LOCUS BC052303 3387 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens Rho GTPase activating protein 4, mRNA (cDNA clone
MGC:59737 IMAGE:6379390), complete cds.
ACCESSION BC052303
VERSION BC052303.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3387)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3387)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (02-MAY-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 47 Row: l Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 11386132.
FEATURES Location/Qualifiers
source 1..3387
/db_xref="H-InvDB:HIT000053777"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:59737 IMAGE:6379390"
/tissue_type="Pancreas, epithelioid carcinoma"
/clone_lib="NIH_MGC_42"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3387
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/db_xref="GeneID:393"
/db_xref="MIM:300023"
CDS 59..3019
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/codon_start=1
/product="ARHGAP4 protein"
/protein_id="AAH52303.1"
/db_xref="GeneID:393"
/db_xref="MIM:300023"
/translation="MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRE
LLQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHC
WAVLLQHTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEV
VSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSL
KKGGRLVEKLWPPQRPVAASSCAPVCWLQAGFLVHPPWWGAMCAPSTHQRQAKFMEHK
LKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRT
QASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEM
ELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPS
TESLKSTSSDPGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEAL
QRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES
CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLY
FRSLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHL
AQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTS
LPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYT
GRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQ
TAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQN
MDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKGFSRGPGAPASPS
ASHPQGLDTTPKPH"
misc_feature 212..430
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/note="FCH; Region: Fes/CIP4 homology domain. Alignment
extended from. Highly alpha-helical"
/db_xref="CDD:pfam00611"
misc_feature 1730..2254
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/note="RhoGAP; Region: GTPase-activator protein for
Rho-like GTPases"
/db_xref="CDD:smart00324"
misc_feature 2417..2584
/gene="ARHGAP4"
/gene_synonym="C1"
/gene_synonym="KIAA0131"
/gene_synonym="RGC1"
/gene_synonym="RhoGAP4"
/note="SH3; Region: Src homology 3 domains"
/db_xref="CDD:smart00326"
BASE COUNT 642 a 1064 c 1143 g 538 t
ORIGIN
1 ggcccgctca cggccgcgtg ggagcagtgg ggttcgacgg cgcggccgcg aggccgccat
61 ggccgctcac gggaagctgc ggcgggagcg ggggctgcag gctgagtatg agacgcaagt
121 caaagagatg cgctggcagc tgagcgagca gctgcgctgc ctggagctgc agggcgagct
181 gcggcgggag ttgctgcagg agctggcaga gttcatgcgg cgccgcgctg aggtggagct
241 ggaatactcc cggggcctgg aaaagctggc cgagcgcttc tccagccgtg gaggccgcct
301 ggggagcagc cgggagcacc aaagcttccg gaaggagccg tccctcctgt cgcccttgca
361 ctgctgggcg gtgctgctgc agcacacgcg gcagcagagc cgggagagcg cggccctgag
421 tgaggtgctg gccgggcccc tggcccagcg cctgagtcac attgcagagg acgtggggcg
481 cctggtcaag aagagcaggg atctggagca gcagctgcag gatgagctcc tggaggtggt
541 ctcagagctc cagacggcca agaagacgta ccaggcatat cacatggaga gcgtgaatgc
601 cgaggccaag ctccgggagg ccgagcggca ggaggagaag cgggcaggcc ggagtgtccc
661 caccaccacc gctggtgcca ctgaggcagg gcccctccgc aagagctccc tcaagaaggg
721 agggaggctg gtggagaagc tctggccccc gcagaggcct gtggccgctt ccagctgtgc
781 acctgtgtgc tggctccaag ctgggtttct cgtgcaccct ccatggtggg gtgccatgtg
841 cgcaccttcc actcatcagc ggcaggccaa gttcatggag cacaaactca agtgcacaaa
901 ggcgcgcaac gagtacctgc ttagcctggc tagtgtcaac gctgctgtca gtaactacta
961 cctgcatgac gtcttggacc tcatggactg ctgtgacaca gggttccacc tggccctggg
1021 gcaggtgctc cggagctaca cggccgctga gagccgcacc caagcctccc aagtgcaggg
1081 cctgggcagc ctggaagaag ctgtggaggc cctggatcct ccaggggaca aagccaaggt
1141 tctcgaggtg catgctaccg tcttctgtcc cccgctgcgc tttgactacc acccccatga
1201 tggggatgag gtggctgaga tctgcgttga aatggagctg cgggacgaga ttctgcccag
1261 agcccagaac atccagagcc gcctggaccg acagaccatt gagacagagg aggtgaacaa
1321 gactctgaag gcgacactgc aggccctgct ggaggtggtg gcctcggatg acggggatgt
1381 gcttgattcc ttccagacca gcccctccac cgagtccctc aagtccacca gctcagaccc
1441 aggcagccgg caggcgggcc ggaggcgcgg ccagcagcag gagaccgaaa ccttctacct
1501 cacgaagctc caggagtatc tgagtggacg gagcatcctc gccaagctgc aggccaagca
1561 cgagaagctg caggaggccc ttcagcgagg tgacaaggag gagcaggagg tgtcttggac
1621 ccagtacaca cagagaaaat tccagaagag ccgccagccc cgccccagct cccagtataa
1681 ccagagactc tttgggggag acatggagaa gtttatccag agctcaggcc agcctgtgcc
1741 cctggtggtg gagagctgca ttcgcttcat caacctcaat ggcctgcagc atgaaggcat
1801 cttccgggta tcgggtgccc agctccgggt ctcagagatc cgtgatgcct tcgagagagg
1861 ggaggaccca ctggtggagg gctgcactgc ccacgacctg gactcggtgg ccggggtgct
1921 gaagctctac ttccggagcc tggagccccc actcttcccc ccagacctgt tcggcgagct
1981 gctggcttct tcggagctgg aggccacagc ggagagggtg gagcacgtga gccgcctgct
2041 gtggcggctg cccgcgccgg tgctggtggt tctgcgctac ctcttcacct tcctcaacca
2101 cctggcccag tacagcgatg agaacatgat ggacccctac aacctggccg tgtgcttcgg
2161 gcccacgctg ctaccggtgc ccgctgggca ggacccggtg gcgctgcagg gccgggtgaa
2221 ccagctggtg cagacgctca tagtgcagcc cgatcgggtc ttcccgcccc tgacctcgct
2281 gcctggcccc gtctacgaga agtgcatggc accgccttcc gccagctgcc tgggggacgc
2341 ccagctggag agcctggggg cggacaatga gccggagctg gaagccgaga tgcccgcaca
2401 ggaggatgac ctggaggggg tcgtggaggc tgtggcctgc tttgcctaca cgggccgcac
2461 agcccaggag ctgagcttcc ggcgggggga cgtactgcgg ctgcacgaga gggcctcgag
2521 cgactggtgg cggggggagc acaacggcat gcggggcctc atcccccaca agtatatcac
2581 gctgcccgcc gggacggaga agcaggtggt gggcgcaggg ctgcagactg caggggagtc
2641 tgggagcagt cccgagggcc tcctggcatc ggagctggtc caccggccag agccatgcac
2701 ctcacctgag gccatgggac cctctggaca cagacgacgc tgcttggtcc cagcctcccc
2761 agagcaacac gtggaggtgg ataaggctgt ggcacagaac atggactctg tgtttaagga
2821 gctcttggga aagacctctg tccgccaggg ccttgggcca gcatctacca cctctcccag
2881 tcctgggccc cgaagcccaa aggccccgcc cagcagccgc ctgggcagga acaaaggctt
2941 ctcccggggc cctggggccc cagcctcacc ctcagcttcc cacccccagg gcctagacac
3001 gacccccaag ccacactgag gtgccgctgc tggagatgcg tgcccccggc ggctacccgc
3061 tggaccggcc actctcccca gcccccttgc ttctctccag ccctgtccag caagtgcagg
3121 gtgcctgcac ttcaccctgt gcagagaggt gggatggggc cgtgcacaca gggatgcccg
3181 ctccacatcc tgcctgcccc tcagccctgg cccaggcccc ttttggaggc agctgaggaa
3241 ggatgctggg gaaagccctc ttctgcagct ttgtggaagg ctgatcagtg gctgctgggt
3301 ggcgggtacc cttgctcaga tgcctggcag ggctgggtgg cgattcataa agacctcgtg
3361 ttgattccca aaaaaaaaaa aaaaaaa
//