LOCUS       AAF87716.1               239 aa    PRT              HUM 26-JUL-2000
DEFINITION  Homo sapiens Smac protein.
ACCESSION   AF262240-1
PROTEIN_ID  AAF87716.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Du,C., Fang,M., Li,Y., Li,L. and Wang,X.
  TITLE     Smac, a mitochondrial protein that promotes cytochrome c-dependent
            caspase activation by eliminating IAP inhibition
  JOURNAL   Cell 102 (1), 33-42 (2000)
   PUBMED   10929711
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Du,C., Fang,M., Li,Y. and Wang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAY-2000) Howard Hughes Medical Institute and
            Department of Biochemstry, University of Texas Southwestern Medical
            Center, 5323 Harry Hines Blvd., Dallas, TX 75235, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000075451"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     protein         /function="binds IAPs and neutralizes their inhibition on
                     caspase activation and activity"
                     /note="antagonist of IAPs (inhibitors of apoptosis)"
BEGIN
        1 MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA
       61 QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL
      121 LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS
      181 ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED
//