LOCUS BC028220 1585 bp mRNA linear HUM 07-OCT-2003
DEFINITION Homo sapiens sirtuin (silent mating type information regulation 2
homolog) 6 (S. cerevisiae), mRNA (cDNA clone MGC:40041
IMAGE:5217599), complete cds.
ACCESSION BC028220
VERSION BC028220.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1585)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1585)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 62 Row: j Column: 10
This clone was selected for full length sequencing because it
passed the following selection criteria: Hexamer frequency ORF
analysis, Similarity but not identity to protein.
FEATURES Location/Qualifiers
source 1..1585
/db_xref="H-InvDB:HIT000040494"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:40041 IMAGE:5217599"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..1585
/gene="SIRT6"
/gene_synonym="SIR2L6"
/db_xref="GeneID:51548"
/db_xref="MIM:606211"
CDS 12..998
/gene="SIRT6"
/gene_synonym="SIR2L6"
/codon_start=1
/product="SIRT6 protein"
/protein_id="AAH28220.1"
/db_xref="GeneID:51548"
/db_xref="MIM:606211"
/translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQS
SNVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLE
RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLK
ATGRLCTVAKARGLRACRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTK
HDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEES
PTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS"
misc_feature 141..662
/gene="SIRT6"
/gene_synonym="SIR2L6"
/note="sir2; Region: Catalytic domain of the SIR2 like
Histonde deacetylases and ADP ribosyl transferase"
/db_xref="CDD:LOAD_sir2"
BASE COUNT 350 a 506 c 470 g 259 t
ORIGIN
1 ggcagtcgag gatgtcggtg aattacgcgg cggggctgtc gccgtacgcg gacaagggca
61 agtgcggcct cccggagatc ttcgaccccc cggaggagct ggagcggaag gtgtgggaac
121 tggcgaggct ggtctggcag tcttccaatg tggtgttcca cacgggtgcc ggcatcagca
181 ctgcctctgg catccccgac ttcaggggtc cccacggagt ctggaccatg gaggagcgag
241 gtctggcccc caagttcgac accacctttg agagcgcgcg gcccacgcag acccacatgg
301 cgctggtgca gctggagcgc gtgggcctcc tccgcttcct ggtcagccag aacgtggacg
361 ggctccatgt gcgctcaggc ttccccaggg acaaactggc agagctccac gggaacatgt
421 ttgtggaaga atgtgccaag tgtaagacgc agtacgtccg agacacagtc gtgggcacca
481 tgggcctgaa ggccacgggc cggctctgca ccgtggctaa ggcaaggggg ctgcgagcct
541 gcaggaacgc cgacctgtcc atcacgctgg gtacatcgct gcagatccgg cccagcggga
601 acctgccgct ggctaccaag cgccggggag gccgcctggt catcgtcaac ctgcagccca
661 ccaagcacga ccgccatgct gacctccgca tccatggcta cgttgacgag gtcatgaccc
721 ggctcatgaa gcacctgggg ctggagatcc ccgcctggga cggcccccgt gtgctggaga
781 gggcgctgcc acccctgccc cgcccgccca cccccaagct ggagcccaag gaggaatctc
841 ccacccggat caacggctct atccccgccg gccccaagca ggagccctgc gcccagcaca
901 acggctcaga gcccgccagc cccaaacggg agcggcccac cagccctgcc ccccacagac
961 cccccaaaag ggtgaaggcc aaggcggtcc ccagctgacc agggtgcttg gggagggtgg
1021 ggctttttgt agaaactgtg gattcttttt ctctcgtggt ctcactttgt tacttgtttc
1081 tgtccccggg agcctcaggg ctctgagagc tgtgctccag gccaggggtt acacctgccc
1141 tccgtggtcc ctccctgggc tccaggggcc tctggtgcgg ttccgggaag aagccacacc
1201 ccagaggtga cagctgagcc cctgccacac cccagcctct gacttgctgt gttgtccaga
1261 ggtgaggctg ggccctccct ggtctccagc ttaaacagga gtgaactccc tctgtcccca
1321 gggcctccct tctgggcccc ctacagccca ccctacccct cctccatggg ccctgcagga
1381 ggggagaccc accttgaagt gggggatcag tagaggcttg cactgccttt ggggctggag
1441 ggagacgtgg gtccaccagg cttctggaaa agtcctcaat gcaataaaaa caatttcttt
1501 cttgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1561 aaaaaaaaaa aaaaaaaaaa aaaaa
//