LOCUS BC024218 3210 bp mRNA linear HUM 11-DEC-2003 DEFINITION Homo sapiens pumilio homolog 2 (Drosophila), mRNA (cDNA clone IMAGE:3841907), partial cds. ACCESSION BC024218 VERSION BC024218.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3210) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 3210) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (26-FEB-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Dec 9, 2003 this sequence version replaced BC024218.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Institute for Systems Biology http://www.systemsbiology.org contact: amadan@systemsbiology.org Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 14 Row: g Column: 12. FEATURES Location/Qualifiers source 1..3210 /db_xref="H-InvDB:HIT000039773" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="IMAGE:3841907" /tissue_type="Placenta, choriocarcinoma" /clone_lib="NIH_MGC_21" /lab_host="DH10B-R" /note="Vector: pOTB7" gene <1..3210 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /db_xref="GeneID:23369" /db_xref="MIM:607205" CDS <1..1470 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /codon_start=1 /product="PUM2 protein" /protein_id="AAH24218.2" /db_xref="GeneID:23369" /db_xref="MIM:607205" /translation="ASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSP IGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASST SSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQD QHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLAL ATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHV VQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQ HTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHA SRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPH ITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML" misc_feature 448..552 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" misc_feature 553..645 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" misc_feature 664..753 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" misc_feature 775..879 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="PUF; Region: Pumilio-family RNA binding repeat. Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. One member, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences" /db_xref="CDD:pfam00806" misc_feature 886..987 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="PUF; Region: Pumilio-family RNA binding repeat. Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. One member, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences" /db_xref="CDD:pfam00806" misc_feature 991..1095 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" misc_feature 1099..1206 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" misc_feature 1234..1335 /gene="PUM2" /gene_synonym="KIAA0235" /gene_synonym="PUMH2" /gene_synonym="PUML2" /note="Pumilio; Region: Pumilio-like repeats" /db_xref="CDD:smart00025" BASE COUNT 1016 a 547 c 616 g 1031 t ORIGIN 1 gcaagtagta gtgccacaag gagagagtct ctatctacta gctctgactt gtacaaaaga 61 tctagtagca gcctagcacc catagggcaa ccattttaca atagtctggg attttcctcc 121 tctccaagtc caataggcat gcctctgcca agccaaactc caggacattc acttacgcca 181 ccgccatcac tttcatcaca tggatcctca tccagtttgc atttaggagg actgacaaat 241 ggtagtggtc gatatatctc tgcagcacct ggagcagaag caaaatatcg aagtgcttca 301 agcacttcca gtctatttag ctccagcagc cagctctttc ctccttcccg gcttcggtat 361 aataggtctg atattatgcc ttctggccgc agtagattat tggaagattt cagaaacaac 421 cgcttcccaa accttcagct tagagacttg attggacata tagttgagtt ttctcaagac 481 cagcatggtt ctagattcat acagcaaaaa ctagagagag ctactccagc tgagcgacag 541 atggtattta atgaaattct gcaagcagcc tatcaattaa tgactgatgt ttttggcaac 601 tatgttatac agaagttttt tgagtttggg agtctggatc aaaaattagc cctggctact 661 cgtattcgtg gtcatgttct acccttagcc ttgcagatgt atggctgccg cgttattcag 721 aaagcattag aatctatttc ttctgaccag caggtaatta gtgaaatggt aaaggagctg 781 gatggtcatg tgctcaaatg tgtgaaagat cagaatggaa accatgttgt acaaaaatgt 841 atcgaatgtg ttcagccaca gtcactacag ttcatcattg atgctttcaa gggacaagta 901 tttgtgcttt caactcatcc ttatggctgc agagtaattc agcgcatcct agagcattgc 961 actgcagaac agaccttacc tatcttagaa gaactccacc aacatacaga gcagttggta 1021 caggatcagt atggcaatta tgttattcag catgtactgg aacacggtcg acctgaagac 1081 aagagcaaaa ttgtttccga aatcagggga aaggttttag ccctgagtca acacaaattt 1141 gccagcaatg tagtagaaaa gtgtgttact catgcctccc gtgctgagag agctttactg 1201 attgacgagg tttgctgcca gaatgatggt cctcacagtg ccttatacac catgatgaag 1261 gaccagtatg ccaattacgt ggttcaaaag atgattgata tggctgaacc tgctcagaga 1321 aagataatca tgcacaagat tcgacctcac attactactt tgcgcaaata cacatacggg 1381 aagcatatac tggccaagtt ggaaaagtat tatttgaaga atagcccgga cctaggacct 1441 attggaggac caccaaatgg aatgctgtaa attacaggag caagagaaag aagataattt 1501 aaccatgtga aaagaatttt tttgtgtgtg aattatcaaa acacaactca actatgaatc 1561 ttcaattttt ttttaaagca aaactattta ttgactttat tcatccattt gtaaattttt 1621 taaggttctt gtgtatattt ggggggtggg ggatgaatta taaattatat tcagccctga 1681 gtggagacct atcagattgg attgctggca aagcacagaa tgcctgtata tgatgtaact 1741 gtatcaaaaa taaaaagctg tcacatattt tgtaaatttt taccttgtaa agtcacaaaa 1801 atagttttta aaggaaaaag tacagtattc ttttaataaa ctggctcaca gtctggtagg 1861 tctacaaccc catagcacaa caggtttata gagatgtata tagaattata gtccttattt 1921 ttttcctttg cgtgaaacct tttataacag attaacaatc aactgcataa atattattaa 1981 tattttaaaa agagttaagt tgtattttga taattcacaa actatcatgc aaataacgag 2041 taagtagaca agaataaagt ggtttgagat gaaaagaacc taacattatt tacagtagat 2101 gtggttttaa tacaattact gccctaaaat gtctctggca atgtacagaa atattgtata 2161 tacttacata tgtaattgtt gtaagagtta aatacaaaat catggtgaca cttccaatta 2221 agtgcactaa atgaaaagtt aagtcactta ttaacttttc agtttggttt gcaatgagaa 2281 agagtggaaa tttgtatttt gttttgctta tagaattaca gacatgttga ggaagtgttg 2341 agctttattt tgctttttca tagaggcaga aagtaggaac cagatagaga tgaaaagggg 2401 ccactgaaaa gtgaatttga tagctcagca tttaagcatg attacatatt cagatagctc 2461 tttttgcttt ctataaatat atgcattgtg tgtgtagtaa tagatgtaag tttacacttt 2521 gaaaggaaat cttgtttcaa tgtttattat aaaagccttg ctaatttagt agtgatgctt 2581 tccttggttg tacaggtgta catttgtaaa ccttcatgct gtaaatggaa tttgttttat 2641 ctctttggga tacatttgca ttttagtgta catttacgtc cctgccctct ttgacctggc 2701 aatatagtgt tgtataatgt aaatttattt ctccaaatcg agagtgattt tttaaaaatt 2761 ttttatcttt atatggtttc agaagtatga accagctttc tttttattat tgtgagatca 2821 ttttgtttta taacatagtt gttgactgtt aatatggacc tgctagaatt tggatcactt 2881 tcaattgaag tcagggtatt gtgcataata gaaagtattg gactgagata tttggttacc 2941 atggaggcca atgctttttt catcttatta aatgtgatgt gacttttttc tttgtacaga 3001 agagtactgt atttttgaat agcctactcc caagtaagag caaatctgta tgataacatt 3061 ttttcctctg gacataagac ataacagtaa cacgatgtac atttacaagc ggccttatgt 3121 acatttccca acaatctttt taaggcaaaa ttgtgaccat atgtgtataa ttaaaatcgt 3181 ttttaatcct taaaaaaaaa aaaaaaaaaa //