LOCUS BC033692 3774 bp mRNA linear HUM 01-SEP-2006
DEFINITION Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, mRNA
(cDNA clone MGC:45281 IMAGE:5212903), complete cds.
ACCESSION BC033692
VERSION BC033692.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3774)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3774)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (02-JUL-2002) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Life Technologies, Inc.
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 68 Row: o Column: 13
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 4557642.
FEATURES Location/Qualifiers
source 1..3774
/db_xref="H-InvDB:HIT000041908"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:45281 IMAGE:5212903"
/tissue_type="Blood, adult leukocytes"
/clone_lib="NIH_MGC_118"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..3774
/gene="HMGCR"
/db_xref="GeneID:3156"
/db_xref="HGNC:HGNC:5006"
/db_xref="MIM:142910"
CDS 93..2600
/gene="HMGCR"
/codon_start=1
/product="HMGCR protein"
/protein_id="AAH33692.1"
/db_xref="GeneID:3156"
/db_xref="HGNC:HGNC:5006"
/db_xref="MIM:142910"
/translation="MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKIC
GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFS
SFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARG
MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL
VLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIAD
PSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAV
KYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGIN
RERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQ
ILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSS
LQYLPYRDYNYSLLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIK
EAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPE
MQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINK
NLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYI
SCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGEL
SLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA"
BASE COUNT 1168 a 707 c 816 g 1083 t
ORIGIN
1 cgactgcgtt aactggagcc aggctgagcg tcggcgccgg ggttcggtgg cctctagtga
61 gatctggagg atccaaggat tctgtagcta caatgttgtc aagacttttt cgaatgcatg
121 gcctctttgt ggcctcccat ccctgggaag tcatagtggg gacagtgaca ctgaccatct
181 gcatgatgtc catgaacatg tttactggta acaataagat ctgtggttgg aattatgaat
241 gtccaaagtt tgaagaggat gttttgagca gtgacattat aattctgaca ataacacgat
301 gcatagccat cctgtatatt tacttccagt tccagaattt acgtcaactt ggatcaaaat
361 atattttggg tattgctggc cttttcacaa ttttctcaag ttttgtattc agtacagttg
421 tcattcactt cttagacaaa gaattgacag gcttgaatga agctttgccc tttttcctac
481 ttttgattga cctttccaga gcaagcacat tagcaaagtt tgccctcagt tccaactcac
541 aggatgaagt aagggaaaat attgctcgtg gaatggcaat tttaggtcct acgtttaccc
601 tcgatgctct tgttgaatgt cttgtgattg gagttggtac catgtcaggg gtacgtcagc
661 ttgaaattat gtgctgcttt ggctgcatgt cagttcttgc caactacttc gtgttcatga
721 ctttcttccc agcttgtgtg tccttggtat tagagctttc tcgggaaagc cgcgagggtc
781 gtccaatttg gcagctcagc cattttgccc gagttttaga agaagaagaa aataagccga
841 atcctgtaac tcagagggtc aagatgatta tgtctctagg cttggttctt gttcatgctc
901 acagtcgctg gatagctgat ccttctcctc aaaacagtac agcagatact tctaaggttt
961 cattaggact ggatgaaaat gtgtccaaga gaattgaacc aagtgtttcc ctctggcagt
1021 tttatctctc taaaatgatc agcatggata ttgaacaagt tattacccta agtttagctc
1081 tccttctggc tgtcaagtac atcttctttg aacaaacaga gacagaatct acactctcat
1141 taaaaaaccc tatcacatct cctgtagtga cacaaaagaa agtcccagac aattgttgta
1201 gacgtgaacc tatgctggtc agaaataacc agaaatgtga ttcagtagag gaagagacag
1261 ggataaaccg agaaagaaaa gttgaggtta taaaaccctt agtggctgaa acagataccc
1321 caaacagagc tacatttgtg gttggtaact cctccttact cgatacttca tcagtactgg
1381 tgacacagga acctgaaatt gaacttccca gggaacctcg gcctaatgaa gaatgtctac
1441 agatacttgg gaatgcagag aaaggtgcaa aattccttag tgatgctgag atcatccagt
1501 tagtcaatgc taagcatatc ccagcctaca agttggaaac tctgatggaa actcatgagc
1561 gtggtgtatc tattcgccga cagttacttt ccaagaagct ttcagaacct tcttctctcc
1621 agtacctacc ttacagggat tataattact ccttgcttgg tggaggtgcc agcagccgag
1681 tccttgcaga tgggatgact cgtggcccag ttgtgcgtct tccacgtgct tgtgactctg
1741 cagaagtgaa agcctggctc gaaacatctg aagggttcgc agtgataaag gaggcatttg
1801 acagcactag cagatttgca cgtctacaga aacttcatac aagtatagct ggacgcaacc
1861 tttatatccg tttccagtcc aggtcagggg atgccatggg gatgaacatg atttcaaagg
1921 gtacagagaa agcactttca aaacttcacg agtatttccc tgaaatgcag attctagccg
1981 ttagtggtaa ctattgtact gacaagaaac ctgctgctat aaattggata gagggaagag
2041 gaaaatctgt tgtttgtgaa gctgtcattc cagccaaggt tgtcagagaa gtattaaaga
2101 ctaccacaga ggctatgatt gaggtcaaca ttaacaagaa tttagtgggc tctgccatgg
2161 ctgggagcat aggaggctac aacgcccatg cagcaaacat tgtcaccgcc atctacattg
2221 cctgtggaca ggatgcagca cagaatgttg gtagttcaaa ctgtattact ttaatggaag
2281 caagtggtcc cacaaatgaa gatttatata tcagctgcac catgccatct atagagatag
2341 gaacggtggg tggtgggacc aacctactac ctcagcaagc ctgtttgcag atgctaggtg
2401 ttcaaggagc atgcaaagat aatcctgggg aaaatgcccg gcagcttgcc cgaattgtgt
2461 gtgggaccgt aatggctggg gaattgtcac ttatggcagc attggcagca ggacatcttg
2521 tcaaaagtca catgattcac aacaggtcga agatcaattt acaagacctc caaggagctt
2581 gcaccaagaa gacagcctga atagcccgac agttctgaac tggaacatgg gcattgggtt
2641 ctaaaggact aacataaaat ctgtgaatta aaaaagctca atgcattgtc ttgtggagga
2701 tgaatagatg tgatcactga gacagccact tggtttttgg ctctttcaga gaggtctcag
2761 gttctttcca tgcagactcc tcagatctga acacagttta gtgctttaca tgctgtgctc
2821 tttgaagaga tttcaacaag aatattgtat gttaaagcat cagagatggt aatctacagc
2881 tcacctctga aggcaaatat aagctgggaa aaaagttttg atgaaattct tgaagttcat
2941 ggtgatcagt gcaattgacc ttctccctca ctcctgccag ttgaaaatgg atttttaaat
3001 tatactgtag ctgatgaaac tcctgatttt gtagttaatt tattaagtct gggatgtaga
3061 acttcaagaa gtaagagcta agttctaagt tcatgtttgt aaattaatac ttcatttggt
3121 gctggtctat tttgattttg gggggtaatc agcattattc ttcagaaggg gacctgtttt
3181 cttcaaggga agaaacactc ttattcccaa actacagaat aatgtgttaa acatgctaaa
3241 tagttctatc aggaaaacaa atcactgtat ttatctccgc aggctatttg ttcagagagg
3301 ccttttgttt aaatataaat gtttaaatat aaatgtttgt ctggattggc tataacatgt
3361 ctttcagcat taggctttta agaaacacag ggttttgtat tctttactaa agatatcaga
3421 gctcttaatg ttgcttagat gagggtgact gtcaagtaca agcaagactg ggaccttaga
3481 aatcattgta gaaacacagt tttgaaagaa aaataccatg tctctaagcc aactttaatt
3541 gcttaaaaga catttttatt tagttgaaaa atctagtttt ttttgtaaac tgtatcaaat
3601 ctgtatatgt tgtaataaaa cttatgctag tttattggaa gtgttcaaga aataaaaatc
3661 aacttgtgta ctgataaaat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
3721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//