LOCUS Y00978 2583 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for dihydrolipoamide acetyltransferase (PDC-E2) (EC
2.3.1.12).
ACCESSION Y00978 X13969
VERSION Y00978.1
KEYWORDS dihydrolipoamide acetyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2583)
AUTHORS Patel M.S.
JOURNAL Submitted (16-FEB-1989) to the INSDC. Patel M.S., Case Western
Reserve University, Dept. of Biochemistry, School of Medicine, 2119
Abington Road, Cleveland, Ohio USA 44106.
REFERENCE 2 (bases 1 to 2583)
AUTHORS Thekkumkara T.J., Ho L., Wexler I.D., Pon G., Liu T., Patel M.S.
TITLE Nucleotide sequence of a cDNA for the dihydrolipoamide
acetyltransferase component of human pyruvate dehydrogenase complex
JOURNAL FEBS Lett. 240(1-2), 45-48(1988).
PUBMED 3191998
COMMENT The sequence overlaps with that reported by Coppel et. al. in
Proc. Natl. Acad. Sci. USA 85:7317-7321(1988) J03866.
Data kindly reviewed (29th March 1989) by Patel M.S.
FEATURES Location/Qualifiers
source 1..2583
/db_xref="H-InvDB:HIT000325334"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/tissue_type="liver."
/db_xref="taxon:9606"
CDS <1..1848
/codon_start=1
/product="PDC-E2 precursor (AA -54 to 561)"
/db_xref="GOA:P10515"
/db_xref="H-InvDB:HIT000325334.13"
/db_xref="HGNC:HGNC:2896"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001078"
/db_xref="InterPro:IPR003016"
/db_xref="InterPro:IPR004167"
/db_xref="InterPro:IPR006257"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR036625"
/db_xref="PDB:1FYC"
/db_xref="PDB:1Y8N"
/db_xref="PDB:1Y8O"
/db_xref="PDB:1Y8P"
/db_xref="PDB:2DNE"
/db_xref="PDB:2PNR"
/db_xref="PDB:2Q8I"
/db_xref="PDB:3B8K"
/db_xref="PDB:3CRK"
/db_xref="PDB:3CRL"
/db_xref="PDB:6CT0"
/db_xref="PDB:6H55"
/db_xref="UniProtKB/Swiss-Prot:P10515"
/protein_id="CAA68787.1"
/translation="RVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPRNRLLLQ
LLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWKKKEGDKINEGDLIAEVETDKAT
VGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAA
PAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGD
LLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRP
TEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPLAKKLAV
EKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIP
ISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIK
ASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIAND
VVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLV
PADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITMLL"
transit_peptide <1..162
/codon_start=1
/note="leader peptide (AA -54 to -1)"
mat_peptide 163..1845
/product="mature PDC-E2 (AA 1-561)"
BASE COUNT 742 a 562 c 564 g 715 t
ORIGIN
1 cgagtgacct cgcgatctgg cccggctccc gctcgtcgca acagcgtgac tacagggtat
61 ggcggggtcc gggcactgtg cggctggacc cccagttctg gggccacgcc gcggaaccgc
121 ttactgctgc agcttttggg gtcgcccggc cgccgctatt acagtcttcc cccgcatcag
181 aaggttccat tgccttctct ttcccccaca atgcaggcag gcaccatagc ccgttggaaa
241 aaaaaagagg gggacaaaat caatgaaggt gacctaattg cagaggttga aactgataaa
301 gccactgttg gatttgagag cctggaggag tgttatatgg caaagatact tgttgctgaa
361 ggtaccaggg atgttcccat cggagcgatc atctgtatca cagttggcaa gcctgaggat
421 attgaggcct ttaaaaatta tacactggat tcctcagcag cacctacccc acaagcggcc
481 ccagcaccaa cccctgctgc cactgcttcg ccacctacac cttctgctca ggctcctggt
541 agctcatatc cccctcacat gcaggtactt cttcctgccc tctctcccac catgaccatg
601 ggcacagttc agagatggga aaaaaaagtg ggtgagaagc taagtgaagg agacttactg
661 gcagagatag aaactgacaa agccactata ggttttgaag tacaggaaga aggttatctg
721 gcaaaaatcc tggtccctga aggcacaaga gatgtccctc taggaacccc actctgtatc
781 attgtagaaa aagaggcaga tatatcagca tttgctgact ataggccaac cgaagtaaca
841 gatttaaaac cacaagtgcc accacctacc ccacccccgg tggccgctgt tcctccaact
901 ccccagcctt tagctcctac accttcagca ccctgcccag ctactcctgc tggaccaaag
961 ggaagggtgt ttgttagccc tcttgcaaag aagttggcag tagagaaagg gattgatctt
1021 acacaagtaa aagggacagg accagatggt agaatcacca agaaggatat cgactctttt
1081 gtgcctagta aagttgctcc tgctccggca gctgttgtgc ctcccacagg tcctggaatg
1141 gcaccagttc ctacaggtgt cttcacagat atcccaatca gcaacattcg tcgggttatt
1201 gcacagcgat taatgcaatc aaagcaaacc atacctcatt attacctttc tatcgatgta
1261 aatatgggag aagttttgtt ggtacggaaa gaacttaata agatattaga agggagaagc
1321 aaaatttctg tcaatgactt catcataaaa gcttcagctt tggcatgttt aaaagttccc
1381 gaagcaaatt cttcttggat ggacacagtt ataagacaaa atcatgttgt tgatgtcagt
1441 gttgcggtca gtactcctgc aggactcatc acacctattg tgtttaatgc acatataaaa
1501 ggagtggaaa ccattgctaa tgatgttgtt tctttagcaa ccaaagcaag agagggtaaa
1561 ctacagccac atgaattcca gggtggcact tttacgatct ccaatttagg aatgtttgga
1621 attaagaatt tctctgctat tattaaccca cctcaagcat gtattttggc aattggtgct
1681 tcagaggata aactggtccc tgcagataat gaaaaagggt ttgatgtggc tagcatgatg
1741 tctgttacac tcagttgtga tcaccgggtg gtggatggag cagttggagc ccagtggctt
1801 gctgagttta gaaagtacct tgaaaaacct atcactatgt tgttgtaact aactcaagaa
1861 tttctaaact ctcccaggtc acactgattc attcttaaca agatatttat atgttattaa
1921 acaggtggtt gctttttatt ttaaccagtt atttttatta ttgagtctgc tcagataagt
1981 tatttataat gggcattact gaatttttaa aatgccgatt acacccaaat attgtgcaca
2041 tttaataatc agacaccaga tttttagctc tgtactccta attaagggac atgtatgtgg
2101 ccttgcctag ccctttggtg ataagtactt cctctaggaa atgtacgata ggtagaattg
2161 tggttcccta aagacaagta cataaaggtg accctgatga aaccttgaag ttctgaaatt
2221 taactgccta aaatgttctc cttagatgtg agagaaagag aaatcagaaa aattaattct
2281 cttgggggaa gggcttgaat tgaagcttta ctttagaatt tagccctggt ttgaaatttt
2341 ccattacatg atcttggttt atcatcgatg ggaagggtag aaaacttcaa ggaaaataag
2401 tgaaatttta aaagtcagca ttttcttaga cctcttcagc tgattgttta tttttctatg
2461 aattctgtac tcaaaattac acatttgttt aaataaatat ccacacaaat tctcagttac
2521 atcaagtagc tggtttatat ttagattatc tcaagtaggg gggaataacc atgtgtagga
2581 att
//