LOCUS BC069243 4123 bp mRNA linear HUM 27-APR-2004 DEFINITION Homo sapiens histone deacetylase 6, mRNA (cDNA clone MGC:78509 IMAGE:6584427), complete cds. ACCESSION BC069243 VERSION BC069243.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4123) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4123) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (26-APR-2004) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Genome Sequence Centre, BC Cancer Agency, Vancouver, BC, Canada info@bcgsc.bc.ca Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield, Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao, Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin, Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu, Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie Schein, Asim Siddiqui, Rob Holt, Marco Marra. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 54 Row: p Column: 22 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 13128863. FEATURES Location/Qualifiers source 1..4123 /db_xref="H-InvDB:HIT000263397" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:78509 IMAGE:6584427" /tissue_type="Ovary, teratocarcinoma" /clone_lib="NIH_MGC_109" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..4123 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /db_xref="GeneID:10013" /db_xref="MIM:300272" CDS 100..3747 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /codon_start=1 /product="HDAC6 protein" /protein_id="AAH69243.1" /db_xref="GeneID:10013" /db_xref="MIM:300272" /translation="MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSI PNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWD DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMN EGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQ HSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIH RYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEF QPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA EGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNM EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRIL RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNF DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFN SVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPM GDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAG FDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSL LGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAP QPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAA TGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVG GATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQ TPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMAD SMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCL SCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKDIAHQ NKFGEDMPHPH" misc_feature 358..1263 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /note="HisDeac1; Region: RPD3 like Histone decetylase domain" /db_xref="CDD:LOAD_HisDeac1" misc_feature 1543..2451 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /note="HisDeac1; Region: RPD3 like Histone decetylase domain" /db_xref="CDD:LOAD_HisDeac1" misc_feature 2746..3303 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /note="Podocalyxin; Region: Podocalyxin. This family consists of several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion" /db_xref="CDD:pfam05471" misc_feature 3496..3711 /gene="HDAC6" /gene_synonym="HD6" /gene_synonym="JM21" /gene_synonym="KIAA0901" /note="zf-UBP; Region: Zn-finger in ubiquitin-hydrolases and other protein" /db_xref="CDD:pfam02148" BASE COUNT 924 a 1199 c 1169 g 831 t ORIGIN 1 gctggttgaa acgctagggg cgggatctgg cggagtggaa ggtaccggtc cggcccgata 61 aggggtggaa accgcggcag gggccaagcc tcctcaacta tgacctcaac cggccaggat 121 tccaccacaa ccaggcagcg aagaagtagg cagaaccccc agtcgccccc tcaggactcc 181 agtgtcactt cgaagcgaaa tattaaaaag ggagccgttc cccgctctat ccccaatcta 241 gcggaggtaa agaagaaagg caaaatgaag aagctcggcc aagcaatgga agaagaccta 301 atcgtgggac tgcaagggat ggatctgaac cttgaggctg aagcactggc tggcactggc 361 ttggtgttgg atgagcagtt aaatgaattc cattgcctct gggatgacag cttcccggaa 421 ggccctgagc ggctccatgc catcaaggag caactgatcc aggagggcct cctagatcgc 481 tgcgtgtcct ttcaggcccg gtttgctgaa aaggaagagc tgatgttggt tcacagccta 541 gaatatattg atctgatgga aacaacccag tacatgaatg agggagaact ccgtgtccta 601 gcagacacct acgactcagt ttatctgcat ccgaactcat actcctgtgc ctgcctggcc 661 tcaggctctg tcctcaggct ggtggatgcg gtcctggggg ctgagatccg gaatggcatg 721 gccatcatta ggcctcctgg acatcacgcc cagcacagtc ttatggatgg ctattgcatg 781 ttcaaccacg tggctgtggc agcccgctat gctcaacaga aacaccgcat ccggagggtc 841 cttatcgtag attgggatgt gcaccacggt caaggaacac agttcacctt cgaccaggac 901 cccagtgtcc tctatttctc catccaccgc tacgagcagg gtaggttctg gccccacctg 961 aaggcctcta actggtccac cacaggtttc ggccaaggcc aaggatatac catcaatgtg 1021 ccttggaacc aggtggggat gcgggatgct gactacattg ctgctttcct gcacgtcctg 1081 ctgccagtcg ccctcgagtt ccagcctcag ctggtcctgg tggctgctgg atttgatgcc 1141 ctgcaagggg accccaaggg tgagatggcc gccactccgg cagggttcgc ccagctaacc 1201 cacctgctca tgggtctggc aggaggcaag ctgatcctgt ctctggaggg tggctacaac 1261 ctccgcgccc tggctgaagg cgtcagtgct tcgctccaca cccttctggg agacccttgc 1321 cccatgctgg agtcacctgg tgccccctgc cggagtgccc aggcttcagt ttcctgtgct 1381 ctggaagccc ttgagccctt ctgggaggtt cttgtgagat caactgagac cgtggagagg 1441 gacaacatgg aggaggacaa tgtagaggag agcgaggagg aaggaccctg ggagccccct 1501 gtgctcccaa tcctgacatg gccagtgcta cagtctcgca cagggctggt ctatgaccaa 1561 aatatgatga atcactgcaa cttgtgggac agccaccacc ctgaggtacc ccagcgcatc 1621 ttgcggatca tgtgccgtct ggaggagctg ggccttgccg ggcgctgcct caccctgaca 1681 ccgcgccctg ccacagaggc tgagctgctc acctgtcaca gtgctgagta cgtgggtcat 1741 ctccgggcca cagagaaaat gaaaacccgg gagctgcacc gtgagagttc caactttgac 1801 tccatctata tctgccccag taccttcgcc tgtgcacagc ttgccactgg cgctgcctgc 1861 cgcctggtgg aggctgtgct ctcaggagag gttctgaatg gtgctgctgt ggtgcgtccc 1921 ccaggacacc acgcagagca ggatgcagct tgcggttttt gctttttcaa ctctgtggct 1981 gtggctgctc gccatgccca gactatcagt gggcatgccc tacggatcct gattgtggat 2041 tgggatgtcc accacggtaa tggaactcag cacatgtttg aggatgaccc cagtgtgcta 2101 tatgtgtccc tgcaccgcta tgatcatggc accttcttcc ccatggggga tgagggtgcc 2161 agcagccaga tcggccgggc tgcgggcaca ggcttcaccg tcaacgtggc atggaacggg 2221 ccccgcatgg gtgatgctga ctacctagct gcctggcatc gcctggtgct tcccattgcc 2281 tacgagttta acccagaact ggtgctggtc tcagctggct ttgatgctgc acggggggat 2341 ccgctggggg gctgccaggt gtcacctgag ggttatgccc acctcaccca cctgctgatg 2401 ggccttgcca gtggccgcat tatccttatc ctagagggtg gctataacct gacatccatc 2461 tcagagtcca tggctgcctg cactcgctcc ctccttggag acccaccacc cctgctgacc 2521 ctgccacggc ccccactatc aggggccctg gcctcaatca ctgagaccat ccaagtccat 2581 cgcagatact ggcgcagctt acgggtcatg aaggtagaag acagagaagg accctccagt 2641 tctaagttgg tcaccaagaa ggcaccccaa ccagccaaac ctaggttagc tgagcggatg 2701 accacacgag aaaagaaggt tctggaagca ggcatgggga aagtcacctc ggcatcattt 2761 ggggaagagt ccactccagg ccagactaac tcagagacag ctgtggtggc cctcactcag 2821 gaccagccct cagaggcagc cacaggggga gccactctgg cccagaccat ttctgaggca 2881 gccattgggg gagccatgct gggccagacc acctcagagg aggctgtcgg gggagccact 2941 ccggaccaga ccacctcaga ggagactgtg ggaggagcca ttctggacca gaccacctca 3001 gaggatgctg ttgggggagc cacgctgggc cagactacct cagaggaggc tgtaggagga 3061 gctacactgg cccagaccac ctcggaggca gccatggagg gagccacact ggaccagact 3121 acgtcagagg aggctccagg gggcaccgag ctgatccaaa ctcctctagc ctcgagcaca 3181 gaccaccaga cccccccaac ctcacctgtg cagggaacta caccccagat atctcccagt 3241 acactgattg ggagtctcag gaccttggag ctaggcagcg aatctcaggg ggcctcagaa 3301 tctcaggccc caggagagga gaacctacta ggagaggcag ctggaggtca ggacatggct 3361 gattcgatgc tgatgcaggg atctaggggc ctcactgatc aggccatatt ttatgctgtg 3421 acaccactgc cctggtgtcc ccatttggtg gcagtatgcc ccatacctgc agcaggccta 3481 gacgtgaccc aaccttgtgg ggactgtgga acaatccaag agaattgggt gtgtctctct 3541 tgctatcagg tctactgtgg tcgttacatc aatggccaca tgctccaaca ccatggaaat 3601 tctggacacc cgctggtcct cagctacatc gacctgtcag cctggtgtta ctactgtcag 3661 gcctatgtcc accaccaggc tctcctagat gtgaaggaca tcgcccacca gaacaagttt 3721 ggggaggata tgccccaccc acactaagcc ccagaatacg gtccctcttc accttctgag 3781 gcccacgata gaccagctgt agctcattcc agcctgtacc ttggatgagg ggtagcctcc 3841 cactgcatcc catcctgaat atcctttgca actccccaag agtgcttatt taagtgttaa 3901 tacttttaag agaactgcga cgattaattg tggatctccc cctgcccatt gcctgcttga 3961 ggggcaccac tactccagcc cagaaggaaa ggggggcagc tcagtggccc caagagggag 4021 ctgatatcat gaggataaca ttggcgggag gggagttaac tggcaggcat ggcaaggttg 4081 catatgtaat aaagtacaag ctgttaaaaa aaaaaaaaaa aaa //