LOCUS BC000440 2479 bp mRNA linear HUM 04-OCT-2003
DEFINITION Homo sapiens cystathionine-beta-synthase, mRNA (cDNA clone MGC:8402
IMAGE:2820694), complete cds.
ACCESSION BC000440
VERSION BC000440.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2479)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2479)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC000440.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 1 Row: d Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4557414.
FEATURES Location/Qualifiers
source 1..2479
/db_xref="H-InvDB:HIT000029626"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:8402 IMAGE:2820694"
/tissue_type="Lung, small cell carcinoma"
/clone_lib="NIH_MGC_7"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2479
/gene="CBS"
/gene_synonym="HIP4"
/db_xref="GeneID:875"
/db_xref="MIM:236200"
CDS 121..1776
/gene="CBS"
/gene_synonym="HIP4"
/codon_start=1
/product="CBS protein"
/protein_id="AAH00440.1"
/db_xref="GeneID:875"
/db_xref="MIM:236200"
/translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI
RPDAPSRCTWQLGRPASESPHHHTPPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK
CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV
RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH
ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR
IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF
ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML
QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD
EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF
ALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
misc_feature 346..1272
/gene="CBS"
/gene_synonym="HIP4"
/note="CysK; Region: Cysteine synthase [Amino acid
transport and metabolism]"
/db_xref="CDD:COG0031"
misc_feature 1384..1527
/gene="CBS"
/gene_synonym="HIP4"
/note="Region: Domain in cystathionine beta-synthase and
other proteins. Domain present in all 3 forms of cellular
life. Present in two copies in inosine monophosphate
dehydrogenase, of which one is disordered in the crystal
structure. A number of disease states are associated with
CBS-containing proteins including homocystinuria, Becker's
and Thomsen disease"
/db_xref="CDD:smart00116"
BASE COUNT 565 a 683 c 752 g 479 t
ORIGIN
1 cagccgctcg cccctctttt ccatgtatcc gtccaggatc ccatgacaga ttctgttgtc
61 acgtctcctt acagagtttg agcggtgctg aactgtcagc accatctgtc cggtcccagc
121 atgccttctg agacccccca ggcagaagtg gggcccacag gctgccccca ccgctcaggg
181 ccacactcgg cgaaggggag cctggagaag gggtccccag aggataagga agccaaggag
241 cccctgtgga tccggcccga tgctccgagc aggtgcacct ggcagctggg ccggcctgcc
301 tccgagtccc cacatcacca cactcccccg gcaaaatctc caaaaatctt gccagatatt
361 ctgaagaaaa tcggggacac ccctatggtc agaatcaaca agattgggaa gaagttcggc
421 ctgaagtgtg agctcttggc caagtgtgag ttcttcaacg cgggcgggag cgtgaaggac
481 cgcatcagcc tgcggatgat tgaggatgct gagcgcgacg ggacgctgaa gcccggggac
541 acgattatcg agccgacatc cgggaacacc gggatcgggc tggccctggc tgcggcagtg
601 aggggctatc gctgcatcat cgtgatgcca gagaagatga gctccgagaa ggtggacgtg
661 ctgcgggcac tgggggctga gattgtgagg acgcccacca atgccaggtt cgactccccg
721 gagtcacacg tgggggtggc ctggcggctg aagaacgaaa tccccaattc tcacatccta
781 gaccagtacc gcaacgccag caaccccctg gctcactacg acaccaccgc tgatgagatc
841 ctgcagcagt gtgatgggaa gctggacatg ctggtggctt cagtgggcac gggcggcacc
901 atcacgggca ttgccaggaa gctgaaggag aagtgtcctg gatgcaggat cattggggtg
961 gatcccgaag ggtccatcct cgcagagccg gaggagctga accagacgga gcagacaacc
1021 tacgaggtgg aagggatcgg ctacgacttc atccccacgg tgctggacag gacggtggtg
1081 gacaagtggt tcaagagcaa cgatgaggag gcgttcacct ttgcccgcat gctgatcgcg
1141 caagaggggc tgctgtgcgg tggcagtgct ggcagcacgg tggcggtggc cgtgaaggcc
1201 gcgcaggagc tgcaggaggg ccagcgctgc gtggtcattc tgcccgactc agtgcggaac
1261 tacatgacca agttcctgag cgacaggtgg atgctgcaga agggctttct gaaggaggag
1321 gacctcacgg agaagaagcc ctggtggtgg cacctccgtg ttcaggagct gggcctgtca
1381 gccccgctga ccgtgctccc gaccatcacc tgtgggcaca ccatcgagat cctccgggag
1441 aagggcttcg accaggcgcc cgtggtggat gaggcggggg taatcctggg aatggtgacg
1501 cttgggaaca tgctctcgtc cctgcttgcc gggaaggtgc agccgtcaga ccaagttggc
1561 aaagtcatct acaagcagtt caaacagatc cgcctcacgg acacgctggg caggctctcg
1621 cacatcctgg agatggacca cttcgccctg gtggtgcacg agcagatcca gtaccacagc
1681 accgggaagt ccagtcagcg gcagatggtg ttcggggtgg tcaccgccat tgacttgctg
1741 aacttcgtgg ccgcccagga gcgggaccag aagtgaagtc cggagagctg ggcggtgcgg
1801 agcgggcccg ccacccttgc ccacttctcc ttcgctttcc tgagccctaa acacacgcgt
1861 gattggtaac tgcctggcac cgttatccct gcagacggca cagagcatcc gtctcccctc
1921 gttaacacat ggcttcctaa atggccctgt ttacggccta tgagatgaaa tatgtgattt
1981 tctctaatgt aacttcctct taggatgttt caccaaggaa atattgagag agaagtcggc
2041 caggtaggat gaacacaggc aatgactgca cagagtggat taaaggcaaa agagagaaga
2101 gtccaggaag gggcggggag aagcctgggt ggctcagcat cctccacggg ctgcgccgtc
2161 tgctcggggc tgagctggcg ggagcagttt gcgtgtttgg gttttttaat tgagatgaaa
2221 ttcaaataac ctaaaaatca atcacttgaa agtgaacaat cagcggcatt tagtacatcc
2281 agaaagttgt gtaggcacca cctctgtcac gttctggaac attctgtcat caccccgtga
2341 agcaatcatt tcccctcccg tcttcctcct cccctggcaa ctgctgatcg actttgtgtc
2401 tctgttgtct aaaataggtt ttccctgttc tggacatttc atataaatgg aatcacacaa
2461 aaaaaaaaaa aaaaaaaaa
//