LOCUS       BC058831                2703 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens von Hippel-Lindau tumor suppressor, mRNA (cDNA clone
            MGC:61974 IMAGE:6457060), complete cds.
ACCESSION   BC058831
VERSION     BC058831.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2703)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 2703)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: NCI
            cDNA Library Preparation: Michael Brownstein /  Ted Usdin
            Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 48 Row: i Column: 4
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 38045904.
FEATURES             Location/Qualifiers
     source          1..2703
                     /db_xref="H-InvDB:HIT000259868"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:61974 IMAGE:6457060"
                     /tissue_type="Pooled, 40 cell lines"
                     /clone_lib="NIH_MGC_142"
                     /lab_host="DH10B"
                     /note="Vector: pDNR-LIB"
     gene            1..2703
                     /gene="VHL"
                     /gene_synonym="HRCA1"
                     /gene_synonym="RCA1"
                     /gene_synonym="VHL1"
                     /db_xref="GeneID:7428"
                     /db_xref="HGNC:HGNC:12687"
                     /db_xref="MIM:608537"
     CDS             65..583
                     /gene="VHL"
                     /gene_synonym="HRCA1"
                     /gene_synonym="RCA1"
                     /gene_synonym="VHL1"
                     /codon_start=1
                     /product="von Hippel-Lindau tumor suppressor"
                     /protein_id="AAH58831.1"
                     /db_xref="GeneID:7428"
                     /db_xref="HGNC:HGNC:12687"
                     /db_xref="MIM:608537"
                     /translation="MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESG
                     PEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLP
                     PGTGRRIYSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERL
                     TQERIAHQRMGD"
BASE COUNT          673 a          580 c          671 g          779 t
ORIGIN      
        1 ggggcccgcg tccgacccgc ggatcccgcg gcgtccggcc cgggtggtct ggatcgcgga
       61 gggaatgccc cggagggcgg agaactggga cgaggccgag gtaggcgcgg aggaggcagg
      121 cgtcgaagag tacggccctg aagaagacgg cggggaggag tcgggcgccg aggagtccgg
      181 cccggaagag tccggcccgg aggaactggg cgccgaggag gagatggagg ccgggcggcc
      241 gcggcccgtg ctgcgctcgg tgaactcgcg cgagccctcc caggtcatct tctgcaatcg
      301 cagtccgcgc gtcgtgctgc ccgtatggct caacttcgac ggcgagccgc agccctaccc
      361 aacgctgccg cctggcacgg gccgccgcat ctacagctac cgagtgtata ctctgaaaga
      421 gcgatgcctc caggttgtcc ggagcctagt caagcctgag aattacagga gactggacat
      481 cgtcaggtcg ctctacgaag atctggaaga ccacccaaat gtgcagaaag acctggagcg
      541 gctgacacag gagcgcattg cacatcaacg gatgggagat tgaagatttc tgttgaaact
      601 tacactgttt catctcagct tttgatggta ctgatgagtc ttgatctaga tacaggactg
      661 gttccttcct tagtttcaaa gtgtctcatt ctcagagtaa aataggcacc attgcttaaa
      721 agaaagttaa ctgacttcac taggcattgt gatgtttagg ggcaaacatc acaaaatgta
      781 atttaatgcc tgcccattag agaagtattt atcaggagaa ggtggtggca tttttgcttc
      841 ctagtaagtc aggacagctt gtatgtaagg aggtttatat aagtaattca gtgggaattg
      901 cagcatatcg tttaatttta agaaggcatt ggcatctgct tttaatggat gtataataca
      961 tccattctac atccgtagcg gttggtgact tgtctgcctc ctgctttggg aagactgagg
     1021 catccgtgag gcagggacaa gtctttctcc tctttgagac cccagtgcct gcacatcatg
     1081 agccttcagt cagggtttgt cagaggaaca aaccagggga cactttgtta gaaagtgctt
     1141 agaggttctg cctctatttt tgttgggggg tgggagaggg gaccttaaaa tgtgtacagt
     1201 gaacaaatgt cttaaaggga atcatttttg taggaagcat tttttataat tttctaagtc
     1261 gtgcactttc tcggtccact cttgttgaag tgctgtttta ttactgtttc taaactagga
     1321 ttgacattct acagttgtga taatagcatt tttgtaactt gccatccgca cagaaaatac
     1381 gagaaaatct gcatgtttga ttatagtatt aatggacaaa taagtttttg ctaaatgtga
     1441 gtatttctgt tcctttttgt aaatatgtga cattcctgat tgatttgggt ttttttgttg
     1501 ttgttgtttt gttttgtttt gtttttttga gatggagtct cgctcttgtc gcccaggctg
     1561 gagtgcagtg gcgccatctc ggctcactgc aacctctgcc tcctgagttc acgtaatcct
     1621 cctgagtggc tgggattaca ggtgcctgcc accacgctgg ccaatttttg tacttttagt
     1681 ggagacagtg tttcgccatg ttggccaggc tggtttcaaa ctcctgacct caggtgatcc
     1741 gcccgcctca gcctcccaga atggtgggat tacaggtgtg tgggccaccg tgcctggctg
     1801 attcagcatt ttttatcagg caggaccagg tggcacttcc acctccagcc tctggtccta
     1861 ccaatggatt catggagtag cctggactgt ttcatagttt tctaaatgta caaattctta
     1921 taggctagac ttagattcat taactcaaat tcaatgcttc tatcagactc agttttttgt
     1981 aactaataga tttttttttt ccacttttgt tctactcctt ccctaatagc tttttaaaaa
     2041 aatctcccca gtagagaaac atttggaaaa gacagaaaac taaaaaggaa gaaaaaagat
     2101 ccctattaga tacacttctt aaatacaatc acattaacat tttgagctat ttccttccag
     2161 cctttttagg gcagattttg gttggttttt acatagttga gattgtactg ttcatacagt
     2221 tttataccct ttttcattta actttataac ttaaatattg ctctatgtta gtataagctt
     2281 ttcacaaaca ttagtatagt ctccctttta taattaatgt ttgtgggtat ttcttggcat
     2341 gcatctttaa ttccttatcc tagcctttgg gcacaattcc tgtgctcaaa aatgagagtg
     2401 acggctggcg tggtggctcc cgcctgtaat cccagtactt tgggaagcca aggtaagagg
     2461 attgcttgag cccagaactt caagatgagc ctgggctcat agtgagaacc catctataca
     2521 aaaattttta aaaattagca tggcggcaca catctgtaat cctagctact tggcaggctg
     2581 aggtgagaag atcattggag tttaggaatt ggaggcggca gtgagccatg agtatgccac
     2641 tgcactccag cctgggggac agagcaagac cctgccttaa aaaaaaaaaa aaaaaaaaaa
     2701 aaa
//