LOCUS AAD48509.1 153 aa PRT HUM 11-AUG-1999 DEFINITION Homo sapiens interleukin 2 precursor protein. ACCESSION J00264-1 PROTEIN_ID AAD48509.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443) AUTHORS Taniguchi,T., Matsui,H., Fujita,T., Takaoka,C., Kashima,N., Yoshimoto,R. and Hamuro,J. TITLE Structure and expression of a cloned cDNA for human interleukin-2 JOURNAL Nature 302 (5906), 305-310 (1983) PUBMED 6403867 REFERENCE 2 (bases 371 to 624; 715 to 774; 3068 to 3211; 5057 to 5439) AUTHORS Devos,R., Plaetinck,G., Cheroutre,H., Simons,G., Degrave,W., Tavernier,J., Remaut,E. and Fiers,W. TITLE Molecular cloning of human interleukin 2 cDNA and its expression in E. coli JOURNAL Nucleic Acids Res. 11 (13), 4307-4323 (1983) PUBMED 6306584 REFERENCE 3 (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443) AUTHORS Maeda,S., Nishino,N., Obaru,K., Mita,S., Nomiyama,H., Shimada,K., Fujimoto,K., Teranishi,T., Hirano,T. and Onoue,K. TITLE Cloning of interleukin 2 mRNAs from human tonsils JOURNAL Biochem. Biophys. Res. Commun. 115 (3), 1040-1047 (1983) PUBMED 6312994 REFERENCE 4 (bases 282 to 480) AUTHORS Mita,S., Maeda,S., Obaru,K., Nishino,N., Shimada,K., Hirano,T., Onoue,K., Ogawa,T. and Ogawa,H. TITLE Isolation and characterization of a human interleukin 2 gene JOURNAL Biochem. Biophys. Res. Commun. 117 (1), 114-121 (1983) PUBMED 6318743 REFERENCE 5 (bases 1 to 5737) AUTHORS Fujita,T., Takaoka,C., Matsui,H. and Taniguchi,T. TITLE Structure of the human interleukin 2 gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (24), 7437-7441 (1983) PUBMED 6324170 REFERENCE 6 (bases 436 to 624; 715 to 774; 3068 to 3211; 5057 to 5443) AUTHORS Clark,S.C., Arya,S.K., Wong-Staal,F., Matsumoto-Kobayashi,M., Kay,R.M., Kaufman,R.J., Brown,E.L., Shoemaker,C., Copeland,T., Oroszlan,S., Smith,K., Sarngadharan,M.G., Lindner,S.G. and Gallo,R.C. TITLE Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (8), 2543-2547 (1984) PUBMED 6201860 REFERENCE 7 (sites) AUTHORS Cullen,B.R. TITLE Expression of a cloned human interleukin-2 cDNA is enhanced by the substitution of a heterologous mRNA leader region JOURNAL DNA 7 (9), 645-650 (1988) PUBMED 3265909 FEATURES Qualifiers source /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="4" /map="4q26-q27" /note="sequence shown is presented in citation 5" protein /gene="IL2" /function="involved in immune response" /note="T-cell growth factor; lymphokine" intron_pos 50:0 (1/3) intron_pos 70:0 (2/3) intron_pos 118:0 (3/3) BEGIN 1 MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 61 TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE 121 TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT //