LOCUS BC032348 3089 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens kelch-like 6 (Drosophila), mRNA (cDNA clone MGC:40562
IMAGE:5213743), complete cds.
ACCESSION BC032348
VERSION BC032348.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3089)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3089)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 64 Row: k Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 18482382.
FEATURES Location/Qualifiers
source 1..3089
/db_xref="H-InvDB:HIT000041504"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:40562 IMAGE:5213743"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3089
/gene="KLHL6"
/gene_synonym="FLJ00029"
/db_xref="GeneID:89857"
CDS 70..1902
/gene="KLHL6"
/gene_synonym="FLJ00029"
/codon_start=1
/product="KLHL6 protein"
/protein_id="AAH32348.1"
/db_xref="GeneID:89857"
/translation="MGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLS
LILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRI
IIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNP
ENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYV
TEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV
FPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRR
SRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQ
IEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSF
AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIY
VVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL
CWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV"
misc_feature 220..543
/gene="KLHL6"
/gene_synonym="FLJ00029"
/note="BTB; Region: BTB/POZ domain. The BTB (for BR-C, ttk
and bab) or POZ (for Pox virus and Zinc finger) domain is
present near the N-terminus of a fraction of zinc finger
(pfam00096) proteins and in proteins that contain the
pfam01344 motif such as Kelch and a family of pox virus
proteins. The BTB/POZ domain mediates homomeric
dimerisation and in some instances heteromeric
dimerisation. The structure of the dimerised PLZF BTB/POZ
domain has been solved and consists of a tightly
intertwined homodimer. The central scaffolding of the
protein is made up of a cluster of alpha-helices flanked
by short beta-sheets at both the top and bottom of the
molecule. POZ domains from several zinc finger proteins
have been shown to mediate transcriptional repression and
to interact with components of histone deacetylase
co-repressor complexes including N-CoR and SMRT. The POZ
or BTB domain is also known as BR-C/Ttk or ZiN"
/db_xref="CDD:pfam00651"
misc_feature 1300..1440
/gene="KLHL6"
/gene_synonym="FLJ00029"
/note="Kelch; Region: Kelch domain"
/db_xref="CDD:smart00612"
BASE COUNT 808 a 771 c 789 g 721 t
ORIGIN
1 gggcctgcct gacacttggg cgctccttca gtctcgatgt tgatggcagg acaaaggggc
61 gcctggacca tgggtgatgt ggtcgagaag agtttggaag ggcccctggc accttctaca
121 gatgagccct cccagaaaac aggagacttg gtcgagatct taaatgggga aaaggtcaaa
181 tttgacgacg cgggactctc cttaattctt cagaatggcc tggaaaccct gcgaatggaa
241 aacgctctga cagatgtcat cttgtgtgtg gacattcagg aattctcctg ccaccgcgtg
301 gtgcttgccg cagccagcaa ctatttcagg gccatgttct gcaacgattt aaaggaaaag
361 tatgagaaaa ggatcattat taaaggggtt gatgctgaga ccatgcacac tctgttggac
421 tacacgtaca ccagcaaggc gctgatcacc aagcagaatg tccagcgggt cctggaggct
481 gctaacctct tccagttcct gcggatggtg gatgcctgtg ccagcttcct cactgaagcc
541 ttgaacccag aaaactgcgt tggaatactg aggctggctg acacacactc gctggacagt
601 ctaaagaagc aggttcagag ttacatcatt caaaactttg tgcagattct gaactctgag
661 gagtttcttg acctgcccgt ggacactctg caccacatct tgaagagtga tgacctttac
721 gtgaccgagg aggctcaggt gtttgagacc gtgatgagct gggtccggca caagccatca
781 gaacgactct gcttactccc ctatgtcctc gagaacgtgc gcttaccgct tctggacccg
841 tggtactttg tggagacggt ggaagcagat cctctcatca ggcagtgccc agaggtcttc
901 ccgctgctcc aggaagccag gatgtaccac ctttctggca atgagatcat ttcggaacgc
961 accaagccca ggatgcatga gttccagtct gaggtgttca tgatcattgg cggctgcacg
1021 aaggatgaac ggtttgtggc agaggtgacc tgcctggacc ccctgaggcg cagccgcctg
1081 gaggtggcca agctcccgct aacagagcat gagctggaga gtgagaataa gaagtgggtg
1141 gagtttgcat gcgtgacatt gaaaaatgag gtctacatct caggtggcaa agaaacacag
1201 catgatgttt ggaaatataa ttcttcgatc aacaagtgga ttcagattga gtatttaaac
1261 ataggccgct ggaggcataa gatggtggtg ttgggtggca aggtctatgt gatcggaggc
1321 tttgacggct tacagagaat caacaacgtg gagacctacg acccctttca caactgctgg
1381 tcagaggccg cacccctcct tgtccatgtc agttcctttg cagccaccag ccataagaag
1441 aagctgtatg tgatcggggg agggcccaat gggaaactgg ccacagacaa gactcagtgt
1501 tatgaccctt ccaccaacaa gtggagtttg aaggcggcca tgcccgtgga ggctaaatgc
1561 atcaatgcag tgagtttccg ggaccgcatc tatgtcgttg gtggggccat gagagcgctg
1621 tacgcctaca gcccgctgga agacagctgg tgcctggtga cccagctcag ccacgagcgg
1681 gccagctgcg gtatcgcgcc ctgcaacaac cggctctaca tcaccggcgg gcgggacgag
1741 aagaacgagg ttatcgccac ggtgctgtgc tgggaccccg aggcccagaa actgacagag
1801 gagtgcgtcc tgccccgggg cgtgtcgcac cacggcagcg tcaccatcag gaagtcgtac
1861 acccacatcc gcaggatcgt gcccggagca gtgtctgtct gacggcagga tggggagctg
1921 gagagccccc ccgaccctca gcgtacccgc ctcacctctc accctcctcc agtcccactt
1981 caggcagcag gctcgagttt gaggccatac atcaggggat ccccttgact cactttgggg
2041 gaaccttgga agtcacagtt tggggtcact tgagaccggc caggaatgtt tgcatgacct
2101 acctcaggag gggaggcgag gaagagtaat atttagcatt caggacccac ccaccctatg
2161 ccggcttctg tgccaggcac ttccttttat cggttcattt aacctggtga ctggctctta
2221 tcacttctag tttacaggtg agggaaccaa gtttcacaga ggctaagtgg cgtgcccctg
2281 atcactcaga tagcaagtag ctaccccagg agtctaaaat ccaggtcttt catctccgaa
2341 gtcaatgctc tttccaccat gctgcctatc tcagagcagg aaaaacaaac aaaaaacaac
2401 aacaaaaccg cctcggcctc ccgaagtgct gggattgcag gtgtgagcca ctgggcccgg
2461 tctttttttt ttttaaatga tcataagatg gcccattttg gaccggaact gtcattgcca
2521 gacagaattg tacctttagc acattctggt gccctggcct cttagtgttc accagttgta
2581 ctgcaatata gacaagatgt ctctagagac tcaaactact gttttattaa aaaagtaaac
2641 acctgagcac agctggccta cacaggagcg acagattctc cttgatggta cactttctag
2701 tttttacaca gtgatttagg tccacgttcc tgatacccca tcctcctgaa gccttcgttt
2761 tcaagacttt taaaaagcac ttctacttgg ttttttgatc agtgtagctc aattgtgact
2821 taaagaacag aatctgtcct tcactgtaag agctacagct ttcaaatgag ctcactggaa
2881 attcattcta atccccaagc tggagaaaca ggttaagaga tcctgtttca tatgctgtat
2941 ttaaaaagca acaatgataa caacatagta actgcgttac ccaatggact ttattttcat
3001 catatgattt caattctctt tatagagttt tatttcaaaa aaaaaaaaaa aaaaaaaaaa
3061 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//