LOCUS BC024218 3210 bp mRNA linear HUM 11-DEC-2003
DEFINITION Homo sapiens pumilio homolog 2 (Drosophila), mRNA (cDNA clone
IMAGE:3841907), partial cds.
ACCESSION BC024218
VERSION BC024218.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3210)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3210)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (26-FEB-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Dec 9, 2003 this sequence version replaced BC024218.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 14 Row: g Column: 12.
FEATURES Location/Qualifiers
source 1..3210
/db_xref="H-InvDB:HIT000039773"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3841907"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..3210
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/db_xref="GeneID:23369"
/db_xref="MIM:607205"
CDS <1..1470
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/codon_start=1
/product="PUM2 protein"
/protein_id="AAH24218.2"
/db_xref="GeneID:23369"
/db_xref="MIM:607205"
/translation="ASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSP
IGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASST
SSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQD
QHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLAL
ATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHV
VQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQ
HTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHA
SRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPH
ITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML"
misc_feature 448..552
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
misc_feature 553..645
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
misc_feature 664..753
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
misc_feature 775..879
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="PUF; Region: Pumilio-family RNA binding repeat. Puf
repeats (aka PUM-HD, Pumilio homology domain) are
necessary and sufficient for sequence specific RNA binding
in fly Pumilio and worm FBF-1 and FBF-2. Both proteins
function as translational repressors in early embryonic
development by binding sequences in the 3' UTR of target
mRNAs (e.g. the nanos response element (NRE) in fly
Hunchback mRNA, or the point mutation element (PME) in
worm fem-3 mRNA). Other proteins that contain Puf domains
are also plausible RNA binding proteins. One member, for
instance, appears to also contain a single RRM domain by
HMM analysis. Puf domains usually occur as a tandem repeat
of 8 domains. The Pfam model does not necessarily
recognise all 8 repeats in all sequences"
/db_xref="CDD:pfam00806"
misc_feature 886..987
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="PUF; Region: Pumilio-family RNA binding repeat. Puf
repeats (aka PUM-HD, Pumilio homology domain) are
necessary and sufficient for sequence specific RNA binding
in fly Pumilio and worm FBF-1 and FBF-2. Both proteins
function as translational repressors in early embryonic
development by binding sequences in the 3' UTR of target
mRNAs (e.g. the nanos response element (NRE) in fly
Hunchback mRNA, or the point mutation element (PME) in
worm fem-3 mRNA). Other proteins that contain Puf domains
are also plausible RNA binding proteins. One member, for
instance, appears to also contain a single RRM domain by
HMM analysis. Puf domains usually occur as a tandem repeat
of 8 domains. The Pfam model does not necessarily
recognise all 8 repeats in all sequences"
/db_xref="CDD:pfam00806"
misc_feature 991..1095
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
misc_feature 1099..1206
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
misc_feature 1234..1335
/gene="PUM2"
/gene_synonym="KIAA0235"
/gene_synonym="PUMH2"
/gene_synonym="PUML2"
/note="Pumilio; Region: Pumilio-like repeats"
/db_xref="CDD:smart00025"
BASE COUNT 1016 a 547 c 616 g 1031 t
ORIGIN
1 gcaagtagta gtgccacaag gagagagtct ctatctacta gctctgactt gtacaaaaga
61 tctagtagca gcctagcacc catagggcaa ccattttaca atagtctggg attttcctcc
121 tctccaagtc caataggcat gcctctgcca agccaaactc caggacattc acttacgcca
181 ccgccatcac tttcatcaca tggatcctca tccagtttgc atttaggagg actgacaaat
241 ggtagtggtc gatatatctc tgcagcacct ggagcagaag caaaatatcg aagtgcttca
301 agcacttcca gtctatttag ctccagcagc cagctctttc ctccttcccg gcttcggtat
361 aataggtctg atattatgcc ttctggccgc agtagattat tggaagattt cagaaacaac
421 cgcttcccaa accttcagct tagagacttg attggacata tagttgagtt ttctcaagac
481 cagcatggtt ctagattcat acagcaaaaa ctagagagag ctactccagc tgagcgacag
541 atggtattta atgaaattct gcaagcagcc tatcaattaa tgactgatgt ttttggcaac
601 tatgttatac agaagttttt tgagtttggg agtctggatc aaaaattagc cctggctact
661 cgtattcgtg gtcatgttct acccttagcc ttgcagatgt atggctgccg cgttattcag
721 aaagcattag aatctatttc ttctgaccag caggtaatta gtgaaatggt aaaggagctg
781 gatggtcatg tgctcaaatg tgtgaaagat cagaatggaa accatgttgt acaaaaatgt
841 atcgaatgtg ttcagccaca gtcactacag ttcatcattg atgctttcaa gggacaagta
901 tttgtgcttt caactcatcc ttatggctgc agagtaattc agcgcatcct agagcattgc
961 actgcagaac agaccttacc tatcttagaa gaactccacc aacatacaga gcagttggta
1021 caggatcagt atggcaatta tgttattcag catgtactgg aacacggtcg acctgaagac
1081 aagagcaaaa ttgtttccga aatcagggga aaggttttag ccctgagtca acacaaattt
1141 gccagcaatg tagtagaaaa gtgtgttact catgcctccc gtgctgagag agctttactg
1201 attgacgagg tttgctgcca gaatgatggt cctcacagtg ccttatacac catgatgaag
1261 gaccagtatg ccaattacgt ggttcaaaag atgattgata tggctgaacc tgctcagaga
1321 aagataatca tgcacaagat tcgacctcac attactactt tgcgcaaata cacatacggg
1381 aagcatatac tggccaagtt ggaaaagtat tatttgaaga atagcccgga cctaggacct
1441 attggaggac caccaaatgg aatgctgtaa attacaggag caagagaaag aagataattt
1501 aaccatgtga aaagaatttt tttgtgtgtg aattatcaaa acacaactca actatgaatc
1561 ttcaattttt ttttaaagca aaactattta ttgactttat tcatccattt gtaaattttt
1621 taaggttctt gtgtatattt ggggggtggg ggatgaatta taaattatat tcagccctga
1681 gtggagacct atcagattgg attgctggca aagcacagaa tgcctgtata tgatgtaact
1741 gtatcaaaaa taaaaagctg tcacatattt tgtaaatttt taccttgtaa agtcacaaaa
1801 atagttttta aaggaaaaag tacagtattc ttttaataaa ctggctcaca gtctggtagg
1861 tctacaaccc catagcacaa caggtttata gagatgtata tagaattata gtccttattt
1921 ttttcctttg cgtgaaacct tttataacag attaacaatc aactgcataa atattattaa
1981 tattttaaaa agagttaagt tgtattttga taattcacaa actatcatgc aaataacgag
2041 taagtagaca agaataaagt ggtttgagat gaaaagaacc taacattatt tacagtagat
2101 gtggttttaa tacaattact gccctaaaat gtctctggca atgtacagaa atattgtata
2161 tacttacata tgtaattgtt gtaagagtta aatacaaaat catggtgaca cttccaatta
2221 agtgcactaa atgaaaagtt aagtcactta ttaacttttc agtttggttt gcaatgagaa
2281 agagtggaaa tttgtatttt gttttgctta tagaattaca gacatgttga ggaagtgttg
2341 agctttattt tgctttttca tagaggcaga aagtaggaac cagatagaga tgaaaagggg
2401 ccactgaaaa gtgaatttga tagctcagca tttaagcatg attacatatt cagatagctc
2461 tttttgcttt ctataaatat atgcattgtg tgtgtagtaa tagatgtaag tttacacttt
2521 gaaaggaaat cttgtttcaa tgtttattat aaaagccttg ctaatttagt agtgatgctt
2581 tccttggttg tacaggtgta catttgtaaa ccttcatgct gtaaatggaa tttgttttat
2641 ctctttggga tacatttgca ttttagtgta catttacgtc cctgccctct ttgacctggc
2701 aatatagtgt tgtataatgt aaatttattt ctccaaatcg agagtgattt tttaaaaatt
2761 ttttatcttt atatggtttc agaagtatga accagctttc tttttattat tgtgagatca
2821 ttttgtttta taacatagtt gttgactgtt aatatggacc tgctagaatt tggatcactt
2881 tcaattgaag tcagggtatt gtgcataata gaaagtattg gactgagata tttggttacc
2941 atggaggcca atgctttttt catcttatta aatgtgatgt gacttttttc tttgtacaga
3001 agagtactgt atttttgaat agcctactcc caagtaagag caaatctgta tgataacatt
3061 ttttcctctg gacataagac ataacagtaa cacgatgtac atttacaagc ggccttatgt
3121 acatttccca acaatctttt taaggcaaaa ttgtgaccat atgtgtataa ttaaaatcgt
3181 ttttaatcct taaaaaaaaa aaaaaaaaaa
//