LOCUS BC012527 3933 bp mRNA linear HUM 18-MAR-2009
DEFINITION Homo sapiens hypoxia inducible factor 1, alpha subunit (basic
helix-loop-helix transcription factor), mRNA (cDNA clone MGC:10483
IMAGE:3842146), complete cds.
ACCESSION BC012527
VERSION BC012527.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3933)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3933)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-AUG-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC012527.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 14 Row: c Column: 12
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 31077210.
FEATURES Location/Qualifiers
source 1..3933
/db_xref="H-InvDB:HIT000035850"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:10483 IMAGE:3842146"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3933
/gene="HIF1A"
/gene_synonym="bHLHe78"
/gene_synonym="HIF-1alpha"
/gene_synonym="HIF1"
/gene_synonym="HIF1-ALPHA"
/gene_synonym="MOP1"
/gene_synonym="PASD8"
/db_xref="GeneID:3091"
/db_xref="HGNC:HGNC:4910"
/db_xref="MIM:603348"
CDS 255..2735
/gene="HIF1A"
/gene_synonym="bHLHe78"
/gene_synonym="HIF-1alpha"
/gene_synonym="HIF1"
/gene_synonym="HIF1-ALPHA"
/gene_synonym="MOP1"
/gene_synonym="PASD8"
/codon_start=1
/product="hypoxia inducible factor 1, alpha subunit (basic
helix-loop-helix transcription factor)"
/protein_id="AAH12527.1"
/db_xref="GeneID:3091"
/db_xref="HGNC:HGNC:4910"
/db_xref="MIM:603348"
/translation="MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQL
PLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMV
LTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKE
QNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMT
CLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIY
EYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQC
IVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKK
EPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQ
SSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYI
PMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDEL
KTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEK
SHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQ
PDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSY
DCEVNAPIQGSRNLLQGEELLRALDQVN"
BASE COUNT 1245 a 785 c 748 g 1155 t
ORIGIN
1 caccctcttc gtcgcttcgg ccagtgtgtc gggctgggcc ctgacaagcc acctgaggag
61 aggctcggag ccgggcccgg accccggcga ttgccgcccg cttctctcta gtctcacgag
121 gggtttcccg cctcgcaccc ccacctctgg acttgccttt ccttctcttc tccgcgtgtg
181 gagggagcca gcgcttaggc cggagcgagc ctgggggccg cccgccgtga agacatcgcg
241 gggaccgatt caccatggag ggcgccggcg gcgcgaacga caagaaaaag ataagttctg
301 aacgtcgaaa agaaaagtct cgagatgcag ccagatctcg gcgaagtaaa gaatctgaag
361 ttttttatga gcttgctcat cagttgccac ttccacataa tgtgagttcg catcttgata
421 aggcctctgt gatgaggctt accatcagct atttgcgtgt gaggaaactt ctggatgctg
481 gtgatttgga tattgaagat gacatgaaag cacagatgaa ttgcttttat ttgaaagcct
541 tggatggttt tgttatggtt ctcacagatg atggtgacat gatttacatt tctgataatg
601 tgaacaaata catgggatta actcagtttg aactaactgg acacagtgtg tttgatttta
661 ctcatccatg tgaccatgag gaaatgagag aaatgcttac acacagaaat ggccttgtga
721 aaaagggtaa agaacaaaac acacagcgaa gcttttttct cagaatgaag tgtaccctaa
781 ctagccgagg aagaactatg aacataaagt ctgcaacatg gaaggtattg cactgcacag
841 gccacattca cgtatatgat accaacagta accaacctca gtgtgggtat aagaaaccac
901 ctatgacctg cttggtgctg atttgtgaac ccattcctca cccatcaaat attgaaattc
961 ctttagatag caagactttc ctcagtcgac acagcctgga tatgaaattt tcttattgtg
1021 atgaaagaat taccgaattg atgggatatg agccagaaga acttttaggc cgctcaattt
1081 atgaatatta tcatgctttg gactctgatc atctgaccaa aactcatcat gatatgttta
1141 ctaaaggaca agtcaccaca ggacagtaca ggatgcttgc caaaagaggt ggatatgtct
1201 gggttgaaac tcaagcaact gtcatatata acaccaagaa ttctcaacca cagtgcattg
1261 tatgtgtgaa ttacgttgtg agtggtatta ttcagcacga cttgattttc tcccttcaac
1321 aaacagaatg tgtccttaaa ccggttgaat cttcagatat gaaaatgact cagctattca
1381 ccaaagttga atcagaagat acaagtagcc tctttgacaa acttaagaag gaacctgatg
1441 ctttaacttt gctggcccca gccgctggag acacaatcat atctttagat tttggcagca
1501 acgacacaga aactgatgac cagcaacttg aggaagtacc attatataat gatgtaatgc
1561 tcccctcacc caacgaaaaa ttacagaata taaatttggc aatgtctcca ttacccaccg
1621 ctgaaacgcc aaagccactt cgaagtagtg ctgaccctgc actcaatcaa gaagttgcat
1681 taaaattaga accaaatcca gagtcactgg aactttcttt taccatgccc cagattcagg
1741 atcagacacc tagtccttcc gatggaagca ctagacaaag ttcacctgag cctaatagtc
1801 ccagtgaata ttgtttttat gtggatagtg atatggtcaa tgaattcaag ttggaattgg
1861 tagaaaaact ttttgctgaa gacacagaag caaagaaccc attttctact caggacacag
1921 atttagactt ggagatgtta gctccctata tcccaatgga tgatgacttc cagttacgtt
1981 ccttcgatca gttgtcacca ttagaaagca gttccgcaag ccctgaaagc gcaagtcctc
2041 aaagcacagt tacagtattc cagcagactc aaatacaaga acctactgct aatgccacca
2101 ctaccactgc caccactgat gaattaaaaa cagtgacaaa agaccgtatg gaagacatta
2161 aaatattgat tgcatctcca tctcctaccc acatacataa agaaactact agtgccacat
2221 catcaccata tagagatact caaagtcgga cagcctcacc aaacagagca ggaaaaggag
2281 tcatagaaca gacagaaaaa tctcatccaa gaagccctaa cgtgttatct gtcgctttga
2341 gtcaaagaac tacagttcct gaggaagaac taaatccaaa gatactagct ttgcagaatg
2401 ctcagagaaa gcgaaaaatg gaacatgatg gttcactttt tcaagcagta ggaattggaa
2461 cattattaca gcagccagac gatcatgcag ctactacatc actttcttgg aaacgtgtaa
2521 aaggatgcaa atctagtgaa cagaatggaa tggagcaaaa gacaattatt ttaataccct
2581 ctgatttagc atgtagactg ctggggcaat caatggatga aagtggatta ccacagctga
2641 ccagttatga ttgtgaagtt aatgctccta tacaaggcag cagaaaccta ctgcagggtg
2701 aagaattact cagagctttg gatcaagtta actgagcttt ttcttaattt cattcctttt
2761 tttggacact ggtggctcac tacctaaagc agtctattta tattttctac atctaatttt
2821 agaagcctgg ctacaatact gcacaaactt ggttagttca atttttgatc ccctttctac
2881 ttaatttaca ttaatgctct tttttagtat gttctttaat gctggatcac agacagctca
2941 ttttctcagt tttttggtat ttaaaccatt gcattgcagt agcatcattt taaaaaatgc
3001 acctttttat ttatttattt ttggctaggg agtttatccc tttttcgaat tatttttaag
3061 aagatgccaa tataattttt gtaagaaggc agtaaccttt catcatgatc ataggcagtt
3121 gaaaaatttt tacacctttt ttttcacatt ttacataaat aataatgctt tgccagcagt
3181 acgtggtagc cacaattgca caatatattt tcttaaaaaa taccagcagt tactcatgga
3241 atatattctg cgtttataaa actagttttt aagaagaaat tttttttggc ctatgaaatt
3301 gttaaacctg gaacatgaca ttgttaatca tataataatg attcttaaat gctgtatggt
3361 ttattattta aatgggtaaa gccatttaca taatatagaa agatatgcat atatctagaa
3421 ggtatgtggc atttatttgg ataaaattct caattcagag aaatcatctg atgtttctat
3481 agtcactttg ccagctcaaa agaaaacaat accctatgta gttgtggaag tttatgctaa
3541 tattgtgtaa ctgatattaa acctaaatgt tctgcctacc ctgttggtat aaagatattt
3601 tgagcagact gtaaacaaga aaaaaaaaat catgcattct tagcaaaatt gcctagtatg
3661 ttaatttgct caaaatacaa tgtttgattt tatgcacttt gtcgctatta acatcctttt
3721 tttcatgtag atttcaataa ttgagtaatt ttagaagcat tattttagga atatatagtt
3781 gtcacagtaa atatcttgtt ttttctatgt acattgtaca aatttttcat tccttttgct
3841 ctttgtggtt ggatctaaca ctaactgtat tgttttgtta catcaaataa acatcttctg
3901 tggaccaggc aaaaaaaaaa aaaaaaaaaa aaa
//