LOCUS BC040546 4686 bp mRNA linear HUM 21-JUL-2005
DEFINITION Homo sapiens proprotein convertase subtilisin/kexin type 2, mRNA
(cDNA clone MGC:39745 IMAGE:5284427), complete cds.
ACCESSION BC040546
VERSION BC040546.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4686)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4686)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (29-NOV-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Miklos Palkovits, M.D., Ph.D.
cDNA Library Preparation: Michael J. Brownstein (NHGRI) & Shiraki
Toshiyuki and Piero Carninci (RIKEN)
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 63 Row: k Column: 14.
FEATURES Location/Qualifiers
source 1..4686
/db_xref="H-InvDB:HIT000052425"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:39745 IMAGE:5284427"
/tissue_type="Brain, hippocampus"
/clone_lib="NIH_MGC_95"
/lab_host="DH10B"
/note="Vector: pBluescriptR"
gene 1..4686
/gene="PCSK2"
/gene_synonym="PC2"
/gene_synonym="SPC2"
/db_xref="GeneID:5126"
/db_xref="MIM:162151"
CDS 307..2166
/gene="PCSK2"
/gene_synonym="PC2"
/gene_synonym="SPC2"
/codon_start=1
/product="PCSK2 protein"
/protein_id="AAH40546.1"
/db_xref="GeneID:5126"
/db_xref="MIM:162151"
/translation="MVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFA
EGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINM
NDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAS
NYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAG
IRMLDQQFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNK
GRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLAS
TFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQH
LTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCV
GGSVQDPEKIPSTGELVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTS
PMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLK
EWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN"
BASE COUNT 1326 a 1116 c 1076 g 1168 t
ORIGIN
1 aactagcacc ctcgctgtcc ttgtgcagtg gaacgtcccc aggtctgaga atgcacctcc
61 cgccgtgtcc accccggccg cgtctctcct gaaggcagat cttggaggtg cagccaggac
121 tcctagagga gcctcctcca gtcaccatcg cgggtggggc gagccgggtc tcctgctggg
181 cttcccagcc gcttcgctcc ggacctgcct ggagcctaca aaaaacaagg gctcgtcctt
241 gcactctcgc cccccatgga tcacccctag aagtggaagg cggccgccgg gttcctcttc
301 tgtgtcatgg tttttgcatc tgctgagcga ccggtcttca cgaatcattt tcttgtggag
361 ttgcataaag ggggagagga caaagctcgc caagttgcag cagaacacgg ctttggagtc
421 cgaaagcttc cctttgctga aggtctgtac cacttttatc acaatggcct tgcaaaggcc
481 aagagaagac gcagcctaca ccacaagcag cagctggaga gagaccccag ggtaaagatg
541 gctttgcagc aggaaggatt tgaccgaaaa aagcgaggtt acagagacat caatgagatc
601 gacatcaaca tgaacgatcc tctttttaca aagcagtggt atctgatcaa tactgggcaa
661 gctgatggca ctcctggcct tgatttgaat gtggctgaag cctgggagct gggatacaca
721 gggaaaggtg ttaccattgg aattatggat gatgggattg actatctcca cccggacctg
781 gcctccaact ataatgccga agcaagttac gacttcagca gcaacgaccc ctatccttac
841 cctcggtaca cagatgactg gtttaacagc cacgggaccc gatgtgcagg agaagtttct
901 gctgccgcca acaacaatat ctgtggagtt ggagtagcat acaactccaa ggttgcaggc
961 atccggatgc tggaccagca attcatgaca gacatcatcg aggcctcctc catcagtcat
1021 atgccacagc tgattgacat ctacagcgcc agctggggcc ccacagacaa cggcaagaca
1081 gtggatgggc cccgggagct cacgctgcag gccatggccg atggcgtgaa caagggccgc
1141 ggcggcaaag gcagcatcta cgtgtgggcc tccggggacg gcggcagcta tgacgactgc
1201 aactgcgacg gctacgcctc cagcatgtgg accatctcca tcaactcagc catcaacgac
1261 ggcaggactg ccctgtacga cgagagctgc tcttccacct tggcttccac cttcagcaac
1321 gggaggaaaa ggaaccccga ggccggtgtg gcaaccacag atttgtacgg caactgcact
1381 ctgaggcatt ctgggacatc tgcagctgcg cccgaggcag ctggtgtgtt tgcactggct
1441 ctggaggcta acctgggtct gacctggcgg gacatgcagc atctgactgt gctcacctcc
1501 aaacggaacc agcttcacga cgaggtccat cagtggcggc gcaatggggt cggcctggaa
1561 tttaatcacc tctttggcta cggggtcctt gatgcaggtg ccatggtgaa aatggctaaa
1621 gactggaaaa ccgtgcctga gagattccac tgtgtgggag gctccgtgca ggaccctgag
1681 aaaataccat ccactggcga gttggtgctg acactcacaa ccgacgcctg tgaggggaag
1741 gaaaattttg tccgctacct ggagcatgtc caggctgtca tcacggtcaa cgcaaccaga
1801 agaggagacc tgaacatcaa catgacttcc cctatgggca ccaagtccat tttgctgagc
1861 cggcgtccaa gggatgacga ctccaaggtg ggctttgaca agtggccttt catgaccact
1921 cacacgtggg gggaagacgc ccgaggcacc tggaccctgg agctgggatt tgtcggcagc
1981 gccccgcaga agggggtgct gaaggagtgg accctgatgc tgcatggcac tcagagtgcc
2041 ccgtacatcg accaggtggt gcgggattac cagtccaagt tggccatgtc caagaaagag
2101 gagctggagg aagagctgga cgaagccgtg gagagaagcc tgaaaagcat ccttaacaag
2161 aactagcgct gcacatccgc ctttcccacc gccctccctc cccagctccg cccctgtcct
2221 cgctccacgt ttcaggcagg cacctagcaa ttccatcacc cgtacaggca attccgtctt
2281 cttaatctga agcttcactc actgtcaatg attattttca ttacaatgga aacaatcttt
2341 ttttactcta tgccccaaat atagcgttcc caacaacatc catgtcctat gtgtgactct
2401 aaattcttta tttctgtcat tcaaatgggt gatatcctga aaaaaaaaaa aaaaaaaaac
2461 tgggacagct ttcccctcat tttttttttt gtttctgaga aaagaacgta ttttaaaagc
2521 cacatagagt gactccaaga acaattgtcc atggtctcaa acaaggggct gttacataac
2581 aagaaaatca aagctgagga cagggtgtga gcgccacatc tctgaaagca caggagacac
2641 tgtgctataa atcctttggg gagcgatgtt ttgaatttag tgagatttac cagggatgta
2701 gattaaggtg atgtgattca aaagatgcca ttcatagaga gccctagtta ctgcatgggg
2761 aaagagatcc aggaagcatg agtgctggat attttactac caatgccaag ataattcact
2821 ctactcagcc ggcgtggcaa atataaaact tacagagcgt ggctgtgctc tcaccagctg
2881 ctgctctgag ttatgttaaa atccgctaga gcagcccaaa tttttctcag tttgtataga
2941 gttcatccca gccccaattt tctggggctc ctcacatagc tacccaaaag agaaaaaaaa
3001 ttaagacaag cctggcaaca cacctggtga agagtagttt actagctttt caaacaagaa
3061 tgtccctttt cctaagtcac tttgaggtgt ctcaatctga tctgagtgag aggcgacagg
3121 agtatttttt ttttttacag ctttacacac acagatgtgg gctttgattt ccaagtaata
3181 taatggaaga gaaatctcat actcccccac agtttgatgt cattaatgtg ttgggaaaaa
3241 ggcctctgtc ccggaagagt catgggaggt gaaaggggca cgtttgaaga tgcgagcgct
3301 atcttcacat agttctccag ttgtatggag cctcttctgc caagagaggg ccatgcaatt
3361 catcccagag gaacctgagg cctgaaggag gtgagagaag acctctgtga ggaaagcaca
3421 cagtcacctt ctcggcaact aagcagtccc tgagaccatt taacatgcaa cccgaaggtt
3481 atggtcaatc ccaaaagtca ccactccatt cccaactaga cattaccaaa gtgacctacc
3541 cagagattgc ttctcatccc cagtcccaat gcacatccat tcccaagaaa tgctttgtct
3601 tcagcctctc caggcaccat ctcccttcct gtgggagcag agagcttagc ctggagcacc
3661 tttccttcaa gccagcaaca cagagcacta ggttcaattc cctgaaggtg gccactttaa
3721 gagagaaatc tgaaaacccc atttgctttc ttttctccca tattggcatg gatttctgtc
3781 ttctctaaca ccttgtgacc ttctctatat catgctttaa agtgtaataa tatgattttt
3841 taaaagaaat ttattacttg ttgcaaaggt ctttttaaac cagtttagat ttcaagaaaa
3901 aataaatgga aatcatcgaa aattcatttc acattaatgg tctaaaaata aaccaaagga
3961 cattatgtgt gcatgtgtgt ataagtgcac acagaaatat atatacatat gtagactata
4021 tacatgtgtg tatatatgtg tatatataca tacacttgta taaatgtata tacacatata
4081 cctataatgt gtgtatgtgt atttattgaa gaaacagata ccatactcat ttctaaaaga
4141 atattcagag aatatcaaga tgattctggc tgaaaaaggc cagtggaaat tctggtgaaa
4201 atgttcatca attcccattg catcacctct gtaatttttc agctctctgt ataaacatta
4261 aatgtcttat atagcagcaa aaatataaaa tagttgtcca tattttcaca ggtgtggtgt
4321 aatttataaa attagaaagc aacttatcag ctacttaaga gaaatggcaa gttttgatat
4381 gagtatacaa tatataaaaa tatatatagt gctatatata taaatatttg gtctctattt
4441 cattttttgc atcagtatta atactaaaat atgtctcgct agtgatgttt ttatgatatc
4501 cctgatccta actgaagaga cagttattta tagtcattta ttttaaaaaa tgaaaataag
4561 tgaataataa ttaggttaac attgttgctc cctgtgacaa aattttataa gcaaatttca
4621 aaagacatgt tgtaaattag gaggctcaac aataaaacat tatgctccag aaaaaaaaaa
4681 aaaaaa
//