LOCUS       HUMIL1BCE               1373 bp    mRNA    linear   HUM 18-MAY-1995
DEFINITION  Homo sapien interleukin-1 beta convertase (IL1BCE) mRNA, complete
            cds.
ACCESSION   M87507
VERSION     M87507.1
KEYWORDS    cysteine protease; interleukin-1 beta convertase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Cerretti,D.P., Kozlosky,C.J., Mosley,B., Nelson,N., Van Ness,K.,
            Greenstreet,T.A., March,C.J., Kronheim,S.R., Druck,T.,
            Cannizzaro,L.A., Huebner,K. and Black,R.A.
  TITLE     Molecular cloning of the interleukin-1 beta converting enzyme
  JOURNAL   Science 256 (5053), 97-100 (1992)
   PUBMED   1373520
COMMENT     On Dec 18, 1993 this sequence version replaced gi:186285.
            Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1373
                     /db_xref="H-InvDB:HIT000196669"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23"
                     /cell_type="nuetrophil"
     gene            1..1373
                     /gene="IL1BCE"
     CDS             18..1232
                     /gene="IL1BCE"
                     /codon_start=1
                     /product="interleukin 1-beta convertase"
                     /protein_id="AAA66942.1"
                     /translation="MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVK
                     RENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQ
                     DSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSS
                     RTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAF
                     AHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDK
                     PKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSST
                     PDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERV
                     TLTRCFYLFPGH"
     mat_peptide     375..1229
                     /gene="IL1BCE"
                     /product="interleukin 1-beta convertase"
                     /function="cleaves pro-interleukin-1 beta to mature
                     interleukin-1 beta"
                     /note="active protein"
     intron          23^24
                     /gene="IL1BCE"
                     /number=1
     intron          291^292
                     /gene="IL1BCE"
                     /number=2
     intron          354^355
                     /gene="IL1BCE"
                     /number=3
     intron          470^471
                     /gene="IL1BCE"
                     /number=4
     intron          644^645
                     /gene="IL1BCE"
                     /number=5
     intron          879^880
                     /gene="IL1BCE"
                     /number=6
     intron          1023^1024
                     /gene="IL1BCE"
                     /number=7
     intron          1133^1134
                     /gene="IL1BCE"
                     /number=8
     intron          1264^1265
                     /gene="IL1BCE"
                     /number=9
BASE COUNT          441 a          270 c          323 g          339 t
ORIGIN      
        1 gggaggagag aaaagccatg gccgacaagg tcctgaagga gaagagaaag ctgtttatcc
       61 gttccatggg tgaaggtaca ataaatggct tactggatga attattacag acaagggtgc
      121 tgaacaagga agagatggag aaagtaaaac gtgaaaatgc tacagttatg gataagaccc
      181 gagctttgat tgactccgtt attccgaaag gggcacaggc atgccaaatt tgcatcacat
      241 acatttgtga agaagacagt tacctggcag ggacgctggg actctcagca gatcaaacat
      301 ctggaaatta ccttaatatg caagactctc aaggagtact ttcttccttt ccagctcctc
      361 aggcagtgca ggacaaccca gctatgccca catcctcagg ctcagaaggg aatgtcaagc
      421 tttgctccct agaagaagct caaaggatat ggaaacaaaa gtcggcagag atttatccaa
      481 taatggacaa gtcaagccgc acacgtcttg ctctcattat ctgcaatgaa gaatttgaca
      541 gtattcctag aagaactgga gctgaggttg acatcacagg catgacaatg ctgctacaaa
      601 atctggggta cagcgtagat gtgaaaaaaa atctcactgc ttcggacatg actacagagc
      661 tggaggcatt tgcacaccgc ccagagcaca agacctctga cagcacgttc ctggtgttca
      721 tgtctcatgg tattcgggaa ggcatttgtg ggaagaaaca ctctgagcaa gtcccagata
      781 tactacaact caatgcaatc tttaacatgt tgaataccaa gaactgccca agtttgaagg
      841 acaaaccgaa ggtgatcatc atccaggcct gccgtggtga cagccctggt gtggtgtggt
      901 ttaaagattc agtaggagtt tctggaaacc tatctttacc aactacagaa gagtttgagg
      961 atgatgctat taagaaagcc cacatagaga aggattttat cgctttctgc tcttccacac
     1021 cagataatgt ttcttggaga catcccacaa tgggctctgt ttttattgga agactcattg
     1081 aacatatgca agaatatgcc tgttcctgtg atgtggagga aattttccgc aaggttcgat
     1141 tttcatttga gcagccagat ggtagagcgc agatgcccac cactgaaaga gtgactttga
     1201 caagatgttt ctacctcttc ccaggacatt aaaataagga aactgtatga atgtctgcgg
     1261 gcaggaagtg aagagatcgt tctgtaaaag gtttttggaa ttatgtctgc tgaataataa
     1321 actttttttg aaataataaa tctggtagaa aaatgaaaaa aaaaaaaaaa aaa
//