LOCUS       BC040546                4686 bp    mRNA    linear   HUM 21-JUL-2005
DEFINITION  Homo sapiens proprotein convertase subtilisin/kexin type 2, mRNA
            (cDNA clone MGC:39745 IMAGE:5284427), complete cds.
ACCESSION   BC040546
VERSION     BC040546.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4686)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 4686)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2002) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
            cDNA Library Preparation: Michael J. Brownstein (NHGRI) &  Shiraki
            Toshiyuki and Piero Carninci (RIKEN)
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Sequencing Group at the Stanford Human Genome
            Center, Stanford University School of Medicine, Stanford, CA  94305
            Web site:       http://www-shgc.stanford.edu
            Contact:  (Dickson, Mark) mcd@paxil.stanford.edu
            Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
            R. M.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAK Plate: 63 Row: k Column: 14.
FEATURES             Location/Qualifiers
     source          1..4686
                     /db_xref="H-InvDB:HIT000052425"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:39745 IMAGE:5284427"
                     /tissue_type="Brain, hippocampus"
                     /clone_lib="NIH_MGC_95"
                     /lab_host="DH10B"
                     /note="Vector: pBluescriptR"
     gene            1..4686
                     /gene="PCSK2"
                     /gene_synonym="PC2"
                     /gene_synonym="SPC2"
                     /db_xref="GeneID:5126"
                     /db_xref="MIM:162151"
     CDS             307..2166
                     /gene="PCSK2"
                     /gene_synonym="PC2"
                     /gene_synonym="SPC2"
                     /codon_start=1
                     /product="PCSK2 protein"
                     /protein_id="AAH40546.1"
                     /db_xref="GeneID:5126"
                     /db_xref="MIM:162151"
                     /translation="MVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFA
                     EGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINM
                     NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAS
                     NYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAG
                     IRMLDQQFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNK
                     GRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLAS
                     TFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQH
                     LTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCV
                     GGSVQDPEKIPSTGELVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTS
                     PMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLK
                     EWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN"
BASE COUNT         1326 a         1116 c         1076 g         1168 t
ORIGIN      
        1 aactagcacc ctcgctgtcc ttgtgcagtg gaacgtcccc aggtctgaga atgcacctcc
       61 cgccgtgtcc accccggccg cgtctctcct gaaggcagat cttggaggtg cagccaggac
      121 tcctagagga gcctcctcca gtcaccatcg cgggtggggc gagccgggtc tcctgctggg
      181 cttcccagcc gcttcgctcc ggacctgcct ggagcctaca aaaaacaagg gctcgtcctt
      241 gcactctcgc cccccatgga tcacccctag aagtggaagg cggccgccgg gttcctcttc
      301 tgtgtcatgg tttttgcatc tgctgagcga ccggtcttca cgaatcattt tcttgtggag
      361 ttgcataaag ggggagagga caaagctcgc caagttgcag cagaacacgg ctttggagtc
      421 cgaaagcttc cctttgctga aggtctgtac cacttttatc acaatggcct tgcaaaggcc
      481 aagagaagac gcagcctaca ccacaagcag cagctggaga gagaccccag ggtaaagatg
      541 gctttgcagc aggaaggatt tgaccgaaaa aagcgaggtt acagagacat caatgagatc
      601 gacatcaaca tgaacgatcc tctttttaca aagcagtggt atctgatcaa tactgggcaa
      661 gctgatggca ctcctggcct tgatttgaat gtggctgaag cctgggagct gggatacaca
      721 gggaaaggtg ttaccattgg aattatggat gatgggattg actatctcca cccggacctg
      781 gcctccaact ataatgccga agcaagttac gacttcagca gcaacgaccc ctatccttac
      841 cctcggtaca cagatgactg gtttaacagc cacgggaccc gatgtgcagg agaagtttct
      901 gctgccgcca acaacaatat ctgtggagtt ggagtagcat acaactccaa ggttgcaggc
      961 atccggatgc tggaccagca attcatgaca gacatcatcg aggcctcctc catcagtcat
     1021 atgccacagc tgattgacat ctacagcgcc agctggggcc ccacagacaa cggcaagaca
     1081 gtggatgggc cccgggagct cacgctgcag gccatggccg atggcgtgaa caagggccgc
     1141 ggcggcaaag gcagcatcta cgtgtgggcc tccggggacg gcggcagcta tgacgactgc
     1201 aactgcgacg gctacgcctc cagcatgtgg accatctcca tcaactcagc catcaacgac
     1261 ggcaggactg ccctgtacga cgagagctgc tcttccacct tggcttccac cttcagcaac
     1321 gggaggaaaa ggaaccccga ggccggtgtg gcaaccacag atttgtacgg caactgcact
     1381 ctgaggcatt ctgggacatc tgcagctgcg cccgaggcag ctggtgtgtt tgcactggct
     1441 ctggaggcta acctgggtct gacctggcgg gacatgcagc atctgactgt gctcacctcc
     1501 aaacggaacc agcttcacga cgaggtccat cagtggcggc gcaatggggt cggcctggaa
     1561 tttaatcacc tctttggcta cggggtcctt gatgcaggtg ccatggtgaa aatggctaaa
     1621 gactggaaaa ccgtgcctga gagattccac tgtgtgggag gctccgtgca ggaccctgag
     1681 aaaataccat ccactggcga gttggtgctg acactcacaa ccgacgcctg tgaggggaag
     1741 gaaaattttg tccgctacct ggagcatgtc caggctgtca tcacggtcaa cgcaaccaga
     1801 agaggagacc tgaacatcaa catgacttcc cctatgggca ccaagtccat tttgctgagc
     1861 cggcgtccaa gggatgacga ctccaaggtg ggctttgaca agtggccttt catgaccact
     1921 cacacgtggg gggaagacgc ccgaggcacc tggaccctgg agctgggatt tgtcggcagc
     1981 gccccgcaga agggggtgct gaaggagtgg accctgatgc tgcatggcac tcagagtgcc
     2041 ccgtacatcg accaggtggt gcgggattac cagtccaagt tggccatgtc caagaaagag
     2101 gagctggagg aagagctgga cgaagccgtg gagagaagcc tgaaaagcat ccttaacaag
     2161 aactagcgct gcacatccgc ctttcccacc gccctccctc cccagctccg cccctgtcct
     2221 cgctccacgt ttcaggcagg cacctagcaa ttccatcacc cgtacaggca attccgtctt
     2281 cttaatctga agcttcactc actgtcaatg attattttca ttacaatgga aacaatcttt
     2341 ttttactcta tgccccaaat atagcgttcc caacaacatc catgtcctat gtgtgactct
     2401 aaattcttta tttctgtcat tcaaatgggt gatatcctga aaaaaaaaaa aaaaaaaaac
     2461 tgggacagct ttcccctcat tttttttttt gtttctgaga aaagaacgta ttttaaaagc
     2521 cacatagagt gactccaaga acaattgtcc atggtctcaa acaaggggct gttacataac
     2581 aagaaaatca aagctgagga cagggtgtga gcgccacatc tctgaaagca caggagacac
     2641 tgtgctataa atcctttggg gagcgatgtt ttgaatttag tgagatttac cagggatgta
     2701 gattaaggtg atgtgattca aaagatgcca ttcatagaga gccctagtta ctgcatgggg
     2761 aaagagatcc aggaagcatg agtgctggat attttactac caatgccaag ataattcact
     2821 ctactcagcc ggcgtggcaa atataaaact tacagagcgt ggctgtgctc tcaccagctg
     2881 ctgctctgag ttatgttaaa atccgctaga gcagcccaaa tttttctcag tttgtataga
     2941 gttcatccca gccccaattt tctggggctc ctcacatagc tacccaaaag agaaaaaaaa
     3001 ttaagacaag cctggcaaca cacctggtga agagtagttt actagctttt caaacaagaa
     3061 tgtccctttt cctaagtcac tttgaggtgt ctcaatctga tctgagtgag aggcgacagg
     3121 agtatttttt ttttttacag ctttacacac acagatgtgg gctttgattt ccaagtaata
     3181 taatggaaga gaaatctcat actcccccac agtttgatgt cattaatgtg ttgggaaaaa
     3241 ggcctctgtc ccggaagagt catgggaggt gaaaggggca cgtttgaaga tgcgagcgct
     3301 atcttcacat agttctccag ttgtatggag cctcttctgc caagagaggg ccatgcaatt
     3361 catcccagag gaacctgagg cctgaaggag gtgagagaag acctctgtga ggaaagcaca
     3421 cagtcacctt ctcggcaact aagcagtccc tgagaccatt taacatgcaa cccgaaggtt
     3481 atggtcaatc ccaaaagtca ccactccatt cccaactaga cattaccaaa gtgacctacc
     3541 cagagattgc ttctcatccc cagtcccaat gcacatccat tcccaagaaa tgctttgtct
     3601 tcagcctctc caggcaccat ctcccttcct gtgggagcag agagcttagc ctggagcacc
     3661 tttccttcaa gccagcaaca cagagcacta ggttcaattc cctgaaggtg gccactttaa
     3721 gagagaaatc tgaaaacccc atttgctttc ttttctccca tattggcatg gatttctgtc
     3781 ttctctaaca ccttgtgacc ttctctatat catgctttaa agtgtaataa tatgattttt
     3841 taaaagaaat ttattacttg ttgcaaaggt ctttttaaac cagtttagat ttcaagaaaa
     3901 aataaatgga aatcatcgaa aattcatttc acattaatgg tctaaaaata aaccaaagga
     3961 cattatgtgt gcatgtgtgt ataagtgcac acagaaatat atatacatat gtagactata
     4021 tacatgtgtg tatatatgtg tatatataca tacacttgta taaatgtata tacacatata
     4081 cctataatgt gtgtatgtgt atttattgaa gaaacagata ccatactcat ttctaaaaga
     4141 atattcagag aatatcaaga tgattctggc tgaaaaaggc cagtggaaat tctggtgaaa
     4201 atgttcatca attcccattg catcacctct gtaatttttc agctctctgt ataaacatta
     4261 aatgtcttat atagcagcaa aaatataaaa tagttgtcca tattttcaca ggtgtggtgt
     4321 aatttataaa attagaaagc aacttatcag ctacttaaga gaaatggcaa gttttgatat
     4381 gagtatacaa tatataaaaa tatatatagt gctatatata taaatatttg gtctctattt
     4441 cattttttgc atcagtatta atactaaaat atgtctcgct agtgatgttt ttatgatatc
     4501 cctgatccta actgaagaga cagttattta tagtcattta ttttaaaaaa tgaaaataag
     4561 tgaataataa ttaggttaac attgttgctc cctgtgacaa aattttataa gcaaatttca
     4621 aaagacatgt tgtaaattag gaggctcaac aataaaacat tatgctccag aaaaaaaaaa
     4681 aaaaaa
//