LOCUS AH003329 5471 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens CTLA-4 counter-receptor B7.2 (B7.2) gene, complete cds. ACCESSION AH003329 U17715 U17716 U17717 U17718 U17719 U17720 U17721 U17722 VERSION AH003329.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (sites) AUTHORS Azuma,M., Ito,D., Yagita,H., Okumura,K., Phillips,J.H., Lanier,L.L. and Somoza,C. TITLE B70 antigen is a second ligand for CTLA-4 and CD28 JOURNAL Nature 366 (6450), 76-79 (1993) PUBMED 7694153 REFERENCE 2 (bases 173 to 292; 579 to 1050; 1151 to 1634; 1735 to 2475; 2576 to 3312; 3413 to 3983; 4084 to 4741; 4842 to 5471) AUTHORS Freeman,G.J., Gribben,J.G., Boussiotis,V.A., Ng,J.W., Restivo,V.A. Jr., Lombard,L.A., Gray,G.S. and Nadler,L.M. TITLE Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation JOURNAL Science 262 (5135), 909-911 (1993) PUBMED 7694363 REFERENCE 3 (bases 1 to 5471) AUTHORS Jellis,C.L., Wang,S.S., Rennert,P., Borriello,F., Sharpe,A.H., Green,N.R. and Gray,G.S. TITLE Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86) JOURNAL Immunogenetics 42 (2), 85-89 (1995) PUBMED 7541777 REFERENCE 4 (bases 1 to 5471) AUTHORS Jellis,C.L. TITLE Direct Submission JOURNAL Submitted (29-NOV-1994) Cindy L. Jellis, Molecular Biology, Repligen Corporation, One Kendall Square, Building 700, Cambridge, MA 02139, USA COMMENT On or before Jun 10, 2016 this sequence version replaced U17715.1, U17716.1, U17717.1, U17718.1, U17719.1, U17720.1, U17721.1, U17722.1, AH003329.1. FEATURES Location/Qualifiers source 1..5471 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 1..478 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1390-A1 hB7.2 genomic DNA (exon 1)" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 579..1050 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1390-A1" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 1151..1634 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1307-7C Human B7.2 genomic DNA" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 1735..2475 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1307-7C" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 2576..3312 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1307-7C" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 3413..3983 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1307-7C" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 4084..4741 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1-1307-7C" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" source 4842..5471 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /clone="DMPC-HFF no.1" /sex="male" /cell_type="fibroblast" /tissue_type="foreskin" /clone_lib="Du Pont Merck Pharmaceutical Company Human foreskin Fibroblast P1 Library no.1" gene 173..5177 /gene="B7.2" exon 173..292 /gene="B7.2" /note="alternative 5' exon" /citation=[2] /citation=[3] /number=1 mRNA join(279..292,1411..1460,1975..2310,2727..3029,3582..3725, 4357..4402,5064..5177) /gene="B7.2" /note="starts with alternative first exon 1" /citation=[2] gap 479..578 /estimated_length=unknown mRNA join(678..819,1411..1460,1975..2310,2727..3029,3582..3725, 4357..4402,5064..5177) /gene="B7.2" /note="starts with alternative first exon 2" /citation=[1] exon 678..819 /gene="B7.2" /note="alternative 5' exon" /citation=[1] /citation=[3] /number=2 gap 1051..1150 /estimated_length=unknown exon 1411..1460 /gene="B7.2" /number=3 CDS join(1415..1460,1975..2310,2727..3029,3582..3725, 4357..4402,5064..5160) /gene="B7.2" /codon_start=1 /product="CTLA-4 counter-receptor B7.2" /protein_id="AAA86473.1" /translation="MGLSNILFVMAFLLSGAAPLEIQAYFNETADLPCQFANSQNQSL SELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLY QCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEP KKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDK TRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKC GTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF" gap 1635..1734 /estimated_length=unknown exon 1975..2310 /gene="B7.2" /number=4 gap 2476..2575 /estimated_length=unknown exon 2727..3029 /gene="B7.2" /number=5 gap 3313..3412 /estimated_length=unknown exon 3582..3725 /gene="B7.2" /number=6 gap 3984..4083 /estimated_length=unknown exon 4357..4402 /gene="B7.2" /number=7 gap 4742..4841 /estimated_length=unknown exon 5064..5177 /gene="B7.2" /number=8 BASE COUNT 1302 a 1014 c 1062 g 1393 t ORIGIN 1 actgaattat atattcttta atacatatag acctacgtca atgagtttaa actgcaagga 61 aagggttaaa tttcttcctc aagtgtggtc aaaatctgta gagaaaagag gaacagcttc 121 tcttaaagaa agttagctgg gtaggtatac agacattgcc gaggaaggct tgcacagggt 181 gaaagctttg cttctctgct gctgtaacag ggactagcac agacacacgg atgagtgggg 241 tcatttccag atattaggtc acagcagaag cagccaaaat ggatccccag tggtgagtaa 301 taattcttat tctttgcaga gaagttatga gttgtgactg cagggaaagg ctgaggttga 361 agatggtgct ttgatgtgtg tccttcactt agttcctaag tggagaagct ttctttttct 421 acaaaagatc tttggcacat aaaggcaaga attatttgca atgcccaaag cagttcatnn 481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntc cctggctgtg gtgttgtttc 601 tctgtttctt ttcccccttc tgtttttttc tgtatttgag ttctaccgtc agtcctggca 661 ttatttctct ctcgacaagg agccttagga ggtgcgggga gctcgcgata ctccttttgg 721 tttattctta ccaccttgct tctgtgttcc ttgggaatgc tgctgtgctt atgcatctgg 781 tctctttttg gagctacagt ggacaggcat ttgtgacagg tatgtttgtg gaggctcaga 841 cgcctaggga gtggcatgag ataaagctgc aagctgcatc tggggcagaa atgctgatgt 901 gctaatggcc ggccagagaa tgagtaaaag ggattgcaga gagcatgctt aaaacctctg 961 accatgcagg tttgcttctc agattgacta cattggaggt gggatattac aaaaatctgt 1021 ctcttcctgc cagatccctt catctgtttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1141 nnnnnnnnnn agaaacatct tttctgccca caattccatt ggctagaaac cagtctcatg 1201 gcctgtataa ctgcagggga ggctgggaaa tgtgacctat cgatggagct aagagcaaaa 1261 ggaaatggct ttgatgaagc cctggcattg tctctgcaca cccgagaacc caagtgaatc 1321 ccaaactcca cgtccaggtc atgttttggt gaacatcggt tttcagtttc cttttctaat 1381 caagttttac cttttttttc tcgactctag cactatggga ctgagtaaca ttctctttgt 1441 gatggccttc ctgctctctg gtaagaacct ttcagctttg ttaagtcctg gaatcctact 1501 gtctcctgat gagtctgacc acaggaagcc aggcctgaga cttggggggt tttactcact 1561 ttctactgag cattggacaa gaccacatgc aaaaaagact ttcctggaga agaaggaagt 1621 gttatgattg agagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaactga 1741 ggctcatgaa gagttgcagg ttgtaccagg ccacacattt agtcagcggt gaagccagga 1801 ccaaggtcct aatctccaga tgcccagcag atgtgcacag ttccagaact taatatctta 1861 ttcttcagca tgattactga taagatagta tctgggtatt gtataaagag aaatggaggt 1921 tttttcccct ttcctcttgt ttctccctcc ctaatcctta accttctttt ttaggtgctg 1981 ctcctctgga gattcaagct tatttcaatg agactgcaga cctgccatgc caatttgcaa 2041 actctcaaaa ccaaagcctg agtgagctag tagtattttg gcaggaccag gaaaacttgg 2101 ttctgaatga ggtatactta ggcaaagaga aatttgacag tgttcattcc aagtatatgg 2161 gccgcacaag ttttgattcg gacagttgga ccctgagact tcacaatctt cagatcaagg 2221 acaagggctt gtatcaatgt atcatccatc acaaaaagcc cacaggaatg attcgcatcc 2281 accagatgaa ttctgaactg tcagtgcttg gtatgtggtc aatggtgtgt gttcagattc 2341 ttagccttct cagatgagac tgcaaatgag ttagaaaaac actggagggg gacttgaggg 2401 gcccagggga aaaggggggt ctatagagag aaggcagagg acagccactt ctgggaagtg 2461 catttgaagg gagtgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnctcac 2581 cttgggctga gggtcacatt ttagacaccc tgaggctccc aggtgtgccc caatgagccc 2641 cagatcaagt acccagttat ttgctattcc ctcctagata catctaaact tagattgatt 2701 tttttttatc tctcttctgc tttcagctaa cttcagtcaa cctgaaatag taccaatttc 2761 taatataaca gaaaatgtgt acataaattt gacctgctca tctatacacg gttacccaga 2821 acctaagaag atgagtgttt tgctaagaac caagaattca actatcgagt atgatggtat 2881 tatgcagaaa tctcaagata atgtcacaga actgtacgac gtttccatca gcttgtctgt 2941 ttcattccct gatgttacga gcaatatgac catcttctgt attctggaaa ctgacaagac 3001 gcggctttta tcttcacctt tctctatagg taaagctgtt ttccaagact atttctttca 3061 gcaggtatta tacacaaatg cttaaggcag atcatccaat gtccccgact tgctaggaaa 3121 cctccaactg ggccatttta tgacgctgtt aggaaggacc cagatggagg tctcctgctt 3181 ctcctgagtg atgcagggtc caggaggcta cgagcctatg ttgcacttga agaaatatgc 3241 ttttagccct gaaactgact cagtctcttg gcttaccttt ggatggagga ttctgaagtc 3301 tcgattttaa aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnctgaggcc 3421 ctgagcctgg gactttctat ggcctcctat tgtggatttc aggcttctct ggccttagag 3481 ccctggggag aggctggcag gtaaatggag agaagagcag ctagcagaaa ccttttgtaa 3541 atgactctcc tggctgattg aaaatttgtg gtcatttgta gagcttgagg accctcagcc 3601 tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta tatgtgtgat 3661 ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca actcttataa 3721 atgtggtgag tgagtccttg tcctccccac agactgtcac tttgcaccta cttcccaatc 3781 ggctggctgc cttccggagc ttgttggctg agcctagact ggcaaaaagt caggaagttg 3841 ttgggaaaaa aggttttccc ttggagtttt gagcctatac agactggcag tagcagataa 3901 tgctgctctc ggacttcata gaaaggcgac atttctaacc tctggtttta caatgtactt 3961 ctggtttcca ggaaaactga attnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4081 nnnttttggt tagccaggat agagatataa gtgggagatc tatttccagt gttagaattt 4141 aaggcacagt gagaaaggga aggcatatac tttttgaatg caagaaactt cttcccaatc 4201 cccctgaaat tgcatcattt gagtaactat ctcttccata tataaagtca caacaatttc 4261 tctctcagtc ccagaacttt gaagcctttt caaactttcc ttcttttggt atctaggagg 4321 aatagatttt tgaagattgt tcttggtgtc tttcaggaac caacacaatg gagagggaag 4381 agagtgaaca gaccaagaaa aggcaaatcc tgaccctgag acattgatga gagaggtata 4441 atccccagag tgcctgttac ttgaataggc ttatgcctaa catatgttga gacctcagca 4501 aacctgaact aatggagagg gagaggaaaa taaaactagt taagaactgg aagaaaataa 4561 cctgataatg gatgacaggg tatccaatgc acaatgccca gaaagcatga caagctctgt 4621 catggtcaag taaaagtcaa taccaaagac ttcagaggtg gtgaacatgg gcttcatctt 4681 atctgccaca gtaaccccag gtacctggca cagtgcccta gatttagtgg gcatcccctc 4741 annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ncatgggaag gcccaggcag 4861 aaataaaggg tagctcatga agcatagatg acagtgtaga ccgtggttct tttctcttgc 4921 tttctccacc tttctcttca atagtttgtt tctcctcatt gctgttccaa tggcaacctc 4981 tattctgccc tatcattgaa atctagaaaa agaaagtagc tcaaatgtga aatatcacct 5041 aatcttttct tctatttctc cagagaaaaa atccatatac ctgaaagatc tgatgaagcc 5101 cagcgtgttt ttaaaagttc gaagacatct tcatgcgaca aaagtgatac atgtttttaa 5161 ttaaagagta aagcccatac aagtattcat tttttctacc ctttcctttg taagttcctg 5221 ggcaaccttt ttgatttctt ccagaaggca aaaagacatt accatgagta ataagggggc 5281 tccaggactc cctctaagtg gaatagcctc cctgtaactc cagctctgct ccgtatgaca 5341 agaggagact ttaattctct tactgcttct tttcacttca gagcacactt atgggccaag 5401 cccagcttaa tggctcatga cctggaaata aaatttagga ccaatacctc ctccagatca 5461 gattcttctc t //