LOCUS MUSIL6A 8258 bp DNA linear ROD 27-APR-1993 DEFINITION Mouse interleukin 6 (IL-6) gene, complete cds. ACCESSION M20572 VERSION M20572.1 KEYWORDS interleukin. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 8258) AUTHORS Tanabe,O., Akira,S., Kamiya,T., Wong,G.G., Hirano,T. and Kishimoto,T. TITLE Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human JOURNAL J. Immunol. 141 (11), 3875-3881 (1988) PUBMED 3263439 COMMENT Original source text: Mouse (BALB/c) liver DNA, (library of Clontech). Draft entry and computer-readable sequence for [1] kindly provided by T. Kishimoto, 08-SEP-1988. FEATURES Location/Qualifiers source 1..8258 /organism="Mus musculus" /mol_type="genomic DNA" /db_xref="taxon:10090" prim_transcript 1279..>8025 /note="IL6 mRNA and introns" CDS join(1328..1346,1509..1693,2947..3060,6042..6191, 7453..7620) /note="interleukin 6" /codon_start=1 /protein_id="AAA39302.1" /translation="MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRP VYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQT GYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDL HKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT" exon <1328..1346 /note="interleukin 6" /number=1 intron 1347..1508 /note="IL6 intron A" exon 1509..1693 /number=2 intron 1694..2946 /note="IL6 intron B" exon 2947..3060 /number=3 intron 3061..6041 /note="IL6 intron C" exon 6042..6191 /number=4 intron 6192..7452 /note="IL6 intron D" exon 7453..>7620 /note="interleukin 6" /number=5 BASE COUNT 2338 a 1679 c 1707 g 2534 t ORIGIN 1 bp upstream of BamHI site; chromosome 5. 1 ggatcctgag agtgtgtttt gtaaatggtt ttggatttta tgtacagagc ctactttcaa 61 gcctggaatc attctgaatg ctagctagat atctggagac aggtggacag aaaaccagga 121 actagtctga aaaagaaact aaccaaaggg aagaagtctg tttaagtttg acccagccta 181 gaagacttga gcattggagg ggttattcag agtgagacgt accaccttca gattcaaatc 241 ctgtcatcca gtagaaggga gcttcaaaca caagctagct aagatacaat gaggtccttc 301 ttcgatatct ttatcttcca tataccatga atcaaagaaa cttcaacaac atgaggactg 361 caacagacct tcaagcctcc ttgcatgacc tggaaattgg gtgttttggg gtgtcgggca 421 gcagcagtgg gatcagcact aacagataag ggcaactctc acagagacta aaggtcttaa 481 ctaagaagat agccaagaga ccactgggga gaatgcagag aataggcttg gacttggaag 541 ccaagattgc ttgacaacag acagaagata tttctgtact tcacccactt tacccacctg 601 gcaactcctg gaaacaactg cacaaaattt ggaggtgaac aaaccattag aaacaactgg 661 tcctgacaag acacaggaaa aacaagcaat atgcaacatt actgtctgtt gtccaggttg 721 ggtgctgggg gtgggagagg gagtgtgtgt ctttgtatga tctgaaaaaa ctcaggtcag 781 aacatctgta gatccttaca gacatacaaa agaatcctag cctcttattc atgtgtgtgt 841 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gtgtgtgtcg tctgtcatgc 901 gcgcgtgcct gcgtttaaat aacatcagct ttacgttctc tttctcctta taaaacattg 961 tgaatttcag ttttctttcc catcaagaca tgctcaagtg ctgagtcact tttaaagaaa 1021 aaaagaagag tgctcatgct tcttagggct agcctcaagg atgacttaag cacacttttc 1081 ccttcctagt tgtgattctt tcgatgctaa acgacgtcac attgtgcaat cttaataagg 1141 tttccaatca gccccaccca ctctggcccc acccccaccc tccaacaaag atttttatca 1201 aatgtgggat tttcccatga gtctcaaaat tagagagttg actcctaata aatatgagac 1261 tggggatgtc tgtagctcat tctgctctgg agcccaccaa gaacgatagt caattccaga 1321 aaccgctatg aagttcctct ctgcaagtaa gtgaaggcag ttccttgccc tctggcggac 1381 gtattgagac tgtgagagag gagtgtgagg cagagagcca gcattgtggg ttggccagca 1441 gcatcagcta gcagcaggtc caactgtgct atctgctcac ttgccggttt ttccttttct 1501 ccacgcagga gacttccatc cagttgcctt cttgggactg atgctggtga caaccacggc 1561 cttccctact tcacaagtcc ggagaggaga cttcacagag gataccactc ccaacagacc 1621 tgtctatacc acttcacaag tcggaggctt aattacacat gttctctggg aaatcgtgga 1681 aatgagaaaa gaggtgggta ggctgtgaaa ctgatgaaga cccagtgtgg cgtccattca 1741 ttctctttgc tcttgaatta gaaattctct gctgggatct agggccctta ggatttgaag 1801 ctaaaggtca gactagacgt gttctctctt tctcacctct ttgctggttt tgagtggagg 1861 ttgggaaggg gttcctttcc tgtctggaag atacagaatg tgactgcatt tctagaaaat 1921 tcacagtggg ccattctctg ttccaattta gctattgctt cttaggtggg gattcctttt 1981 ccctcattat tcctttttcc ttatctcttt gccttcattt atcccttgaa gtctacaagg 2041 accagaaagt gctttttggc tgaatgtagt aagtcctgtg tgtgtgtgaa atcaggatgc 2101 tctagggtca gcccagataa gatgcatatt gtatagagcc caataaagtg ctaacacaca 2161 cacacacaca cacacacaca cacaacctag attaggctgg gcatggtggt ggatgcctcc 2221 cagcacttgg gcagcacgca ggaagatctc tgtgagttag aggccagctt ggtctacata 2281 ttgagttcca ggatatccaa gactacattg agagatcctt ctcaaaaaaa aaaaaaaaaa 2341 aaaaaaaaac aacaacaaca aacaaacaaa caaacaagaa aaaaaaaacc caaccaaccc 2401 tacctagatt aaaatatctc catctttaaa tgaaagtatt tgactctgct gacagaagaa 2461 aaatcacaaa caagattaat agcctaggtc tgggtgtgta gaaccaactt tgtaatcttg 2521 ggaaaatcct caactattta gtactcttta tctgcataat tatggagtta aaacagataa 2581 tggcacagac ccttccagat ggcaatatcc tgtgacttaa atttataagc cccaagatat 2641 catcaaaatt tctgtccttt accaagttcc tactctatgc tgggcagttt ttatcgttga 2701 atccttgaga caaatgtata agagggacat caataattct ttatgaaaca taggaaatac 2761 ttaggagagt aacaagctta agggactgag cctaagggtg catttttatt tattgggctg 2821 cttagtaggg ttctaagaag gtatagcttc cctttctgtg tcctggctat gaaagagcat 2881 gacttggccc tctagggtgc ttgttgtaag aggtgtttaa gtgattgctc tggtaatctt 2941 ttgcagttgt gcaatggcaa ttctgattgt atgaacaacg atgatgcact tgcagaaaac 3001 aatctgaaac ttccagagat acaaagaaat gatggatgct accaaactgg atataatcag 3061 gtagaaactt gtcacgttta ctttcaacaa ttcttcaagg ttctctcttg cacgtgatac 3121 ctgcatttgt acagtcccag tcaggcaaca aagatggggg gatacatcaa taccacttga 3181 tgtaactggc ctgcagtagc ttgaatacaa aaggagattg agaggtacct cagcagctgc 3241 tagggtgagg gaaagtttac caaccagtgc tataaatgtt cactcaatct atgtccatca 3301 ggagctaaat gtttaaagtc tctattctca tcttggcttt gaggtgttag atgattaaaa 3361 aaaaaacatt ttttttgtct aaaaaagtgg aagagtagat ataaaacatg ttatgtaaac 3421 gtcatgagga aagtaactta cagatttaat taaaaagcag tttatttaaa caggtaaagg 3481 cccactatgc tgggattctt caccactgtt aaatgttaga agtcatagca agtttagcta 3541 gttcatgagc catctcttct ctggctgccc ctggaaggat ccaggcctac actccctact 3601 gagaacactc ttcacacccc tctccttcca gccggtgaga tagtctacat caggtctcag 3661 gacaagtcag acaagaacaa gagtacagga agggcactgc aggatagaag ggaaggagtg 3721 agggtcagaa gtggattccc actgccacac tctggggagg gggtgggggg atattaagtg 3781 gtgcctctct ctacttgtcc agataattca ggagctgatg ctgcctgttg tctaattctg 3841 tagaagatac tgaacagcag gaatcttttt ttcaattttt tattagatat tttcttcatt 3901 tacatttcaa atgctatccc cacagtcccc tatccctatg cccctatacc ctcccccccc 3961 tccccgctcc cttacccacc aactcccact tcttggccct ggcattccct gtactggggc 4021 atataaagtt tgcaagacca aggggcctct attcccaatg atggctgact aggccatctt 4081 ctgctacata tgcagctaga gatatgagct ctgggggtac tggttagttc atattgttgt 4141 tccaacctat agggttgcag accccttcag ctccttgggt actttctcta gctcctccat 4201 tgggggccct gtgttccatc caatagaaga ctgtgagcat ccactttttg ccagcattgc 4261 ctagcctcac acgagacagc tatatcaggg tcctttcagc aaaatcttgc tggtatatgc 4321 aatactgtcg tggtttggtg gctgattatg ggatggatcc ctaggtgggg tagtctctgg 4381 atcttccatc cttttgtctt agctccaaac tttgtctctg taactccttc catgggtatt 4441 ttgttcccca ttctaaggag gaatgaagta tccacatgtt ggtcttcctt cttcttgatt 4501 ttcttgtgtt ttggaaattg taccttgggt attctaagtt tctgggctaa taatatccac 4561 ttatcagtga gtgcatatca agtgacttat tttgtgattg ggttacctca ctaaggatca 4621 tactctccag atacatccat ttgaccaaga atttcataaa tccattgttt ttaatagctg 4681 aatagtactc catttgtaaa tgtaccacat tttctgtatc cattcctctg ttgaggacat 4741 ctgggttctt tccagcttct ggctattatg aataaggctg ctatgaacat agtggagcat 4801 atgtccttat taccagttgg aacattctgc gtatatgccc agaagaggta ttgctggatc 4861 ttccggtagt actatgtcta attttttgag gaacagccag actgatttcc agagtggtta 4921 tacaagcttg caatcccaac agcaatggag gagtgttcct ctttctccac atccttacca 4981 gcatctgctg tcacctgaat ttttgatctt agccattctg actggtgtga ggtggaatct 5041 cagggttgtt ttgatttgca tttccctgat gattaaggat gttgaacatt ttttcaagtg 5101 cttctcagcc attcagtatt cctcagttga gaattctttg tttagctttg tacacatttt 5161 taatggggtt atttgaattt gaatttctgg agttcagctt cttgagctct ttgtatatat 5221 tggatattag tcccctatca gatttaggat tggtaaaaat cctttcccaa tctgttggtg 5281 gcctttttgt ctttattgac agtgtctttt cccttacaga agctttgcaa ttttatgagg 5341 tccatttgtc gattctcgat tttactgtac aagccattgc tgttctgttc aggaattttt 5401 cccctgttcc catatctacg agggtttttt tcccactttc tcctctataa atttcagtgt 5461 ctctggtttt atgtggagtt ctttgatcca cttagacttg agctttgtac aaggagataa 5521 gaatggatca attcgggctg gagagatggc tcagtggtta agagcactga ctgctctttc 5581 agaagtcctg agttcaaatc ccagcaacat ggtggttcat aaccatctat aataagatct 5641 gatgtccttt tctggtgtgt ctgaagacag ctacagtgta cttacatgta ataaataaat 5701 aaaactagtt atttaaaaaa aaaaaaaaag aatggatcaa ttcacactct tctacatgat 5761 aaccaccagt tgagcccgca ccaattgttg aaaatgctct ctttttccca ctggatggtt 5821 ttagctccct tgtcaaagat caagtgacca taagtgtgtg ggttcatttc tgtgtcttca 5881 attgtgttcc attgactacc tgtctgttgc tgtatcaata ccatgcagtt ttttttatca 5941 caattgctct gtagtttttt ttttttttga cagcaggaat cttattctca aattgaatct 6001 attcctagaa agaactgact tccttttcca tttacttata ggaaatttgc ctattgaaaa 6061 tttcctctgg tcttctggag taccatagct acctggagta catgaagaac aacttaaaag 6121 ataacaagaa agacaaagcc agagtccttc agagagatac agaaactcta attcatatct 6181 tcaaccaaga ggtgagtgct tccccatctc tcatgcagtg tgggaaagag acacccggca 6241 cctcagggta gcggcacttt ttccagacag ctgctcagaa gggagagagt ctgaacaaca 6301 ggccttgctt tgttttactt tggggttttg tttgaggttc tcttttgcaa agaacatcaa 6361 tacctgcttt aaactgtatt aatagaatgt tactaattgt gtaagaggta tgaaaactat 6421 gacagccata catagtcacc cattatgaga gcacagagac aaaagtgact ttaatattta 6481 atccttggca agtgacattt ttgtaaccag agttctaatg cagagaagtt tagccaaaag 6541 ctaaaatgtc agggaaggag ggatcagggc ttctggctac attagccaga agaagaatgg 6601 tagatatgag ataatgactc agagtgtggg cgaacaaagc cagatgcaat aagaagggcc 6661 tggaatgaaa ccctcttgct aaggctgctt ttgccacttg tagtttcttg ccttaaacca 6721 gagagttttt gctaaggctg cttttgccac ttgtagtttc ttgccttaaa ccagagagtt 6781 tcccaattta atgtgcacag gaaccactta gggtcttgtt ccagcagggt cttacttagg 6841 aggtctagga agggaactaa gattcatttt tgtaaacagc tgcttgttta tgaccctgct 6901 atatagtatt caggctccta agtagtgggc aagccttcca gttagtcttc cccatcgcag 6961 tgggcccatg gaagggtgtt tccagacttc ttcatgctac cacactaaga gactctcaac 7021 agagtctgaa tggaaaccac gaaggaacac atttgtttta gattcctctg tgccaccttt 7081 actgatggga gcttctgttt tccagtagat acagtatgtt agcatggatg cttggataac 7141 agacaaataa gatggtggtg ctgacctctg gacgcttact ctctagtggc agacagaaca 7201 gtaaggttag aattctgttg ctattaaaaa actaataatt aatcaccttg aaaaagaatg 7261 gagttgttag gcatgggtct ctctcgagta agcttggaac aaagcttctc cctggcttgg 7321 gtgagtcaaa gcagatggac ttagctcgtc tcattcattc taaattagaa cttcttccca 7381 cagcccagaa cacgccacaa gaaaaaaaaa aatgtgcaat atttaaccag tctttgtttt 7441 ttcctccttt aggtaaaaga tttacataaa atagtccttc ctaccccaat ttccaatgct 7501 ctcctaacag ataagctgga gtcacagaag gagtggctaa ggaccaagac catccaattc 7561 atcttgaaat cacttgaaga atttctaaaa gtcactttga gatctactcg gcaaacctag 7621 tgcgttatgc cctaagcata tcagtttgtg gacattcctc actgtggtca gaaaatatat 7681 tcctgttgtc aggtatctga cttatgttgt tctctacgaa gaactgacaa tatgaatgtt 7741 gggacactat tttaattatt tttaatttat tgataattta aataagtaaa ctttaagtta 7801 atttatgatt gatatttatt atttttatga agtgtcactt gaaatgttat atgttatagt 7861 tttgaaatga taacctaaaa atctatttga tataaatatt ctgttactag cagatggttc 7921 ttggaatgta taagttacct caatgaattg ctaatttaaa tatgttttta aagaaatctt 7981 tgtgatgtat ttttataatg tttagactgt cttcaaacaa ataaattata ttatatttaa 8041 aaaccagtga ctgaaagacg catctcagct ggtaaagttc ttacccaaca tgagcaaggt 8101 cctaagttac atccaaacat cctcccccaa atcaataatt aagcactttt tatgacatgt 8161 aaagttaaat aagaagtgaa agctgcacat tagttaattt caggtcttgt acattctttt 8221 ctggactgag agtaagggat ctaactaagc cgcctttg //