LOCUS       Z47994                   761 bp    mRNA    linear   HUM 14-NOV-2006
DEFINITION  H.sapiens FAS Del 2 mRNA.
ACCESSION   Z47994
VERSION     Z47994.1
KEYWORDS    FAS gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   2  (bases 1 to 761)
  AUTHORS   Ruberti G.
  JOURNAL   Submitted (24-JAN-1995) to the INSDC. Ruberti G., Cell Biology
            Institute, C.N.R., Immunology, viale C.Marx 43, Rome, Italy,
            I-00137
REFERENCE   3  (bases 1 to 761)
  AUTHORS   Cascino I., Fiucci G., Papoff G., Ruberti G.
  TITLE     Three functional soluble forms of the human apoptosis-inducing Fas
            molecule are produced by alternative splicing
  JOURNAL   J. Immunol. 154(6), 2706-2713(1995).
   PUBMED   7533181
FEATURES             Location/Qualifiers
     source          1..761
                     /db_xref="H-InvDB:HIT000327395"
                     /organism="Homo sapiens"
                     /chromosome="10"
                     /isolate="GF"
                     /mol_type="mRNA"
                     /clone="FAS DEL2"
                     /cell_type="PHA-activated PBMC"
                     /db_xref="taxon:9606"
     CDS             1..312
                     /standard_name="FAS/Apo 1"
                     /product="FAS soluble protein"
                     /note="Alternative splicing variant of FAS gene missing
                     exons 3 and 4. Exons 5 and 6 translated in a different
                     frame up to new stop codon at 310."
                     /db_xref="GOA:P25445"
                     /db_xref="H-InvDB:HIT000327395.13"
                     /db_xref="HGNC:HGNC:11920"
                     /db_xref="InterPro:IPR000488"
                     /db_xref="InterPro:IPR001368"
                     /db_xref="InterPro:IPR008063"
                     /db_xref="InterPro:IPR011029"
                     /db_xref="InterPro:IPR033998"
                     /db_xref="InterPro:IPR033999"
                     /db_xref="PDB:1BZI"
                     /db_xref="PDB:1DDF"
                     /db_xref="PDB:2NA7"
                     /db_xref="PDB:3EWT"
                     /db_xref="PDB:3EZQ"
                     /db_xref="PDB:3THM"
                     /db_xref="PDB:3TJE"
                     /db_xref="UniProtKB/Swiss-Prot:P25445"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAA88032.1"
                     /translation="MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTV
                     ETQNLEGLHHDGQFCHKPCPPDVNMESSRNAHSPATPSAKRKDPDLTWGGFVFFFCQF
                     H"
     exon            <1..30
                     /standard_name="FAS/Apo 1"
                     /number=1
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            31..196
                     /standard_name="FAS/Apo 1"
                     /number=2
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            197..258
                     /standard_name="FAS/Apo 1"
                     /number=5
                     /note="Translated in a different frame in this variant."
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            259..321
                     /standard_name="FAS/Apo 1"
                     /number=6
                     /note="Translated in a different frame in this variant up
                     to a new stop codon at 310."
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            322..404
                     /standard_name="FAS/Apo 1"
                     /number=7
                     /note="Not translated in this variant."
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            405..429
                     /standard_name="FAS/Apo 1"
                     /number=8
                     /note="Not translated in this variant."
                     /experiment="experimental evidence, no additional details
                     recorded"
     exon            430..>761
                     /standard_name="FAS/Apo 1"
                     /number=9
                     /note="Not translated in this variant."
                     /experiment="experimental evidence, no additional details
                     recorded"
BASE COUNT          261 a          154 c          156 g          190 t
ORIGIN      
        1 atgctgggca tctggaccct cctacctctg gttcttacgt ctgttgctag attatcgtcc
       61 aaaagtgtta atgcccaagt gactgacatc aactccaagg gattggaatt gaggaagact
      121 gttactacag ttgagactca gaacttggaa ggcctgcatc atgatggcca attctgccat
      181 aagccctgtc ctccagatgt gaacatggaa tcatcaagga atgcacactc accagcaaca
      241 ccaagtgcaa agaggaagga tccagatcta acttggggtg gctttgtctt cttcttttgc
      301 caattccact aattgtttgg gtgaagagaa aggaagtaca gaaaacatgc agaaagcaca
      361 gaaaggaaaa ccaaggttct catgaatctc caaccttaaa tcctgaaaca gtggcaataa
      421 atttatctga tgttgacttg agtaaatata tcaccactat tgctggagtc atgacactaa
      481 gtcaagttaa aggctttgtt cgaaagaatg gtgtcaatga agccaaaata gatgagatca
      541 agaatgacaa tgtccaagac acagcagaac agaaagttca actgcttcgt aattggcatc
      601 aacttcatgg aaagaaagaa gcgtatgaca cattgattaa agatctcaaa aaagccaatc
      661 tttgtactct tgcagagaaa attcagacta tcatcctcaa ggacattact agtgactcag
      721 aaaattcaaa cttcagaaat gaaatccaaa gcttggtcta g
//