LOCUS AF262240 1358 bp mRNA linear HUM 26-JUL-2000
DEFINITION Homo sapiens Smac mRNA, complete cds; nuclear gene for
mitochondrial product.
ACCESSION AF262240
VERSION AF262240.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1358)
AUTHORS Du,C., Fang,M., Li,Y., Li,L. and Wang,X.
TITLE Smac, a mitochondrial protein that promotes cytochrome c-dependent
caspase activation by eliminating IAP inhibition
JOURNAL Cell 102 (1), 33-42 (2000)
PUBMED 10929711
REFERENCE 2 (bases 1 to 1358)
AUTHORS Du,C., Fang,M., Li,Y. and Wang,X.
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2000) Howard Hughes Medical Institute and
Department of Biochemstry, University of Texas Southwestern Medical
Center, 5323 Harry Hines Blvd., Dallas, TX 75235, USA
FEATURES Location/Qualifiers
source 1..1358
/db_xref="H-InvDB:HIT000075451"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 20..739
/function="binds IAPs and neutralizes their inhibition on
caspase activation and activity"
/note="antagonist of IAPs (inhibitors of apoptosis)"
/codon_start=1
/product="Smac"
/protein_id="AAF87716.1"
/translation="MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHK
TVTIGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITE
YTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTA
VGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQ
KTQEEGEERAESEQEAYLRED"
transit_peptide 20..184
/note="mitochondrial targeting sequence"
BASE COUNT 341 a 314 c 358 g 345 t
ORIGIN
1 ggcgtccgcg cgctgcacaa tggcggctct gaagagttgg ctgtcgcgca gcgtaacttc
61 attcttcagg tacagacagt gtttgtgtgt tcctgttgtg gctaacttta agaagcggtg
121 tttctcagaa ttgataagac catggcacaa aactgtgacg attggctttg gagtaaccct
181 gtgtgcggtt cctattgcac agaaatcaga gcctcattcc cttagtagtg aagcattgat
241 gaggagagca gtgtctttgg taacagatag cacctctacc tttctctctc agaccacata
301 tgcgttgatt gaagctatta ctgaatatac taaggctgtt tataccttaa cttctcttta
361 ccgacaatat acaagtttac ttgggaaaat gaattcagag gaggaagatg aagtgtggca
421 ggtgatcata ggagccagag ctgagatgac ttcaaaacac caagagtact tgaagctgga
481 aaccacttgg atgactgcag ttggtctttc agagatggca gcagaagctg catatcaaac
541 tggcgcagat caggcctcta taaccgccag gaatcacatt cagctggtga aactgcaggt
601 ggaagaggtg caccagctct cccggaaagc agaaaccaag ctggcagaag cacagataga
661 agagctccgt cagaaaacac aggaggaagg ggaggagcgg gctgagtcgg agcaggaggc
721 ctacctgcgt gaggattgag ggcctgagca cactgccctg tctccccact cagtggggaa
781 agcaggggca gatgccaccc tgcccagggt tggcatgact gtctgtgcac cgagaagagg
841 cggcaggtcc tgccctggcc aatcaggcga gacgcctttg tgagctgtga gtgcctcctg
901 tggtctcagg cttgcgctgg acctggttct tagcccttgg gcactgcacc ctgtttaaca
961 tttcacccca ctctgtacag ctgctcttac ccattttttt tacctcacac ccaaagcatt
1021 ttgcctacct gggtcagaga gaggagtcct ttttgtcatg cccttaagtt cagcaactgt
1081 ttaacctgtt ttcagtctta tttacgtcgt caaaaatgat ttagtacttg ttccctctgt
1141 tgggatgcca gttgtggcag ggggagggga acctgtccag tttgtacgat ttctttgtat
1201 gtatttctga tgtgttctct gatctgcccc cactgtcctg tgaggacagc tgaggccaag
1261 gagtgaaaaa cctattacta ctaagagaag gggtgcagag tgtttacctg gtgctctcaa
1321 caggacttaa catcaacagg acttaacaca gaaaaaaa
//