LOCUS BC022996 2278 bp mRNA linear HUM 04-OCT-2003 DEFINITION Homo sapiens SH3-domain binding protein 2, mRNA (cDNA clone MGC:29882 IMAGE:5103986), complete cds. ACCESSION BC022996 VERSION BC022996.1 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2278) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2278) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (04-FEB-2002) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Life Technologies, Inc. cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: Baylor College of Medicine Human Genome Sequencing Center Center code: BCM-HGSC Web site: http://www.hgsc.bcm.tmc.edu/cdna/ Contact: amg@bcm.tmc.edu Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H., Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati, A.N., Gibbs, R.A. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 42 Row: l Column: 3 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 19923154. FEATURES Location/Qualifiers source 1..2278 /db_xref="H-InvDB:HIT000039693" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:29882 IMAGE:5103986" /tissue_type="Cervix, carcinoma" /clone_lib="NIH_MGC_12" /lab_host="DH10B" /note="Vector: pCMV-SPORT6" gene 1..2278 /gene="SH3BP2" /gene_synonym="CRBM" /gene_synonym="CRPM" /gene_synonym="RES4-23" /db_xref="GeneID:6452" /db_xref="MIM:602104" CDS 117..1802 /gene="SH3BP2" /gene_synonym="CRBM" /gene_synonym="CRPM" /gene_synonym="RES4-23" /codon_start=1 /product="SH3BP2 protein" /protein_id="AAH22996.1" /db_xref="GeneID:6452" /db_xref="MIM:602104" /translation="MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLL KWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHIS KKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPV DISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFS DMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRR MSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKL KSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPV PEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEK VPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKV RNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR" misc_feature 195..509 /gene="SH3BP2" /gene_synonym="CRBM" /gene_synonym="CRPM" /gene_synonym="RES4-23" /note="PH; Region: Pleckstrin homology domain. Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids" /db_xref="CDD:smart00233" misc_feature 1512..1748 /gene="SH3BP2" /gene_synonym="CRBM" /gene_synonym="CRPM" /gene_synonym="RES4-23" /note="SH2; Region: Src homology 2 domains" /db_xref="CDD:smart00252" BASE COUNT 471 a 779 c 661 g 367 t ORIGIN 1 gcgggcggga cggagctgcg gcggcggcgg gtcccgcggg cgggagcgcc tggcggccga 61 gtcaagccgc cgcctcgacc cagggcccgc gggccaggag agcgctcggc ggcttcatgg 121 cggctgaaga gatgcattgg cctgtcccta tgaaggccat tggtgcccag aacctgctaa 181 ccatgcctgg gggcgtggcc aaggctggct acctgcacaa gaagggcggt acccagctgc 241 agctgctgaa atggcccctg cgctttgtca tcatccacaa acgctgcgtc tactacttca 301 agagtagcac ctctgcctcc ccgcagggcg ccttctccct gagtggctat aaccgggtga 361 tgcgggcggc tgaggagacc acgtccaaca acgttttccc cttcaagatc atccacatca 421 gcaagaagca ccgcacgtgg ttcttctcgg cctcctccga ggaggagcgc aagagctgga 481 tggccttgct gcgcagggag attggccact tccacgaaaa gaaagacctg cccttggaca 541 ccagcgactc cagctcggac acagacagct tctacggcgc agttgagcgg cctgtggata 601 tcagcctttc cccgtacccc acggacaatg aagactatga gcacgacgat gaggatgact 661 cctacctgga gcctgactcc ccggagcccg gaaggcttga ggatgccctg atgcacccac 721 cggcttaccc accaccccca gtgcccacgc ccaggaagcc agccttctct gacatgcccc 781 gggcccactc ctttacctcc aagggccccg gtcccctact gccacccccg ccccctaagc 841 acggcctccc agatgttggc ctggctgctg aggactccaa gagggaccca ctgtgcccga 901 ggcgggctga gccttgcccc agggtacctg ctaccccccg aaggatgagc gatccccctc 961 tgagcaccat gcccaccgca cccggcctcc ggaaaccccc ttgcttccgg gagagtgcca 1021 gccccagccc ggagccctgg acccctggcc acggggcctg ctccacttcc agtgctgcca 1081 tcatggccac tgccacctcc agaaactgtg acaaactcaa gtccttccac ctgtcccccc 1141 gaggaccacc cacatctgag cccccacctg tgccagccaa caagcccaag ttcctgaaga 1201 tagctgaaga ggacccccca agggaggcag ccatgcccgg actctttgtg ccccccgtgg 1261 ctccccggcc tcctgcgctg aagctgccag tgcctgaggc catggcgcgg cccgcagtcc 1321 tgcccaggcc agagaagccg cagctcccgc acctccagcg atcacccccc gatgggcaga 1381 gtttcaggag cttctccttt gaaaagcccc ggcaaccctc acaggctgac actggcgggg 1441 acgactcgga cgaggactat gagaaggtgc cactgcccaa ctcggtcttc gtcaacacca 1501 cggagtcctg cgaagtggaa aggttgttca aggctacaag cccccgggga gagccccagg 1561 atggactcta ctgcatccgg aactcctcta ccaagtcggg gaaggtcctg gttgtgtggg 1621 acgaaacctc taacaaagtg aggaactatc gcatttttga gaaggactct aagttctacc 1681 tggagggcga ggtcctgttt gtgagtgtgg gcagcatggt ggagcactac cacacccacg 1741 tgctgcccag ccaccagagc ctgctgctgc ggcaccccta cggctacact gggcctaggt 1801 gatggcagtc catgtggctg ccaggccaag gcagtcacag gggccctgac cccaggccac 1861 acagacggac atgggcccac atgggagggt gagcaggagc aaggctgtgc ttgcctaggg 1921 cctctgtgat ggacatctcg taggacccag ccagtctcat ccagcaggtt gggttctagg 1981 gctgaaccag gcgccaggct ccagaggacg aagggactct gttgccccac actaacttgc 2041 cctgtcccaa tcccagaaac ccaggaccaa gctgtgcctg ggctccaagg acaggaacac 2101 tggtcccccc atcacactca cccctaagtg ggctgggagc caggcagggc cagggcagct 2161 gggtgggggc cggggctggc cctgggaccc ccaggaacgc taagacacag gctccagtag 2221 gggctgttgc ctccaataaa gcagcagtga gctttgcctt gaaaaaaaaa aaaaaaaa //