LOCUS AF175265 2726 bp mRNA linear HUM 22-DEC-2000
DEFINITION Homo sapiens vacuolar sorting protein 35 (VPS35) mRNA, complete
cds.
ACCESSION AF175265
VERSION AF175265.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2726)
AUTHORS Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
and Taylor,S.I.
TITLE Human orthologs of yeast vacuolar protein sorting proteins Vps26,
29, and 35: assembly into multimeric complexes
JOURNAL Mol. Biol. Cell 11 (12), 4105-4116 (2000)
PUBMED 11102511
REFERENCE 2 (bases 1 to 2726)
AUTHORS Renfrew Haft,C., Sierra,L. and Taylor,S.I.
TITLE Direct Submission
JOURNAL Submitted (04-AUG-1999) Diabetes Branch, National Institutes of
Health, 10 Center Dr., MSC-1770, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..2726
/db_xref="H-InvDB:HIT000072619"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HCC"
/cell_type="carcinoma"
/tissue_type="colon"
gene 1..2726
/gene="VPS35"
CDS 58..2448
/gene="VPS35"
/note="retromer protein; similar to MEM3"
/codon_start=1
/product="vacuolar sorting protein 35"
/protein_id="AAF89953.1"
/translation="MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALK
HASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAG
NIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNI
LPDEGEPPDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRI
LVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHL
QTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVAT
VIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSS
AVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTE
IVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYL
ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQ
TISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQ
LAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRN
TDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTI
QVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLRRESPESEGPIYEGLIL"
BASE COUNT 823 a 545 c 599 g 759 t
ORIGIN
1 aggaattcgg cacgaggcgg ggcgggtgct gcttgctgca ggctctgggg agtcgccatg
61 cctacaacac agcagtcccc tcaggatgag caggaaaagc tcttggatga agccatacag
121 gctgtgaagg tccagtcatt ccaaatgaag agatgcctgg acaaaaacaa gcttatggat
181 gctctaaaac atgcttctaa tatgcttggt gaactccgga cttctatgtt atcaccaaag
241 agttactatg aactttatat ggccatttct gatgaactgc actacttgga ggtctacctg
301 acagatgagt ttgctaaagg aaggaaagtg gcagatctct acgaacttgt acagtatgct
361 ggaaacatta tcccaaggct ttaccttttg atcacagttg gagttgtata tgtcaagtca
421 tttcctcagt ccaggaagga tattttgaaa gatttggtag aaatgtgccg tggtgtgcaa
481 catcccttga ggggtctgtt tcttcgaaat taccttcttc agtgtaccag aaatatctta
541 cctgatgaag gagagccacc agatgaagaa acaactggtg acatcagtga ttccatggat
601 tttgtactgc tcaactttgc agaaatgaac aagctctggg tgcgaatgca gcatcaggga
661 catagccgag atagagaaaa aagagaacga gaaagacaag aactgagaat tttagtggga
721 acaaatttgg tgcgcctcag tcagttggaa ggtgtaaatg tggaacgtta caaacagatt
781 gttttgactg gcatattgga gcaagttgta aactgtaggg atgctttggc tcaagaatat
841 ctcatggagt gtattattca ggttttccct gatgaatttc acctccagac tttgaatcct
901 tttcttcggg cctgtgctga gttacaccag aatgtaaatg tgaagaacat aatcattgct
961 ttaattgata gattagcttt atttgctcac cgtgaagatg gacctggaat cccagcggat
1021 attaaacttt ttgatatatt ttcacagcag gtggctacag tgatacagtc tagacaagac
1081 atgccttcag aggatgttgt atctttacaa gtctctctga ttaatcttgc catgaaatgt
1141 taccctgatc gtgtggacta tgttgataaa gttctagaaa caacagtgga gatattcaat
1201 aagctcaacc ttgaacatat tgctaccagt agtgcagttt caaaggaact caccagactt
1261 ttgaaaatac cagttgacac ttacaacaat attttaacag tcttgaaatt aaaacatttt
1321 cacccactct ttgagtactt tgactacgag tccagaaaga gcatgagttg ttatgtgctt
1381 agtaatgttc tggattataa cacagaaatt gtctctcaag accaggtgga ttccataatg
1441 aatttggtat ccacgttgat tcaagatcag ccagatcaac ctgtagaaga ccctgatcca
1501 gaagattttg ctgatgagca gagccttgtg ggccgcttca ttcatctgct gcgctctgag
1561 gaccctgacc agcagtactt gattttgaac acagcacgaa aacattttgg agctggtgga
1621 aatcagcgga ttcgcttcac actgccacct ttggtatttg cagcttacca gctggctttt
1681 cgatataaag agaattctaa agtggatgac aaatgggaaa agaaatgcca gaagattttt
1741 tcatttgccc accagactat cagtgctttg atcaaagcag agctggcaga attgccctta
1801 agactttttc ttcaaggagc actagctgct ggggaaattg gttttgaaaa tcatgagaca
1861 gtcgcatatg aattcatgtc ccaggcattt tctctgtatg aagatgaaat cagcgattcc
1921 aaagcacagc tagctgccat caccttgatc attggcactt ttgaaaggat gaagtgcttc
1981 agtgaagaga atcatgaacc tctgaggact cagtgtgccc ttgctgcatc caaacttcta
2041 aagaaacctg atcagggccg agctgtgagc acctgtgcac atctcttctg gtctggcaga
2101 aacacggaca aaaatgggga ggagcttcac ggaggcaaga gggtaatgga gtgcctaaaa
2161 aaagctctaa aaatagcaaa tcagtgcatg gacccctctc tacaagtgca gctttttata
2221 gaaattctga acagatatat ctatttttat gaaaaggaaa atgatgcggt aacaattcag
2281 gttttaaacc agcttatcca aaagattcga gaagacctcc cgaatcttga atccagtgaa
2341 gaaacagagc agattaacaa acattttcat aacacactgg agcatttgcg cttgcggcgg
2401 gaatcaccag aatccgaggg gccaatttat gaaggtctca tcctttaaaa aggaaatagc
2461 tcaccatact cctttccatg tacatccagt gagggtttta ttacgctagg tttcccttcc
2521 atagattgtg cctttcagaa atgctgaggt aggtttccca tttcttacct gtgatgtgtt
2581 ttacccagca cctccggaca ctcaccttca ggaccttaat aaaattattc acttggtaag
2641 tgttcaagtc tttctgatca ccccaagtag catgactgat ctgcaattta aaattcctgt
2701 gatctgtaaa aaaaaaaaaa aaaaaa
//