LOCUS BC039894 3466 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens glutamate-cysteine ligase, catalytic subunit, mRNA
(cDNA clone MGC:47730 IMAGE:6052162), complete cds.
ACCESSION BC039894
VERSION BC039894.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3466)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3466)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 82 Row: o Column: 9
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 45359851.
FEATURES Location/Qualifiers
source 1..3466
/db_xref="H-InvDB:HIT000052285"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:47730 IMAGE:6052162"
/tissue_type="Testis, embryonal carcinoma"
/clone_lib="NIH_MGC_92"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3466
/gene="GCLC"
/gene_synonym="GCS"
/db_xref="GeneID:2729"
/db_xref="HGNC:HGNC:4311"
/db_xref="MIM:606857"
CDS 83..1996
/gene="GCLC"
/gene_synonym="GCS"
/codon_start=1
/product="glutamate-cysteine ligase, catalytic subunit"
/protein_id="AAH39894.1"
/db_xref="GeneID:2729"
/db_xref="HGNC:HGNC:4311"
/db_xref="MIM:606857"
/translation="MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDV
LKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMI
EGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEV
KPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFI
ETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIV
MALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDS
YLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDA
NESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTR
VILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNST
ELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRA
SGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFR
KVKYSGSKTDSSN"
BASE COUNT 1072 a 643 c 748 g 1003 t
ORIGIN
1 ccacgcgtcc gccgtctcgc gcccggagcg ggcgaccgcc gtcagcccgg aggaggagga
61 ggaggaggag gagggggcgg ccatggggct gctgtcccag ggctcgccgc tgagctggga
121 ggaaaccaag cgccatgccg accacgtgcg gcggcacggg atcctccagt tcctgcacat
181 ctaccacgcc gtcaaggacc ggcacaagga cgttctcaag tggggcgatg aggtggaata
241 catgttggta tcttttgatc atgaaaataa aaaagtccgg ttggtcctgt ctggggagaa
301 agttcttgaa actctgcaag agaaggggga aaggacaaac ccaaaccatc ctaccctttg
361 gagaccagag tatgggagtt acatgattga agggacacca ggacagccct acggaggaac
421 aatgtccgag ttcaatacag ttgaggccaa catgcgaaaa cgccggaagg aggctacttc
481 tatattagaa gaaaatcagg ctctttgcac aataacttca tttcccagat taggctgtcc
541 tgggttcaca ctgcccgagg tcaaacccaa cccagtggaa ggaggagctt ccaagtccct
601 cttctttcca gatgaagcaa taaacaagca ccctcgcttc agtaccttaa caagaaatat
661 ccgacatagg agaggagaaa aggttgtcat caatgtacca atatttaagg acaagaatac
721 accatctcca tttatagaaa catttactga ggatgatgaa gcttcaaggg cttctaagcc
781 ggatcatatt tacatggatg ccatgggatt tggaatgggc aattgctgtc tccaggtgac
841 attccaagcc tgcagtatat ctgaggccag atacctttat gatcagttgg ctactatctg
901 tccaattgtt atggctttga gtgctgcatc tcccttttac cgaggctatg tgtcagacat
961 tgattgtcgc tggggagtga tttctgcatc tgtagatgat agaactcggg aggagcgagg
1021 actggagcca ttgaagaaca ataactatag gatcagtaaa tcccgatatg actcaataga
1081 cagctattta tctaagtgtg gtgagaaata taatgacatc gacttgacga tagataaaga
1141 gatctacgaa cagctgttgc aggaaggcat tgatcatctc ctggcccagc atgttgctca
1201 tctctttatt agagacccac tgacactgtt tgaagagaaa atacacctgg atgatgctaa
1261 tgagtctgac cattttgaga atattcagtc cacaaattgg cagacaatga gatttaagcc
1321 ccctcctcca aactcagaca ttggatggag agtagaattt cgacccatgg aggtgcaatt
1381 aacagacttt gagaactctg cctatgtggt gtttgtggta ctgctcacca gagtgatcct
1441 ttcctacaaa ttggattttc tcattccact gtcaaaggtt gatgagaaca tgaaggtagc
1501 acagaaaaga gatgctgtct tgcagggaat gttttatttc aggaaagata tttgcaaagg
1561 tggcaatgca gtggtggatg gttgtggcaa ggcccagaac agcacggagc tcgctgcaga
1621 ggagtacacc ctcatgagca tagacaccat catcaatggg aaggaaggtg tgtttcctgg
1681 actgatccca attctgaact cttaccttga aaacatggaa gtggatgtgg acaccagatg
1741 tagtattctg aactacctaa agctaattaa gaagagagca tctggagaac taatgacagt
1801 tgccagatgg atgagggagt ttatcgcaaa ccatcctgac tacaagcaag acagtgtcat
1861 aactgatgaa atgaattata gccttatttt gaagtgtaac caaattgcaa atgaattatg
1921 tgaatgccca gagttacttg gatcagcatt taggaaagta aaatatagtg gaagtaaaac
1981 tgactcatcc aactagacat tctacagaaa gaaaaatgca ttattgacga actggctaca
2041 gtaccatgcc tctcagccag cccgtgtgta taatatgaag accaaatgat agaactgtac
2101 tgttttctgg gccagtgagc cagaaattga ttaaggcttt ctttggtagg taaatctaga
2161 gtttatacag tgtacatgta catagtaaag tatttttgat taacaatgta ttttaataac
2221 atatctaaag tcatcatgaa ctggcttgta catttttaaa ttcttactct ggagcaacct
2281 actgtctaag cagttttgta aatgtactgg taattgtaca atacttgcat tccagagtta
2341 aaatgtttac tgtaaatttt tgttctttta aagactacct gggacctgat ttattgaaat
2401 ttttctcttt aaaaacattt tctctcgtta attttccttt gtcatttcct ttgttgtcta
2461 cattaaatca cttgaatcca ttgaaagtgc ttcaagggta atcttgggtt tctagcacct
2521 tatctatgat gtttcttttg caattggaat aatcacttgg tcaccttgcc ccaagctttc
2581 ccctctgaat aaatacccat tgaactctga tggctgttat caaaggaact tttctttgtt
2641 taaatttgct gatgcaggaa ttaagtttaa acacaactct atagaaagaa aggagattat
2701 tacccagaat tcacatgtag tgattattaa ggacaatttt tttttttaac taaaaaagtt
2761 ggtggcaggg gtggggggtg gcaatcattt ttcttcctat acatacaaag gatattgtca
2821 aaatggcgtt cttctcttgt ggcctgttat tctgattgct gctgtataca gttttgtcac
2881 tctttagttt ttagttaagc atactgatag actttcctct aaaagccatt cactccagat
2941 tttacctggg gaatattcta catactgctt actttctcta taaaactcat caataaatca
3001 tgaaaggcac tgagttttgt aaatcaggac cctaaatgtt taattgtaaa taagtttcag
3061 ataattatta tagctttgcg ttgaagtttg ttgttttttt tctcaactag ttaagtcaac
3121 tgcttctgaa ataactctgt attgtagatt atgcagatct ttacaggcat aaatatttaa
3181 actgtaatat gctaacttga agagattgca ataaagctgc ttcagctaac cctgtttatg
3241 tttaaatact agggtttgtt ctatatttta tacatgcatt ttggatgatt aaagaatgcc
3301 tggttttcgt ttgcaatttg cttgtgtaaa tcaggttgta aaaaggcaga taaattgaaa
3361 tgtttgtggt atgaggaaat aaaagaatgg aattagcttt cattcagaaa aaaaaaaaaa
3421 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//