LOCUS BC058831 2703 bp mRNA linear HUM 15-JUL-2006 DEFINITION Homo sapiens von Hippel-Lindau tumor suppressor, mRNA (cDNA clone MGC:61974 IMAGE:6457060), complete cds. ACCESSION BC058831 VERSION BC058831.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2703) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2703) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (30-SEP-2003) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: NCI cDNA Library Preparation: Michael Brownstein / Ted Usdin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 48 Row: i Column: 4 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 38045904. FEATURES Location/Qualifiers source 1..2703 /db_xref="H-InvDB:HIT000259868" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:61974 IMAGE:6457060" /tissue_type="Pooled, 40 cell lines" /clone_lib="NIH_MGC_142" /lab_host="DH10B" /note="Vector: pDNR-LIB" gene 1..2703 /gene="VHL" /gene_synonym="HRCA1" /gene_synonym="RCA1" /gene_synonym="VHL1" /db_xref="GeneID:7428" /db_xref="HGNC:HGNC:12687" /db_xref="MIM:608537" CDS 65..583 /gene="VHL" /gene_synonym="HRCA1" /gene_synonym="RCA1" /gene_synonym="VHL1" /codon_start=1 /product="von Hippel-Lindau tumor suppressor" /protein_id="AAH58831.1" /db_xref="GeneID:7428" /db_xref="HGNC:HGNC:12687" /db_xref="MIM:608537" /translation="MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESG PEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLP PGTGRRIYSYRVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERL TQERIAHQRMGD" BASE COUNT 673 a 580 c 671 g 779 t ORIGIN 1 ggggcccgcg tccgacccgc ggatcccgcg gcgtccggcc cgggtggtct ggatcgcgga 61 gggaatgccc cggagggcgg agaactggga cgaggccgag gtaggcgcgg aggaggcagg 121 cgtcgaagag tacggccctg aagaagacgg cggggaggag tcgggcgccg aggagtccgg 181 cccggaagag tccggcccgg aggaactggg cgccgaggag gagatggagg ccgggcggcc 241 gcggcccgtg ctgcgctcgg tgaactcgcg cgagccctcc caggtcatct tctgcaatcg 301 cagtccgcgc gtcgtgctgc ccgtatggct caacttcgac ggcgagccgc agccctaccc 361 aacgctgccg cctggcacgg gccgccgcat ctacagctac cgagtgtata ctctgaaaga 421 gcgatgcctc caggttgtcc ggagcctagt caagcctgag aattacagga gactggacat 481 cgtcaggtcg ctctacgaag atctggaaga ccacccaaat gtgcagaaag acctggagcg 541 gctgacacag gagcgcattg cacatcaacg gatgggagat tgaagatttc tgttgaaact 601 tacactgttt catctcagct tttgatggta ctgatgagtc ttgatctaga tacaggactg 661 gttccttcct tagtttcaaa gtgtctcatt ctcagagtaa aataggcacc attgcttaaa 721 agaaagttaa ctgacttcac taggcattgt gatgtttagg ggcaaacatc acaaaatgta 781 atttaatgcc tgcccattag agaagtattt atcaggagaa ggtggtggca tttttgcttc 841 ctagtaagtc aggacagctt gtatgtaagg aggtttatat aagtaattca gtgggaattg 901 cagcatatcg tttaatttta agaaggcatt ggcatctgct tttaatggat gtataataca 961 tccattctac atccgtagcg gttggtgact tgtctgcctc ctgctttggg aagactgagg 1021 catccgtgag gcagggacaa gtctttctcc tctttgagac cccagtgcct gcacatcatg 1081 agccttcagt cagggtttgt cagaggaaca aaccagggga cactttgtta gaaagtgctt 1141 agaggttctg cctctatttt tgttgggggg tgggagaggg gaccttaaaa tgtgtacagt 1201 gaacaaatgt cttaaaggga atcatttttg taggaagcat tttttataat tttctaagtc 1261 gtgcactttc tcggtccact cttgttgaag tgctgtttta ttactgtttc taaactagga 1321 ttgacattct acagttgtga taatagcatt tttgtaactt gccatccgca cagaaaatac 1381 gagaaaatct gcatgtttga ttatagtatt aatggacaaa taagtttttg ctaaatgtga 1441 gtatttctgt tcctttttgt aaatatgtga cattcctgat tgatttgggt ttttttgttg 1501 ttgttgtttt gttttgtttt gtttttttga gatggagtct cgctcttgtc gcccaggctg 1561 gagtgcagtg gcgccatctc ggctcactgc aacctctgcc tcctgagttc acgtaatcct 1621 cctgagtggc tgggattaca ggtgcctgcc accacgctgg ccaatttttg tacttttagt 1681 ggagacagtg tttcgccatg ttggccaggc tggtttcaaa ctcctgacct caggtgatcc 1741 gcccgcctca gcctcccaga atggtgggat tacaggtgtg tgggccaccg tgcctggctg 1801 attcagcatt ttttatcagg caggaccagg tggcacttcc acctccagcc tctggtccta 1861 ccaatggatt catggagtag cctggactgt ttcatagttt tctaaatgta caaattctta 1921 taggctagac ttagattcat taactcaaat tcaatgcttc tatcagactc agttttttgt 1981 aactaataga tttttttttt ccacttttgt tctactcctt ccctaatagc tttttaaaaa 2041 aatctcccca gtagagaaac atttggaaaa gacagaaaac taaaaaggaa gaaaaaagat 2101 ccctattaga tacacttctt aaatacaatc acattaacat tttgagctat ttccttccag 2161 cctttttagg gcagattttg gttggttttt acatagttga gattgtactg ttcatacagt 2221 tttataccct ttttcattta actttataac ttaaatattg ctctatgtta gtataagctt 2281 ttcacaaaca ttagtatagt ctccctttta taattaatgt ttgtgggtat ttcttggcat 2341 gcatctttaa ttccttatcc tagcctttgg gcacaattcc tgtgctcaaa aatgagagtg 2401 acggctggcg tggtggctcc cgcctgtaat cccagtactt tgggaagcca aggtaagagg 2461 attgcttgag cccagaactt caagatgagc ctgggctcat agtgagaacc catctataca 2521 aaaattttta aaaattagca tggcggcaca catctgtaat cctagctact tggcaggctg 2581 aggtgagaag atcattggag tttaggaatt ggaggcggca gtgagccatg agtatgccac 2641 tgcactccag cctgggggac agagcaagac cctgccttaa aaaaaaaaaa aaaaaaaaaa 2701 aaa //