LOCUS       BC052303                3387 bp    mRNA    linear   HUM 07-OCT-2003
DEFINITION  Homo sapiens Rho GTPase activating protein 4, mRNA (cDNA clone
            MGC:59737 IMAGE:6379390), complete cds.
ACCESSION   BC052303
VERSION     BC052303.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2003) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site: http://www.nisc.nih.gov/
            Contact: nisc_mgc@nhgri.nih.gov
            Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
            Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
            Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
            Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
            McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
            Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
            Young,A., Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 47 Row: l Column: 20
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 11386132.
FEATURES             Location/Qualifiers
     source          1..3387
                     /db_xref="H-InvDB:HIT000053777"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:59737 IMAGE:6379390"
                     /tissue_type="Pancreas, epithelioid carcinoma"
                     /clone_lib="NIH_MGC_42"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..3387
                     /gene="ARHGAP4"
                     /gene_synonym="C1"
                     /gene_synonym="KIAA0131"
                     /gene_synonym="RGC1"
                     /gene_synonym="RhoGAP4"
                     /db_xref="GeneID:393"
                     /db_xref="MIM:300023"
     CDS             59..3019
                     /gene="ARHGAP4"
                     /gene_synonym="C1"
                     /gene_synonym="KIAA0131"
                     /gene_synonym="RGC1"
                     /gene_synonym="RhoGAP4"
                     /codon_start=1
                     /product="ARHGAP4 protein"
                     /protein_id="AAH52303.1"
                     /db_xref="GeneID:393"
                     /db_xref="MIM:300023"
                     /translation="MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRE
                     LLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHC
                     WAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEV
                     VSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSL
                     KKGGRLVEKLWPPQRPVAASSCAPVCWLQAGFLVHPPWWGAMCAPSTHQRQAKFMEHK
                     LKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRT
                     QASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEM
                     ELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPS
                     TESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEAL
                     QRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES
                     CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLY
                     FRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHL
                     AQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTS
                     LPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYT
                     GRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQ
                     TAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQN
                     MDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPS
                     ASHPQGLDTTPKPH"
     misc_feature    212..430
                     /gene="ARHGAP4"
                     /gene_synonym="C1"
                     /gene_synonym="KIAA0131"
                     /gene_synonym="RGC1"
                     /gene_synonym="RhoGAP4"
                     /note="FCH; Region: Fes/CIP4 homology domain. Alignment
                     extended from. Highly alpha-helical"
                     /db_xref="CDD:pfam00611"
     misc_feature    1730..2254
                     /gene="ARHGAP4"
                     /gene_synonym="C1"
                     /gene_synonym="KIAA0131"
                     /gene_synonym="RGC1"
                     /gene_synonym="RhoGAP4"
                     /note="RhoGAP; Region: GTPase-activator protein for
                     Rho-like GTPases"
                     /db_xref="CDD:smart00324"
     misc_feature    2417..2584
                     /gene="ARHGAP4"
                     /gene_synonym="C1"
                     /gene_synonym="KIAA0131"
                     /gene_synonym="RGC1"
                     /gene_synonym="RhoGAP4"
                     /note="SH3; Region: Src homology 3 domains"
                     /db_xref="CDD:smart00326"
BASE COUNT          642 a         1064 c         1143 g          538 t
ORIGIN      
        1 ggcccgctca cggccgcgtg ggagcagtgg ggttcgacgg cgcggccgcg aggccgccat
       61 ggccgctcac gggaagctgc ggcgggagcg ggggctgcag gctgagtatg agacgcaagt
      121 caaagagatg cgctggcagc tgagcgagca gctgcgctgc ctggagctgc agggcgagct
      181 gcggcgggag ttgctgcagg agctggcaga gttcatgcgg cgccgcgctg aggtggagct
      241 ggaatactcc cggggcctgg aaaagctggc cgagcgcttc tccagccgtg gaggccgcct
      301 ggggagcagc cgggagcacc aaagcttccg gaaggagccg tccctcctgt cgcccttgca
      361 ctgctgggcg gtgctgctgc agcacacgcg gcagcagagc cgggagagcg cggccctgag
      421 tgaggtgctg gccgggcccc tggcccagcg cctgagtcac attgcagagg acgtggggcg
      481 cctggtcaag aagagcaggg atctggagca gcagctgcag gatgagctcc tggaggtggt
      541 ctcagagctc cagacggcca agaagacgta ccaggcatat cacatggaga gcgtgaatgc
      601 cgaggccaag ctccgggagg ccgagcggca ggaggagaag cgggcaggcc ggagtgtccc
      661 caccaccacc gctggtgcca ctgaggcagg gcccctccgc aagagctccc tcaagaaggg
      721 agggaggctg gtggagaagc tctggccccc gcagaggcct gtggccgctt ccagctgtgc
      781 acctgtgtgc tggctccaag ctgggtttct cgtgcaccct ccatggtggg gtgccatgtg
      841 cgcaccttcc actcatcagc ggcaggccaa gttcatggag cacaaactca agtgcacaaa
      901 ggcgcgcaac gagtacctgc ttagcctggc tagtgtcaac gctgctgtca gtaactacta
      961 cctgcatgac gtcttggacc tcatggactg ctgtgacaca gggttccacc tggccctggg
     1021 gcaggtgctc cggagctaca cggccgctga gagccgcacc caagcctccc aagtgcaggg
     1081 cctgggcagc ctggaagaag ctgtggaggc cctggatcct ccaggggaca aagccaaggt
     1141 tctcgaggtg catgctaccg tcttctgtcc cccgctgcgc tttgactacc acccccatga
     1201 tggggatgag gtggctgaga tctgcgttga aatggagctg cgggacgaga ttctgcccag
     1261 agcccagaac atccagagcc gcctggaccg acagaccatt gagacagagg aggtgaacaa
     1321 gactctgaag gcgacactgc aggccctgct ggaggtggtg gcctcggatg acggggatgt
     1381 gcttgattcc ttccagacca gcccctccac cgagtccctc aagtccacca gctcagaccc
     1441 aggcagccgg caggcgggcc ggaggcgcgg ccagcagcag gagaccgaaa ccttctacct
     1501 cacgaagctc caggagtatc tgagtggacg gagcatcctc gccaagctgc aggccaagca
     1561 cgagaagctg caggaggccc ttcagcgagg tgacaaggag gagcaggagg tgtcttggac
     1621 ccagtacaca cagagaaaat tccagaagag ccgccagccc cgccccagct cccagtataa
     1681 ccagagactc tttgggggag acatggagaa gtttatccag agctcaggcc agcctgtgcc
     1741 cctggtggtg gagagctgca ttcgcttcat caacctcaat ggcctgcagc atgaaggcat
     1801 cttccgggta tcgggtgccc agctccgggt ctcagagatc cgtgatgcct tcgagagagg
     1861 ggaggaccca ctggtggagg gctgcactgc ccacgacctg gactcggtgg ccggggtgct
     1921 gaagctctac ttccggagcc tggagccccc actcttcccc ccagacctgt tcggcgagct
     1981 gctggcttct tcggagctgg aggccacagc ggagagggtg gagcacgtga gccgcctgct
     2041 gtggcggctg cccgcgccgg tgctggtggt tctgcgctac ctcttcacct tcctcaacca
     2101 cctggcccag tacagcgatg agaacatgat ggacccctac aacctggccg tgtgcttcgg
     2161 gcccacgctg ctaccggtgc ccgctgggca ggacccggtg gcgctgcagg gccgggtgaa
     2221 ccagctggtg cagacgctca tagtgcagcc cgatcgggtc ttcccgcccc tgacctcgct
     2281 gcctggcccc gtctacgaga agtgcatggc accgccttcc gccagctgcc tgggggacgc
     2341 ccagctggag agcctggggg cggacaatga gccggagctg gaagccgaga tgcccgcaca
     2401 ggaggatgac ctggaggggg tcgtggaggc tgtggcctgc tttgcctaca cgggccgcac
     2461 agcccaggag ctgagcttcc ggcgggggga cgtactgcgg ctgcacgaga gggcctcgag
     2521 cgactggtgg cggggggagc acaacggcat gcggggcctc atcccccaca agtatatcac
     2581 gctgcccgcc gggacggaga agcaggtggt gggcgcaggg ctgcagactg caggggagtc
     2641 tgggagcagt cccgagggcc tcctggcatc ggagctggtc caccggccag agccatgcac
     2701 ctcacctgag gccatgggac cctctggaca cagacgacgc tgcttggtcc cagcctcccc
     2761 agagcaacac gtggaggtgg ataaggctgt ggcacagaac atggactctg tgtttaagga
     2821 gctcttggga aagacctctg tccgccaggg ccttgggcca gcatctacca cctctcccag
     2881 tcctgggccc cgaagcccaa aggccccgcc cagcagccgc ctgggcagga acaaaggctt
     2941 ctcccggggc cctggggccc cagcctcacc ctcagcttcc cacccccagg gcctagacac
     3001 gacccccaag ccacactgag gtgccgctgc tggagatgcg tgcccccggc ggctacccgc
     3061 tggaccggcc actctcccca gcccccttgc ttctctccag ccctgtccag caagtgcagg
     3121 gtgcctgcac ttcaccctgt gcagagaggt gggatggggc cgtgcacaca gggatgcccg
     3181 ctccacatcc tgcctgcccc tcagccctgg cccaggcccc ttttggaggc agctgaggaa
     3241 ggatgctggg gaaagccctc ttctgcagct ttgtggaagg ctgatcagtg gctgctgggt
     3301 ggcgggtacc cttgctcaga tgcctggcag ggctgggtgg cgattcataa agacctcgtg
     3361 ttgattccca aaaaaaaaaa aaaaaaa
//