LOCUS AF002715 5445 bp mRNA linear HUM 03-SEP-1997 DEFINITION Homo sapiens MAP kinase kinase kinase (MTK1) mRNA, complete cds. ACCESSION AF002715 VERSION AF002715.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5445) AUTHORS Takekawa,M., Posas,F. and Saito,H. TITLE A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinase, MTK1, regulates the p38 and JNK pathways JOURNAL Unpublished REFERENCE 2 (bases 1 to 5445) AUTHORS Takekawa,M., Posas,F. and Saito,H. TITLE Direct Submission JOURNAL Submitted (06-MAY-1997) Division of Tumor Immunology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA FEATURES Location/Qualifiers source 1..5445 /db_xref="H-InvDB:HIT000061693" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" gene 1..5445 /gene="MTK1" CDS 143..4966 /gene="MTK1" /codon_start=1 /product="MAP kinase kinase kinase" /protein_id="AAB68804.1" /translation="MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEP ECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRN NVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKN VQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDC PADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRT INDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKI VGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQA LCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGE LKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGA PDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR PVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLL NVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEK PDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYI RGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIIRSVIEIS RALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIP GLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSE DSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTL CQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQ YYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTR PRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHR NSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAVAASRP SPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYP RGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN DHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQE HVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTM PGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQ IMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE" BASE COUNT 1550 a 1199 c 1381 g 1315 t ORIGIN 1 aagatggccg cggcgcgcac ggctcctgcg gcggggtaga ggcggaggcg gagtcgagtc 61 actcccgcac ttcggggctc cggtgccccg cgccaggctg cagcttactg cccgccgcgg 121 ccatgcgggg ctccgtgcac ggatgagaga agccgctgcc gcgctggtcc ctcctcccgc 181 ctttgccgtc acgcctgccg ccgccatgga ggagccgccg ccaccgccgc cgccgccacc 241 accgccaccg gaacccgaga ccgagtcaga acccgagtgc tgcttggcgg cgaggcaaga 301 gggcacattg ggagattcag cttgcaagag tcctgaatct gatctagaag acttctccga 361 tgaaacaaat acagagaatc tttatggtac ctctcccccc agcacacctc gacagatgaa 421 acgcatgtca accaaacatc agaggaataa tgtggggagg ccagccagtc ggtctaattt 481 gaaagaaaaa atgaatgcac caaatcagcc tccacataaa gacactggaa aaacagtgga 541 gaatgtggaa gaatacagct ataagcagga gaaaaagatc cgagcagctc ttagaacaac 601 agagcgtgat cataaaaaaa atgtacagtg ctcattcatg ttagactcag tgggtggatc 661 tttgccaaaa aaatcaattc cagatgtgga tctcaataag ccttacctca gccttggctg 721 tagcaatgct aagcttccag tatctgtgcc catgcctata gccagacctg cacgccagac 781 ttctaggact gactgtccag cagatcgttt aaagtttttt gaaactttac gacttttgct 841 aaagcttacc tcagtctcaa agaaaaaaga cagggagcaa agaggacaag aaaatacgtc 901 tggtttctgg cttaaccgat ctaacgaact gatctggtta gagctacaag cctggcatgc 961 aggacggaca attaacgacc aggacttctt tttatataca gcccgtcaag ccatcccaga 1021 tattattaat gaaatcctta ctttcaaagt cgactatggg agcttcgcct ttgttagaga 1081 tagagctggt tttaatggta cttcagtaga agggcagtgc aaagccactc ctggaacaaa 1141 gattgtaggt tactcaacac atcatgagca tctccaacgc cagagggtct catttgagca 1201 ggtaaaacgg ataatggagc tgctagagta catagaagca ctttatccat cattgcaggc 1261 tcttcagaag gactatgaaa aatatgctgc aaaagacttc caggacaggg tgcaggcact 1321 ctgtttgtgg ttaaacatca caaaagactt aaatcagaaa ttaaggatta tgggcactgt 1381 tttgggcatc aagaatttat cagacattgg ctggccagtg tttgaaatcc cttcccctcg 1441 accatccaaa ggtaatgagc cggagtatga gggtgatgac acagaaggag aattaaagga 1501 gttggaaagt agtacggatg agagtgaaga agaacaaatc tctgatccta gggtaccgga 1561 aatcagacag cccatagata acagcttcga catccagtcg cgggactgca tatccaagaa 1621 gcttgagagg ctcgaatctg aggatgattc tcttggctgg ggagcaccag actggagcac 1681 agaagcaggc tttagtagac attgtctgac ttctatttat agaccatttg tagacaaagc 1741 actgaagcag atggggttaa gaaagttaat tttaagactt cacaagctaa tggatggttc 1801 cttgcaaagg gcacgtatag cattggtaaa gaacgatcgt ccagtggagt tttctgaatt 1861 tccagatccc atgtggggtt cagattatgt gcagttgtca aggacaccac cttcatctga 1921 ggagaaatgc agtgctgtgt cgtgggagga gctgaaggcc atggatttac cttcattcga 1981 acctgccttc ctagttctct gccgagtcct tctgaatgtc atacatgagt gtctgaagtt 2041 aagattggag cagagacctg ctggagaacc atctctcttg agtattaagc agctggtgag 2101 agagtgtaag gaggtcctga agggcggcct gctgatgaag cagtactacc agttcatgct 2161 gcaggaggtt ctggaggact tggagaagcc cgactgcaac attgacgctt ttgaagagga 2221 tctacataaa atgcttatgg tgtattttga ttacatgaga agctggatcc aaatgctaca 2281 gcaattacct caagcatcgc atagtttaaa aaatctgtta gaagaagaat ggaatttcac 2341 caaagaaata actcattaca tacggggagg agaagcacag gccgggaagc ttttctgtga 2401 cattgcagga atgctgctga aatctacagg aagtttttta gaatttggct tacaggagag 2461 ctgtgctgaa ttttggacta gtgcggatga cagcagtgct tccgacgaaa tcatcaggtc 2521 tgttatagag atcagtcgag ccctgaagga gctcttccat gaagccagag aaagggcttc 2581 caaagcactt ggatttgcta aaatgttgag aaaggacctg gaaatagcag cagaattcag 2641 gctttcagcc ccagttagag acctcctgga tgttctgaaa tcaaaacagt atgtcaaggt 2701 gcaaattcct gggttagaaa acttgcaaat gtttgttcca gacactcttg ctgaggagaa 2761 gagtattatt ttgcagttac tcaatgcagc tgcaggaaag gactgttcaa aagattcaga 2821 tgacgtactc atcgatgcct atctgcttct gaccaagcac ggtgatcgag cccgtgattc 2881 agaggacagc tggggcacct gggaggcaca gcctgtcaaa gtcgtgcctc aggtggagac 2941 tgttgacacc ctgagaagca tgcaggtgga taatctttta ctagttgtca tgcagtctgc 3001 gcatctcaca attcagagaa aagctttcca gcagtccatt gagggactta tgactctgtg 3061 ccaggagcag acatccagtc agccggtcat cgccaaagct ttgcagcagc tgaagaatga 3121 tgcattggag ctatgcaaca ggataagcaa tgccattgac cgcgtggacc acatgttcac 3181 atcagaattt gatgctgagg ttgatgaatc tgaatctgtc accttgcaac agtactaccg 3241 agaagcaatg attcaggggt acaattttgg atttgagtat cataaagaag ttgttcgttt 3301 gatgtctggg gagtttagac agaagatagg agacaaatat ataagctttg cccggaagtg 3361 gatgaattat gtcctgacta aatgtgagag tggtagaggt acaagaccca ggtgggcgac 3421 tcaaggattt gattttctac aagcaattga acctgccttt atttcagctt taccagaaga 3481 tgacttcttg agtttacaag ccttgatgaa tgaatgcatt ggccatgtca taggaaaacc 3541 acacagtcct gttacaggtt tgtaccttgc cattcatcgg aacagccccc gtcctatgaa 3601 ggtacctcga tgccatagtg accctcctaa cccacacctc attatcccca ctccagaggg 3661 attcagcact cggagcatgc cttccgacgc gcggagccat ggcagccctg ctgctgctgc 3721 tgctgctgct gctgctgttg ctgccagtcg gcccagcccc tctggtggtg actctgtgct 3781 gcccaaatcc atcagcagtg cccatgatac caggggttcc agcgttcctg aaaatgatcg 3841 attggcttcc atagctgctg aattgcagtt taggtccctg agtcgtcact caagccccac 3901 ggaggagcga gatgaaccag catatccaag aggagattca agtgggtcca caagaagaag 3961 ttgggaactt cggacactaa tcagccagag taaagatact gcttctaaac taggacccat 4021 agaagctatc cagaagtcag tccgattgtt tgaagaaaag aggtaccgag aaatgaggag 4081 aaagaatatc attggtcaag tttgtgatac gcctaagtcc tatgataatg ttatgcacgt 4141 tggcttgagg aaggtgacct tcaaatggca aagaggaaac aaaattggag aaggccagta 4201 tgggaaggtg tacacctgca tcagcgtcga caccggggag ctgatggcca tgaaagagat 4261 tcgatttcaa cctaatgacc ataagactat caaggaaact gcagacgaat tgaaaatatt 4321 cgaaggcatc aaacacccca atctggttcg gtattttggt gtggagctcc atagagaaga 4381 aatgtacatc ttcatggagt actgcgatga ggggacttta gaagaggtgt caaggctggg 4441 acttcaggaa catgtgatta ggctgtattc aaagcagatc accattgcga tcaacgtcct 4501 ccatgagcat ggcatagtcc accgtgacat taaaggtgcc aatatcttcc ttacctcatc 4561 tggattaatc aaactgggag attttggatg ttcagtaaag ctcaaaaaca atgcccagac 4621 catgcctggt gaagtgaaca gcaccctggg gacagcagca tacatggcac ctgaagtcat 4681 cactcgtgcc aaaggagagg gccatgggcg tgcggccgac atctggagtc tggggtgtgt 4741 tgtcatagag atggtgactg gcaagaggcc ttggcatgag tatgagcaca actttcaaat 4801 tatgtataaa gtggggatgg gacataagcc accaatccct gaaagattaa gccctgaagg 4861 aaaggacttc ctttctcact gccttgagag tgacccaaag atgagatgga ccgccagcca 4921 gctcctcgac cattcgtttg tcaaggtttg cacagatgaa gaatgaagcc tagtagaata 4981 tggacttgga aaattctctt aatcactact gtatgtaata tttacataaa gactgtgctg 5041 agaagcagta taagcctttt taaccttcca agactgaaga ctgcacaggt gacaagcgtc 5101 acttctcctg ctgctcctgt ttgtctgatg tggcaaaagg ccctctggag ggctggtggc 5161 cacgaggtta aagaagctgc atgttaagtg ccattactac tgtacacgga ccatcgcctc 5221 tgtctcctcc gtgtctcgcg cgactgagaa ccgtgacatc agcgtagtgt tttgaccttt 5281 ctaggttcaa aagaagttgt agtgttatca ggcgtcccat accttgtttt taatctcctg 5341 tttgttgagt gcactgactg tgaaaccttt accttttttg ttgttgttgg caagctgcag 5401 gtttgtaatg caaaaggctg attactgaaa tttaagaaaa aggtt //