LOCUS BC035638 4213 bp mRNA linear HUM 26-JUL-2018 DEFINITION Homo sapiens lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase), mRNA (cDNA clone MGC:46212 IMAGE:5547173), complete cds. ACCESSION BC035638 VERSION BC035638.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4213) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 4213) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (31-JUL-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov REFERENCE 3 (bases 1 to 4213) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (26-JUL-2018) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK Sequence update by database staff to remove vector contamination COMMENT On Jul 26, 2018 this sequence version replaced BC035638.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 79 Row: a Column: 3 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 47933394. FEATURES Location/Qualifiers source 1..4213 /db_xref="H-InvDB:HIT000051454" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:46212 IMAGE:5547173" /tissue_type="Eye, retinoblastoma" /clone_lib="NIH_MGC_67" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..4213 /gene="LSS" /gene_synonym="OSC" /db_xref="GeneID:4047" /db_xref="HGNC:HGNC:6708" /db_xref="MIM:600909" CDS 20..2218 /gene="LSS" /gene_synonym="OSC" /codon_start=1 /product="lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)" /protein_id="AAH35638.1" /db_xref="GeneID:4047" /db_xref="HGNC:HGNC:6708" /db_xref="MIM:600909" /translation="MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERA GREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPL FLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLF PDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQ RNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSIS IGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFA IQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCG WIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRG GHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEF CRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQM ADGGWGEDFESCEERRYVQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL PNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP" BASE COUNT 793 a 1230 c 1279 g 911 t ORIGIN 1 gtagagcact gcagcagcaa tgacggaggg cacgtgtctg cggcgccgag ggggccccta 61 caagaccgag cccgccaccg acctcggccg ctggcgactc aactgcgaga ggggccggca 121 gacgtggacc tacctgcagg acgagcgcgc cggccgcgag cagaccggcc tggaagccta 181 cgccctgggg ctggacacca agaattactt taaggacttg cccaaagccc acaccgcctt 241 tgagggggct ctgaacggga tgacatttta cgtggggctg caggctgagg atgggcactg 301 gacgggtgat tatggtggcc cacttttcct cctgccaggc ctcctgatca cttgccacgt 361 ggcacgcatc cctctgccag ccggatacag agaagagatt gtgcggtacc tgcggtcagt 421 gcagctccct gacggtggct ggggcctgca cattgaggat aagtccaccg tgtttgggac 481 tgcgctcaac tatgtgtctc tcagaattct gggtgttggg cctgacgatc ctgacctggt 541 acgagcccgg aacattcttc acaagaaagg tggtgctgtg gccatcccct cctgggggaa 601 gttctggctg gctgtcctga atgtttacag ctgggaaggc ctcaataccc tgttcccaga 661 gatgtggctg tttcctgact gggcaccggc acacccctcc acactctggt gccactgccg 721 gcaggtgtac ctgcccatga gctactgcta cgccgttcgg ctgagtgccg cggaagaccc 781 gctggtccag agcctccgcc aggagctcta tgtggaggac ttcgccagca ttgactggct 841 ggcgcagagg aacaacgtgg cccccgacga gctgtacacg ccccacagct ggctgctccg 901 cgtggtatat gcgctcctca acctgtatga gcaccaccac agtgcccacc tgcggcagcg 961 ggccgtgcag aagctgtatg aacacattgt ggccgacgac cgattcacca agagcatcag 1021 catcggcccg atctcgaaaa ccatcaacat gcttgtgcgc tggtatgtgg acgggcccgc 1081 ctccactgcc ttccaggagc atgtctccag aatcccggac tatctctgga tgggccttga 1141 cggcatgaaa atgcagggca ccaacggctc acagatctgg gacaccgcat tcgccatcca 1201 ggctctgctt gaggcgggcg ggcaccacag gcccgagttt tcgtcctgcc tgcagaaggc 1261 tcatgagttc ctgaggctct cacaggtccc agataaccct cccgactacc agaagtacta 1321 ccgccagatg cgcaagggtg gcttctcctt cagtacgctg gactgcggct ggatcgtttc 1381 tgactgcacg gctgaggcct tgaaggctgt gctgctcctg caggagaagt gtccccatgt 1441 caccgagcac atccccagag aacggctctg cgatgctgtg gctgtgctgc tgaacatgag 1501 aaatccagat ggagggttcg ccacctatga gaccaagcgt ggggggcact tgctggagct 1561 gctgaacccc tcggaggtct tcggggacat catgattgac tacacctatg tggagtgcac 1621 ctcagccgtg atgcaggcgc ttaagtattt ccacaagcgt ttcccggagc acagggcagc 1681 ggagatccgg gagaccctca cgcagggctt agagttctgt cggcggcagc agagggccga 1741 tggctcctgg gaaggctcct ggggagtttg cttcacctac ggcacctggt ttggcctgga 1801 ggccttcgcc tgtatggggc agacctaccg agatgggact gcctgtgcag aggtctcccg 1861 ggcctgtgac ttcctgctgt cccggcagat ggcagacgga ggctgggggg aggactttga 1921 gtcctgcgag gagcggcgtt atgtgcagag tgcccagtcc cagatccata acacatgctg 1981 ggccatgatg gggctgatgg ccgttcggca tcctgacatc gaggcccagg agagaggagt 2041 ccggtgtcta cttgagaaac agctccccaa tggcgactgg ccgcaggaaa acattgctgg 2101 ggtcttcaac aagtcctgtg ccatctccta cacgagctac aggaacatct tccccatctg 2161 ggccctcggc cgcttctccc agctgtaccc tgagagagcc cttgctggcc acccctgaga 2221 acatgcctac ctgctgggtg ccgtctgtgc gttccagtga ggccaagggg tcctggccgg 2281 gttggggagc cctcccataa ccctgtcttg ggctccaacc cctcaacctc tatctcatag 2341 atgtgaatct gggggccagg ctggaggcag ggatggggac agggtgggtg gcttagactc 2401 ttgattttta ctgtaggttc atttctgaaa gtagcttgtc gggcttgggt gaggaagggg 2461 gcacaggagc cgtgacccct gaggaggcac agcgccttct gccacctctg ggcacggcct 2521 caaggtagtg aggctaggag gttttttctg accaatagct gagttcttgg gagaggagca 2581 gctgtgcctg tgtgattcct tagtgtcgag tgggctctgg gctggggtcg gccctgggca 2641 ggcttctcct gcaccttttg tctgctgggc tgagggacac gagggcaacc ctgtgacaat 2701 ggcaggtagt gtgcatccgt gaatagccca gtgcgggggt tgctcatgga gcatcctgag 2761 gccgtgcagc agggagcccc atgcccctgg gtcgtgagct tgcctgcgta tggggtggtg 2821 tcatggagcc tcatgcccct gggtcgtgag ctcgcctgag tatggggtgg tgtcatggag 2881 ccgcataccc ctgggttgtg agctcgcctg catatgcagg gtctgtcatg gaacatccca 2941 agtctgtgca gcagggagcc ccatgcccct gggacatgaa cccacctgcg tggaatgctg 3001 tttgtgaggt gtctacaggg tttatagtag tcttgtggac acagaaatgc acaggggaca 3061 cttacggaca cagaaatgca caggggaggc cgagcataac caggggtgag gggcaggcag 3121 cagttgtagt tactgccgcg gggcactgct atgtgcaggg acagccagcg cccagcccat 3181 caccactccc tgggctggct ggcaggtatg gcaccctggg agcccggcat atacccaggg 3241 cacccctacg gctgccgcca gtctcatgcc caggtgggtg ctctgggctg gagcgagggc 3301 caggttttgg gccgaggctt ccccaggcaa tcctgtgagc tcccttctag cctctgaccc 3361 agtctggtct ggcttgcatg gatgtagggc ttggggtggg aagttcaggt cctggctttg 3421 cctttgcctg atgtggatga gcagctcaca tgctcagggc cacctgagac tgtcactgct 3481 ctcccctggc tactgggagg agtcactgag agcttcgtta cccctgctgc cttgcccagg 3541 gcacacccta tacctcctca tctgctcttc ccctccctgc cgccttctgg gcaggtagca 3601 gtccctggcc tctccccctg gctgatcact ctccctcagg cagtggagat ctgcgtctgg 3661 acaccctcag atcctgtcat tgcctgccca gagtccttca ggggcacccc tctgccttgg 3721 tgtgcggtcc agggctctca cccaggtgcc gcaccctctg gggtcttctg tccagctccc 3781 ttgccccatg tgctgtcact gactctcctt gggactcgcc tgcctgctca gagccctgca 3841 gggcttggtc agctgcctgt tcagtgtcaa cacttccctg cacatcttaa aactgggctt 3901 tattttcgct gaaggaactg tgttgggacc cttgacatct gtcaggtttg cacatgctgt 3961 ttttttttct cagcccacgt gttctccccc acgtggggta gcagcaggac agacagtgaa 4021 tcacagagtc tgccctgagc agaggctgct gtccctggga ctcctagcca tggtcagact 4081 gtacaaaacg gttttccaga aatgaaatgt aaatccattt ttatactgaa aatgttactg 4141 aaagtcactt ttatgagcat ctgccttaat aaacagacat tgattccctt atcaaaaaaa 4201 aaaaaaaaaa aaa //