LOCUS       BC003557                1186 bp    mRNA    linear   HUM 15-JUL-2006
DEFINITION  Homo sapiens apolipoprotein E, mRNA (cDNA clone MGC:1571
            IMAGE:3355712), complete cds.
ACCESSION   BC003557
VERSION     BC003557.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 1186)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2001) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 6 Row: h Column: 23
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 48762938.
FEATURES             Location/Qualifiers
     source          1..1186
                     /db_xref="H-InvDB:HIT000031595"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:1571 IMAGE:3355712"
                     /tissue_type="Eye, retinoblastoma"
                     /clone_lib="NIH_MGC_16"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     gene            1..1186
                     /gene="APOE"
                     /gene_synonym="AD2"
                     /gene_synonym="apoprotein"
                     /gene_synonym="MGC1571"
                     /db_xref="GeneID:348"
                     /db_xref="HGNC:HGNC:613"
                     /db_xref="MIM:107741"
     CDS             46..999
                     /gene="APOE"
                     /gene_synonym="AD2"
                     /gene_synonym="apoprotein"
                     /gene_synonym="MGC1571"
                     /codon_start=1
                     /product="apolipoprotein E"
                     /protein_id="AAH03557.1"
                     /db_xref="GeneID:348"
                     /db_xref="HGNC:HGNC:613"
                     /db_xref="MIM:107741"
                     /translation="MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRW
                     ELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTP
                     VAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLR
                     KLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
                     QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQ
                     ARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH"
BASE COUNT          248 a          366 c          425 g          147 t
ORIGIN      
        1 ggacgtcctt ccccaggagc cgactggcca atcacaggca ggaagatgaa ggttctgtgg
       61 gctgcgttgc tggtcacatt cctggcagga tgccaggcca aggtggagca agcggtggag
      121 acagagccgg agcccgagct gcgccagcag accgagtggc agagcggcca gcgctgggaa
      181 ctggcactgg gtcgcttttg ggattacctg cgctgggtgc agacactgtc tgagcaggtg
      241 caggaggagc tgctcagctc ccaggtcacc caggaactga gggcgctgat ggacgagacc
      301 atgaaggagt tgaaggccta caaatcggaa ctggaggaac aactgacccc ggtggcggag
      361 gagacgcggg cacggctgtc caaggagctg caggcggcgc aggcccggct gggcgcggac
      421 atggaggacg tgtgcggccg cctggtgcag taccgcggcg aggtgcaggc catgctcggc
      481 cagagcaccg aggagctgcg ggtgcgcctc gcctcccacc tgcgcaagct gcgtaagcgg
      541 ctcctccgcg atgccgatga cctgcagaag cgcctggcag tgtaccaggc cggggcccgc
      601 gagggcgccg agcgcggcct cagcgccatc cgcgagcgcc tggggcccct ggtggaacag
      661 ggccgcgtgc gggccgccac tgtgggctcc ctggccggcc agccgctaca ggagcgggcc
      721 caggcctggg gcgagcggct gcgcgcgcgg atggaggaga tgggcagccg gacccgcgac
      781 cgcctggacg aggtgaagga gcaggtggcg gaggtgcgcg ccaagctgga ggagcaggcc
      841 cagcagatac gcctgcaggc cgaggccttc caggcccgcc tcaagagctg gttcgagccc
      901 ctggtggaag acatgcagcg ccagtgggcc gggctggtgg agaaggtgca ggctgccgtg
      961 ggcaccagcg ccgcccctgt gcccagcgac aatcactgaa cgccgaagcc tgcagccatg
     1021 cgaccccacg ccaccccgtg cctcctgcct ccgcgcagcc tgcagcggga gaccctgtcc
     1081 ccgccccagc cgtcctcctg gggtggaccc tagtttaata aagattcacc aagtttcacg
     1141 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaac
//