LOCUS BC028220 1585 bp mRNA linear HUM 07-OCT-2003 DEFINITION Homo sapiens sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), mRNA (cDNA clone MGC:40041 IMAGE:5217599), complete cds. ACCESSION BC028220 VERSION BC028220.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1585) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1585) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: Life Technologies, Inc. cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 62 Row: j Column: 10 This clone was selected for full length sequencing because it passed the following selection criteria: Hexamer frequency ORF analysis, Similarity but not identity to protein. FEATURES Location/Qualifiers source 1..1585 /db_xref="H-InvDB:HIT000040494" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:40041 IMAGE:5217599" /tissue_type="Blood, adult leukocytes" /clone_lib="NIH_MGC_118" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..1585 /gene="SIRT6" /gene_synonym="SIR2L6" /db_xref="GeneID:51548" /db_xref="MIM:606211" CDS 12..998 /gene="SIRT6" /gene_synonym="SIR2L6" /codon_start=1 /product="SIRT6 protein" /protein_id="AAH28220.1" /db_xref="GeneID:51548" /db_xref="MIM:606211" /translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQS SNVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLE RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLK ATGRLCTVAKARGLRACRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTK HDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEES PTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS" misc_feature 141..662 /gene="SIRT6" /gene_synonym="SIR2L6" /note="sir2; Region: Catalytic domain of the SIR2 like Histonde deacetylases and ADP ribosyl transferase" /db_xref="CDD:LOAD_sir2" BASE COUNT 350 a 506 c 470 g 259 t ORIGIN 1 ggcagtcgag gatgtcggtg aattacgcgg cggggctgtc gccgtacgcg gacaagggca 61 agtgcggcct cccggagatc ttcgaccccc cggaggagct ggagcggaag gtgtgggaac 121 tggcgaggct ggtctggcag tcttccaatg tggtgttcca cacgggtgcc ggcatcagca 181 ctgcctctgg catccccgac ttcaggggtc cccacggagt ctggaccatg gaggagcgag 241 gtctggcccc caagttcgac accacctttg agagcgcgcg gcccacgcag acccacatgg 301 cgctggtgca gctggagcgc gtgggcctcc tccgcttcct ggtcagccag aacgtggacg 361 ggctccatgt gcgctcaggc ttccccaggg acaaactggc agagctccac gggaacatgt 421 ttgtggaaga atgtgccaag tgtaagacgc agtacgtccg agacacagtc gtgggcacca 481 tgggcctgaa ggccacgggc cggctctgca ccgtggctaa ggcaaggggg ctgcgagcct 541 gcaggaacgc cgacctgtcc atcacgctgg gtacatcgct gcagatccgg cccagcggga 601 acctgccgct ggctaccaag cgccggggag gccgcctggt catcgtcaac ctgcagccca 661 ccaagcacga ccgccatgct gacctccgca tccatggcta cgttgacgag gtcatgaccc 721 ggctcatgaa gcacctgggg ctggagatcc ccgcctggga cggcccccgt gtgctggaga 781 gggcgctgcc acccctgccc cgcccgccca cccccaagct ggagcccaag gaggaatctc 841 ccacccggat caacggctct atccccgccg gccccaagca ggagccctgc gcccagcaca 901 acggctcaga gcccgccagc cccaaacggg agcggcccac cagccctgcc ccccacagac 961 cccccaaaag ggtgaaggcc aaggcggtcc ccagctgacc agggtgcttg gggagggtgg 1021 ggctttttgt agaaactgtg gattcttttt ctctcgtggt ctcactttgt tacttgtttc 1081 tgtccccggg agcctcaggg ctctgagagc tgtgctccag gccaggggtt acacctgccc 1141 tccgtggtcc ctccctgggc tccaggggcc tctggtgcgg ttccgggaag aagccacacc 1201 ccagaggtga cagctgagcc cctgccacac cccagcctct gacttgctgt gttgtccaga 1261 ggtgaggctg ggccctccct ggtctccagc ttaaacagga gtgaactccc tctgtcccca 1321 gggcctccct tctgggcccc ctacagccca ccctacccct cctccatggg ccctgcagga 1381 ggggagaccc accttgaagt gggggatcag tagaggcttg cactgccttt ggggctggag 1441 ggagacgtgg gtccaccagg cttctggaaa agtcctcaat gcaataaaaa caatttcttt 1501 cttgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1561 aaaaaaaaaa aaaaaaaaaa aaaaa //