LOCUS BC069243 4123 bp mRNA linear HUM 27-APR-2004
DEFINITION Homo sapiens histone deacetylase 6, mRNA (cDNA clone MGC:78509
IMAGE:6584427), complete cds.
ACCESSION BC069243
VERSION BC069243.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4123)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4123)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (26-APR-2004) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 54 Row: p Column: 22
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 13128863.
FEATURES Location/Qualifiers
source 1..4123
/db_xref="H-InvDB:HIT000263397"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:78509 IMAGE:6584427"
/tissue_type="Ovary, teratocarcinoma"
/clone_lib="NIH_MGC_109"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..4123
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/db_xref="GeneID:10013"
/db_xref="MIM:300272"
CDS 100..3747
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/codon_start=1
/product="HDAC6 protein"
/protein_id="AAH69243.1"
/db_xref="GeneID:10013"
/db_xref="MIM:300272"
/translation="MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSI
PNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWD
DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMN
EGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQ
HSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIH
RYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEF
QPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA
EGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNM
EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRIL
RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNF
DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFN
SVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPM
GDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAG
FDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSL
LGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAP
QPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAA
TGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVG
GATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQ
TPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMAD
SMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCL
SCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKDIAHQ
NKFGEDMPHPH"
misc_feature 358..1263
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/note="HisDeac1; Region: RPD3 like Histone decetylase
domain"
/db_xref="CDD:LOAD_HisDeac1"
misc_feature 1543..2451
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/note="HisDeac1; Region: RPD3 like Histone decetylase
domain"
/db_xref="CDD:LOAD_HisDeac1"
misc_feature 2746..3303
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/note="Podocalyxin; Region: Podocalyxin. This family
consists of several eukaryotic podocalyxin proteins.
Podocalyxin is a major membrane protein of the glomerular
epithelium and is thought to be involved in maintenance of
the architecture of the foot processes and filtration
slits characteristic of this unique epithelium by virtue
of its high negative charge. Podocalyxin functions as an
anti-adhesin that maintains an open filtration pathway
between neighbouring foot processes in the glomerular
epithelium by charge repulsion"
/db_xref="CDD:pfam05471"
misc_feature 3496..3711
/gene="HDAC6"
/gene_synonym="HD6"
/gene_synonym="JM21"
/gene_synonym="KIAA0901"
/note="zf-UBP; Region: Zn-finger in ubiquitin-hydrolases
and other protein"
/db_xref="CDD:pfam02148"
BASE COUNT 924 a 1199 c 1169 g 831 t
ORIGIN
1 gctggttgaa acgctagggg cgggatctgg cggagtggaa ggtaccggtc cggcccgata
61 aggggtggaa accgcggcag gggccaagcc tcctcaacta tgacctcaac cggccaggat
121 tccaccacaa ccaggcagcg aagaagtagg cagaaccccc agtcgccccc tcaggactcc
181 agtgtcactt cgaagcgaaa tattaaaaag ggagccgttc cccgctctat ccccaatcta
241 gcggaggtaa agaagaaagg caaaatgaag aagctcggcc aagcaatgga agaagaccta
301 atcgtgggac tgcaagggat ggatctgaac cttgaggctg aagcactggc tggcactggc
361 ttggtgttgg atgagcagtt aaatgaattc cattgcctct gggatgacag cttcccggaa
421 ggccctgagc ggctccatgc catcaaggag caactgatcc aggagggcct cctagatcgc
481 tgcgtgtcct ttcaggcccg gtttgctgaa aaggaagagc tgatgttggt tcacagccta
541 gaatatattg atctgatgga aacaacccag tacatgaatg agggagaact ccgtgtccta
601 gcagacacct acgactcagt ttatctgcat ccgaactcat actcctgtgc ctgcctggcc
661 tcaggctctg tcctcaggct ggtggatgcg gtcctggggg ctgagatccg gaatggcatg
721 gccatcatta ggcctcctgg acatcacgcc cagcacagtc ttatggatgg ctattgcatg
781 ttcaaccacg tggctgtggc agcccgctat gctcaacaga aacaccgcat ccggagggtc
841 cttatcgtag attgggatgt gcaccacggt caaggaacac agttcacctt cgaccaggac
901 cccagtgtcc tctatttctc catccaccgc tacgagcagg gtaggttctg gccccacctg
961 aaggcctcta actggtccac cacaggtttc ggccaaggcc aaggatatac catcaatgtg
1021 ccttggaacc aggtggggat gcgggatgct gactacattg ctgctttcct gcacgtcctg
1081 ctgccagtcg ccctcgagtt ccagcctcag ctggtcctgg tggctgctgg atttgatgcc
1141 ctgcaagggg accccaaggg tgagatggcc gccactccgg cagggttcgc ccagctaacc
1201 cacctgctca tgggtctggc aggaggcaag ctgatcctgt ctctggaggg tggctacaac
1261 ctccgcgccc tggctgaagg cgtcagtgct tcgctccaca cccttctggg agacccttgc
1321 cccatgctgg agtcacctgg tgccccctgc cggagtgccc aggcttcagt ttcctgtgct
1381 ctggaagccc ttgagccctt ctgggaggtt cttgtgagat caactgagac cgtggagagg
1441 gacaacatgg aggaggacaa tgtagaggag agcgaggagg aaggaccctg ggagccccct
1501 gtgctcccaa tcctgacatg gccagtgcta cagtctcgca cagggctggt ctatgaccaa
1561 aatatgatga atcactgcaa cttgtgggac agccaccacc ctgaggtacc ccagcgcatc
1621 ttgcggatca tgtgccgtct ggaggagctg ggccttgccg ggcgctgcct caccctgaca
1681 ccgcgccctg ccacagaggc tgagctgctc acctgtcaca gtgctgagta cgtgggtcat
1741 ctccgggcca cagagaaaat gaaaacccgg gagctgcacc gtgagagttc caactttgac
1801 tccatctata tctgccccag taccttcgcc tgtgcacagc ttgccactgg cgctgcctgc
1861 cgcctggtgg aggctgtgct ctcaggagag gttctgaatg gtgctgctgt ggtgcgtccc
1921 ccaggacacc acgcagagca ggatgcagct tgcggttttt gctttttcaa ctctgtggct
1981 gtggctgctc gccatgccca gactatcagt gggcatgccc tacggatcct gattgtggat
2041 tgggatgtcc accacggtaa tggaactcag cacatgtttg aggatgaccc cagtgtgcta
2101 tatgtgtccc tgcaccgcta tgatcatggc accttcttcc ccatggggga tgagggtgcc
2161 agcagccaga tcggccgggc tgcgggcaca ggcttcaccg tcaacgtggc atggaacggg
2221 ccccgcatgg gtgatgctga ctacctagct gcctggcatc gcctggtgct tcccattgcc
2281 tacgagttta acccagaact ggtgctggtc tcagctggct ttgatgctgc acggggggat
2341 ccgctggggg gctgccaggt gtcacctgag ggttatgccc acctcaccca cctgctgatg
2401 ggccttgcca gtggccgcat tatccttatc ctagagggtg gctataacct gacatccatc
2461 tcagagtcca tggctgcctg cactcgctcc ctccttggag acccaccacc cctgctgacc
2521 ctgccacggc ccccactatc aggggccctg gcctcaatca ctgagaccat ccaagtccat
2581 cgcagatact ggcgcagctt acgggtcatg aaggtagaag acagagaagg accctccagt
2641 tctaagttgg tcaccaagaa ggcaccccaa ccagccaaac ctaggttagc tgagcggatg
2701 accacacgag aaaagaaggt tctggaagca ggcatgggga aagtcacctc ggcatcattt
2761 ggggaagagt ccactccagg ccagactaac tcagagacag ctgtggtggc cctcactcag
2821 gaccagccct cagaggcagc cacaggggga gccactctgg cccagaccat ttctgaggca
2881 gccattgggg gagccatgct gggccagacc acctcagagg aggctgtcgg gggagccact
2941 ccggaccaga ccacctcaga ggagactgtg ggaggagcca ttctggacca gaccacctca
3001 gaggatgctg ttgggggagc cacgctgggc cagactacct cagaggaggc tgtaggagga
3061 gctacactgg cccagaccac ctcggaggca gccatggagg gagccacact ggaccagact
3121 acgtcagagg aggctccagg gggcaccgag ctgatccaaa ctcctctagc ctcgagcaca
3181 gaccaccaga cccccccaac ctcacctgtg cagggaacta caccccagat atctcccagt
3241 acactgattg ggagtctcag gaccttggag ctaggcagcg aatctcaggg ggcctcagaa
3301 tctcaggccc caggagagga gaacctacta ggagaggcag ctggaggtca ggacatggct
3361 gattcgatgc tgatgcaggg atctaggggc ctcactgatc aggccatatt ttatgctgtg
3421 acaccactgc cctggtgtcc ccatttggtg gcagtatgcc ccatacctgc agcaggccta
3481 gacgtgaccc aaccttgtgg ggactgtgga acaatccaag agaattgggt gtgtctctct
3541 tgctatcagg tctactgtgg tcgttacatc aatggccaca tgctccaaca ccatggaaat
3601 tctggacacc cgctggtcct cagctacatc gacctgtcag cctggtgtta ctactgtcag
3661 gcctatgtcc accaccaggc tctcctagat gtgaaggaca tcgcccacca gaacaagttt
3721 ggggaggata tgccccaccc acactaagcc ccagaatacg gtccctcttc accttctgag
3781 gcccacgata gaccagctgt agctcattcc agcctgtacc ttggatgagg ggtagcctcc
3841 cactgcatcc catcctgaat atcctttgca actccccaag agtgcttatt taagtgttaa
3901 tacttttaag agaactgcga cgattaattg tggatctccc cctgcccatt gcctgcttga
3961 ggggcaccac tactccagcc cagaaggaaa ggggggcagc tcagtggccc caagagggag
4021 ctgatatcat gaggataaca ttggcgggag gggagttaac tggcaggcat ggcaaggttg
4081 catatgtaat aaagtacaag ctgttaaaaa aaaaaaaaaa aaa
//