LOCUS BC003631 1314 bp mRNA linear HUM 05-NOV-2003
DEFINITION Homo sapiens S-adenosylhomocysteine hydrolase-like 1, mRNA (cDNA
clone IMAGE:3010755), partial cds.
ACCESSION BC003631
VERSION BC003631.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1314)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 1314)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (26-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Oct 28, 2003 this sequence version replaced BC003631.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Institute for Systems Biology
http://www.systemsbiology.org
contact: amadan@systemsbiology.org
Anup Madan, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha
Madan, Stephanie Rodrigues, Amy Sanchez and Michelle Whiting
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 3 Row: b Column: 6.
FEATURES Location/Qualifiers
source 1..1314
/db_xref="H-InvDB:HIT000086259"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:3010755"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene <1..1314
/gene="AHCYL1"
/gene_synonym="DCAL"
/gene_synonym="IRBIT"
/gene_synonym="XPVKONA"
/db_xref="GeneID:10768"
/db_xref="MIM:607826"
CDS <1..602
/gene="AHCYL1"
/gene_synonym="DCAL"
/gene_synonym="IRBIT"
/gene_synonym="XPVKONA"
/codon_start=3
/product="AHCYL1 protein"
/protein_id="AAH03631.2"
/db_xref="GeneID:10768"
/db_xref="MIM:607826"
/translation="ALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTG
NKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKR
VVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEY
VASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY"
misc_feature 3..575
/gene="AHCYL1"
/gene_synonym="DCAL"
/gene_synonym="IRBIT"
/gene_synonym="XPVKONA"
/note="AdoHcyase; Region: S-adenosyl-L-homocysteine
hydrolase (AdoHycase) catalyzes the hydrolysis of
S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado)
and homocysteine (Hcy). The equilibrium lies far on the
side of AdoHyc synthesis, but in nature the removal of Ado
and Hyc is sufficiently fast, so that the net reaction is
in the direction of hydrolysis. Since AdoHyc is a potent
inhibitor of S-adenosyl-L-methionine dependent
methyltransferases, AdoHycase plays a critical role in the
modulation of the activity of various methyltransferases.
The enzyme forms homooligomers of 45-50kDa subunits, each
binding one molecule of NAD+"
/db_xref="CDD:cd00401"
BASE COUNT 363 a 301 c 266 g 384 t
ORIGIN
1 aagctcttgg agcaattgtc tacattaccg aaatcgaccc catctgtgct ctgcaggcct
61 gcatggatgg gttcagggtg gtaaagctaa atgaagtcat ccggcaagtc gatgtcgtaa
121 taacttgcac aggaaataag aatgtagtga cacgggagca cttggatcgc atgaaaaaca
181 gttgtatcgt atgcaatatg ggccactcca acacagaaat cgatgtgacc agcctccgca
241 ctccggagct gacgtgggag cgagtacgtt ctcaggtgga ccatgtcatc tggccagatg
301 gcaaacgagt tgtcctcctg gcagagggtc gtctactcaa tttgagctgc tccacagttc
361 ccacctttgt tctgtccatc acagccacaa cacaggcttt ggcactgata gaactctata
421 atgcacccga ggggcgatac aagcaggatg tgtacttgct tcctaagaaa atggatgaat
481 acgttgccag cttgcatctg ccatcatttg atgcccacct tacagagctg acagatgacc
541 aagcaaaata tctgggactc aacaaaaatg ggccattcaa acctaattat tacagatact
601 aatggaccat actaccaagg accagtccac ctgaaccaca cactctaaag aaatattttt
661 taagataact tttattttct tcttactcct ttcctcttga tttttttcct ataatttcat
721 tcttgttttt tcatctcatt atccaagttc tgcagaccac acaggaactt gcttcatggc
781 tctttagatg aaatagaagt tcagggttcc tcactctagt cactaaagaa ggattttact
841 ctcccagccc agaaaggtga ttctttcttt accatttctg gggactttag tcttaattag
901 gtaccttatt aacaggaaat gctaaggtac cttctctgtg gaacaatctg caatgtctaa
961 atcgccttaa aagagcccat ttcttagctg ctgaaatcag tgctctttca cttcttcaga
1021 gaagcaggga tggtacctac ccggcaggta ggttagatgt gggtggtgca tgttaatttc
1081 ccttagaagt tccaagccct gtttcctgcg taaaggtggt atgtccagtt cagagatgtg
1141 tataatgagc atggcttgtt aagatcagga ggcccacttg gatttatagt atagcccttc
1201 ctccactccc accagacttg ctcatttttc gagtttttaa ctagactaca ctctattgag
1261 tttaattttg tcctctagga tttatttctg ttgtccaaaa aaaaaaaaaa aaaa
//