LOCUS AF105378 3201 bp mRNA linear HUM 16-OCT-2007
DEFINITION Homo sapiens heparan sulfate 3-O-sulfotransferase-4 (HS3ST4) mRNA,
complete cds.
ACCESSION AF105378
VERSION AF105378.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1008 to 3201)
AUTHORS Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
TITLE Multiple isoforms of heparan sulfate D-glucosaminyl
3-O-sulfotransferase. Isolation, characterization, and expression
of human cdnas and identification of distinct genomic loci
JOURNAL J. Biol. Chem. 274 (8), 5170-5184 (1999)
PUBMED 9988767
REFERENCE 2 (bases 1 to 3201)
AUTHORS Lawrence,R., Yabe,T., Hajmohammadi,S., Rhodes,J., McNeely,M.,
Liu,J., Lamperti,E.D., Toselli,P.A., Lech,M., Spear,P.G.,
Rosenberg,R.D. and Shworak,N.W.
TITLE The principal neuronal gD-type 3-O-sulfotransferases and their
products in central and peripheral nervous system tissues
JOURNAL Matrix Biol. 26 (6), 442-455 (2007)
PUBMED 17482450
REFERENCE 3 (bases 1008 to 3201)
AUTHORS Shworak,N.W., Liu,J. and Rosenberg,R.D.
TITLE Direct Submission
JOURNAL Submitted (12-NOV-1998) Biology, Massachusetts Institute of
Technology, 31 Ames St, Cambridge, MA 02139, USA
REFERENCE 4 (bases 1 to 3201)
AUTHORS Lawrence,R., Yabe,T., HajMohammadi,S., Rhodes,J., McNeely,M.,
Liu,J., Lamperti,E.D., Toselli,P.A., Spear,P.G., Rosenberg,R.D. and
Shworak,N.W.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-2003) Medicine, Dartmouth Medical School, One
Medical Center Drive, Lebanon, NH 03756, USA
REMARK Nucleotide sequence updated by submitter
COMMENT On Apr 16, 2004 this sequence version replaced AF105378.1.
FEATURES Location/Qualifiers
source 1..3201
/db_xref="H-InvDB:HIT000069486"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p11.2"
/tissue_type="brain"
/dev_stage="infant"
/note="isolated by hybridization screening using IMAGE
Consortium clone 23279 found in GenBank Accession Number
T75445"
gene 1..3201
/gene="HS3ST4"
/gene_synonym="3OST4"
5'UTR 1..389
/gene="HS3ST4"
/gene_synonym="3OST4"
stem_loop join(282..311,352..363)
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="paired inverted repeat"
CDS 390..1760
/gene="HS3ST4"
/gene_synonym="3OST4"
/EC_number="2.8.2.23"
/note="heparan sulfate D-glucosaminyl
3-O-sulfotransferase-4; similar to EC 2.8.2.30; creates
3-O-sulfated HS motifs that trigger cellular entry of
herpes simplex virus-1"
/codon_start=1
/product="heparan sulfate 3-O-sulfotransferase-4"
/protein_id="AAD30210.2"
/translation="MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLS
VTYLCYSLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPP
LDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPERE
AQESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIR
VHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHS
MAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIG
IYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTKKHFYFNKTK
GFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWE
QEEGDK"
misc_feature 492..548
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative; transmembrane region"
misc_feature 591..593
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 621..623
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 636..638
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 672..674
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 702..710
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative N-linked; glycosylation site"
misc_feature 840..842
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 849..851
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative O-linked; glycosylation site"
misc_feature 921..929
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative N-linked; glycosylation site"
misc_feature 966..1757
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="Region: putative protein sulfotransferase domain"
misc_feature 1341..1349
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative N-linked; glycosylation site"
misc_feature 1353..1364
/gene="HS3ST4"
/gene_synonym="3OST4"
/note="putative N-linked; glycosylation site"
3'UTR 1761..3201
/gene="HS3ST4"
/gene_synonym="3OST4"
regulatory 3178..3182
/regulatory_class="polyA_signal_sequence"
/gene="HS3ST4"
/gene_synonym="3OST4"
polyA_site 3201
/gene="HS3ST4"
/gene_synonym="3OST4"
BASE COUNT 696 a 931 c 945 g 629 t
ORIGIN
1 cagcgcgcgg cggcggcggc agaggctgaa gcagaagccg cggcggagcc ggggaagcgg
61 gggcgctgca gacggagcag gtgccgccgg cgggtccgcg cgcccccctc ggtccccttg
121 cctgaggctg aggggggggc ggtggtgggg gggccactcg gactcggcgg gcagcgtggg
181 gcggggggcc atgcggccgg gctcccccct ggcgcagcgg gacagcggcc agggccgggg
241 gcgcagcggc gtcgcttcat gcagccgggg cggctgggca gcggcggcgg cggcggcggc
301 ggcggcggcg ggggcggcgg ctgaaaccat gtccgggcag cgccgggggc tgccgccgcc
361 gccgccgccg ccgcgagccg ggagccgcga tggcccggtg gcccgcacct cctccgcctc
421 cgcctccgcc tccacctctg gccgcgccgc cgccgcccgg cgcctctgct aaggggccgc
481 cggcgcgcaa gctgcttttt atgtgcacct tgtccctgtc tgtcacctac ctgtgctaca
541 gcctcctggg cggctcgggc tccctgcaat tccctctggc gctgcaggag tcgccgggcg
601 ccgccgccga gcccccgccg agcccgccgc caccctctct gctgcctacc cccgtgcgcc
661 tcggcgcccc ctcgcagccg cccgcgccgc cgccgctgga caacgcgagc cacggggagc
721 cgcccgagcc cccagagcag ccagccgccc ccgggaccga cggctggggg ctgccgagcg
781 gcggcggagg cgcccgggac gcctggctcc ggaccccgct ggcccccagc gagatgatca
841 cggctcagag cgcgctgccg gagagggaag cgcaggagtc cagcaccacc gacgaggatc
901 tcgcaggccg gagagcggcc aacgggagca gcgagagggg cggcgccgtc agcacccccg
961 actatgggga gaagaagctg ccacaggcgc tcatcatcgg ggtcaagaaa ggagggaccc
1021 gcgcgctgct ggaggcgatc cgcgtgcacc cggacgtgcg ggcggtgggc gtagagccgc
1081 acttcttcga caggaactac gaaaaggggt tggagtggta cagaaatgtg atgcccaaga
1141 ctttggatgg gcaaataacc atggagaaga ctccaagtta ctttgtgaca aatgaggctc
1201 ccaagcgcat tcactccatg gccaaggaca tcaaactgat tgtggtggtg agaaaccccg
1261 tgaccagggc catctctgac tacacgcaga cactgtcaaa gaaacccgag atccccacct
1321 ttgaggtgct ggccttcaaa aaccggaccc tcgggctgat cgatgcttcc tggagtgcca
1381 ttcgaatagg gatctatgcg ctgcatctgg aaaactggct ccagtatttc cccctctccc
1441 agatcctctt tgtcagtggt gagcgactca ttgtggaccc cgccggggaa atggccaaag
1501 tacaggattt tctaggcctc aaacgtgttg tgactaagaa gcatttctat ttcaacaaaa
1561 ccaaggggtt cccttgccta aagaagccag aagacagcag tgccccgagg tgcttaggca
1621 agagcaaagg tcggactcat cctcgcattg acccagatgt catccacaga ctgaggaaat
1681 tctacaaacc cttcaacttg atgttttacc aaatgactgg tcaagatttt cagtgggaac
1741 aggaagaggg tgataaatga ggctagagag gcagaggaag gctagtcaat aagctaagga
1801 ggctccttgc ctgagtcctt gaatacccca gcttctgcag cttcacttgc tggagtgcca
1861 agtagatctc ctcctccttc atgcagccag gattgcctcc agtgctgtta gcttaggcaa
1921 acaggtggat cccatggcat ccccatggag gaaccaggcc catctgggca gcagcatctg
1981 gttgaccaga tggccaccag aacccactgt tcattcttat cttctgctag ttaatatagc
2041 ctgaagacag aggataaata gttgtcaatg tcagagacag tgctattaat gtatatgtga
2101 gcgacaaaaa aggtctgctt tataggggtt ctcactctag cttggggagc ccagggttct
2161 agccctgtat ctgtcatggg cacctgctgt ctaaacctct gcttgggctt ctccccagaa
2221 tgcactttgt ggctgagtgc tccaggactc ctagggagca agctcctccc tctaaggtgt
2281 ttctagtctt ctctttaaag gtctcatccc acaacccctg acttcctccc tccccacatc
2341 atgaaggcag aggcatgcac attcctcact gaaaaagaaa acacacaccc acccacacac
2401 acacacacag aagaaaatga aagctgacac acctcgaagc cttctttcca agagccctct
2461 aaatggggtt gggtctcact cttcatgagt atcctgggtt gtgcagaagc ttagcatatg
2521 cccttgtgtt cggatcaggc ccacagggct gctcaaagag tagagtaatt gtaaccgagg
2581 tcagagctct ggggttggca gagatgagtg gccatatctg ggggtaaaag aagaaatcct
2641 gtcctcttgg tgggaggtta ccttacctga agaccatctc tcccaagcac tgtagttctg
2701 agcatgtttt tggggtggac tctgtcccct agggtcccta gaagggcaaa gaccagagag
2761 ttgacaagtc tgttattagg aataatcctt agccatgtaa tggagaaagg agcagtcagc
2821 attcttccaa tttgccccac caccacctcc tcgggcttca ttttctctat ttagagatgg
2881 cagagagtga ggtagtggcg agaaagctga ctccattcat cagatccagt ttatgagggt
2941 tgggggtgag caagggctgt ctgcagaaac ccccatcaag agctgctgaa tgaagtgtcc
3001 cttcccatca gtttgattca attaaaatgc atcatttgac ataaagcact tgttcacaga
3061 tctccaaaac caggaattgt tctagtaaaa ctggaaattt gtatgagtgg ggggagttaa
3121 atctgttcag ctgttattaa actgtcattt ctcccgctaa atgaaaaccg tgttgttata
3181 aagcttaatg caacctgatt a
//