LOCUS AAF87716.1 239 aa PRT HUM 26-JUL-2000 DEFINITION Homo sapiens Smac protein. ACCESSION AF262240-1 PROTEIN_ID AAF87716.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1358) AUTHORS Du,C., Fang,M., Li,Y., Li,L. and Wang,X. TITLE Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition JOURNAL Cell 102 (1), 33-42 (2000) PUBMED 10929711 REFERENCE 2 (bases 1 to 1358) AUTHORS Du,C., Fang,M., Li,Y. and Wang,X. TITLE Direct Submission JOURNAL Submitted (01-MAY-2000) Howard Hughes Medical Institute and Department of Biochemstry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235, USA FEATURES Qualifiers source /db_xref="H-InvDB:HIT000075451" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" protein /function="binds IAPs and neutralizes their inhibition on caspase activation and activity" /note="antagonist of IAPs (inhibitors of apoptosis)" BEGIN 1 MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA 61 QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL 121 LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS 181 ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED //