LOCUS BC053357 2547 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens thrombomodulin, mRNA (cDNA clone MGC:61509
IMAGE:6007870), complete cds.
ACCESSION BC053357
VERSION BC053357.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2547)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2547)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-JUN-2003) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: DCTD/DTP/Gazdar
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 115 Row: i Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 40288292.
FEATURES Location/Qualifiers
source 1..2547
/db_xref="H-InvDB:HIT000053883"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:61509 IMAGE:6007870"
/tissue_type="Lung, large cell carcinoma"
/clone_lib="NIH_MGC_68"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2547
/gene="THBD"
/gene_synonym="CD141"
/gene_synonym="THRM"
/gene_synonym="TM"
/db_xref="GeneID:7056"
/db_xref="HGNC:HGNC:11784"
/db_xref="MIM:188040"
CDS 125..1852
/gene="THBD"
/gene_synonym="CD141"
/gene_synonym="THRM"
/gene_synonym="TM"
/codon_start=1
/product="thrombomodulin"
/protein_id="AAH53357.1"
/db_xref="GeneID:7056"
/db_xref="HGNC:HGNC:11784"
/db_xref="MIM:188040"
/translation="MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPAT
FLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRL
GPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEV
KADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPL
GLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQAD
GRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPS
PCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAE
GFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGF
CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPP
AVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHV
RTERTPQRL"
BASE COUNT 427 a 867 c 749 g 504 t
ORIGIN
1 tgtctgggct gggacggaca ggagaggctg tcgccatcgg cgtcctgtgc ccctctgctc
61 cggcacggcc ctgtcgcagt gcccgcgctt tccccggcgc ctgcacgcgg cgcgcctggg
121 taacatgctt ggggtcctgg tccttggcgc gctggccctg gccggcctgg ggttccccgc
181 acccgcagag ccgcagccgg gtggcagcca gtgcgtcgag cacgactgct tcgcgctcta
241 cccgggcccc gcgaccttcc tcaatgccag tcagatctgc gacggactgc ggggccacct
301 aatgacagtg cgctcctcgg tggctgccga tgtcatttcc ttgctactga acggcgacgg
361 cggcgttggc cgccggcgcc tctggatcgg cctgcagctg ccacccggct gcggcgaccc
421 caagcgcctc gggcccctgc gcggcttcca gtgggttacg ggagacaaca acaccagcta
481 tagcaggtgg gcacggctcg acctcaatgg ggctcccctc tgcggcccgt tgtgcgtcgc
541 tgtctccgct gctgaggcca ctgtgcccag cgagccgatc tgggaggagc agcagtgcga
601 agtgaaggcc gatggcttcc tctgcgagtt ccacttccca gccacctgca ggccactggc
661 tgtggagccc ggcgccgcgg ctgccgccgt ctcgatcacc tacggcaccc cgttcgcggc
721 ccgcggagcg gacttccagg cgctgccggt gggcagctcc gccgcggtgg ctcccctcgg
781 cttacagcta atgtgcaccg cgccgcccgg agcggtccag gggcactggg ccagggaggc
841 gccgggcgct tgggactgca gcgtggagaa cggcggctgc gagcacgcgt gcaatgcgat
901 ccctggggct ccccgctgcc agtgcccagc cggcgccgcc ctgcaggcag acgggcgctc
961 ctgcaccgca tccgcgacgc agtcctgcaa cgacctctgc gagcacttct gcgttcccaa
1021 ccccgaccag ccgggctcct actcgtgcat gtgcgagacc ggctaccggc tggcggccga
1081 ccaacaccgg tgcgaggacg tggatgactg catactggag cccagtccgt gtccgcagcg
1141 ctgtgtcaac acacagggtg gcttcgagtg ccactgctac cctaactacg acctggtgga
1201 cggcgagtgt gtggagcccg tggacccgtg cttcagagcc aactgcgagt accagtgcca
1261 gcccctgaac caaactagct acctctgcgt ctgcgccgag ggcttcgcgc ccattcccca
1321 cgagccgcac aggtgccaga tgttttgcaa ccagactgcc tgtccagccg actgcgaccc
1381 caacacccag gctagctgtg agtgccctga aggctacatc ctggacgacg gtttcatctg
1441 cacggacatc gacgagtgcg aaaacggcgg cttctgctcc ggggtgtgcc acaacctccc
1501 cggtaccttc gagtgcatct gcgggcccga ctcggccctt gcccgccaca ttggcaccga
1561 ctgtgactcc ggcaaggtgg acggtggcga cagcggctct ggcgagcccc cgcccagccc
1621 gacgcccggc tccaccttga ctcctccggc cgtggggctc gtgcattcgg gcttgctcat
1681 aggcatctcc atcgcgagcc tgtgcctggt ggtggcgctt ttggcgctcc tctgccacct
1741 gcgcaagaag cagggcgccg ccagggccaa gatggagtac aagtgcgcgg ccccttccaa
1801 ggaggtagtg ctgcagcacg tgcggaccga gcggacgccg cagagactct gagcggcctc
1861 cgtccaggag cctggctccg tccaggagcc tgtgcctcct cacccccagc tttgctacca
1921 aagcacctta gctggcatta cagctggaga agaccctccc cgcacccccc aagctgtttt
1981 cttctattcc atggctaact ggcgaggggg tgattagagg gaggagaatg agcctcggcc
2041 tcttccgtga cgtcactgga ccactgggca atgatggcaa ttttgtaacg aagacacaga
2101 ctgcgatttg tcccaggtcc tcactaccgg gcgcaggagg gtgagcgtta ttggtcggca
2161 gccttctggg cagaccttga cctcgtgggc tagggatgac taaaatattt atttttttta
2221 agtatttagg tttttgtttg tttcctttgt tcttacctgt atgtctccag tatccacttt
2281 gcacagctct ccggtctctc tctctctaca aactcccact tgtcatgtga caggtaaact
2341 atcttggtga attttttttt cctagccctc tcacatttat gaagcaagcc ccacttattc
2401 cccattcttc ctagttttct cctcccagga actgggccaa ctcacctgag tcaccctacc
2461 tgtgcctgac cctacttctt ttgctcttag ctgtctgctc agacagaacc cctacatgaa
2521 acagaaacaa aaaaaaaaaa aaaaaaa
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