LOCUS HUMIL2 5737 bp DNA linear HUM 11-AUG-1999
DEFINITION Homo sapiens interleukin 2 precursor (IL2) gene, complete cds.
ACCESSION J00264
VERSION J00264.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
AUTHORS Taniguchi,T., Matsui,H., Fujita,T., Takaoka,C., Kashima,N.,
Yoshimoto,R. and Hamuro,J.
TITLE Structure and expression of a cloned cDNA for human interleukin-2
JOURNAL Nature 302 (5906), 305-310 (1983)
PUBMED 6403867
REFERENCE 2 (bases 371 to 624; 715 to 774; 3068 to 3211; 5057 to 5439)
AUTHORS Devos,R., Plaetinck,G., Cheroutre,H., Simons,G., Degrave,W.,
Tavernier,J., Remaut,E. and Fiers,W.
TITLE Molecular cloning of human interleukin 2 cDNA and its expression in
E. coli
JOURNAL Nucleic Acids Res. 11 (13), 4307-4323 (1983)
PUBMED 6306584
REFERENCE 3 (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
AUTHORS Maeda,S., Nishino,N., Obaru,K., Mita,S., Nomiyama,H., Shimada,K.,
Fujimoto,K., Teranishi,T., Hirano,T. and Onoue,K.
TITLE Cloning of interleukin 2 mRNAs from human tonsils
JOURNAL Biochem. Biophys. Res. Commun. 115 (3), 1040-1047 (1983)
PUBMED 6312994
REFERENCE 4 (bases 282 to 480)
AUTHORS Mita,S., Maeda,S., Obaru,K., Nishino,N., Shimada,K., Hirano,T.,
Onoue,K., Ogawa,T. and Ogawa,H.
TITLE Isolation and characterization of a human interleukin 2 gene
JOURNAL Biochem. Biophys. Res. Commun. 117 (1), 114-121 (1983)
PUBMED 6318743
REFERENCE 5 (bases 1 to 5737)
AUTHORS Fujita,T., Takaoka,C., Matsui,H. and Taniguchi,T.
TITLE Structure of the human interleukin 2 gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (24), 7437-7441 (1983)
PUBMED 6324170
REFERENCE 6 (bases 436 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
AUTHORS Clark,S.C., Arya,S.K., Wong-Staal,F., Matsumoto-Kobayashi,M.,
Kay,R.M., Kaufman,R.J., Brown,E.L., Shoemaker,C., Copeland,T.,
Oroszlan,S., Smith,K., Sarngadharan,M.G., Lindner,S.G. and
Gallo,R.C.
TITLE Human T-cell growth factor: partial amino acid sequence, cDNA
cloning, and organization and expression in normal and leukemic
cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (8), 2543-2547 (1984)
PUBMED 6201860
REFERENCE 7 (sites)
AUTHORS Cullen,B.R.
TITLE Expression of a cloned human interleukin-2 cDNA is enhanced by the
substitution of a heterologous mRNA leader region
JOURNAL DNA 7 (9), 645-650 (1988)
PUBMED 3265909
FEATURES Location/Qualifiers
source 1..5737
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q26-q27"
/note="sequence shown is presented in citation 5"
gene 413..5443
/gene="IL2"
mRNA join(<413..624,715..774,3068..3211,5057..5443)
/gene="IL2"
/product="interleukin 2 precursor"
exon <413..624
/gene="IL2"
/note="G00-119-344"
/number=1
CDS join(478..624,715..774,3068..3211,5057..5167)
/gene="IL2"
/function="involved in immune response"
/note="T-cell growth factor; lymphokine"
/codon_start=1
/product="interleukin 2 precursor"
/protein_id="AAD48509.1"
/translation="MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMI
LNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRP
RDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT"
sig_peptide 478..537
/gene="IL2"
/note="G00-119-344"
mat_peptide join(538..624,715..774,3068..3211,5057..5164)
/gene="IL2"
/product="interleukin 2"
/note="G00-119-344"
exon 715..774
/gene="IL2"
/note="G00-119-344"
/number=2
exon 3068..3211
/gene="IL2"
/note="G00-119-344"
/number=3
exon 5057..5443
/gene="IL2"
/note="G00-119-344"
/number=4
misc_difference 5161
/gene="IL2"
/note="conflict"
/citation=[6]
/replace=""
misc_difference 5322..5323
/gene="IL2"
/note="conflict"
/citation=[6]
/replace=""
misc_difference 5396..5398
/gene="IL2"
/note="conflict"
/citation=[6]
/replace=""
BASE COUNT 1995 a 932 c 922 g 1888 t
ORIGIN
1 ttaatcaaca aatctaaaca tttattcttt tcatctgttt actcttgctc ttgttcacca
61 caatatgcta ttcacatgtt cagtgtagtt ttatgacaaa gaaaattttc tgagttactt
121 ttgtatcccc acccccttaa agaaaggagg aaaaactgtt tcatacagaa ggcgttaatt
181 gcatgaatta gagctatcac ctaagtgtgg gctaatgtaa caaagaggga tttcacctac
241 atccattcag tcagtctttg ggggtttaaa gaattccaaa gagtcatcag aagaggaaaa
301 atgaaggtaa tgttttttca gacaggtaaa gtctttgaaa atatgtgtaa tatgtaaaac
361 attttgacac ccccataata tttttccaga attaacagta taaattgcat ctcttgttca
421 agagttccct atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg
481 tacaggatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca
541 cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta
601 cagatgattt tgaatggaat taatgtaagt atatttcctt tcttactaaa attattacat
661 ttagtaatct agctggagat catttcttaa taacaatgca ttatactttc ttagaattac
721 aagaatccca aactcaccag gatgctcaca tttaagtttt acatgcccaa gaaggtaagt
781 acaatatttt atgttcaatt tctgttttaa taaaattcaa agtaatatga aaatttgcac
841 agatgggact aatagcagct catctgaggt aaagagtaac tttaatttgt ttttttgaaa
901 acccaagttt gataatgaag cctctattaa aacagtttta cctatatttt taatatatat
961 ttgtgtgttg gtgggggtgg gaagaaaaca taaaaataat attctcacct ttatcgataa
1021 gacaattcta aacaaaaatg ttcatttatg gtttcattta aaaatgtaaa actctaaaat
1081 atttgattat gtcattttag tatgtaaaat accaaaatct atttccaagg agcccacttt
1141 taaaaatctt ttcttgtttt aggaaaggtt tctaagtgag aggcagcata acactaatag
1201 cacagagtct ggggccagat atctgaagtg aaatctcagc tctgccatgt cctagctttc
1261 atgatctttg gcaaattacc tactctgttt gtgattcagt ttcatgtcta cttaaatgaa
1321 taactgtata tacttaatat ggctttgtga gaattagtaa gttaaatgta aagcactcag
1381 aaccgtgtct ggcataaggt aaataccata caagcattag ctattattag tagtattaaa
1441 gataaaattt tcactgagaa atacaaagta aaattttgga ctttatcttt ttaccaatag
1501 aacttgagat ttataatgct atatgactta ttttccaaga ttaaaagctt cattaggttg
1561 tttttggatt cagatagagc ataagcataa tcatccaagc tcctaggcta cattaggtgt
1621 gtaaagctac ctagtagttg tgccagttaa gagagaatga acaaaatctg gtgccagaaa
1681 gagcttgtgc cagggtgaat ccaagcccag aaaataatag gatttaaggg gacacagatg
1741 caatcccatt gactcaaatt ctattaattc aagagaaatc tgcttctaac tacccttctg
1801 aaagatgtaa aggagacagc ttacagatgt tactctagtt taatcagagc cacataatgc
1861 aactccagca acataaagat actagatgct gttttctgaa gaaaatttct ccacattgtt
1921 catgccaaaa acttaaaccc gaatttgtag aatttgtagt ggtgaattga aagcgcaata
1981 gatggacata tcaggggatt ggtattgtct tgacctacct ttcccactaa agagtgttag
2041 aaagatgaga ttatgtgcat aatttagggg gtggtagaat tcatggaaat ctaagtttga
2101 aaccaaaagt aatgataaac tctattcatt tgttcattta accctcattg cacatttaca
2161 aaagatttta gaaactaata aaaatatttg attccaagga tgctatgtta atgctataat
2221 gagaaagaaa tgaaatctaa ttctggctct acctacttat gtggtcaaat tctgagattt
2281 agtgtgctta tttataaagt ggagatgata cttcactgcc tacttcaaaa gatgactgtg
2341 agaagtaaat gggcctattt tggagaaaat tcttttaaat tgtaatatac catagaaata
2401 tgaaatatta tatataatat agaatcaaga ggcctgtcca aaagtcctcc caaagtatta
2461 taatctttta tttcactggg acaaacattt ttaaaatgca tcttaatgta gtgattgtag
2521 aaaagtaaaa tttaagacat atttaaaaat gtgtcttgct caaggctata ttgagagcca
2581 ctactacatg attattgtta cctagtgtaa aatgttggga ttgtgataga tggcattcaa
2641 gagttccttc tctctcaaca ttctgtgatt cttaactctt agactatcaa atattataat
2701 catagaatgt gatttttatg cttccacatt ctaactcatc tggttctaat gattttctat
2761 gcagattgga aaagtaatca gcctgcatct gtgataggca cttacgatgc agaaagtcta
2821 acattttgca aagccaaatt aagctaaaac cagtgagtca actatcactt aacgctagtc
2881 ataggtactt gagccctagt ttttccagtt ttataatgta aactctactg gtccattctt
2941 tacagtgaca ttgagaacag agagaatggt aaaaactaca tactgctact ccaaataaaa
3001 taaattggaa attaatttct gattctgacc tctatgtaaa ctgagctgat gataattatt
3061 attctaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga
3121 ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag
3181 caatatcaac gtaatagttc tggaactaaa ggtaaggcat tactttattt gctctcctgg
3241 aaataaaaaa aaaaaagtca gggggaaaag taccacattt taaagtgaca taacattttt
3301 ggtatttgta aagtacccat gcatgtaatt agcctacatt ttaagtacac tgtgaacatg
3361 aatcatttct aatgttaaat gattaactgg ggagtataag ctactgagtt tgcacctacc
3421 atctactaat ggacaagcct catcccaaac tccatcacct ttcatattaa cacaaaactg
3481 ggagtgagag aaggtactga gttgagtttc acagaaagca ggcagatttt attatatatt
3541 tttcgattct tcagatcatt tactgaaata gccaatactg attacctgaa aggcttttca
3601 aatggtgttt ccttatcatt tgatggaagg actacccata agagatttgt cttaaaaaaa
3661 aaaactggag ccattaaaat ggccagtgga ctaaacaaac aacaatcttt ttagaggcaa
3721 tccccacttt cagaatctta agtattttta aatgcacagg aagcataaaa tatgcaaggg
3781 actcaggtga tgtaaaagag attcactttt gtctttttat atcccgtctc ctaaggtata
3841 aaattcatga gttaataggt atcctaaata agcagcataa gtatagtagt aaaagacatt
3901 cctaaaagta actccagttg tgtccaaatg aatcacttat tagtggactg tttcagttga
3961 attaaaaaaa tacattgaga tcaatgtcat ctagacattg acagattcag ttccttatct
4021 atggcaagag ttttactcta aaataattaa catcagaaaa ctcattctta actcttgata
4081 caaatttaag acaaaaccat gcaaaaatct gaaaactgtg tttcaaaagc caaacacttt
4141 ttaaaataaa aaatcccaag atatgacaat atttaaacaa ttatgcttaa gaggatacag
4201 aacactgcaa cagtttttta aaagagaata cttatttaaa gggaacactc tatctcacct
4261 gcttttgttc ccagggtagg aatcacttca aatttgaaaa gctctctttt aaatctcact
4321 atatatcaaa atatttcctc cttagcttat caactagagg aagcgtttaa atagctcctt
4381 tcagcagaga agcctaattt ctaaaaagcc agtccacaga acaaaatttc taatgtttaa
4441 acttttaaaa gttggcaaat tcacctgcat tgatactatg atggggtagg gataggtgta
4501 agtatttaga agatgttctt cacacaaatt tatcccaaac ggaagcatgt cctagcttac
4561 tctagtgtag ttctgttctg ctttggggaa aatataagga gattcactta agtagaaaaa
4621 taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat caattcatac
4681 atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt ttatttcaca
4741 tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg cacccaattt
4801 agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc tcagcttctg
4861 tgttactatc atttggtatc ataacaaaat atgtaatttt ggcattcatt ttgatcattt
4921 caagaaaatg cgaataatta atatgtttgg taagcttgaa aataaaggca acaggcctat
4981 aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt aaaaaattaa
5041 catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc
5101 aaccattgta gaatttctga acagatggat taccttttgt caaagcatca tctcaacact
5161 gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt atttaaatat
5221 ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact attattctta
5281 atcttaaaac tataaatatg gatcttttat gattcttttt gtgccctagg ggctctaaaa
5341 tggtttcact tatttatccc aaaatattta ttattatgtt gaatgttaaa tatagtgcta
5401 tgtagattgg ttagtaaaac tatttaataa atttgataaa tataaacaag cctggatatt
5461 tgttattttg gaaacagcac agagtaagca tttaaatatt tcttagttac ttgtgtgaac
5521 tgtaggatgg ttaaaatgct tacaaaagtc actctttctc tgaagaaata tgtagaacag
5581 agatgtagac ttctcaaaag cccttgcttt gtcctttcaa gggctgatca gacccttagt
5641 tctggcatct cttagcagat tatattttcc ttcttcttaa aatgccaaac acaaacactc
5701 ttgaaactct tcatagattt ggtgtggcta tgaattc
//