LOCUS MUSIL6A 8258 bp DNA linear ROD 27-APR-1993
DEFINITION Mouse interleukin 6 (IL-6) gene, complete cds.
ACCESSION M20572
VERSION M20572.1
KEYWORDS interleukin.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 8258)
AUTHORS Tanabe,O., Akira,S., Kamiya,T., Wong,G.G., Hirano,T. and
Kishimoto,T.
TITLE Genomic structure of the murine IL-6 gene. High degree conservation
of potential regulatory sequences between mouse and human
JOURNAL J. Immunol. 141 (11), 3875-3881 (1988)
PUBMED 3263439
COMMENT Original source text: Mouse (BALB/c) liver DNA, (library of
Clontech).
Draft entry and computer-readable sequence for [1] kindly provided
by T. Kishimoto, 08-SEP-1988.
FEATURES Location/Qualifiers
source 1..8258
/organism="Mus musculus"
/mol_type="genomic DNA"
/db_xref="taxon:10090"
prim_transcript 1279..>8025
/note="IL6 mRNA and introns"
CDS join(1328..1346,1509..1693,2947..3060,6042..6191,
7453..7620)
/note="interleukin 6"
/codon_start=1
/protein_id="AAA39302.1"
/translation="MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRP
VYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQT
GYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDL
HKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT"
exon <1328..1346
/note="interleukin 6"
/number=1
intron 1347..1508
/note="IL6 intron A"
exon 1509..1693
/number=2
intron 1694..2946
/note="IL6 intron B"
exon 2947..3060
/number=3
intron 3061..6041
/note="IL6 intron C"
exon 6042..6191
/number=4
intron 6192..7452
/note="IL6 intron D"
exon 7453..>7620
/note="interleukin 6"
/number=5
BASE COUNT 2338 a 1679 c 1707 g 2534 t
ORIGIN 1 bp upstream of BamHI site; chromosome 5.
1 ggatcctgag agtgtgtttt gtaaatggtt ttggatttta tgtacagagc ctactttcaa
61 gcctggaatc attctgaatg ctagctagat atctggagac aggtggacag aaaaccagga
121 actagtctga aaaagaaact aaccaaaggg aagaagtctg tttaagtttg acccagccta
181 gaagacttga gcattggagg ggttattcag agtgagacgt accaccttca gattcaaatc
241 ctgtcatcca gtagaaggga gcttcaaaca caagctagct aagatacaat gaggtccttc
301 ttcgatatct ttatcttcca tataccatga atcaaagaaa cttcaacaac atgaggactg
361 caacagacct tcaagcctcc ttgcatgacc tggaaattgg gtgttttggg gtgtcgggca
421 gcagcagtgg gatcagcact aacagataag ggcaactctc acagagacta aaggtcttaa
481 ctaagaagat agccaagaga ccactgggga gaatgcagag aataggcttg gacttggaag
541 ccaagattgc ttgacaacag acagaagata tttctgtact tcacccactt tacccacctg
601 gcaactcctg gaaacaactg cacaaaattt ggaggtgaac aaaccattag aaacaactgg
661 tcctgacaag acacaggaaa aacaagcaat atgcaacatt actgtctgtt gtccaggttg
721 ggtgctgggg gtgggagagg gagtgtgtgt ctttgtatga tctgaaaaaa ctcaggtcag
781 aacatctgta gatccttaca gacatacaaa agaatcctag cctcttattc atgtgtgtgt
841 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gtgtgtgtcg tctgtcatgc
901 gcgcgtgcct gcgtttaaat aacatcagct ttacgttctc tttctcctta taaaacattg
961 tgaatttcag ttttctttcc catcaagaca tgctcaagtg ctgagtcact tttaaagaaa
1021 aaaagaagag tgctcatgct tcttagggct agcctcaagg atgacttaag cacacttttc
1081 ccttcctagt tgtgattctt tcgatgctaa acgacgtcac attgtgcaat cttaataagg
1141 tttccaatca gccccaccca ctctggcccc acccccaccc tccaacaaag atttttatca
1201 aatgtgggat tttcccatga gtctcaaaat tagagagttg actcctaata aatatgagac
1261 tggggatgtc tgtagctcat tctgctctgg agcccaccaa gaacgatagt caattccaga
1321 aaccgctatg aagttcctct ctgcaagtaa gtgaaggcag ttccttgccc tctggcggac
1381 gtattgagac tgtgagagag gagtgtgagg cagagagcca gcattgtggg ttggccagca
1441 gcatcagcta gcagcaggtc caactgtgct atctgctcac ttgccggttt ttccttttct
1501 ccacgcagga gacttccatc cagttgcctt cttgggactg atgctggtga caaccacggc
1561 cttccctact tcacaagtcc ggagaggaga cttcacagag gataccactc ccaacagacc
1621 tgtctatacc acttcacaag tcggaggctt aattacacat gttctctggg aaatcgtgga
1681 aatgagaaaa gaggtgggta ggctgtgaaa ctgatgaaga cccagtgtgg cgtccattca
1741 ttctctttgc tcttgaatta gaaattctct gctgggatct agggccctta ggatttgaag
1801 ctaaaggtca gactagacgt gttctctctt tctcacctct ttgctggttt tgagtggagg
1861 ttgggaaggg gttcctttcc tgtctggaag atacagaatg tgactgcatt tctagaaaat
1921 tcacagtggg ccattctctg ttccaattta gctattgctt cttaggtggg gattcctttt
1981 ccctcattat tcctttttcc ttatctcttt gccttcattt atcccttgaa gtctacaagg
2041 accagaaagt gctttttggc tgaatgtagt aagtcctgtg tgtgtgtgaa atcaggatgc
2101 tctagggtca gcccagataa gatgcatatt gtatagagcc caataaagtg ctaacacaca
2161 cacacacaca cacacacaca cacaacctag attaggctgg gcatggtggt ggatgcctcc
2221 cagcacttgg gcagcacgca ggaagatctc tgtgagttag aggccagctt ggtctacata
2281 ttgagttcca ggatatccaa gactacattg agagatcctt ctcaaaaaaa aaaaaaaaaa
2341 aaaaaaaaac aacaacaaca aacaaacaaa caaacaagaa aaaaaaaacc caaccaaccc
2401 tacctagatt aaaatatctc catctttaaa tgaaagtatt tgactctgct gacagaagaa
2461 aaatcacaaa caagattaat agcctaggtc tgggtgtgta gaaccaactt tgtaatcttg
2521 ggaaaatcct caactattta gtactcttta tctgcataat tatggagtta aaacagataa
2581 tggcacagac ccttccagat ggcaatatcc tgtgacttaa atttataagc cccaagatat
2641 catcaaaatt tctgtccttt accaagttcc tactctatgc tgggcagttt ttatcgttga
2701 atccttgaga caaatgtata agagggacat caataattct ttatgaaaca taggaaatac
2761 ttaggagagt aacaagctta agggactgag cctaagggtg catttttatt tattgggctg
2821 cttagtaggg ttctaagaag gtatagcttc cctttctgtg tcctggctat gaaagagcat
2881 gacttggccc tctagggtgc ttgttgtaag aggtgtttaa gtgattgctc tggtaatctt
2941 ttgcagttgt gcaatggcaa ttctgattgt atgaacaacg atgatgcact tgcagaaaac
3001 aatctgaaac ttccagagat acaaagaaat gatggatgct accaaactgg atataatcag
3061 gtagaaactt gtcacgttta ctttcaacaa ttcttcaagg ttctctcttg cacgtgatac
3121 ctgcatttgt acagtcccag tcaggcaaca aagatggggg gatacatcaa taccacttga
3181 tgtaactggc ctgcagtagc ttgaatacaa aaggagattg agaggtacct cagcagctgc
3241 tagggtgagg gaaagtttac caaccagtgc tataaatgtt cactcaatct atgtccatca
3301 ggagctaaat gtttaaagtc tctattctca tcttggcttt gaggtgttag atgattaaaa
3361 aaaaaacatt ttttttgtct aaaaaagtgg aagagtagat ataaaacatg ttatgtaaac
3421 gtcatgagga aagtaactta cagatttaat taaaaagcag tttatttaaa caggtaaagg
3481 cccactatgc tgggattctt caccactgtt aaatgttaga agtcatagca agtttagcta
3541 gttcatgagc catctcttct ctggctgccc ctggaaggat ccaggcctac actccctact
3601 gagaacactc ttcacacccc tctccttcca gccggtgaga tagtctacat caggtctcag
3661 gacaagtcag acaagaacaa gagtacagga agggcactgc aggatagaag ggaaggagtg
3721 agggtcagaa gtggattccc actgccacac tctggggagg gggtgggggg atattaagtg
3781 gtgcctctct ctacttgtcc agataattca ggagctgatg ctgcctgttg tctaattctg
3841 tagaagatac tgaacagcag gaatcttttt ttcaattttt tattagatat tttcttcatt
3901 tacatttcaa atgctatccc cacagtcccc tatccctatg cccctatacc ctcccccccc
3961 tccccgctcc cttacccacc aactcccact tcttggccct ggcattccct gtactggggc
4021 atataaagtt tgcaagacca aggggcctct attcccaatg atggctgact aggccatctt
4081 ctgctacata tgcagctaga gatatgagct ctgggggtac tggttagttc atattgttgt
4141 tccaacctat agggttgcag accccttcag ctccttgggt actttctcta gctcctccat
4201 tgggggccct gtgttccatc caatagaaga ctgtgagcat ccactttttg ccagcattgc
4261 ctagcctcac acgagacagc tatatcaggg tcctttcagc aaaatcttgc tggtatatgc
4321 aatactgtcg tggtttggtg gctgattatg ggatggatcc ctaggtgggg tagtctctgg
4381 atcttccatc cttttgtctt agctccaaac tttgtctctg taactccttc catgggtatt
4441 ttgttcccca ttctaaggag gaatgaagta tccacatgtt ggtcttcctt cttcttgatt
4501 ttcttgtgtt ttggaaattg taccttgggt attctaagtt tctgggctaa taatatccac
4561 ttatcagtga gtgcatatca agtgacttat tttgtgattg ggttacctca ctaaggatca
4621 tactctccag atacatccat ttgaccaaga atttcataaa tccattgttt ttaatagctg
4681 aatagtactc catttgtaaa tgtaccacat tttctgtatc cattcctctg ttgaggacat
4741 ctgggttctt tccagcttct ggctattatg aataaggctg ctatgaacat agtggagcat
4801 atgtccttat taccagttgg aacattctgc gtatatgccc agaagaggta ttgctggatc
4861 ttccggtagt actatgtcta attttttgag gaacagccag actgatttcc agagtggtta
4921 tacaagcttg caatcccaac agcaatggag gagtgttcct ctttctccac atccttacca
4981 gcatctgctg tcacctgaat ttttgatctt agccattctg actggtgtga ggtggaatct
5041 cagggttgtt ttgatttgca tttccctgat gattaaggat gttgaacatt ttttcaagtg
5101 cttctcagcc attcagtatt cctcagttga gaattctttg tttagctttg tacacatttt
5161 taatggggtt atttgaattt gaatttctgg agttcagctt cttgagctct ttgtatatat
5221 tggatattag tcccctatca gatttaggat tggtaaaaat cctttcccaa tctgttggtg
5281 gcctttttgt ctttattgac agtgtctttt cccttacaga agctttgcaa ttttatgagg
5341 tccatttgtc gattctcgat tttactgtac aagccattgc tgttctgttc aggaattttt
5401 cccctgttcc catatctacg agggtttttt tcccactttc tcctctataa atttcagtgt
5461 ctctggtttt atgtggagtt ctttgatcca cttagacttg agctttgtac aaggagataa
5521 gaatggatca attcgggctg gagagatggc tcagtggtta agagcactga ctgctctttc
5581 agaagtcctg agttcaaatc ccagcaacat ggtggttcat aaccatctat aataagatct
5641 gatgtccttt tctggtgtgt ctgaagacag ctacagtgta cttacatgta ataaataaat
5701 aaaactagtt atttaaaaaa aaaaaaaaag aatggatcaa ttcacactct tctacatgat
5761 aaccaccagt tgagcccgca ccaattgttg aaaatgctct ctttttccca ctggatggtt
5821 ttagctccct tgtcaaagat caagtgacca taagtgtgtg ggttcatttc tgtgtcttca
5881 attgtgttcc attgactacc tgtctgttgc tgtatcaata ccatgcagtt ttttttatca
5941 caattgctct gtagtttttt ttttttttga cagcaggaat cttattctca aattgaatct
6001 attcctagaa agaactgact tccttttcca tttacttata ggaaatttgc ctattgaaaa
6061 tttcctctgg tcttctggag taccatagct acctggagta catgaagaac aacttaaaag
6121 ataacaagaa agacaaagcc agagtccttc agagagatac agaaactcta attcatatct
6181 tcaaccaaga ggtgagtgct tccccatctc tcatgcagtg tgggaaagag acacccggca
6241 cctcagggta gcggcacttt ttccagacag ctgctcagaa gggagagagt ctgaacaaca
6301 ggccttgctt tgttttactt tggggttttg tttgaggttc tcttttgcaa agaacatcaa
6361 tacctgcttt aaactgtatt aatagaatgt tactaattgt gtaagaggta tgaaaactat
6421 gacagccata catagtcacc cattatgaga gcacagagac aaaagtgact ttaatattta
6481 atccttggca agtgacattt ttgtaaccag agttctaatg cagagaagtt tagccaaaag
6541 ctaaaatgtc agggaaggag ggatcagggc ttctggctac attagccaga agaagaatgg
6601 tagatatgag ataatgactc agagtgtggg cgaacaaagc cagatgcaat aagaagggcc
6661 tggaatgaaa ccctcttgct aaggctgctt ttgccacttg tagtttcttg ccttaaacca
6721 gagagttttt gctaaggctg cttttgccac ttgtagtttc ttgccttaaa ccagagagtt
6781 tcccaattta atgtgcacag gaaccactta gggtcttgtt ccagcagggt cttacttagg
6841 aggtctagga agggaactaa gattcatttt tgtaaacagc tgcttgttta tgaccctgct
6901 atatagtatt caggctccta agtagtgggc aagccttcca gttagtcttc cccatcgcag
6961 tgggcccatg gaagggtgtt tccagacttc ttcatgctac cacactaaga gactctcaac
7021 agagtctgaa tggaaaccac gaaggaacac atttgtttta gattcctctg tgccaccttt
7081 actgatggga gcttctgttt tccagtagat acagtatgtt agcatggatg cttggataac
7141 agacaaataa gatggtggtg ctgacctctg gacgcttact ctctagtggc agacagaaca
7201 gtaaggttag aattctgttg ctattaaaaa actaataatt aatcaccttg aaaaagaatg
7261 gagttgttag gcatgggtct ctctcgagta agcttggaac aaagcttctc cctggcttgg
7321 gtgagtcaaa gcagatggac ttagctcgtc tcattcattc taaattagaa cttcttccca
7381 cagcccagaa cacgccacaa gaaaaaaaaa aatgtgcaat atttaaccag tctttgtttt
7441 ttcctccttt aggtaaaaga tttacataaa atagtccttc ctaccccaat ttccaatgct
7501 ctcctaacag ataagctgga gtcacagaag gagtggctaa ggaccaagac catccaattc
7561 atcttgaaat cacttgaaga atttctaaaa gtcactttga gatctactcg gcaaacctag
7621 tgcgttatgc cctaagcata tcagtttgtg gacattcctc actgtggtca gaaaatatat
7681 tcctgttgtc aggtatctga cttatgttgt tctctacgaa gaactgacaa tatgaatgtt
7741 gggacactat tttaattatt tttaatttat tgataattta aataagtaaa ctttaagtta
7801 atttatgatt gatatttatt atttttatga agtgtcactt gaaatgttat atgttatagt
7861 tttgaaatga taacctaaaa atctatttga tataaatatt ctgttactag cagatggttc
7921 ttggaatgta taagttacct caatgaattg ctaatttaaa tatgttttta aagaaatctt
7981 tgtgatgtat ttttataatg tttagactgt cttcaaacaa ataaattata ttatatttaa
8041 aaaccagtga ctgaaagacg catctcagct ggtaaagttc ttacccaaca tgagcaaggt
8101 cctaagttac atccaaacat cctcccccaa atcaataatt aagcactttt tatgacatgt
8161 aaagttaaat aagaagtgaa agctgcacat tagttaattt caggtcttgt acattctttt
8221 ctggactgag agtaagggat ctaactaagc cgcctttg
//