LOCUS AF002715 5445 bp mRNA linear HUM 03-SEP-1997
DEFINITION Homo sapiens MAP kinase kinase kinase (MTK1) mRNA, complete cds.
ACCESSION AF002715
VERSION AF002715.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5445)
AUTHORS Takekawa,M., Posas,F. and Saito,H.
TITLE A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinase,
MTK1, regulates the p38 and JNK pathways
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 5445)
AUTHORS Takekawa,M., Posas,F. and Saito,H.
TITLE Direct Submission
JOURNAL Submitted (06-MAY-1997) Division of Tumor Immunology, Dana-Farber
Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..5445
/db_xref="H-InvDB:HIT000061693"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5445
/gene="MTK1"
CDS 143..4966
/gene="MTK1"
/codon_start=1
/product="MAP kinase kinase kinase"
/protein_id="AAB68804.1"
/translation="MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEP
ECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRN
NVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKN
VQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDC
PADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRT
INDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKI
VGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQA
LCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE
LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGA
PDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR
PVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLL
NVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEK
PDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYI
RGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIIRSVIEIS
RALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIP
GLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSE
DSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTL
CQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQ
YYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTR
PRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHR
NSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAVAASRP
SPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYP
RGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV
CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN
DHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQE
HVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTM
PGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQ
IMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE"
BASE COUNT 1550 a 1199 c 1381 g 1315 t
ORIGIN
1 aagatggccg cggcgcgcac ggctcctgcg gcggggtaga ggcggaggcg gagtcgagtc
61 actcccgcac ttcggggctc cggtgccccg cgccaggctg cagcttactg cccgccgcgg
121 ccatgcgggg ctccgtgcac ggatgagaga agccgctgcc gcgctggtcc ctcctcccgc
181 ctttgccgtc acgcctgccg ccgccatgga ggagccgccg ccaccgccgc cgccgccacc
241 accgccaccg gaacccgaga ccgagtcaga acccgagtgc tgcttggcgg cgaggcaaga
301 gggcacattg ggagattcag cttgcaagag tcctgaatct gatctagaag acttctccga
361 tgaaacaaat acagagaatc tttatggtac ctctcccccc agcacacctc gacagatgaa
421 acgcatgtca accaaacatc agaggaataa tgtggggagg ccagccagtc ggtctaattt
481 gaaagaaaaa atgaatgcac caaatcagcc tccacataaa gacactggaa aaacagtgga
541 gaatgtggaa gaatacagct ataagcagga gaaaaagatc cgagcagctc ttagaacaac
601 agagcgtgat cataaaaaaa atgtacagtg ctcattcatg ttagactcag tgggtggatc
661 tttgccaaaa aaatcaattc cagatgtgga tctcaataag ccttacctca gccttggctg
721 tagcaatgct aagcttccag tatctgtgcc catgcctata gccagacctg cacgccagac
781 ttctaggact gactgtccag cagatcgttt aaagtttttt gaaactttac gacttttgct
841 aaagcttacc tcagtctcaa agaaaaaaga cagggagcaa agaggacaag aaaatacgtc
901 tggtttctgg cttaaccgat ctaacgaact gatctggtta gagctacaag cctggcatgc
961 aggacggaca attaacgacc aggacttctt tttatataca gcccgtcaag ccatcccaga
1021 tattattaat gaaatcctta ctttcaaagt cgactatggg agcttcgcct ttgttagaga
1081 tagagctggt tttaatggta cttcagtaga agggcagtgc aaagccactc ctggaacaaa
1141 gattgtaggt tactcaacac atcatgagca tctccaacgc cagagggtct catttgagca
1201 ggtaaaacgg ataatggagc tgctagagta catagaagca ctttatccat cattgcaggc
1261 tcttcagaag gactatgaaa aatatgctgc aaaagacttc caggacaggg tgcaggcact
1321 ctgtttgtgg ttaaacatca caaaagactt aaatcagaaa ttaaggatta tgggcactgt
1381 tttgggcatc aagaatttat cagacattgg ctggccagtg tttgaaatcc cttcccctcg
1441 accatccaaa ggtaatgagc cggagtatga gggtgatgac acagaaggag aattaaagga
1501 gttggaaagt agtacggatg agagtgaaga agaacaaatc tctgatccta gggtaccgga
1561 aatcagacag cccatagata acagcttcga catccagtcg cgggactgca tatccaagaa
1621 gcttgagagg ctcgaatctg aggatgattc tcttggctgg ggagcaccag actggagcac
1681 agaagcaggc tttagtagac attgtctgac ttctatttat agaccatttg tagacaaagc
1741 actgaagcag atggggttaa gaaagttaat tttaagactt cacaagctaa tggatggttc
1801 cttgcaaagg gcacgtatag cattggtaaa gaacgatcgt ccagtggagt tttctgaatt
1861 tccagatccc atgtggggtt cagattatgt gcagttgtca aggacaccac cttcatctga
1921 ggagaaatgc agtgctgtgt cgtgggagga gctgaaggcc atggatttac cttcattcga
1981 acctgccttc ctagttctct gccgagtcct tctgaatgtc atacatgagt gtctgaagtt
2041 aagattggag cagagacctg ctggagaacc atctctcttg agtattaagc agctggtgag
2101 agagtgtaag gaggtcctga agggcggcct gctgatgaag cagtactacc agttcatgct
2161 gcaggaggtt ctggaggact tggagaagcc cgactgcaac attgacgctt ttgaagagga
2221 tctacataaa atgcttatgg tgtattttga ttacatgaga agctggatcc aaatgctaca
2281 gcaattacct caagcatcgc atagtttaaa aaatctgtta gaagaagaat ggaatttcac
2341 caaagaaata actcattaca tacggggagg agaagcacag gccgggaagc ttttctgtga
2401 cattgcagga atgctgctga aatctacagg aagtttttta gaatttggct tacaggagag
2461 ctgtgctgaa ttttggacta gtgcggatga cagcagtgct tccgacgaaa tcatcaggtc
2521 tgttatagag atcagtcgag ccctgaagga gctcttccat gaagccagag aaagggcttc
2581 caaagcactt ggatttgcta aaatgttgag aaaggacctg gaaatagcag cagaattcag
2641 gctttcagcc ccagttagag acctcctgga tgttctgaaa tcaaaacagt atgtcaaggt
2701 gcaaattcct gggttagaaa acttgcaaat gtttgttcca gacactcttg ctgaggagaa
2761 gagtattatt ttgcagttac tcaatgcagc tgcaggaaag gactgttcaa aagattcaga
2821 tgacgtactc atcgatgcct atctgcttct gaccaagcac ggtgatcgag cccgtgattc
2881 agaggacagc tggggcacct gggaggcaca gcctgtcaaa gtcgtgcctc aggtggagac
2941 tgttgacacc ctgagaagca tgcaggtgga taatctttta ctagttgtca tgcagtctgc
3001 gcatctcaca attcagagaa aagctttcca gcagtccatt gagggactta tgactctgtg
3061 ccaggagcag acatccagtc agccggtcat cgccaaagct ttgcagcagc tgaagaatga
3121 tgcattggag ctatgcaaca ggataagcaa tgccattgac cgcgtggacc acatgttcac
3181 atcagaattt gatgctgagg ttgatgaatc tgaatctgtc accttgcaac agtactaccg
3241 agaagcaatg attcaggggt acaattttgg atttgagtat cataaagaag ttgttcgttt
3301 gatgtctggg gagtttagac agaagatagg agacaaatat ataagctttg cccggaagtg
3361 gatgaattat gtcctgacta aatgtgagag tggtagaggt acaagaccca ggtgggcgac
3421 tcaaggattt gattttctac aagcaattga acctgccttt atttcagctt taccagaaga
3481 tgacttcttg agtttacaag ccttgatgaa tgaatgcatt ggccatgtca taggaaaacc
3541 acacagtcct gttacaggtt tgtaccttgc cattcatcgg aacagccccc gtcctatgaa
3601 ggtacctcga tgccatagtg accctcctaa cccacacctc attatcccca ctccagaggg
3661 attcagcact cggagcatgc cttccgacgc gcggagccat ggcagccctg ctgctgctgc
3721 tgctgctgct gctgctgttg ctgccagtcg gcccagcccc tctggtggtg actctgtgct
3781 gcccaaatcc atcagcagtg cccatgatac caggggttcc agcgttcctg aaaatgatcg
3841 attggcttcc atagctgctg aattgcagtt taggtccctg agtcgtcact caagccccac
3901 ggaggagcga gatgaaccag catatccaag aggagattca agtgggtcca caagaagaag
3961 ttgggaactt cggacactaa tcagccagag taaagatact gcttctaaac taggacccat
4021 agaagctatc cagaagtcag tccgattgtt tgaagaaaag aggtaccgag aaatgaggag
4081 aaagaatatc attggtcaag tttgtgatac gcctaagtcc tatgataatg ttatgcacgt
4141 tggcttgagg aaggtgacct tcaaatggca aagaggaaac aaaattggag aaggccagta
4201 tgggaaggtg tacacctgca tcagcgtcga caccggggag ctgatggcca tgaaagagat
4261 tcgatttcaa cctaatgacc ataagactat caaggaaact gcagacgaat tgaaaatatt
4321 cgaaggcatc aaacacccca atctggttcg gtattttggt gtggagctcc atagagaaga
4381 aatgtacatc ttcatggagt actgcgatga ggggacttta gaagaggtgt caaggctggg
4441 acttcaggaa catgtgatta ggctgtattc aaagcagatc accattgcga tcaacgtcct
4501 ccatgagcat ggcatagtcc accgtgacat taaaggtgcc aatatcttcc ttacctcatc
4561 tggattaatc aaactgggag attttggatg ttcagtaaag ctcaaaaaca atgcccagac
4621 catgcctggt gaagtgaaca gcaccctggg gacagcagca tacatggcac ctgaagtcat
4681 cactcgtgcc aaaggagagg gccatgggcg tgcggccgac atctggagtc tggggtgtgt
4741 tgtcatagag atggtgactg gcaagaggcc ttggcatgag tatgagcaca actttcaaat
4801 tatgtataaa gtggggatgg gacataagcc accaatccct gaaagattaa gccctgaagg
4861 aaaggacttc ctttctcact gccttgagag tgacccaaag atgagatgga ccgccagcca
4921 gctcctcgac cattcgtttg tcaaggtttg cacagatgaa gaatgaagcc tagtagaata
4981 tggacttgga aaattctctt aatcactact gtatgtaata tttacataaa gactgtgctg
5041 agaagcagta taagcctttt taaccttcca agactgaaga ctgcacaggt gacaagcgtc
5101 acttctcctg ctgctcctgt ttgtctgatg tggcaaaagg ccctctggag ggctggtggc
5161 cacgaggtta aagaagctgc atgttaagtg ccattactac tgtacacgga ccatcgcctc
5221 tgtctcctcc gtgtctcgcg cgactgagaa ccgtgacatc agcgtagtgt tttgaccttt
5281 ctaggttcaa aagaagttgt agtgttatca ggcgtcccat accttgtttt taatctcctg
5341 tttgttgagt gcactgactg tgaaaccttt accttttttg ttgttgttgg caagctgcag
5401 gtttgtaatg caaaaggctg attactgaaa tttaagaaaa aggtt
//