LOCUS HSU76308 8239 bp mRNA linear HUM 09-JAN-1997
DEFINITION Human protein kinase ATR mRNA, complete cds.
ACCESSION U76308
VERSION U76308.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8239)
AUTHORS Bentley,N.J., Holtzman,D.A., Flaggs,G., Keegan,K.S., DeMaggio,A.,
Ford,J.C., Hoekstra,M. and Carr,A.M.
TITLE The Schizosaccharomyces pombe rad3 checkpoint gene
JOURNAL EMBO J. 15 (23), 6641-6651 (1996)
PUBMED 8978690
REFERENCE 2 (bases 1 to 8239)
AUTHORS Bentley,N.J., Holtzman,D.A., Flaggs,G., Keegan,K.S., DeMaggio,A.,
Ford,J.C., Hoekstra,M. and Carr,A.M.
TITLE Direct Submission
JOURNAL Submitted (25-OCT-1996) MRC Cell Mutation Unit, Sussex University,
Falmer, Brighton BN1 9RR, UK
FEATURES Location/Qualifiers
source 1..8239
/db_xref="H-InvDB:HIT000221284"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q22-3q23"
CDS 80..8014
/note="large lipid kinase like family, similar to ATM gene
and yeast checkpoint genes S. pombe rad3 and S. cerevisiae
MEC1"
/codon_start=1
/product="protein kinase ATR"
/protein_id="AAC50929.1"
/translation="MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRI
LTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHERKGSCIEFSNW
IITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLH
RRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIA
IVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLEL
LKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVL
MRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYL
LGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE
IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCS
HQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKV
VKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRI
SDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQ
NSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDL
FCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFRED
ETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTH
AQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRAL
VAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMAL
NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILI
NNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQ
QVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIE
DKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLD
HACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELK
KIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQG
KDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETN
GPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASW
AGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEI
MAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSN
RNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQN
IQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAI
QLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQW
DLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERG
SYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPI
LALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVE
RAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANF
ESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR
SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNY
LAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR
VNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKK
LVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASL
QKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRT
YAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLK
VFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGEN
ILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEV
TMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIE
QRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM"
BASE COUNT 2555 a 1540 c 1730 g 2414 t
ORIGIN
1 gcgctcttcc ggcagcggta cgtttggaga cgccgggaac ccgcgttggc gtggttgact
61 agtgcctcgc agcctcagca tgggggaaca tggcctggag ctggcttcca tgatccccgc
121 cctgcgggag ctgggcagtg ccacaccaga ggaatataat acagttgtac agaagccaag
181 acaaattctg tgtcaattca ttgaccggat acttacagat gtaaatgttg ttgctgtaga
241 acttgtaaag aaaactgact ctcagccaac ctccgtgatg ttgcttgatt tcatccagca
301 tatcatgaaa tcctccccac ttatgtttgt aaatgtgagt ggaagccatg agcgcaaagg
361 cagttgtatt gaattcagta attggatcat aacgagactt ctgcggattg cagcaactcc
421 ctcctgtcat ttgttacaca agaaaatctg tgaagtcatc tgttcattat tatttctttt
481 taaaagcaag agtcctgcta tttttggggt actcacaaaa gaattattac aactttttga
541 agacttggtt tacctccata gaagaaatgt gatgggtcat gctgtggaat ggccagtggt
601 catgagccga tttttaagtc aattagatga acacatggga tatttacaat cagctccttt
661 gcagttgatg agtatgcaaa atttagaatt tattgaagtc actttattaa tggttcttac
721 tcgtattatt gcaattgtgt tttttagaag gcaagaactc ttactttggc agataggttg
781 tgttctgcta gagtatggta gtccaaaaat taaatcccta gcaattagct ttttaacaga
841 actttttcag cttggaggac taccagcaca accagctagc acttttttca gctcattttt
901 ggaattatta aaacaccttg tagaaatgga tactgaccaa ttgaaactct atgaagagcc
961 attatcaaag ctgataaaga cactatttcc ctttgaagca gaagcttata gaaatattga
1021 acctgtctat ttaaatatgc tgctggaaaa actctgtgtc atgtttgaag acggtgtgct
1081 catgcggctt aagtctgatt tgctaaaagc agctttgtgc catttactgc agtatttcct
1141 taaatttgtg ccagctgggt atgaatctgc tttacaagtc aggaaggtct atgtgagaaa
1201 tatttgtaaa gctcttttgg atgtgcttgg aattgaggta gatgcagagt acttgttggg
1261 cccactttat gcagctttga aaatggaaag tatggaaatc attgaggaga ttcaatgcca
1321 aactcaacag gaaaacctca gcagtaatag tgatggaata tcacccaaaa ggcgtcgtct
1381 cagctcgtct ctaaaccctt ctaaaagagc accaaaacag actgaggaaa ttaaacatgt
1441 ggacatgaac caaaagagca tattatggag tgcactgaaa cagaaagctg aatcccttca
1501 gatttccctt gaatacagtg gcctaaagaa tcctgttatt gagatgttag aaggaattgc
1561 tgttgtctta caactgactg ctctgtgtac tgttcattgt tctcatcaaa acatgaactg
1621 ccgtactttc aaggactgtc aacataaatc caagaagaaa ccttctgtag tgataacttg
1681 gatgtcattg gatttttaca caaaagtgct taagagctgt agaagtttgt tagaatctgt
1741 tcagaaactg gacctggagg caaccattga taaggtggtg aaaatttatg atgctttgat
1801 ttatatgcaa gtaaacagtt catttgaaga tcatatcctg gaagatttat gtggtatgct
1861 ctcacttcca tggatttatt cccattctga tgatggctgt ttaaagttga ccacatttgc
1921 cgctaatctt ctaacattaa gctgtaggat ttcagatagc tattcaccac aggcacaatc
1981 acgatgtgtg tttcttctga ctctgtttcc aagaagaata ttccttgagt ggagaacagc
2041 agtttacaac tgggccctgc agagctccca tgaagtaatc cgggctagtt gtgttagtgg
2101 attttttatc ttattgcagc agcagaattc ttgtaacaga gttcccaaga ttcttataga
2161 taaagtcaaa gatgattctg acattgtcaa gaaagaattt gcttctatac ttggtcaact
2221 tgtctgtact cttcacggca tgttttatct gacaagttct ttaacagaac ctttctctga
2281 acacggacat gtggacctct tctgtaggaa cttgaaagcc acttctcaac atgaatgttc
2341 atcttctcaa ctaaaagctt ctgtctgcaa gccattcctt ttcctactga aaaaaaaaat
2401 acctagtcca gtaaaacttg ctttcataga taatctacat catctttgta agcatcttga
2461 ttttagagaa gatgaaacag atgtaaaagc agttcttgga actttattaa atttaatgga
2521 agatccagac aaagatgtta gagtggcttt tagtggaaat atcaagcaca tattggaatc
2581 cttggactct gaagatggat ttataaagga gctttttgtc ttaagaatga aggaagcata
2641 tacacatgcc caaatatcaa gaaataatga gctgaaggat accttgattc ttacaacagg
2701 ggatattgga agggccgcaa aaggagattt ggtaccattt gcactcttac acttattgca
2761 ttgtttgtta tccaagtcag catctgtctc tggagcagca tacacagaaa ttagagctct
2821 ggttgcagct aaaagtgtta aactgcaaag ttttttcagc cagtataaga aacccatctg
2881 tcagtttttg gtagaatccc ttcactctag tcagatgaca gcacttccga atactccatg
2941 ccagaatgct gacgtgcgaa aacaagatgt ggctcaccag agagaaatgg ctttaaatac
3001 gttgtctgaa attgccaacg ttttcgactt tcctgatctt aatcgttttc ttactaggac
3061 attacaagtt ctactacctg atcttgctgc caaagcaagc cctgcagctt ctgctctcat
3121 tcgaacttta ggaaaacaat taaatgtcaa tcgtagagag attttaataa acaacttcaa
3181 atatattttt tctcatttgg tctgttcttg ttccaaagat gaattagaac gtgcccttca
3241 ttatctgaag aatgaaacag aaattgaact ggggagcctg ttgagacaag atttccaagg
3301 attgcataat gaattattgc tgcgtattgg agaacactat caacaggttt ttaatggttt
3361 gtcaatactt gcctcatttg catccagtga tgatccatat cagggcccga gagatatcat
3421 atcacctgaa ctgatggctg attatttaca acccaaattg ttgggcattt tggctttttt
3481 taacatgcag ttactgagct ctagtgttgg cattgaagat aagaaaatgg ccttgaacag
3541 tttgatgtct ttgatgaagt taatgggacc caaacatgtc agttctgtga gggtgaagat
3601 gatgaccaca ctgagaactg gccttcgatt caaggatgat tttcctgaat tgtgttgcag
3661 agcttgggac tgctttgttc gctgcctgga tcatgcttgt ctgggctccc ttctcagtca
3721 tgtaatagta gctttgttac ctcttataca catccagcct aaagaaactg cagctatctt
3781 ccactacctc ataattgaaa acagggatgc tgtgcaagat tttcttcatg aaatatattt
3841 tttacctgat catccagaat taaaaaagat aaaagccgtt ctccaggaat acagaaagga
3901 gacctctgag agcactgatc ttcagacaac tcttcagctc tctatgaagg ccattcaaca
3961 tgaaaatgtc gatgttcgta ttcatgctct tacaagcttg aaggaaacct tgtataaaaa
4021 tcaggaaaaa ctgataaagt atgcaacaga cagtgaaaca gtagaaccta ttatctcaca
4081 gttggtgaca gtgcttttga aaggttgcca agatgcaaac tctcaagctc ggttgctctg
4141 tggggaatgt ttaggggaat tgggggcgat agatccaggt cgattagatt tctcaacaac
4201 tgaaactcaa ggaaaagatt ttacatttgt gactggagta gaagattcaa gctttgccta
4261 tggattattg atggagctaa caagagctta ccttgcgtat gctgataata gccgagctca
4321 agattcagct gcctatgcca ttcaggagtt gctttctatt tatgactgta gagagatgga
4381 gaccaacggc ccaggtcacc aattgtggag gagatttcct gagcatgttc gggaaatact
4441 agaacctcat ctaaatacca gatacaagag ttctcagaag tcaaccgatt ggtctggagt
4501 aaagaagcca atttacttaa gtaaattggg tagtaacttt gcagaatggt cagcatcttg
4561 ggcaggttat cttattacaa aggttcgaca tgatcttgcc agtaaaattt tcacctgctg
4621 tagcattatg atgaagcatg atttcaaagt gaccatctat cttcttccac atattctggt
4681 gtatgtctta ctgggttgta atcaagaaga tcagcaggag gtttatgcag aaattatggc
4741 agttctaaag catgacgatc agcataccat aaatacccaa gacattgcat ctgatctgtg
4801 tcaactcagt acacagactg tgttctccat gcttgaccat ctcacacagt gggcaaggca
4861 caaatttcag gcactgaaag ctgagaaatg tccacacagc aaatcaaaca gaaataaggt
4921 agactcaatg gtatctactg tggattatga agactatcag agtgtaaccc gttttctaga
4981 cctcataccc caggatactc tggcagtagc ttcctttcgc tccaaagcat acacacgagc
5041 tgtaatgcac tttgaatcat ttattacaga aaagaagcaa aatattcagg aacatcttgg
5101 atttttacag aaattgtatg ctgctatgca tgaacctgat ggagtggccg gagtcagtgc
5161 aattagaaag gcagaaccat ctctaaaaga acagatcctt gaacatgaaa gccttggctt
5221 gctgagggat gccactgctt gttatgacag ggctattcag ctagaaccag accagatcat
5281 tcattatcat ggtgtagtaa agtccatgtt aggtcttggt cagctgtcta ctgttatcac
5341 tcaggtgaat ggagtgcatg ctaacaggtc cgagtggaca gatgaattaa acacgtacag
5401 agtggaagca gcttggaaat tgtcacagtg ggatttggtg gaaaactatt tggcagcaga
5461 tggaaaatct acaacatgga gtgtcagact gggacagcta ttattatcag ccaaaaaaag
5521 agatatcaca gctttttatg actcactgaa actagtgaga gcagaacaaa ttgtacctct
5581 ttcagctgca agctttgaaa gaggctccta ccaacgagga tatgaatata ttgtgagatt
5641 gcacatgtta tgtgagttgg agcatagcat caaaccactt ttccagcatt ctccaggtga
5701 cagttctcaa gaagattctc taaactgggt agctcgacta gaaatgaccc agaattccta
5761 cagagccaag gagcctatcc tggctctccg gagggcttta ctaagcctca acaaaagacc
5821 agattacaat gaaatggttg gagaatgctg gctgcagagt gccagggtag ctagaaaggc
5881 tggtcaccac cagacagcct acaatgctct ccttaatgca ggggaatcac gactcgctga
5941 actgtacgtg gaaagggcaa agtggctctg gtccaagggt gatgttcacc aggcactaat
6001 tgttcttcaa aaaggtgttg aattatgttt tcctgaaaat gaaaccccac ctgagggtaa
6061 gaacatgtta atccatggtc gagctatgct actagtgggc cgatttatgg aagaaacagc
6121 taactttgaa agcaatgcaa ttatgaaaaa atataaggat gtgaccgcgt gcctgccaga
6181 atgggaggat gggcattttt accttgccaa gtactatgac aaattgatgc ccatggtcac
6241 agacaacaaa atggaaaagc aaggtgatct catccggtat atagttcttc attttggcag
6301 atctctacaa tatggaaatc agttcatata tcagtcaatg ccacgaatgt taactctatg
6361 gcttgattat ggtacaaagg catatgaatg ggaaaaagct ggccgctccg atcgtgtaca
6421 aatgaggaat gatttgggta aaataaacaa ggttatcaca gagcatacaa actatttagc
6481 tccatatcaa tttttgactg ctttttcaca attgatctct cgaatttgtc attctcacga
6541 tgaagttttt gttgtcttga tggaaataat agccaaagta tttctagcct atcctcaaca
6601 agcaatgtgg atgatgacag ctgtgtcaaa gtcatcttat cccatgcgtg tgaacagatg
6661 caaggaaatc ctcaataaag ctattcatat gaaaaaatcc ttagagaagt ttgttggaga
6721 tgcaactcgc ctaacagata agcttctaga attgtgcaat aaaccggttg atggaagtag
6781 ttccacatta agcatgagca ctcattttaa aatgcttaaa aagctggtag aagaagcaac
6841 atttagtgaa atcctcattc ctctacaatc agtcatgata cctacacttc catcaattct
6901 gggtacccat gctaaccatg ctagccatga accatttcct ggacattggg cctatattgc
6961 agggtttgat gatatggtgg aaattcttgc ttctcttcag aaaccaaaga agatttcttt
7021 aaaaggctca gatggaaagt tctacatcat gatgtgtaag ccaaaagatg acctgagaaa
7081 ggattgtaga ctaatggaat tcaattcctt gattaataag tgcttaagaa aagatgcaga
7141 gtctcgtaga agagaacttc atattcgaac atatgcagtt attccactaa atgatgaatg
7201 tgggattatt gaatgggtga acaacactgc tggtttgaga cctattctga ccaaactata
7261 taaagaaaag ggagtgtata tgacaggaaa agaacttcgc cagtgtatgc taccaaagtc
7321 agcagcttta tctgaaaaac tcaaagtatt ccgagaattt ctcctgccca ggcatcctcc
7381 tatttttcat gagtggtttc tgagaacatt ccctgatcct acatcatggt acagtagtag
7441 atcagcttac tgccgttcca ctgcagtaat gtcaatggtt ggttatattc tggggcttgg
7501 agaccgtcat ggtgaaaata ttctctttga ttctttgact ggtgaatgcg tacatgtaga
7561 tttcaattgt cttttcaata agggagaaac ctttgaagtt ccagaaattg tgccatttcg
7621 cctgactcat aatatggtta atggaatggg tcctatggga acagagggtc tttttcgaag
7681 agcatgtgaa gttacaatga ggctgatgcg tgatcagcga gagcctttaa tgagtgtctt
7741 aaagactttt ctacatgatc ctcttgtgga atggagtaaa ccagtgaaag ggcattccaa
7801 agcgccactg aatgaaactg gagaagttgt caatgaaaag gccaagaccc atgttcttga
7861 cattgagcag cgactacaag gtgtaatcaa gactcgaaat agagtgacag gactgccgtt
7921 atctattgaa ggacatgtgc attaccttat acaagaagct actgatgaaa acttactatg
7981 ccagatgtat cttggttgga ctccatatat gtgaaatgaa attatgtaaa agaatatgtt
8041 aataatctaa aagtaatgca tttggtatga atctgtggtt gtatctgttc aattctaaag
8101 tacaacataa atttacgttc tcagcaactg ttatttctct ctgatcatta attatatgta
8161 aaataatata cattcagtta ttaagaaata aactgctttc ttaataaaaa aaaaaaaaaa
8221 aaaaaaaaaa aaaaaaaaa
//