LOCUS BC000440 2479 bp mRNA linear HUM 04-OCT-2003 DEFINITION Homo sapiens cystathionine-beta-synthase, mRNA (cDNA clone MGC:8402 IMAGE:2820694), complete cds. ACCESSION BC000440 VERSION BC000440.2 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2479) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 2479) AUTHORS Strausberg,R. TITLE Direct Submission JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 19, 2003 this sequence version replaced BC000440.1. Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: DCTD/DTP cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 1 Row: d Column: 9 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 4557414. FEATURES Location/Qualifiers source 1..2479 /db_xref="H-InvDB:HIT000029626" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:8402 IMAGE:2820694" /tissue_type="Lung, small cell carcinoma" /clone_lib="NIH_MGC_7" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..2479 /gene="CBS" /gene_synonym="HIP4" /db_xref="GeneID:875" /db_xref="MIM:236200" CDS 121..1776 /gene="CBS" /gene_synonym="HIP4" /codon_start=1 /product="CBS protein" /protein_id="AAH00440.1" /db_xref="GeneID:875" /db_xref="MIM:236200" /translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI RPDAPSRCTWQLGRPASESPHHHTPPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF ALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK" misc_feature 346..1272 /gene="CBS" /gene_synonym="HIP4" /note="CysK; Region: Cysteine synthase [Amino acid transport and metabolism]" /db_xref="CDD:COG0031" misc_feature 1384..1527 /gene="CBS" /gene_synonym="HIP4" /note="Region: Domain in cystathionine beta-synthase and other proteins. Domain present in all 3 forms of cellular life. Present in two copies in inosine monophosphate dehydrogenase, of which one is disordered in the crystal structure. A number of disease states are associated with CBS-containing proteins including homocystinuria, Becker's and Thomsen disease" /db_xref="CDD:smart00116" BASE COUNT 565 a 683 c 752 g 479 t ORIGIN 1 cagccgctcg cccctctttt ccatgtatcc gtccaggatc ccatgacaga ttctgttgtc 61 acgtctcctt acagagtttg agcggtgctg aactgtcagc accatctgtc cggtcccagc 121 atgccttctg agacccccca ggcagaagtg gggcccacag gctgccccca ccgctcaggg 181 ccacactcgg cgaaggggag cctggagaag gggtccccag aggataagga agccaaggag 241 cccctgtgga tccggcccga tgctccgagc aggtgcacct ggcagctggg ccggcctgcc 301 tccgagtccc cacatcacca cactcccccg gcaaaatctc caaaaatctt gccagatatt 361 ctgaagaaaa tcggggacac ccctatggtc agaatcaaca agattgggaa gaagttcggc 421 ctgaagtgtg agctcttggc caagtgtgag ttcttcaacg cgggcgggag cgtgaaggac 481 cgcatcagcc tgcggatgat tgaggatgct gagcgcgacg ggacgctgaa gcccggggac 541 acgattatcg agccgacatc cgggaacacc gggatcgggc tggccctggc tgcggcagtg 601 aggggctatc gctgcatcat cgtgatgcca gagaagatga gctccgagaa ggtggacgtg 661 ctgcgggcac tgggggctga gattgtgagg acgcccacca atgccaggtt cgactccccg 721 gagtcacacg tgggggtggc ctggcggctg aagaacgaaa tccccaattc tcacatccta 781 gaccagtacc gcaacgccag caaccccctg gctcactacg acaccaccgc tgatgagatc 841 ctgcagcagt gtgatgggaa gctggacatg ctggtggctt cagtgggcac gggcggcacc 901 atcacgggca ttgccaggaa gctgaaggag aagtgtcctg gatgcaggat cattggggtg 961 gatcccgaag ggtccatcct cgcagagccg gaggagctga accagacgga gcagacaacc 1021 tacgaggtgg aagggatcgg ctacgacttc atccccacgg tgctggacag gacggtggtg 1081 gacaagtggt tcaagagcaa cgatgaggag gcgttcacct ttgcccgcat gctgatcgcg 1141 caagaggggc tgctgtgcgg tggcagtgct ggcagcacgg tggcggtggc cgtgaaggcc 1201 gcgcaggagc tgcaggaggg ccagcgctgc gtggtcattc tgcccgactc agtgcggaac 1261 tacatgacca agttcctgag cgacaggtgg atgctgcaga agggctttct gaaggaggag 1321 gacctcacgg agaagaagcc ctggtggtgg cacctccgtg ttcaggagct gggcctgtca 1381 gccccgctga ccgtgctccc gaccatcacc tgtgggcaca ccatcgagat cctccgggag 1441 aagggcttcg accaggcgcc cgtggtggat gaggcggggg taatcctggg aatggtgacg 1501 cttgggaaca tgctctcgtc cctgcttgcc gggaaggtgc agccgtcaga ccaagttggc 1561 aaagtcatct acaagcagtt caaacagatc cgcctcacgg acacgctggg caggctctcg 1621 cacatcctgg agatggacca cttcgccctg gtggtgcacg agcagatcca gtaccacagc 1681 accgggaagt ccagtcagcg gcagatggtg ttcggggtgg tcaccgccat tgacttgctg 1741 aacttcgtgg ccgcccagga gcgggaccag aagtgaagtc cggagagctg ggcggtgcgg 1801 agcgggcccg ccacccttgc ccacttctcc ttcgctttcc tgagccctaa acacacgcgt 1861 gattggtaac tgcctggcac cgttatccct gcagacggca cagagcatcc gtctcccctc 1921 gttaacacat ggcttcctaa atggccctgt ttacggccta tgagatgaaa tatgtgattt 1981 tctctaatgt aacttcctct taggatgttt caccaaggaa atattgagag agaagtcggc 2041 caggtaggat gaacacaggc aatgactgca cagagtggat taaaggcaaa agagagaaga 2101 gtccaggaag gggcggggag aagcctgggt ggctcagcat cctccacggg ctgcgccgtc 2161 tgctcggggc tgagctggcg ggagcagttt gcgtgtttgg gttttttaat tgagatgaaa 2221 ttcaaataac ctaaaaatca atcacttgaa agtgaacaat cagcggcatt tagtacatcc 2281 agaaagttgt gtaggcacca cctctgtcac gttctggaac attctgtcat caccccgtga 2341 agcaatcatt tcccctcccg tcttcctcct cccctggcaa ctgctgatcg actttgtgtc 2401 tctgttgtct aaaataggtt ttccctgttc tggacatttc atataaatgg aatcacacaa 2461 aaaaaaaaaa aaaaaaaaa //