LOCUS BC006334 1741 bp mRNA linear HUM 08-OCT-2003
DEFINITION Homo sapiens potassium voltage-gated channel, subfamily H
(eag-related), member 6, mRNA (cDNA clone MGC:13157 IMAGE:4303609),
complete cds.
ACCESSION BC006334
VERSION BC006334.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1741)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1741)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC006334.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 17 Row: o Column: 13
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 27886650.
FEATURES Location/Qualifiers
source 1..1741
/db_xref="H-InvDB:HIT000032765"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:13157 IMAGE:4303609"
/tissue_type="Uterus, leiomyosarcoma"
/clone_lib="NIH_MGC_46"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..1741
/gene="KCNH6"
/gene_synonym="ERG2"
/gene_synonym="HERG2"
/gene_synonym="Kv11.2"
/db_xref="GeneID:81033"
CDS 59..1567
/gene="KCNH6"
/gene_synonym="ERG2"
/gene_synonym="HERG2"
/gene_synonym="Kv11.2"
/codon_start=1
/product="KCNH6 protein"
/protein_id="AAH06334.1"
/db_xref="GeneID:81033"
/translation="MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYC
NDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKD
ASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSH
GRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQN
VTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPY
SAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHP
RRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDR
YSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNG
SDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGCE"
misc_feature 179..463
/gene="KCNH6"
/gene_synonym="ERG2"
/gene_synonym="HERG2"
/gene_synonym="Kv11.2"
/note="AtoS; Region: FOG: PAS/PAC domain [Signal
transduction mechanisms]"
/db_xref="CDD:COG2202"
misc_feature 1064..1561
/gene="KCNH6"
/gene_synonym="ERG2"
/gene_synonym="HERG2"
/gene_synonym="Kv11.2"
/note="ion_trans; Region: Ion transport protein. This
family contains Sodium, Potassium, Calcium ion channels.
This family is 6 transmembrane helices in which the last
two helices flank a loop which determines ion selectivity.
In some sub-families (e.g. Na channels) the domain is
repeated four times, whereas in others (e.g. K channels)
the protein forms as a tetramer in the membrane. A
bacterial structure of the protein is known for the last
two helices but is not the Pfam family due to it lacking
the first four helices"
/db_xref="CDD:pfam00520"
BASE COUNT 380 a 549 c 470 g 342 t
ORIGIN
1 gcggagacgc cgggagccag tggcgcctgt ggctccgggc aggggccgcg gccgaaagat
61 gccggtccgc aggggccacg tcgctcccca aaacacttac ctggacacca tcatccgcaa
121 gttcgagggc caaagtcgga agttcctgat tgccaatgct cagatggaga actgcgccat
181 catttactgc aacgacggct tctgcgaact cttcggctac tcccgagtgg aggtgatgca
241 gcaaccctgc acctgcgact tcctcacagg ccccaacaca ccaagcagcg ccgtgtcccg
301 cctagcgcag gccctgctgg gggctgagga gtgcaaggtg gacatcctct actaccgcaa
361 ggatgcctcc agcttccgct gcctggtaga tgtggtgccc gtgaagaacg aggacggggc
421 tgtcatcatg ttcattctca acttcgagga cctggcccag ctcctggcca agtgcagcag
481 ccgcagcttg tcccagcgcc tgttgtccca gagcttcctg ggctccgagg gctctcatgg
541 caggccaggc ggaccagggc caggcacagg caggggcaag tacaggacca tcagccagat
601 cccacagttc acgctcaact tcgtggagtt caacttggag aagcaccgct ccagctccac
661 cacggagatt gagatcatcg cgccccataa ggtggtggag cggacacaga acgtcactga
721 gaaggtcacc caggtcctgt ccctgggcgc ggatgtgctg ccggagtaca agctgcaggc
781 gccgcgcatc caccgctgga ccatcctgca ctacagcccc ttcaaggccg tgtgggactg
841 gctcatcctg ctgctggtca tctacacggc tgtcttcacg ccctactcag ccgccttcct
901 gctcagcgac caggacgaat cacggcgtgg ggcctgcagc tatacctgca gtcccctcac
961 tgtggtggat ctcatcgtgg acatcatgtt cgtcgtggac atcgtcatca acttccgcac
1021 cacctatgtc aacaccaatg atgaggtggt cagccacccc cgccgcatcg ccgtccacta
1081 cttcaagggc tggttcctca ttgacatggt ggccgccatc cctttcgacc tcctgatctt
1141 ccgcactggc tccgatgaga ccacaaccct gattgggcta ttgaagacag cgcggctgct
1201 gcggctggtg cgcgtagcac ggaagctgga ccgctactct gagtatgggg cggctgtgct
1261 cttcttgctc atgtgcacct tcgcgctcat agcgcactgg ctggcctgca tctggtacgc
1321 catcggcaat gtggagcggc cctacctaga acacaagatc ggctggctgg acagcctggg
1381 tgtgcagctt ggcaagcgct acaacggcag cgacccagcc tcgggcccct cggtgcagga
1441 caagtatgtc acagccctct acttcacctt cagcagcctc accagcgtgg gcttcggcaa
1501 tgtctcgccc aacaccaact ccgagaaggt cttctccatc tgcgtcatgc tcatcggctg
1561 tgagtgagac ctcatgccac ggcctaactt catgctctgg tcttacccgt gaaattttat
1621 gtgtagtttt gtactgagat agaacataac acatagcaac aattcatgca gtacactgat
1681 cctaagtgtg cagcacaatg aattaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1741 a
//