LOCUS BC015620 2586 bp mRNA linear HUM 16-SEP-2003
DEFINITION Homo sapiens actinin, alpha 4, mRNA (cDNA clone IMAGE:4843317),
partial cds.
ACCESSION BC015620
VERSION BC015620.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2586)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2586)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (04-OCT-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC015620.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 33 Row: o Column: 3.
FEATURES Location/Qualifiers
source 1..2586
/db_xref="H-InvDB:HIT000088751"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:4843317"
/tissue_type="Eye, normal, pigmented retinal epithelium"
/clone_lib="NIH_MGC_43"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..2586
/gene="ACTN4"
/gene_synonym="FSGS"
/gene_synonym="FSGS1"
/db_xref="GeneID:81"
/db_xref="MIM:604638"
CDS <1..1906
/gene="ACTN4"
/gene_synonym="FSGS"
/gene_synonym="FSGS1"
/codon_start=2
/product="ACTN4 protein"
/protein_id="AAH15620.2"
/db_xref="GeneID:81"
/db_xref="MIM:604638"
/translation="ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVP
QKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKM
VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK
HRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRC
QKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD
MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY
TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNY
TMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGAL
GPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTD
TADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSF
STALYGESDL"
misc_feature 47..379
/gene="ACTN4"
/gene_synonym="FSGS"
/gene_synonym="FSGS1"
/note="spectrin; Region: Spectrin repeat. Spectrin repeats
are found in several proteins involved in cytoskeletal
structure. These include spectrin, alpha-actinin and
dystrophin. The sequence repeat used in this family is
taken from the structural repeat in reference. The
spectrin repeat forms a three helix bundle. The second
helix is interrupted by proline in some sequences. The
repeats are defined by a characteristic tryptophan (W)
residue at position 17 in helix A and a leucine (L) at 2
residues from the carboxyl end of helix C"
/db_xref="CDD:pfam00435"
misc_feature 407..721
/gene="ACTN4"
/gene_synonym="FSGS"
/gene_synonym="FSGS1"
/note="spectrin; Region: Spectrin repeat. Spectrin repeats
are found in several proteins involved in cytoskeletal
structure. These include spectrin, alpha-actinin and
dystrophin. The sequence repeat used in this family is
taken from the structural repeat in reference. The
spectrin repeat forms a three helix bundle. The second
helix is interrupted by proline in some sequences. The
repeats are defined by a characteristic tryptophan (W)
residue at position 17 in helix A and a leucine (L) at 2
residues from the carboxyl end of helix C"
/db_xref="CDD:pfam00435"
misc_feature 1454..1783
/gene="ACTN4"
/gene_synonym="FSGS"
/gene_synonym="FSGS1"
/note="FRQ1; Region: COG5126, FRQ1, Ca2+-binding protein
(EF-Hand superfamily) [Signal transduction mechanisms /
Cytoskeleton / Cell division and chromosome partitioning /
General function prediction only]"
/db_xref="CDD:COG5126"
BASE COUNT 597 a 840 c 741 g 408 t
ORIGIN
1 cgccaaccgg atctgtaagg tgctggctgt caaccaagag aacgagcacc tgatggagga
61 ctacgagaag ctggccagcg acctcctgga gtggatccgg cgcaccatcc cctggctgga
121 ggaccgtgtg ccccaaaaga ctatccagga gatgcagcag aagctggagg acttccgcga
181 ctaccggcgt gtgcacaagc cgcccaaggt gcaggagaag tgccagctgg agatcaactt
241 caacacgctg cagaccaagc tgcgcctcag caaccggccc gccttcatgc cctccgaggg
301 caagatggtc tcggacatca acaatggctg gcagcacttg gagcaggctg agaagggcta
361 cgaggagtgg ctgctgaatg agatccgcag gctggagcgg ctcgaccacc tggcagagaa
421 gttccggcag aaggcctcca tccacgaggc ctggactgac gggaaggaag ccatgctgaa
481 gcaccgggac tacgagacgg ccacactatc ggacatcaaa gccctcattc gcaagcacga
541 ggccttcgag agcgacctgg ctgcgcacca ggaccgcgtg gagcagatcg ccgccattgc
601 ccaggagctc aacgagctgg attactacga ctcccacaat gtcaacaccc ggtgccagaa
661 gatctgtgac cagtgggacg ccctcggctc tctgacacat agtcgcaggg aagccctgga
721 gaaaacagag aagcagctgg aggccatcga ccagctgcac ctggaatacg ccaagcgcgc
781 ggcccccttc aacaactgga tggagagcgc catggaggac ctccaggaca tgttcatcgt
841 ccataccatc gaggagattg agggcctgat ctcagcccat gaccagttca agtccaccct
901 gccggacgcc gatagggagc gcgaggccat cctggccatc cacaaggagg cccagaggat
961 cgctgagagc aaccacatca agctgtcggg cagcaacccc tacaccaccg tcaccccgca
1021 aatcatcaac tccaagtggg agaaggtgca gcagctggtg ccaaaacggg accatgccct
1081 cctggaggag cagagcaagc agcagtccaa cgagcacctg cgccgccagt tcgccagcca
1141 ggccaatgtt gtggggccct ggatccagac caagatggag gagatcgggc gcatctccat
1201 tgagatgaac gggaccctgg aggaccagct gagccacctg aagcagtatg aacgcagcat
1261 cgtggactac aagcccaacc tggacctgct ggagcagcag caccagctca tccaggaggc
1321 cctcatcttc gacaacaagc acaccaacta taccatggag cacatccgcg tgggctggga
1381 gcagctgctc accaccattg cccgcaccat caacgaggtg gagaaccaga tcctcacccg
1441 cgacgccaag ggcatcagcc aggagcagat gcaggagttc cgggcgtcct tcaaccactt
1501 cgacaaggat catggcgggg cgctggggcc cgaggagttc aaggcctgcc tcatcagcct
1561 gggctacgac gtggagaacg accggcaggg tgaggccgag ttcaaccgca tcatgagcct
1621 ggtcgacccc aaccatagcg gccttgtgac cttccaagcc ttcatcgact tcatgtcgcg
1681 ggagaccacc gacacggaca cggctgacca ggtcatcgct tccttcaagg tcctagcagg
1741 ggacaagaac ttcatcacag ctgaggagct gcggagagag ctgccccccg accaggccga
1801 gtactgcatc gcccgcatgg cgccatacca gggccctgac gccgtgcccg gtgccctcga
1861 ctacaagtcc ttctccacgg ccttgtatgg cgagagcgac ctgtgaggcc ccagagacct
1921 gacccaacac ccccgacggc ctccaggagg ggcctgggca gccccacagt cccattcctc
1981 cactctgtat ctatgcaaag cactctctgc agtcctccgg ggtgggtggg tgggcaggga
2041 ggggctgggg caggctctct cctctctctc tttgtgggtt ggccaggagg ttcccccgac
2101 caggttgggg agacttgggg ccagcgcttc tggtctggta aatatgtatg atgtgttgtg
2161 cttttttaac caaggagggg ccagtggatt cccacagcac aaccggtccc ttccatgccc
2221 tgggatgcct caccacaccc aggtctcttc ctttgctctg aggtcccttc aaggcctccc
2281 caatccaggc caaagcccca tgtgccttgt ccaggaactg cctgggccat gcgaggggcc
2341 agcagagggc gccaccacca cctgacggct ggggacccac ccagcccctc tcccctctct
2401 gctccagact cacttgccat tgccaggaga tggccccaac aagcaccccg cttttgcagc
2461 agaggagctg agttggcaga ccgggccccc ctgaaccgca ccccatccca ccagccccgg
2521 ccttgctttg tctggcctca cgtgtctcag attttctaag aaccaaaaaa aaaaaaaaaa
2581 aaaaaa
//