LOCUS AAD30210.2 456 aa PRT HUM 16-OCT-2007 DEFINITION Homo sapiens heparan sulfate 3-O-sulfotransferase-4 protein. ACCESSION AF105378-1 PROTEIN_ID AAD30210.2 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1008 to 3201) AUTHORS Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M., Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D. TITLE Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci JOURNAL J. Biol. Chem. 274 (8), 5170-5184 (1999) PUBMED 9988767 REFERENCE 2 (bases 1 to 3201) AUTHORS Lawrence,R., Yabe,T., Hajmohammadi,S., Rhodes,J., McNeely,M., Liu,J., Lamperti,E.D., Toselli,P.A., Lech,M., Spear,P.G., Rosenberg,R.D. and Shworak,N.W. TITLE The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues JOURNAL Matrix Biol. 26 (6), 442-455 (2007) PUBMED 17482450 REFERENCE 3 (bases 1008 to 3201) AUTHORS Shworak,N.W., Liu,J. and Rosenberg,R.D. TITLE Direct Submission JOURNAL Submitted (12-NOV-1998) Biology, Massachusetts Institute of Technology, 31 Ames St, Cambridge, MA 02139, USA REFERENCE 4 (bases 1 to 3201) AUTHORS Lawrence,R., Yabe,T., HajMohammadi,S., Rhodes,J., McNeely,M., Liu,J., Lamperti,E.D., Toselli,P.A., Spear,P.G., Rosenberg,R.D. and Shworak,N.W. TITLE Direct Submission JOURNAL Submitted (18-NOV-2003) Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA REMARK Nucleotide sequence updated by submitter COMMENT On Apr 16, 2004 this sequence version replaced AF105378.1. FEATURES Qualifiers source /db_xref="H-InvDB:HIT000069486" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16p11.2" /tissue_type="brain" /dev_stage="infant" /note="isolated by hybridization screening using IMAGE Consortium clone 23279 found in GenBank Accession Number T75445" protein /gene="HS3ST4" /gene_synonym="3OST4" /EC_number="2.8.2.23" /note="heparan sulfate D-glucosaminyl 3-O-sulfotransferase-4; similar to EC 2.8.2.30; creates 3-O-sulfated HS motifs that trigger cellular entry of herpes simplex virus-1" BEGIN 1 MARWPAPPPP PPPPPPLAAP PPPGASAKGP PARKLLFMCT LSLSVTYLCY SLLGGSGSLQ 61 FPLALQESPG AAAEPPPSPP PPSLLPTPVR LGAPSQPPAP PPLDNASHGE PPEPPEQPAA 121 PGTDGWGLPS GGGGARDAWL RTPLAPSEMI TAQSALPERE AQESSTTDED LAGRRAANGS 181 SERGGAVSTP DYGEKKLPQA LIIGVKKGGT RALLEAIRVH PDVRAVGVEP HFFDRNYEKG 241 LEWYRNVMPK TLDGQITMEK TPSYFVTNEA PKRIHSMAKD IKLIVVVRNP VTRAISDYTQ 301 TLSKKPEIPT FEVLAFKNRT LGLIDASWSA IRIGIYALHL ENWLQYFPLS QILFVSGERL 361 IVDPAGEMAK VQDFLGLKRV VTKKHFYFNK TKGFPCLKKP EDSSAPRCLG KSKGRTHPRI 421 DPDVIHRLRK FYKPFNLMFY QMTGQDFQWE QEEGDK //