LOCUS       AAD30210.2               456 aa    PRT              HUM 16-OCT-2007
DEFINITION  Homo sapiens heparan sulfate 3-O-sulfotransferase-4 protein.
ACCESSION   AF105378-1
PROTEIN_ID  AAD30210.2
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1008 to 3201)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J. Biol. Chem. 274 (8), 5170-5184 (1999)
   PUBMED   9988767
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Lawrence,R., Yabe,T., Hajmohammadi,S., Rhodes,J., McNeely,M.,
            Liu,J., Lamperti,E.D., Toselli,P.A., Lech,M., Spear,P.G.,
            Rosenberg,R.D. and Shworak,N.W.
  TITLE     The principal neuronal gD-type 3-O-sulfotransferases and their
            products in central and peripheral nervous system tissues
  JOURNAL   Matrix Biol. 26 (6), 442-455 (2007)
   PUBMED   17482450
REFERENCE   3  (bases 1008 to 3201)
  AUTHORS   Shworak,N.W., Liu,J. and Rosenberg,R.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-NOV-1998) Biology, Massachusetts Institute of
            Technology, 31 Ames St, Cambridge, MA 02139, USA
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Lawrence,R., Yabe,T., HajMohammadi,S., Rhodes,J., McNeely,M.,
            Liu,J., Lamperti,E.D., Toselli,P.A., Spear,P.G., Rosenberg,R.D. and
            Shworak,N.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-2003) Medicine, Dartmouth Medical School, One
            Medical Center Drive, Lebanon, NH 03756, USA
  REMARK    Nucleotide sequence updated by submitter
COMMENT     On Apr 16, 2004 this sequence version replaced AF105378.1.
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000069486"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
                     /tissue_type="brain"
                     /dev_stage="infant"
                     /note="isolated by hybridization screening using IMAGE
                     Consortium clone 23279 found in GenBank Accession Number
                     T75445"
     protein         /gene="HS3ST4"
                     /gene_synonym="3OST4"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate D-glucosaminyl
                     3-O-sulfotransferase-4; similar to EC 2.8.2.30; creates
                     3-O-sulfated HS motifs that trigger cellular entry of
                     herpes simplex virus-1"
BEGIN
        1 MARWPAPPPP PPPPPPLAAP PPPGASAKGP PARKLLFMCT LSLSVTYLCY SLLGGSGSLQ
       61 FPLALQESPG AAAEPPPSPP PPSLLPTPVR LGAPSQPPAP PPLDNASHGE PPEPPEQPAA
      121 PGTDGWGLPS GGGGARDAWL RTPLAPSEMI TAQSALPERE AQESSTTDED LAGRRAANGS
      181 SERGGAVSTP DYGEKKLPQA LIIGVKKGGT RALLEAIRVH PDVRAVGVEP HFFDRNYEKG
      241 LEWYRNVMPK TLDGQITMEK TPSYFVTNEA PKRIHSMAKD IKLIVVVRNP VTRAISDYTQ
      301 TLSKKPEIPT FEVLAFKNRT LGLIDASWSA IRIGIYALHL ENWLQYFPLS QILFVSGERL
      361 IVDPAGEMAK VQDFLGLKRV VTKKHFYFNK TKGFPCLKKP EDSSAPRCLG KSKGRTHPRI
      421 DPDVIHRLRK FYKPFNLMFY QMTGQDFQWE QEEGDK
//