LOCUS       AAD48509.1               153 aa    PRT              HUM 11-AUG-1999
DEFINITION  Homo sapiens interleukin 2 precursor protein.
ACCESSION   J00264-1
PROTEIN_ID  AAD48509.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
  AUTHORS   Taniguchi,T., Matsui,H., Fujita,T., Takaoka,C., Kashima,N.,
            Yoshimoto,R. and Hamuro,J.
  TITLE     Structure and expression of a cloned cDNA for human interleukin-2
  JOURNAL   Nature 302 (5906), 305-310 (1983)
   PUBMED   6403867
REFERENCE   2  (bases 371 to 624; 715 to 774; 3068 to 3211; 5057 to 5439)
  AUTHORS   Devos,R., Plaetinck,G., Cheroutre,H., Simons,G., Degrave,W.,
            Tavernier,J., Remaut,E. and Fiers,W.
  TITLE     Molecular cloning of human interleukin 2 cDNA and its expression in
            E. coli
  JOURNAL   Nucleic Acids Res. 11 (13), 4307-4323 (1983)
   PUBMED   6306584
REFERENCE   3  (bases 431 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
  AUTHORS   Maeda,S., Nishino,N., Obaru,K., Mita,S., Nomiyama,H., Shimada,K.,
            Fujimoto,K., Teranishi,T., Hirano,T. and Onoue,K.
  TITLE     Cloning of interleukin 2 mRNAs from human tonsils
  JOURNAL   Biochem. Biophys. Res. Commun. 115 (3), 1040-1047 (1983)
   PUBMED   6312994
REFERENCE   4  (bases 282 to 480)
  AUTHORS   Mita,S., Maeda,S., Obaru,K., Nishino,N., Shimada,K., Hirano,T.,
            Onoue,K., Ogawa,T. and Ogawa,H.
  TITLE     Isolation and characterization of a human interleukin 2 gene
  JOURNAL   Biochem. Biophys. Res. Commun. 117 (1), 114-121 (1983)
   PUBMED   6318743
REFERENCE   5  (bases 1 to 5737)
  AUTHORS   Fujita,T., Takaoka,C., Matsui,H. and Taniguchi,T.
  TITLE     Structure of the human interleukin 2 gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 80 (24), 7437-7441 (1983)
   PUBMED   6324170
REFERENCE   6  (bases 436 to 624; 715 to 774; 3068 to 3211; 5057 to 5443)
  AUTHORS   Clark,S.C., Arya,S.K., Wong-Staal,F., Matsumoto-Kobayashi,M.,
            Kay,R.M., Kaufman,R.J., Brown,E.L., Shoemaker,C., Copeland,T.,
            Oroszlan,S., Smith,K., Sarngadharan,M.G., Lindner,S.G. and
            Gallo,R.C.
  TITLE     Human T-cell growth factor: partial amino acid sequence, cDNA
            cloning, and organization and expression in normal and leukemic
            cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 81 (8), 2543-2547 (1984)
   PUBMED   6201860
REFERENCE   7  (sites)
  AUTHORS   Cullen,B.R.
  TITLE     Expression of a cloned human interleukin-2 cDNA is enhanced by the
            substitution of a heterologous mRNA leader region
  JOURNAL   DNA 7 (9), 645-650 (1988)
   PUBMED   3265909
FEATURES             Qualifiers
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26-q27"
                     /note="sequence shown is presented in citation 5"
     protein         /gene="IL2"
                     /function="involved in immune response"
                     /note="T-cell growth factor; lymphokine"
     intron_pos      50:0 (1/3)
     intron_pos      70:0 (2/3)
     intron_pos      118:0 (3/3)
BEGIN
        1 MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML
       61 TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE
      121 TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT
//