LOCUS BC022996 2278 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens SH3-domain binding protein 2, mRNA (cDNA clone
MGC:29882 IMAGE:5103986), complete cds.
ACCESSION BC022996
VERSION BC022996.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2278)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2278)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (04-FEB-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 42 Row: l Column: 3
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 19923154.
FEATURES Location/Qualifiers
source 1..2278
/db_xref="H-InvDB:HIT000039693"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:29882 IMAGE:5103986"
/tissue_type="Cervix, carcinoma"
/clone_lib="NIH_MGC_12"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2278
/gene="SH3BP2"
/gene_synonym="CRBM"
/gene_synonym="CRPM"
/gene_synonym="RES4-23"
/db_xref="GeneID:6452"
/db_xref="MIM:602104"
CDS 117..1802
/gene="SH3BP2"
/gene_synonym="CRBM"
/gene_synonym="CRPM"
/gene_synonym="RES4-23"
/codon_start=1
/product="SH3BP2 protein"
/protein_id="AAH22996.1"
/db_xref="GeneID:6452"
/db_xref="MIM:602104"
/translation="MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLL
KWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHIS
KKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPV
DISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFS
DMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRR
MSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKL
KSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPV
PEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEK
VPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKV
RNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR"
misc_feature 195..509
/gene="SH3BP2"
/gene_synonym="CRBM"
/gene_synonym="CRPM"
/gene_synonym="RES4-23"
/note="PH; Region: Pleckstrin homology domain. Domain
commonly found in eukaryotic signalling proteins. The
domain family possesses multiple functions including the
abilities to bind inositol phosphates, and various
proteins. PH domains have been found to possess inserted
domains (such as in PLC gamma, syntrophins) and to be
inserted within other domains. Mutations in Brutons
tyrosine kinase (Btk) within its PH domain cause X-linked
agammaglobulinaemia (XLA) in patients. Point mutations
cluster into the positively charged end of the molecule
around the predicted binding site for phosphatidylinositol
lipids"
/db_xref="CDD:smart00233"
misc_feature 1512..1748
/gene="SH3BP2"
/gene_synonym="CRBM"
/gene_synonym="CRPM"
/gene_synonym="RES4-23"
/note="SH2; Region: Src homology 2 domains"
/db_xref="CDD:smart00252"
BASE COUNT 471 a 779 c 661 g 367 t
ORIGIN
1 gcgggcggga cggagctgcg gcggcggcgg gtcccgcggg cgggagcgcc tggcggccga
61 gtcaagccgc cgcctcgacc cagggcccgc gggccaggag agcgctcggc ggcttcatgg
121 cggctgaaga gatgcattgg cctgtcccta tgaaggccat tggtgcccag aacctgctaa
181 ccatgcctgg gggcgtggcc aaggctggct acctgcacaa gaagggcggt acccagctgc
241 agctgctgaa atggcccctg cgctttgtca tcatccacaa acgctgcgtc tactacttca
301 agagtagcac ctctgcctcc ccgcagggcg ccttctccct gagtggctat aaccgggtga
361 tgcgggcggc tgaggagacc acgtccaaca acgttttccc cttcaagatc atccacatca
421 gcaagaagca ccgcacgtgg ttcttctcgg cctcctccga ggaggagcgc aagagctgga
481 tggccttgct gcgcagggag attggccact tccacgaaaa gaaagacctg cccttggaca
541 ccagcgactc cagctcggac acagacagct tctacggcgc agttgagcgg cctgtggata
601 tcagcctttc cccgtacccc acggacaatg aagactatga gcacgacgat gaggatgact
661 cctacctgga gcctgactcc ccggagcccg gaaggcttga ggatgccctg atgcacccac
721 cggcttaccc accaccccca gtgcccacgc ccaggaagcc agccttctct gacatgcccc
781 gggcccactc ctttacctcc aagggccccg gtcccctact gccacccccg ccccctaagc
841 acggcctccc agatgttggc ctggctgctg aggactccaa gagggaccca ctgtgcccga
901 ggcgggctga gccttgcccc agggtacctg ctaccccccg aaggatgagc gatccccctc
961 tgagcaccat gcccaccgca cccggcctcc ggaaaccccc ttgcttccgg gagagtgcca
1021 gccccagccc ggagccctgg acccctggcc acggggcctg ctccacttcc agtgctgcca
1081 tcatggccac tgccacctcc agaaactgtg acaaactcaa gtccttccac ctgtcccccc
1141 gaggaccacc cacatctgag cccccacctg tgccagccaa caagcccaag ttcctgaaga
1201 tagctgaaga ggacccccca agggaggcag ccatgcccgg actctttgtg ccccccgtgg
1261 ctccccggcc tcctgcgctg aagctgccag tgcctgaggc catggcgcgg cccgcagtcc
1321 tgcccaggcc agagaagccg cagctcccgc acctccagcg atcacccccc gatgggcaga
1381 gtttcaggag cttctccttt gaaaagcccc ggcaaccctc acaggctgac actggcgggg
1441 acgactcgga cgaggactat gagaaggtgc cactgcccaa ctcggtcttc gtcaacacca
1501 cggagtcctg cgaagtggaa aggttgttca aggctacaag cccccgggga gagccccagg
1561 atggactcta ctgcatccgg aactcctcta ccaagtcggg gaaggtcctg gttgtgtggg
1621 acgaaacctc taacaaagtg aggaactatc gcatttttga gaaggactct aagttctacc
1681 tggagggcga ggtcctgttt gtgagtgtgg gcagcatggt ggagcactac cacacccacg
1741 tgctgcccag ccaccagagc ctgctgctgc ggcaccccta cggctacact gggcctaggt
1801 gatggcagtc catgtggctg ccaggccaag gcagtcacag gggccctgac cccaggccac
1861 acagacggac atgggcccac atgggagggt gagcaggagc aaggctgtgc ttgcctaggg
1921 cctctgtgat ggacatctcg taggacccag ccagtctcat ccagcaggtt gggttctagg
1981 gctgaaccag gcgccaggct ccagaggacg aagggactct gttgccccac actaacttgc
2041 cctgtcccaa tcccagaaac ccaggaccaa gctgtgcctg ggctccaagg acaggaacac
2101 tggtcccccc atcacactca cccctaagtg ggctgggagc caggcagggc cagggcagct
2161 gggtgggggc cggggctggc cctgggaccc ccaggaacgc taagacacag gctccagtag
2221 gggctgttgc ctccaataaa gcagcagtga gctttgcctt gaaaaaaaaa aaaaaaaa
//