LOCUS BC035638 4213 bp mRNA linear HUM 26-JUL-2018
DEFINITION Homo sapiens lanosterol synthase (2,3-oxidosqualene-lanosterol
cyclase), mRNA (cDNA clone MGC:46212 IMAGE:5547173), complete cds.
ACCESSION BC035638
VERSION BC035638.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4213)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 4213)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (31-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
REFERENCE 3 (bases 1 to 4213)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (26-JUL-2018) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK Sequence update by database staff to remove vector contamination
COMMENT On Jul 26, 2018 this sequence version replaced BC035638.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 79 Row: a Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 47933394.
FEATURES Location/Qualifiers
source 1..4213
/db_xref="H-InvDB:HIT000051454"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:46212 IMAGE:5547173"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..4213
/gene="LSS"
/gene_synonym="OSC"
/db_xref="GeneID:4047"
/db_xref="HGNC:HGNC:6708"
/db_xref="MIM:600909"
CDS 20..2218
/gene="LSS"
/gene_synonym="OSC"
/codon_start=1
/product="lanosterol synthase
(2,3-oxidosqualene-lanosterol cyclase)"
/protein_id="AAH35638.1"
/db_xref="GeneID:4047"
/db_xref="HGNC:HGNC:6708"
/db_xref="MIM:600909"
/translation="MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERA
GREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPL
FLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVS
LRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLF
PDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQ
RNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSIS
IGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFA
IQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCG
WIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRG
GHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEF
CRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQM
ADGGWGEDFESCEERRYVQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL
PNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP"
BASE COUNT 793 a 1230 c 1279 g 911 t
ORIGIN
1 gtagagcact gcagcagcaa tgacggaggg cacgtgtctg cggcgccgag ggggccccta
61 caagaccgag cccgccaccg acctcggccg ctggcgactc aactgcgaga ggggccggca
121 gacgtggacc tacctgcagg acgagcgcgc cggccgcgag cagaccggcc tggaagccta
181 cgccctgggg ctggacacca agaattactt taaggacttg cccaaagccc acaccgcctt
241 tgagggggct ctgaacggga tgacatttta cgtggggctg caggctgagg atgggcactg
301 gacgggtgat tatggtggcc cacttttcct cctgccaggc ctcctgatca cttgccacgt
361 ggcacgcatc cctctgccag ccggatacag agaagagatt gtgcggtacc tgcggtcagt
421 gcagctccct gacggtggct ggggcctgca cattgaggat aagtccaccg tgtttgggac
481 tgcgctcaac tatgtgtctc tcagaattct gggtgttggg cctgacgatc ctgacctggt
541 acgagcccgg aacattcttc acaagaaagg tggtgctgtg gccatcccct cctgggggaa
601 gttctggctg gctgtcctga atgtttacag ctgggaaggc ctcaataccc tgttcccaga
661 gatgtggctg tttcctgact gggcaccggc acacccctcc acactctggt gccactgccg
721 gcaggtgtac ctgcccatga gctactgcta cgccgttcgg ctgagtgccg cggaagaccc
781 gctggtccag agcctccgcc aggagctcta tgtggaggac ttcgccagca ttgactggct
841 ggcgcagagg aacaacgtgg cccccgacga gctgtacacg ccccacagct ggctgctccg
901 cgtggtatat gcgctcctca acctgtatga gcaccaccac agtgcccacc tgcggcagcg
961 ggccgtgcag aagctgtatg aacacattgt ggccgacgac cgattcacca agagcatcag
1021 catcggcccg atctcgaaaa ccatcaacat gcttgtgcgc tggtatgtgg acgggcccgc
1081 ctccactgcc ttccaggagc atgtctccag aatcccggac tatctctgga tgggccttga
1141 cggcatgaaa atgcagggca ccaacggctc acagatctgg gacaccgcat tcgccatcca
1201 ggctctgctt gaggcgggcg ggcaccacag gcccgagttt tcgtcctgcc tgcagaaggc
1261 tcatgagttc ctgaggctct cacaggtccc agataaccct cccgactacc agaagtacta
1321 ccgccagatg cgcaagggtg gcttctcctt cagtacgctg gactgcggct ggatcgtttc
1381 tgactgcacg gctgaggcct tgaaggctgt gctgctcctg caggagaagt gtccccatgt
1441 caccgagcac atccccagag aacggctctg cgatgctgtg gctgtgctgc tgaacatgag
1501 aaatccagat ggagggttcg ccacctatga gaccaagcgt ggggggcact tgctggagct
1561 gctgaacccc tcggaggtct tcggggacat catgattgac tacacctatg tggagtgcac
1621 ctcagccgtg atgcaggcgc ttaagtattt ccacaagcgt ttcccggagc acagggcagc
1681 ggagatccgg gagaccctca cgcagggctt agagttctgt cggcggcagc agagggccga
1741 tggctcctgg gaaggctcct ggggagtttg cttcacctac ggcacctggt ttggcctgga
1801 ggccttcgcc tgtatggggc agacctaccg agatgggact gcctgtgcag aggtctcccg
1861 ggcctgtgac ttcctgctgt cccggcagat ggcagacgga ggctgggggg aggactttga
1921 gtcctgcgag gagcggcgtt atgtgcagag tgcccagtcc cagatccata acacatgctg
1981 ggccatgatg gggctgatgg ccgttcggca tcctgacatc gaggcccagg agagaggagt
2041 ccggtgtcta cttgagaaac agctccccaa tggcgactgg ccgcaggaaa acattgctgg
2101 ggtcttcaac aagtcctgtg ccatctccta cacgagctac aggaacatct tccccatctg
2161 ggccctcggc cgcttctccc agctgtaccc tgagagagcc cttgctggcc acccctgaga
2221 acatgcctac ctgctgggtg ccgtctgtgc gttccagtga ggccaagggg tcctggccgg
2281 gttggggagc cctcccataa ccctgtcttg ggctccaacc cctcaacctc tatctcatag
2341 atgtgaatct gggggccagg ctggaggcag ggatggggac agggtgggtg gcttagactc
2401 ttgattttta ctgtaggttc atttctgaaa gtagcttgtc gggcttgggt gaggaagggg
2461 gcacaggagc cgtgacccct gaggaggcac agcgccttct gccacctctg ggcacggcct
2521 caaggtagtg aggctaggag gttttttctg accaatagct gagttcttgg gagaggagca
2581 gctgtgcctg tgtgattcct tagtgtcgag tgggctctgg gctggggtcg gccctgggca
2641 ggcttctcct gcaccttttg tctgctgggc tgagggacac gagggcaacc ctgtgacaat
2701 ggcaggtagt gtgcatccgt gaatagccca gtgcgggggt tgctcatgga gcatcctgag
2761 gccgtgcagc agggagcccc atgcccctgg gtcgtgagct tgcctgcgta tggggtggtg
2821 tcatggagcc tcatgcccct gggtcgtgag ctcgcctgag tatggggtgg tgtcatggag
2881 ccgcataccc ctgggttgtg agctcgcctg catatgcagg gtctgtcatg gaacatccca
2941 agtctgtgca gcagggagcc ccatgcccct gggacatgaa cccacctgcg tggaatgctg
3001 tttgtgaggt gtctacaggg tttatagtag tcttgtggac acagaaatgc acaggggaca
3061 cttacggaca cagaaatgca caggggaggc cgagcataac caggggtgag gggcaggcag
3121 cagttgtagt tactgccgcg gggcactgct atgtgcaggg acagccagcg cccagcccat
3181 caccactccc tgggctggct ggcaggtatg gcaccctggg agcccggcat atacccaggg
3241 cacccctacg gctgccgcca gtctcatgcc caggtgggtg ctctgggctg gagcgagggc
3301 caggttttgg gccgaggctt ccccaggcaa tcctgtgagc tcccttctag cctctgaccc
3361 agtctggtct ggcttgcatg gatgtagggc ttggggtggg aagttcaggt cctggctttg
3421 cctttgcctg atgtggatga gcagctcaca tgctcagggc cacctgagac tgtcactgct
3481 ctcccctggc tactgggagg agtcactgag agcttcgtta cccctgctgc cttgcccagg
3541 gcacacccta tacctcctca tctgctcttc ccctccctgc cgccttctgg gcaggtagca
3601 gtccctggcc tctccccctg gctgatcact ctccctcagg cagtggagat ctgcgtctgg
3661 acaccctcag atcctgtcat tgcctgccca gagtccttca ggggcacccc tctgccttgg
3721 tgtgcggtcc agggctctca cccaggtgcc gcaccctctg gggtcttctg tccagctccc
3781 ttgccccatg tgctgtcact gactctcctt gggactcgcc tgcctgctca gagccctgca
3841 gggcttggtc agctgcctgt tcagtgtcaa cacttccctg cacatcttaa aactgggctt
3901 tattttcgct gaaggaactg tgttgggacc cttgacatct gtcaggtttg cacatgctgt
3961 ttttttttct cagcccacgt gttctccccc acgtggggta gcagcaggac agacagtgaa
4021 tcacagagtc tgccctgagc agaggctgct gtccctggga ctcctagcca tggtcagact
4081 gtacaaaacg gttttccaga aatgaaatgt aaatccattt ttatactgaa aatgttactg
4141 aaagtcactt ttatgagcat ctgccttaat aaacagacat tgattccctt atcaaaaaaa
4201 aaaaaaaaaa aaa
//