LOCUS BC040546 4686 bp mRNA linear HUM 21-JUL-2005 DEFINITION Homo sapiens proprotein convertase subtilisin/kexin type 2, mRNA (cDNA clone MGC:39745 IMAGE:5284427), complete cds. ACCESSION BC040546 VERSION BC040546.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4686) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4686) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (29-NOV-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Miklos Palkovits, M.D., Ph.D. cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki Toshiyuki and Piero Carninci (RIKEN) cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Sequencing Group at the Stanford Human Genome Center, Stanford University School of Medicine, Stanford, CA 94305 Web site: http://www-shgc.stanford.edu Contact: (Dickson, Mark) mcd@paxil.stanford.edu Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers, R. M. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 63 Row: k Column: 14. FEATURES Location/Qualifiers source 1..4686 /db_xref="H-InvDB:HIT000052425" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:39745 IMAGE:5284427" /tissue_type="Brain, hippocampus" /clone_lib="NIH_MGC_95" /lab_host="DH10B" /note="Vector: pBluescriptR" gene 1..4686 /gene="PCSK2" /gene_synonym="PC2" /gene_synonym="SPC2" /db_xref="GeneID:5126" /db_xref="MIM:162151" CDS 307..2166 /gene="PCSK2" /gene_synonym="PC2" /gene_synonym="SPC2" /codon_start=1 /product="PCSK2 protein" /protein_id="AAH40546.1" /db_xref="GeneID:5126" /db_xref="MIM:162151" /translation="MVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFA EGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINM NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAS NYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAG IRMLDQQFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNK GRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLAS TFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQH LTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCV GGSVQDPEKIPSTGELVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTS PMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLK EWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN" BASE COUNT 1326 a 1116 c 1076 g 1168 t ORIGIN 1 aactagcacc ctcgctgtcc ttgtgcagtg gaacgtcccc aggtctgaga atgcacctcc 61 cgccgtgtcc accccggccg cgtctctcct gaaggcagat cttggaggtg cagccaggac 121 tcctagagga gcctcctcca gtcaccatcg cgggtggggc gagccgggtc tcctgctggg 181 cttcccagcc gcttcgctcc ggacctgcct ggagcctaca aaaaacaagg gctcgtcctt 241 gcactctcgc cccccatgga tcacccctag aagtggaagg cggccgccgg gttcctcttc 301 tgtgtcatgg tttttgcatc tgctgagcga ccggtcttca cgaatcattt tcttgtggag 361 ttgcataaag ggggagagga caaagctcgc caagttgcag cagaacacgg ctttggagtc 421 cgaaagcttc cctttgctga aggtctgtac cacttttatc acaatggcct tgcaaaggcc 481 aagagaagac gcagcctaca ccacaagcag cagctggaga gagaccccag ggtaaagatg 541 gctttgcagc aggaaggatt tgaccgaaaa aagcgaggtt acagagacat caatgagatc 601 gacatcaaca tgaacgatcc tctttttaca aagcagtggt atctgatcaa tactgggcaa 661 gctgatggca ctcctggcct tgatttgaat gtggctgaag cctgggagct gggatacaca 721 gggaaaggtg ttaccattgg aattatggat gatgggattg actatctcca cccggacctg 781 gcctccaact ataatgccga agcaagttac gacttcagca gcaacgaccc ctatccttac 841 cctcggtaca cagatgactg gtttaacagc cacgggaccc gatgtgcagg agaagtttct 901 gctgccgcca acaacaatat ctgtggagtt ggagtagcat acaactccaa ggttgcaggc 961 atccggatgc tggaccagca attcatgaca gacatcatcg aggcctcctc catcagtcat 1021 atgccacagc tgattgacat ctacagcgcc agctggggcc ccacagacaa cggcaagaca 1081 gtggatgggc cccgggagct cacgctgcag gccatggccg atggcgtgaa caagggccgc 1141 ggcggcaaag gcagcatcta cgtgtgggcc tccggggacg gcggcagcta tgacgactgc 1201 aactgcgacg gctacgcctc cagcatgtgg accatctcca tcaactcagc catcaacgac 1261 ggcaggactg ccctgtacga cgagagctgc tcttccacct tggcttccac cttcagcaac 1321 gggaggaaaa ggaaccccga ggccggtgtg gcaaccacag atttgtacgg caactgcact 1381 ctgaggcatt ctgggacatc tgcagctgcg cccgaggcag ctggtgtgtt tgcactggct 1441 ctggaggcta acctgggtct gacctggcgg gacatgcagc atctgactgt gctcacctcc 1501 aaacggaacc agcttcacga cgaggtccat cagtggcggc gcaatggggt cggcctggaa 1561 tttaatcacc tctttggcta cggggtcctt gatgcaggtg ccatggtgaa aatggctaaa 1621 gactggaaaa ccgtgcctga gagattccac tgtgtgggag gctccgtgca ggaccctgag 1681 aaaataccat ccactggcga gttggtgctg acactcacaa ccgacgcctg tgaggggaag 1741 gaaaattttg tccgctacct ggagcatgtc caggctgtca tcacggtcaa cgcaaccaga 1801 agaggagacc tgaacatcaa catgacttcc cctatgggca ccaagtccat tttgctgagc 1861 cggcgtccaa gggatgacga ctccaaggtg ggctttgaca agtggccttt catgaccact 1921 cacacgtggg gggaagacgc ccgaggcacc tggaccctgg agctgggatt tgtcggcagc 1981 gccccgcaga agggggtgct gaaggagtgg accctgatgc tgcatggcac tcagagtgcc 2041 ccgtacatcg accaggtggt gcgggattac cagtccaagt tggccatgtc caagaaagag 2101 gagctggagg aagagctgga cgaagccgtg gagagaagcc tgaaaagcat ccttaacaag 2161 aactagcgct gcacatccgc ctttcccacc gccctccctc cccagctccg cccctgtcct 2221 cgctccacgt ttcaggcagg cacctagcaa ttccatcacc cgtacaggca attccgtctt 2281 cttaatctga agcttcactc actgtcaatg attattttca ttacaatgga aacaatcttt 2341 ttttactcta tgccccaaat atagcgttcc caacaacatc catgtcctat gtgtgactct 2401 aaattcttta tttctgtcat tcaaatgggt gatatcctga aaaaaaaaaa aaaaaaaaac 2461 tgggacagct ttcccctcat tttttttttt gtttctgaga aaagaacgta ttttaaaagc 2521 cacatagagt gactccaaga acaattgtcc atggtctcaa acaaggggct gttacataac 2581 aagaaaatca aagctgagga cagggtgtga gcgccacatc tctgaaagca caggagacac 2641 tgtgctataa atcctttggg gagcgatgtt ttgaatttag tgagatttac cagggatgta 2701 gattaaggtg atgtgattca aaagatgcca ttcatagaga gccctagtta ctgcatgggg 2761 aaagagatcc aggaagcatg agtgctggat attttactac caatgccaag ataattcact 2821 ctactcagcc ggcgtggcaa atataaaact tacagagcgt ggctgtgctc tcaccagctg 2881 ctgctctgag ttatgttaaa atccgctaga gcagcccaaa tttttctcag tttgtataga 2941 gttcatccca gccccaattt tctggggctc ctcacatagc tacccaaaag agaaaaaaaa 3001 ttaagacaag cctggcaaca cacctggtga agagtagttt actagctttt caaacaagaa 3061 tgtccctttt cctaagtcac tttgaggtgt ctcaatctga tctgagtgag aggcgacagg 3121 agtatttttt ttttttacag ctttacacac acagatgtgg gctttgattt ccaagtaata 3181 taatggaaga gaaatctcat actcccccac agtttgatgt cattaatgtg ttgggaaaaa 3241 ggcctctgtc ccggaagagt catgggaggt gaaaggggca cgtttgaaga tgcgagcgct 3301 atcttcacat agttctccag ttgtatggag cctcttctgc caagagaggg ccatgcaatt 3361 catcccagag gaacctgagg cctgaaggag gtgagagaag acctctgtga ggaaagcaca 3421 cagtcacctt ctcggcaact aagcagtccc tgagaccatt taacatgcaa cccgaaggtt 3481 atggtcaatc ccaaaagtca ccactccatt cccaactaga cattaccaaa gtgacctacc 3541 cagagattgc ttctcatccc cagtcccaat gcacatccat tcccaagaaa tgctttgtct 3601 tcagcctctc caggcaccat ctcccttcct gtgggagcag agagcttagc ctggagcacc 3661 tttccttcaa gccagcaaca cagagcacta ggttcaattc cctgaaggtg gccactttaa 3721 gagagaaatc tgaaaacccc atttgctttc ttttctccca tattggcatg gatttctgtc 3781 ttctctaaca ccttgtgacc ttctctatat catgctttaa agtgtaataa tatgattttt 3841 taaaagaaat ttattacttg ttgcaaaggt ctttttaaac cagtttagat ttcaagaaaa 3901 aataaatgga aatcatcgaa aattcatttc acattaatgg tctaaaaata aaccaaagga 3961 cattatgtgt gcatgtgtgt ataagtgcac acagaaatat atatacatat gtagactata 4021 tacatgtgtg tatatatgtg tatatataca tacacttgta taaatgtata tacacatata 4081 cctataatgt gtgtatgtgt atttattgaa gaaacagata ccatactcat ttctaaaaga 4141 atattcagag aatatcaaga tgattctggc tgaaaaaggc cagtggaaat tctggtgaaa 4201 atgttcatca attcccattg catcacctct gtaatttttc agctctctgt ataaacatta 4261 aatgtcttat atagcagcaa aaatataaaa tagttgtcca tattttcaca ggtgtggtgt 4321 aatttataaa attagaaagc aacttatcag ctacttaaga gaaatggcaa gttttgatat 4381 gagtatacaa tatataaaaa tatatatagt gctatatata taaatatttg gtctctattt 4441 cattttttgc atcagtatta atactaaaat atgtctcgct agtgatgttt ttatgatatc 4501 cctgatccta actgaagaga cagttattta tagtcattta ttttaaaaaa tgaaaataag 4561 tgaataataa ttaggttaac attgttgctc cctgtgacaa aattttataa gcaaatttca 4621 aaagacatgt tgtaaattag gaggctcaac aataaaacat tatgctccag aaaaaaaaaa 4681 aaaaaa //