LOCUS BC011399 2557 bp mRNA linear HUM 03-OCT-2003
DEFINITION Homo sapiens spleen tyrosine kinase, mRNA (cDNA clone MGC:9504
IMAGE:3870426), complete cds.
ACCESSION BC011399
VERSION BC011399.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2557)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2557)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (25-JUL-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Life Technologies, Inc.
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Baylor College of Medicine Human Genome
Sequencing Center
Center code: BCM-HGSC
Web site: http://www.hgsc.bcm.tmc.edu/cdna/
Contact: amg@bcm.tmc.edu
Gunaratne, P.H., Garcia, A.M., Lu, X., Hulyk, S.W., Loulseged, H.,
Kowis, C.R., Sneed, A.J., Martin, R.G., Muzny, D.M., Nanavati,
A.N., Gibbs, R.A.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAK Plate: 13 Row: j Column: 7
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 21361552.
FEATURES Location/Qualifiers
source 1..2557
/db_xref="H-InvDB:HIT000035240"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:9504 IMAGE:3870426"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_67"
/lab_host="DH10B"
/note="Vector: pCMV-SPORT6"
gene 1..2557
/gene="SYK"
/db_xref="GeneID:6850"
/db_xref="MIM:600085"
CDS 105..1943
/gene="SYK"
/codon_start=1
/product="SYK protein"
/protein_id="AAH11399.1"
/db_xref="GeneID:6850"
/db_xref="MIM:600085"
/translation="MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQS
RNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCL
LKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIAT
TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI
DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL
PGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEE
IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD
ELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIE
LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH
GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE
RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN"
misc_feature 147..380
/gene="SYK"
/note="SH2; Region: SH2 domain"
/db_xref="CDD:pfam00017"
misc_feature 606..836
/gene="SYK"
/note="SH2; Region: SH2 domain"
/db_xref="CDD:pfam00017"
misc_feature 1155..1913
/gene="SYK"
/note="TyrKc; Region: Tyrosine kinase, catalytic domain"
/db_xref="CDD:smart00219"
BASE COUNT 690 a 644 c 684 g 539 t
ORIGIN
1 ggaggttacg gggaacgacg cgctgctttc atgccctttc ttgttctacc ttcatcggcc
61 gaggtggaca cctgcgcagg tgtgtgccct ccggcccctg aagcatggcc agcagcggca
121 tggctgacag cgccaaccac ctgcccttct ttttcggcaa catcacccgg gaggaggcag
181 aagattacct ggtccagggg ggcatgagtg atgggcttta tttgctgcgc cagagccgca
241 actacctggg tggcttcgcc ctgtccgtgg cccacgggag gaaggcacac cactacacca
301 tcgagcggga gctgaatggc acctacgcca tcgccggtgg caggacccat gccagccccg
361 ccgacctctg ccactaccac tcccaggagt ctgatggcct ggtctgcctc ctcaagaagc
421 ccttcaaccg gccccaaggg gtgcagccca agactgggcc ctttgaggat ttgaaggaaa
481 acctcatcag ggaatatgtg aagcagacat ggaacctgca gggtcaggct ctggagcagg
541 ccatcatcag tcagaagcct cagctggaga agctgatcgc taccacagcc catgaaaaaa
601 tgccttggtt ccatggaaaa atctctcggg aagaatctga gcaaattgtc ctgataggat
661 caaagacaaa tggaaagttc ctgatccgag ccagagacaa caacggctcc tacgccctgt
721 gcctgctgca cgaagggaag gtgctgcact atcgcatcga caaagacaag acagggaagc
781 tctccatccc cgagggaaag aagttcgaca cgctctggca gctagtcgag cattattctt
841 ataaagcaga tggtttgtta agagttctta ctgtcccatg tcaaaaaatc ggcacacagg
901 gaaatgttaa ttttggaggc cgtccacaac ttccaggttc ccatcctgcg tcctcccctg
961 cccaagggaa ccggcaagag agtactgtgt cattcaatcc gtatgagcca gaacttgcac
1021 cctgggctgc agacaaaggc ccccagagag aagccctacc catggacaca gaggtgtacg
1081 agagccccta cgcggacccc gaggagatca ggcccaagga ggtttacctg gaccgaaagc
1141 tgctgacgct ggaagacaaa gaactgggct ctggtaattt tggaactgtg aaaaagggct
1201 actaccaaat gaaaaaagtt gtgaaaaccg tggctgtgaa aatactgaaa aacgaggcca
1261 atgaccccgc tcttaaagat gagttattag cagaagcaaa tgtcatgcag cagctggaca
1321 acccgtacat cgtgcggatg atcgggatat gcgaggccga gtcctggatg ctggttatgg
1381 agatggcaga acttggtccc ctcaataagt atttgcagca gaacagacat gtcaaggata
1441 agaacatcat agaactggtt catcaggttt ccatgggcat gaagtacttg gaggagagca
1501 attttgtgca cagagatctg gctgcaagaa atgtgttgct agttacccaa cattacgcca
1561 agatcagtga tttcggactt tccaaagcac tgcgtgctga tgaaaactac tacaaggccc
1621 agacccatgg aaagtggcct gtcaagtggt acgctccgga atgcatcaac tactacaagt
1681 tctccagcaa aagcgatgtc tggagctttg gagtgttgat gtgggaagca ttctcctatg
1741 ggcagaagcc atatcgaggg atgaaaggaa gtgaagtcac cgctatgtta gagaaaggag
1801 agcggatggg gtgccctgca gggtgtccaa gagagatgta cgatctcatg aatctgtgct
1861 ggacatacga tgtggaaaac aggcccggat tcgcagcagt ggaactgcgg ctgcgcaatt
1921 actactatga cgtggtgaac taaccgctcc cgcacctgtc ggtggctgcc tttgatcaca
1981 ggagcaatca caggaaaatg tatccagagg aattgattgt cagccacctc cctctgccag
2041 tcgggagagc caggcttgga tggaacatgc ccacaacttg tcacccaaag cctgtcccag
2101 gactcaccct ccacaaagca aaggcagtcc cgggagaaaa gacggatggc aggatccaag
2161 gggctagctg gatttgtttg ttttcttgtc tgtgtgattt tcatacaggt tatttttacg
2221 atctgtttcc aaatcccttt catgtctttc cacttctctg ggtcccaggg tgcatttgtt
2281 actcatcggg cccagggaca ttgcagagtg gcctagagca ctctcacccc aagcggcctt
2341 ttccaaatgc ccaaggatgc cttagcatgt gactcctgaa gggaaggcaa aggcagagga
2401 atttggctgc ttctacggcc atgagactga tccctggcca ctgaaaagct ttcctgacaa
2461 taaaaatgtt ttgaggcttt aaaaagaaaa tcaagtttga ccagtgcagt ttctaagcat
2521 gtagccagtt aaggaaagaa agaaaaaaaa aaaaaaa
//