LOCUS AJ006288 1877 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for bcl-10 protein.
ACCESSION AJ006288
VERSION AJ006288.1
KEYWORDS bcl-10 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1877)
AUTHORS Willis A.G.
JOURNAL Submitted (21-MAY-1998) to the INSDC. Willis A.G., Academic
Haematology, Institute Of Cancer Research, Sutton, Surrey SM2 5NG,
UK.
REFERENCE 2
AUTHORS Willis T.G., Jadayel D.M., Du M.Q., Peng H., Perry A.R.,
Abdul-Rauf M., Price H., Karran L., Majekodunmi O., Wlodarska I.,
Pan L., Crook T., Hamoudi R., Isaacson P., Dyer M.J.
TITLE Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and
mutated in multiple tumor types
JOURNAL Cell 96(1), 35-45(1999).
PUBMED 9989495
FEATURES Location/Qualifiers
source 1..1877
/db_xref="H-InvDB:HIT000244101"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="germinal centre B-cell"
/db_xref="taxon:9606"
CDS 691..1392
/gene="bcl-10"
/function="CARD-containing protein. Promotes apoptosis,
activates NF-kappaB and suppresses transformation of rat
embryo fibroblasts (REFs). Bcl10 is mutated in multiple
tumor types"
/db_xref="GOA:O95999"
/db_xref="H-InvDB:HIT000244101.13"
/db_xref="HGNC:HGNC:989"
/db_xref="InterPro:IPR001315"
/db_xref="InterPro:IPR011029"
/db_xref="InterPro:IPR033238"
/db_xref="InterPro:IPR042143"
/db_xref="PDB:2MB9"
/db_xref="PDB:6BZE"
/db_xref="PDB:6GK2"
/db_xref="UniProtKB/Swiss-Prot:O95999"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA06955.1"
/translation="MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK
KILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDE
VLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGES
STTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANS
SEMFLPLRSRTVSRQ"
BASE COUNT 502 a 451 c 409 g 515 t
ORIGIN
1 gctttcccgt ttcttaaaca ttggcgttcc caagtttctc cttggtcctc ctgtcatttt
61 tatctactct cgtagcttca aataccatct agtttatagt ttatttagca tgttgttcaa
121 gccaccgtct tgggcccagg gctctacctg tagcttttca tccacacttc tcaggttgct
181 tcttacacag cgccatagta gttaaaatac ggtctgggga tagtcgtctc ttcatcagtc
241 tcccccgacg acctgcgcag gcgtggcttg aggaaacgcc cgctgtgggc ggagccaccc
301 gaaaggctcc ggtcgggggc gggaacagga tcggcccgcg ggctggcgtc gataggctgc
361 cgcagagaca gggcgggctc tgctaaggga cgcgcctcgc cgtggggcgg tgcctgcgcc
421 tgagcctcta cgagagggaa ggaacgctgc tccgagctcc gcgtcgcgtc gcgtagattc
481 gcgtcgccgt cgacctcaga ggcggggccg gaagcgctac ggtttgaccc ccgagtccct
541 ctgttcccga aggggcggcc gtctttctgc cgacccgctc cgcctcctct ccttcttccc
601 cattacccgg aggccgaagc ccccagccag ggcggggcgg cgcagcccga gctcccggac
661 ccggaagaag cgccatctcc cgcctccacc atggagccca ccgcaccgtc cctgaccgag
721 gaggacctca ctgaagtgaa gaaggacgcc ttagaaaatt tacgtgtata cctgtgtgag
781 aaaatcatag ctgagagaca ttttgatcat ctacgtgcaa aaaaaatact cagtagagaa
841 gacactgaag aaatttcttg tcgaacatca agtagaaaaa gggctggaaa attgttagac
901 tacttacagg aaaacccaaa aggtctggac acccttgttg aatctattcg gcgagaaaaa
961 acacagaact tcctgataca gaagattaca gatgaagtgc tgaaacttag aaatataaaa
1021 ctagaacatc tgaaaggact aaaatgtagc agttgtgaac cttttccaga tggagccacg
1081 aacaacctct ccagatcaaa ttcagatgag agtaatttct ctgaaaaact gagggcatcc
1141 actgtcatgt accatccaga aggagaatcc agcacgacgc cctttttttc tactaattct
1201 tctctgaatt tgcctgttct agaagtaggc agaactgaaa ataccatctt ctcttcaact
1261 acacttccca gacctgggga cccaggggct cctcctttgc caccagatct acagttagaa
1321 gaagaaggaa cttgtgcaaa ctctagtgag atgtttcttc ccttaagatc acgtactgtt
1381 tcacgacaat gacactttat tgccttttaa tttttaatga tgacaaaaaa tgttttaaag
1441 aatatgactt tttataaaat ggctgtaatc atttgtttac atttgatgca tgtcttttaa
1501 aatgcaatgt aagcatactt tgtaaatagg atttttagaa ttaaaaaagc atacttctag
1561 gatagctaac tgtaaatcat gttgatcatg tactttttag taatttcttt ttttcctttt
1621 taaggtcttt cagtactttt ttaaatattt tctattttaa gactgatttt aatagggaat
1681 atatctctat ttgagaatag acccttacta ggaagaacgt tttttcctca gtgcatttgt
1741 gctagaaatt ttcaagagtc taatagtctt tgccagtcat tcagcagcaa attttcagca
1801 ttaagctgtt cctgttcagt aataaaaccg gtcactgatg ggaaaactgc caatatagaa
1861 aaataaaaat ctctttt
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