LOCUS BC032348 3089 bp mRNA linear HUM 07-OCT-2003 DEFINITION Homo sapiens kelch-like 6 (Drosophila), mRNA (cDNA clone MGC:40562 IMAGE:5213743), complete cds. ACCESSION BC032348 VERSION BC032348.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3089) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3089) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (06-JUN-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 64 Row: k Column: 20 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 18482382. FEATURES Location/Qualifiers source 1..3089 /db_xref="H-InvDB:HIT000041504" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:40562 IMAGE:5213743" /tissue_type="Blood, adult leukocytes" /clone_lib="NIH_MGC_118" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..3089 /gene="KLHL6" /gene_synonym="FLJ00029" /db_xref="GeneID:89857" CDS 70..1902 /gene="KLHL6" /gene_synonym="FLJ00029" /codon_start=1 /product="KLHL6 protein" /protein_id="AAH32348.1" /db_xref="GeneID:89857" /translation="MGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLS LILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRI IIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNP ENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYV TEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV FPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRR SRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQ IEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSF AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIY VVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL CWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV" misc_feature 220..543 /gene="KLHL6" /gene_synonym="FLJ00029" /note="BTB; Region: BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN" /db_xref="CDD:pfam00651" misc_feature 1300..1440 /gene="KLHL6" /gene_synonym="FLJ00029" /note="Kelch; Region: Kelch domain" /db_xref="CDD:smart00612" BASE COUNT 808 a 771 c 789 g 721 t ORIGIN 1 gggcctgcct gacacttggg cgctccttca gtctcgatgt tgatggcagg acaaaggggc 61 gcctggacca tgggtgatgt ggtcgagaag agtttggaag ggcccctggc accttctaca 121 gatgagccct cccagaaaac aggagacttg gtcgagatct taaatgggga aaaggtcaaa 181 tttgacgacg cgggactctc cttaattctt cagaatggcc tggaaaccct gcgaatggaa 241 aacgctctga cagatgtcat cttgtgtgtg gacattcagg aattctcctg ccaccgcgtg 301 gtgcttgccg cagccagcaa ctatttcagg gccatgttct gcaacgattt aaaggaaaag 361 tatgagaaaa ggatcattat taaaggggtt gatgctgaga ccatgcacac tctgttggac 421 tacacgtaca ccagcaaggc gctgatcacc aagcagaatg tccagcgggt cctggaggct 481 gctaacctct tccagttcct gcggatggtg gatgcctgtg ccagcttcct cactgaagcc 541 ttgaacccag aaaactgcgt tggaatactg aggctggctg acacacactc gctggacagt 601 ctaaagaagc aggttcagag ttacatcatt caaaactttg tgcagattct gaactctgag 661 gagtttcttg acctgcccgt ggacactctg caccacatct tgaagagtga tgacctttac 721 gtgaccgagg aggctcaggt gtttgagacc gtgatgagct gggtccggca caagccatca 781 gaacgactct gcttactccc ctatgtcctc gagaacgtgc gcttaccgct tctggacccg 841 tggtactttg tggagacggt ggaagcagat cctctcatca ggcagtgccc agaggtcttc 901 ccgctgctcc aggaagccag gatgtaccac ctttctggca atgagatcat ttcggaacgc 961 accaagccca ggatgcatga gttccagtct gaggtgttca tgatcattgg cggctgcacg 1021 aaggatgaac ggtttgtggc agaggtgacc tgcctggacc ccctgaggcg cagccgcctg 1081 gaggtggcca agctcccgct aacagagcat gagctggaga gtgagaataa gaagtgggtg 1141 gagtttgcat gcgtgacatt gaaaaatgag gtctacatct caggtggcaa agaaacacag 1201 catgatgttt ggaaatataa ttcttcgatc aacaagtgga ttcagattga gtatttaaac 1261 ataggccgct ggaggcataa gatggtggtg ttgggtggca aggtctatgt gatcggaggc 1321 tttgacggct tacagagaat caacaacgtg gagacctacg acccctttca caactgctgg 1381 tcagaggccg cacccctcct tgtccatgtc agttcctttg cagccaccag ccataagaag 1441 aagctgtatg tgatcggggg agggcccaat gggaaactgg ccacagacaa gactcagtgt 1501 tatgaccctt ccaccaacaa gtggagtttg aaggcggcca tgcccgtgga ggctaaatgc 1561 atcaatgcag tgagtttccg ggaccgcatc tatgtcgttg gtggggccat gagagcgctg 1621 tacgcctaca gcccgctgga agacagctgg tgcctggtga cccagctcag ccacgagcgg 1681 gccagctgcg gtatcgcgcc ctgcaacaac cggctctaca tcaccggcgg gcgggacgag 1741 aagaacgagg ttatcgccac ggtgctgtgc tgggaccccg aggcccagaa actgacagag 1801 gagtgcgtcc tgccccgggg cgtgtcgcac cacggcagcg tcaccatcag gaagtcgtac 1861 acccacatcc gcaggatcgt gcccggagca gtgtctgtct gacggcagga tggggagctg 1921 gagagccccc ccgaccctca gcgtacccgc ctcacctctc accctcctcc agtcccactt 1981 caggcagcag gctcgagttt gaggccatac atcaggggat ccccttgact cactttgggg 2041 gaaccttgga agtcacagtt tggggtcact tgagaccggc caggaatgtt tgcatgacct 2101 acctcaggag gggaggcgag gaagagtaat atttagcatt caggacccac ccaccctatg 2161 ccggcttctg tgccaggcac ttccttttat cggttcattt aacctggtga ctggctctta 2221 tcacttctag tttacaggtg agggaaccaa gtttcacaga ggctaagtgg cgtgcccctg 2281 atcactcaga tagcaagtag ctaccccagg agtctaaaat ccaggtcttt catctccgaa 2341 gtcaatgctc tttccaccat gctgcctatc tcagagcagg aaaaacaaac aaaaaacaac 2401 aacaaaaccg cctcggcctc ccgaagtgct gggattgcag gtgtgagcca ctgggcccgg 2461 tctttttttt ttttaaatga tcataagatg gcccattttg gaccggaact gtcattgcca 2521 gacagaattg tacctttagc acattctggt gccctggcct cttagtgttc accagttgta 2581 ctgcaatata gacaagatgt ctctagagac tcaaactact gttttattaa aaaagtaaac 2641 acctgagcac agctggccta cacaggagcg acagattctc cttgatggta cactttctag 2701 tttttacaca gtgatttagg tccacgttcc tgatacccca tcctcctgaa gccttcgttt 2761 tcaagacttt taaaaagcac ttctacttgg ttttttgatc agtgtagctc aattgtgact 2821 taaagaacag aatctgtcct tcactgtaag agctacagct ttcaaatgag ctcactggaa 2881 attcattcta atccccaagc tggagaaaca ggttaagaga tcctgtttca tatgctgtat 2941 ttaaaaagca acaatgataa caacatagta actgcgttac ccaatggact ttattttcat 3001 catatgattt caattctctt tatagagttt tatttcaaaa aaaaaaaaaa aaaaaaaaaa 3061 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa //