaatcc ccgcgatcac gagatcccag ttagcgccct cgtcgatgtc
31741 cttgaagacg gccgccgtac cggccaggta gatcttggtg tcctccaatg gggtgccctt
31801 gagagcctcc tcggctgccg tgcgtatcgc gttgatactc gcgatacccg cgacgctggc
31861 gggatccccc cgatgtaaaa taatgaagcg agccgcgtgt ccatccgatg acaggaatga
31921 tttcatcgcg cgcttgaaat cggtgttctt gaagacctcg ggtggaaggt aaaatgagtc
31981 gtcatttttg gcagtgtcga atgccttccc catcgtattg gcgttgtcgc tcagctcgtt
32041 catctgatca aagatcccag acattgtgct gtgcatggtc agcatgatgg tgcgcatgct
32101 ctccatgctt tcgatcatcg gcgggaattg ctccaacatc tgcggcatca gcagatccat
32161 gtttttgatg tcaccaacga tcgagttcag tctctcgtcg atctggtcca cgccgtccag
32221 cgcatcgaat attgatcgaa atgaccagca tatcggaatg ttaaaacatg gtatgttgtg
32281 gtcggtctcg atcattagca attttggctt tatccgggcc tgggaaaaat tccgggcagt
32341 gtcggtagat tcgattttct cgtggtgctt ttaggaaaat aacagaaatt gtcttaatta
32401 gtcttgtacc caagcaaata gagcaattcg ataagagcaa tcacgacaga catagcaaga
32461 atttgctcag gctaacggta cccacctgtg gccatccacg ggtccgcaac ttccgtttgg
32521 gtctaataaa tggaaaactg tcgatagtaa ggacggctca cttcaccgtg gtcgccgaga
32581 tcatgacgac cagcattcct acggagcaca gcaagccgag cgttcggaaa tagggcaacc
32641 gggtgaagca gaggcagtac atagcatcgg ttatggtcag acccgaaccg atggcaacgt
32701 gcgcagttcc atggaacatg gtgtagaaag tttttccccg tccttaccga gagtgcgtgc
32761 ctcttgagac catctaagga ctaatagtgc atagtcagct cacggttcaa tggccagcgg
32821 tacaagcaga tttaccgcta aggttgtgat agtccaatgg tgttattata agctgaaaaa
32881 tgataccttg ccgggccacc atgagctcaa ttaccaccat cacgagggtc aggttcacct
32941 gaacaacaga acagtagaca aaaagcaaca taacaatgtc cactaggaag gtgatcatcg
33001 tgacttgttg aaccctgtgc tcacccgccg ttgactgatc ggcaccggct ggaaccgcac
33061 caccgatcat gtaggccttg atgtccgaca gcgccggcgt gccgttcacg atttgttgga
33121 cagactcgtt ggctaagttt ttgccctggt tactggccag atacatttgc acatagaccg
33181 cttgattgtc cgagctttgc gacccggcca ccgtcaatgg gtcctccagc agttttgtga
33241 cgtgctgagt ctgcttttat ccaccaagac gtccggatta actcgctgta ttatttatta
33301 tcgtggtggg tctcatcgtc aatctgtttt gtcgtctttt aggacgataa taatagcact
33361 gtcggtgttg aacttattga acatttggct ggcccgcttc atcgcctgca tggccggtgt
33421 atcgttggtg gtcattgata ccgtatgttc ttttccgacg gttgtggcac gggtttaccg
33481 acggaaagtg ttgtggtcga ccgaaagcgt ccagggcagc gtcggattaa cttacccgtt
33541 acagttgggc atatatatat atatatatat tggcgttggc cacagtactg gcggggccat
33601 aaaattagtg gactaagtgt ttggtattaa acggctggga tgtcagcgga aagccattgg
33661 taaccgcctt gttgtcgtga aagtaaaaga agaagctgcg gagcagataa acaccgaact
33721 ccattactgc aaccacgatc acgatccgca cttctcgctc cgcgacagca accggaatct
33781 tggccactca atcgtctttc acttatttgg cgccccattg ctcgtgcgac cgctttaacc
33841 atcgtttgcc cccgcattgg catcagccga aaccgttcct gtcccagata agaaagcccg
33901 ctaaaatgcc cctcacctga acgtcgcaca aggcaccggt ggtcaacgtc catttgcttc
33961 gccacagcac aacgtctgtt tctgctcact gcgattcggc gatgaggcca aggcaagtag
34021 cagtgagaaa tcgagtcagc gctgtggcaa agtcaaggtt tcactcggat gggaggatct
34081 ccggttatcc ggcataagcg tcagtgagct gctctggggg tgcgcgattt gccacacggt
34141 agccgccaga gaacaggcag ccagcaagta tgtctaatgc acccgaacgc ccgagcacgg
34201 gcaacatgtt gctggattgc gtacgccaag gtaatcacgg cagtggtact ggcccacttg
34261 acctcgacgt ccacttcgtg ttcaagatgc agtgcagatt ggcgagcaaa tcgcag
//